Daily Papers

Research in cultural evolution aims at providing causal explanations for the change of culture over time. Over the past decades, this field has generated an important body of knowledge, using experimental, historical, and computational methods. While computational models have been very successful at generating testable hypotheses about the effects of several factors, such as population structure or transmission biases, some phenomena have so far been more complex to capture using agent-based and formal models. This is in particular the case for the effect of the transformations of social information induced by evolved cognitive mechanisms. We here propose that leveraging the capacity of Large Language Models (LLMs) to mimic human behavior may be fruitful to address this gap. On top of being an useful approximation of human cultural dynamics, multi-agents models featuring generative agents are also important to study for their own sake. Indeed, as artificial agents are bound to participate more and more to the evolution of culture, it is crucial to better understand the dynamics of machine-generated cultural evolution. We here present a framework for simulating cultural evolution in populations of LLMs, allowing the manipulation of variables known to be important in cultural evolution, such as network structure, personality, and the way social information is aggregated and transformed. The software we developed for conducting these simulations is open-source and features an intuitive user-interface, which we hope will help to build bridges between the fields of cultural evolution and generative artificial intelligence.

In hematology, computational models offer significant potential to improve diagnostic accuracy, streamline workflows, and reduce the tedious work of analyzing single cells in peripheral blood or bone marrow smears. However, clinical adoption of computational models has been hampered by the lack of generalization due to large batch effects, small dataset sizes, and poor performance in transfer learning from natural images. To address these challenges, we introduce DinoBloom, the first foundation model for single cell images in hematology, utilizing a tailored DINOv2 pipeline. Our model is built upon an extensive collection of 13 diverse, publicly available datasets of peripheral blood and bone marrow smears, the most substantial open-source cohort in hematology so far, comprising over 380,000 white blood cell images. To assess its generalization capability, we evaluate it on an external dataset with a challenging domain shift. We show that our model outperforms existing medical and non-medical vision models in (i) linear probing and k-nearest neighbor evaluations for cell-type classification on blood and bone marrow smears and (ii) weakly supervised multiple instance learning for acute myeloid leukemia subtyping by a large margin. A family of four DinoBloom models (small, base, large, and giant) can be adapted for a wide range of downstream applications, be a strong baseline for classification problems, and facilitate the assessment of batch effects in new datasets. All models are available at github.com/marrlab/DinoBloom.

Facing the current debate on whether Large Language Models (LLMs) attain near-human intelligence levels (Mitchell & Krakauer, 2023; Bubeck et al., 2023; Kosinski, 2023; Shiffrin & Mitchell, 2023; Ullman, 2023), the current study introduces a benchmark for evaluating social intelligence, one of the most distinctive aspects of human cognition. We developed a comprehensive theoretical framework for social dynamics and introduced two evaluation tasks: Inverse Reasoning (IR) and Inverse Inverse Planning (IIP). Our approach also encompassed a computational model based on recursive Bayesian inference, adept at elucidating diverse human behavioral patterns. Extensive experiments and detailed analyses revealed that humans surpassed the latest GPT models in overall performance, zero-shot learning, one-shot generalization, and adaptability to multi-modalities. Notably, GPT models demonstrated social intelligence only at the most basic order (order = 0), in stark contrast to human social intelligence (order >= 2). Further examination indicated a propensity of LLMs to rely on pattern recognition for shortcuts, casting doubt on their possession of authentic human-level social intelligence. Our codes, dataset, appendix and human data are released at https://github.com/bigai-ai/Evaluate-n-Model-Social-Intelligence.

Understanding the mechanisms underlying human attention is a fundamental challenge for both vision science and artificial intelligence. While numerous computational models of free-viewing have been proposed, less is known about the mechanisms underlying task-driven image exploration. To address this gap, we present CapMIT1003, a database of captions and click-contingent image explorations collected during captioning tasks. CapMIT1003 is based on the same stimuli from the well-known MIT1003 benchmark, for which eye-tracking data under free-viewing conditions is available, which offers a promising opportunity to concurrently study human attention under both tasks. We make this dataset publicly available to facilitate future research in this field. In addition, we introduce NevaClip, a novel zero-shot method for predicting visual scanpaths that combines contrastive language-image pretrained (CLIP) models with biologically-inspired neural visual attention (NeVA) algorithms. NevaClip simulates human scanpaths by aligning the representation of the foveated visual stimulus and the representation of the associated caption, employing gradient-driven visual exploration to generate scanpaths. Our experimental results demonstrate that NevaClip outperforms existing unsupervised computational models of human visual attention in terms of scanpath plausibility, for both captioning and free-viewing tasks. Furthermore, we show that conditioning NevaClip with incorrect or misleading captions leads to random behavior, highlighting the significant impact of caption guidance in the decision-making process. These findings contribute to a better understanding of mechanisms that guide human attention and pave the way for more sophisticated computational approaches to scanpath prediction that can integrate direct top-down guidance of downstream tasks.

Arabic poetry, with its rich linguistic features and profound cultural significance, presents a unique challenge to the Natural Language Processing (NLP) field. The complexity of its structure and context necessitates advanced computational models for accurate analysis. In this paper, we introduce AraPoemBERT, an Arabic language model pretrained exclusively on Arabic poetry text. To demonstrate the effectiveness of the proposed model, we compared AraPoemBERT with 5 different Arabic language models on various NLP tasks related to Arabic poetry. The new model outperformed all other models and achieved state-of-the-art results in most of the downstream tasks. AraPoemBERT achieved unprecedented accuracy in two out of three novel tasks: poet's gender classification (99.34\% accuracy), and poetry sub-meter classification (97.79\% accuracy). In addition, the model achieved an accuracy score in poems' rhyme classification (97.73\% accuracy) which is almost equivalent to the best score reported in this study. Moreover, the proposed model significantly outperformed previous work and other comparative models in the tasks of poems' sentiment analysis, achieving an accuracy of 78.95\%, and poetry meter classification (99.03\% accuracy), while significantly expanding the scope of these two problems. The dataset used in this study, contains more than 2.09 million verses collected from online sources, each associated with various attributes such as meter, sub-meter, poet, rhyme, and topic. The results demonstrate the effectiveness of the proposed model in understanding and analyzing Arabic poetry, achieving state-of-the-art results in several tasks and outperforming previous works and other language models included in the study. AraPoemBERT model is publicly available on https://huggingface.co/faisalq.

Being prompted to engage in reasoning has emerged as a core technique for using large language models (LLMs), deploying additional inference-time compute to improve task performance. However, as LLMs increase in both size and adoption, inference costs are correspondingly becoming increasingly burdensome. How, then, might we optimize reasoning's cost-performance tradeoff? This work introduces a novel approach based on computational models of metareasoning used in cognitive science, training LLMs to selectively use intermediate reasoning steps only when necessary. We first develop a reward function that incorporates the Value of Computation by penalizing unnecessary reasoning, then use this reward function with Expert Iteration to train the LLM. Compared to few-shot chain-of-thought prompting and STaR, our method significantly reduces inference costs (20-37\% fewer tokens generated across three models) while maintaining task performance across diverse datasets.

Establishing a unified theory of cognition has been a major goal of psychology. While there have been previous attempts to instantiate such theories by building computational models, we currently do not have one model that captures the human mind in its entirety. Here we introduce Centaur, a computational model that can predict and simulate human behavior in any experiment expressible in natural language. We derived Centaur by finetuning a state-of-the-art language model on a novel, large-scale data set called Psych-101. Psych-101 reaches an unprecedented scale, covering trial-by-trial data from over 60,000 participants performing over 10,000,000 choices in 160 experiments. Centaur not only captures the behavior of held-out participants better than existing cognitive models, but also generalizes to new cover stories, structural task modifications, and entirely new domains. Furthermore, we find that the model's internal representations become more aligned with human neural activity after finetuning. Taken together, Centaur is the first real candidate for a unified model of human cognition. We anticipate that it will have a disruptive impact on the cognitive sciences, challenging the existing paradigm for developing computational models.

Virtual cell modeling represents an emerging frontier at the intersection of artificial intelligence and biology, aiming to predict quantities such as responses to diverse perturbations quantitatively. However, autonomously building computational models for virtual cells is challenging due to the complexity of biological systems, the heterogeneity of data modalities, and the need for domain-specific expertise across multiple disciplines. Here, we introduce CellForge, an agentic system that leverages a multi-agent framework that transforms presented biological datasets and research objectives directly into optimized computational models for virtual cells. More specifically, given only raw single-cell multi-omics data and task descriptions as input, CellForge outputs both an optimized model architecture and executable code for training virtual cell models and inference. The framework integrates three core modules: Task Analysis for presented dataset characterization and relevant literature retrieval, Method Design, where specialized agents collaboratively develop optimized modeling strategies, and Experiment Execution for automated generation of code. The agents in the Design module are separated into experts with differing perspectives and a central moderator, and have to collaboratively exchange solutions until they achieve a reasonable consensus. We demonstrate CellForge's capabilities in single-cell perturbation prediction, using six diverse datasets that encompass gene knockouts, drug treatments, and cytokine stimulations across multiple modalities. CellForge consistently outperforms task-specific state-of-the-art methods. Overall, CellForge demonstrates how iterative interaction between LLM agents with differing perspectives provides better solutions than directly addressing a modeling challenge. Our code is publicly available at https://github.com/gersteinlab/CellForge.

Newly-developed large language models (LLM) -- because of how they are trained and designed -- are implicit computational models of humans -- a homo silicus. These models can be used the same way economists use homo economicus: they can be given endowments, information, preferences, and so on and then their behavior can be explored in scenarios via simulation. I demonstrate this approach using OpenAI's GPT3 with experiments derived from Charness and Rabin (2002), Kahneman, Knetsch and Thaler (1986) and Samuelson and Zeckhauser (1988). The findings are qualitatively similar to the original results, but it is also trivially easy to try variations that offer fresh insights. Departing from the traditional laboratory paradigm, I also create a hiring scenario where an employer faces applicants that differ in experience and wage ask and then analyze how a minimum wage affects realized wages and the extent of labor-labor substitution.

This study reveals an unexpected parallel between instructible vision-language models (VLMs) and human cognitive disorders, specifically constructive apraxia. We tested 25 state-of-the-art VLMs, including GPT-4 Vision, DALL-E 3, and Midjourney v5, on their ability to generate images of the Ponzo illusion, a task that requires basic spatial reasoning and is often used in clinical assessments of constructive apraxia. Remarkably, 24 out of 25 models failed to correctly render two horizontal lines against a perspective background, mirroring the deficits seen in patients with parietal lobe damage. The models consistently misinterpreted spatial instructions, producing tilted or misaligned lines that followed the perspective of the background rather than remaining horizontal. This behavior is strikingly similar to how apraxia patients struggle to copy or construct simple figures despite intact visual perception and motor skills. Our findings suggest that current VLMs, despite their advanced capabilities in other domains, lack fundamental spatial reasoning abilities akin to those impaired in constructive apraxia. This limitation in AI systems provides a novel computational model for studying spatial cognition deficits and highlights a critical area for improvement in VLM architecture and training methodologies.

By combining voice and touch interactions, multimodal interfaces can surpass the efficiency of either modality alone. Traditional multimodal frameworks require laborious developer work to support rich multimodal commands where the user's multimodal command involves possibly exponential combinations of actions/function invocations. This paper presents ReactGenie, a programming framework that better separates multimodal input from the computational model to enable developers to create efficient and capable multimodal interfaces with ease. ReactGenie translates multimodal user commands into NLPL (Natural Language Programming Language), a programming language we created, using a neural semantic parser based on large-language models. The ReactGenie runtime interprets the parsed NLPL and composes primitives in the computational model to implement complex user commands. As a result, ReactGenie allows easy implementation and unprecedented richness in commands for end-users of multimodal apps. Our evaluation showed that 12 developers can learn and build a nontrivial ReactGenie application in under 2.5 hours on average. In addition, compared with a traditional GUI, end-users can complete tasks faster and with less task load using ReactGenie apps.

Data visualizations are powerful tools for communicating patterns in quantitative data. Yet understanding any data visualization is no small feat -- succeeding requires jointly making sense of visual, numerical, and linguistic inputs arranged in a conventionalized format one has previously learned to parse. Recently developed vision-language models are, in principle, promising candidates for developing computational models of these cognitive operations. However, it is currently unclear to what degree these models emulate human behavior on tasks that involve reasoning about data visualizations. This gap reflects limitations in prior work that has evaluated data visualization understanding in artificial systems using measures that differ from those typically used to assess these abilities in humans. Here we evaluated eight vision-language models on six data visualization literacy assessments designed for humans and compared model responses to those of human participants. We found that these models performed worse than human participants on average, and this performance gap persisted even when using relatively lenient criteria to assess model performance. Moreover, while relative performance across items was somewhat correlated between models and humans, all models produced patterns of errors that were reliably distinct from those produced by human participants. Taken together, these findings suggest significant opportunities for further development of artificial systems that might serve as useful models of how humans reason about data visualizations. All code and data needed to reproduce these results are available at: https://osf.io/e25mu/?view_only=399daff5a14d4b16b09473cf19043f18.

Vision-Language Models (VLMs) are trained on vast amounts of data captured by humans emulating our understanding of the world. However, known as visual illusions, human's perception of reality isn't always faithful to the physical world. This raises a key question: do VLMs have the similar kind of illusions as humans do, or do they faithfully learn to represent reality? To investigate this question, we build a dataset containing five types of visual illusions and formulate four tasks to examine visual illusions in state-of-the-art VLMs. Our findings have shown that although the overall alignment is low, larger models are closer to human perception and more susceptible to visual illusions. Our dataset and initial findings will promote a better understanding of visual illusions in humans and machines and provide a stepping stone for future computational models that can better align humans and machines in perceiving and communicating about the shared visual world. The code and data are available at https://github.com/vl-illusion/dataset.

Tokenization is a fundamental step in natural language processing, breaking text into units that computational models can process. While learned subword tokenizers have become the de-facto standard, they present challenges such as large vocabularies, limited adaptability to new domains or languages, and sensitivity to spelling errors and variations. To overcome these limitations, we investigate a hierarchical architecture for autoregressive language modelling that combines character-level and word-level processing. It employs a lightweight character-level encoder to convert character sequences into word embeddings, which are then processed by a word-level backbone model and decoded back into characters via a compact character-level decoder. This method retains the sequence compression benefits of word-level tokenization without relying on a rigid, predefined vocabulary. We demonstrate, at scales up to 7 billion parameters, that hierarchical transformers match the downstream task performance of subword-tokenizer-based models while exhibiting significantly greater robustness to input perturbations. Additionally, during continued pretraining on an out-of-domain language, our model trains almost twice as fast, achieves superior performance on the target language, and retains more of its previously learned knowledge. Hierarchical transformers pave the way for NLP systems that are more robust, flexible, and generalizable across languages and domains.

Text-based personality prediction by computational models is an emerging field with the potential to significantly improve on key weaknesses of survey-based personality assessment. We investigate 3848 profiles from Twitter with self-labeled Myers-Briggs personality traits (MBTI) - a framework closely related to the Five Factor Model of personality - to better understand how text-based digital traces from social engagement online can be used to predict user personality traits. We leverage BERT, a state-of-the-art NLP architecture based on deep learning, to analyze various sources of text that hold most predictive power for our task. We find that biographies, statuses, and liked tweets contain significant predictive power for all dimensions of the MBTI system. We discuss our findings and their implications for the validity of the MBTI and the lexical hypothesis, a foundational theory underlying the Five Factor Model that links language use and behavior. Our results hold optimistic implications for personality psychologists, computational linguists, and other social scientists aiming to predict personality from observational text data and explore the links between language and core behavioral traits.

For a given scene, humans can easily reason for the locations and pose to place objects. Designing a computational model to reason about these affordances poses a significant challenge, mirroring the intuitive reasoning abilities of humans. This work tackles the problem of realistic human insertion in a given background scene termed as Semantic Human Placement. This task is extremely challenging given the diverse backgrounds, scale, and pose of the generated person and, finally, the identity preservation of the person. We divide the problem into the following two stages i) learning semantic masks using text guidance for localizing regions in the image to place humans and ii) subject-conditioned inpainting to place a given subject adhering to the scene affordance within the semantic masks. For learning semantic masks, we leverage rich object-scene priors learned from the text-to-image generative models and optimize a novel parameterization of the semantic mask, eliminating the need for large-scale training. To the best of our knowledge, we are the first ones to provide an effective solution for realistic human placements in diverse real-world scenes. The proposed method can generate highly realistic scene compositions while preserving the background and subject identity. Further, we present results for several downstream tasks - scene hallucination from a single or multiple generated persons and text-based attribute editing. With extensive comparisons against strong baselines, we show the superiority of our method in realistic human placement.

Language models provide a key framework for studying linguistic theories based on prediction, but phonological analysis using large language models (LLMs) is difficult; there are few phonological benchmarks beyond English and the standard input representation used in LLMs (subwords of graphemes) is not suitable for analyzing the representation of phonemes. In this work, we demonstrate how word segmentation can be used as a phonological probing task, allowing us to study the representations learned by phoneme-based language models trained on child-directed speech across 31 languages. Following computational models of word segmentation, we present unsupervised methods for extracting word boundaries from a trained model using the observation that prediction-error peaks at the start of words. We also use linear probes to identify that these models implicitly track word boundaries, even when they do not appear in training. This cross-lingual work corroborates statistical learning theories of acquisition and empirically motivates new methods for training subword tokenizers.

Every day, humans perceive objects and communicate these perceptions through various channels. In this paper, we present a computational model designed to track and simulate the perception of objects, as well as their representations as conveyed in communication. We delineate two fundamental components of our internal representation, termed "observed" and "seen", which we correlate with established concepts in computer vision, namely encoding and decoding. These components are integrated into semiotic networks, which simulate perceptual inference of object perception and human communication. Our model of object perception by a person allows us to define object perception by {\em a network}. We demonstrate this with an example of an image baseline classifier by constructing a new network that includes the baseline classifier and an additional layer. This layer produces the images "perceived" by the entire network, transforming it into a perceptualized image classifier. This facilitates visualization of the acquired network. Within our network, the image representations become more efficient for classification tasks when they are assembled and randomized. In our experiments, the perceptualized network outperformed the baseline classifier on MNIST training databases consisting of a restricted number of images. Our model is not limited to persons and can be applied to any system featuring a loop involving the processing from "internal" to "external" representations.

Visual search is a ubiquitous and often challenging daily task, exemplified by looking for the car keys at home or a friend in a crowd. An intriguing property of some classical search tasks is an asymmetry such that finding a target A among distractors B can be easier than finding B among A. To elucidate the mechanisms responsible for asymmetry in visual search, we propose a computational model that takes a target and a search image as inputs and produces a sequence of eye movements until the target is found. The model integrates eccentricity-dependent visual recognition with target-dependent top-down cues. We compared the model against human behavior in six paradigmatic search tasks that show asymmetry in humans. Without prior exposure to the stimuli or task-specific training, the model provides a plausible mechanism for search asymmetry. We hypothesized that the polarity of search asymmetry arises from experience with the natural environment. We tested this hypothesis by training the model on augmented versions of ImageNet where the biases of natural images were either removed or reversed. The polarity of search asymmetry disappeared or was altered depending on the training protocol. This study highlights how classical perceptual properties can emerge in neural network models, without the need for task-specific training, but rather as a consequence of the statistical properties of the developmental diet fed to the model. All source code and data are publicly available at https://github.com/kreimanlab/VisualSearchAsymmetry.

Recognizing the flow of time in a story is a crucial aspect of understanding it. Prior work related to time has primarily focused on identifying temporal expressions or relative sequencing of events, but here we propose computationally annotating each line of a book with wall clock times, even in the absence of explicit time-descriptive phrases. To do so, we construct a data set of hourly time phrases from 52,183 fictional books. We then construct a time-of-day classification model that achieves an average error of 2.27 hours. Furthermore, we show that by analyzing a book in whole using dynamic programming of breakpoints, we can roughly partition a book into segments that each correspond to a particular time-of-day. This approach improves upon baselines by over two hours. Finally, we apply our model to a corpus of literature categorized by different periods in history, to show interesting trends of hourly activity throughout the past. Among several observations we find that the fraction of events taking place past 10 P.M jumps past 1880 - coincident with the advent of the electric light bulb and city lights.

We study the emergence of agency from scratch by using Large Language Model (LLM)-based agents. In previous studies of LLM-based agents, each agent's characteristics, including personality and memory, have traditionally been predefined. We focused on how individuality, such as behavior, personality, and memory, can be differentiated from an undifferentiated state. The present LLM agents engage in cooperative communication within a group simulation, exchanging context-based messages in natural language. By analyzing this multi-agent simulation, we report valuable new insights into how social norms, cooperation, and personality traits can emerge spontaneously. This paper demonstrates that autonomously interacting LLM-powered agents generate hallucinations and hashtags to sustain communication, which, in turn, increases the diversity of words within their interactions. Each agent's emotions shift through communication, and as they form communities, the personalities of the agents emerge and evolve accordingly. This computational modeling approach and its findings will provide a new method for analyzing collective artificial intelligence.

We present a computational model for a symbol emergence system that enables the emergence of lexical knowledge with combinatoriality among agents through a Metropolis-Hastings naming game and cross-situational learning. Many computational models have been proposed to investigate combinatoriality in emergent communication and symbol emergence in cognitive and developmental robotics. However, existing models do not sufficiently address category formation based on sensory-motor information and semiotic communication through the exchange of word sequences within a single integrated model. Our proposed model facilitates the emergence of lexical knowledge with combinatoriality by performing category formation using multimodal sensory-motor information and enabling semiotic communication through the exchange of word sequences among agents in a unified model. Furthermore, the model enables an agent to predict sensory-motor information for unobserved situations by combining words associated with categories in each modality. We conducted two experiments with two humanoid robots in a simulated environment to evaluate our proposed model. The results demonstrated that the agents can acquire lexical knowledge with combinatoriality through interpersonal cross-situational learning based on the Metropolis-Hastings naming game and cross-situational learning. Furthermore, our results indicate that the lexical knowledge developed using our proposed model exhibits generalization performance for novel situations through interpersonal cross-modal inference.

Recent dynamic tokenisation methods operate directly on bytes and pool their latent representations into patches. This bears similarities to computational models of word segmentation that determine lexical boundaries using spikes in an autoregressive model's prediction error. Inspired by this connection, we explore whether grouping predictable bytes - rather than pooling their representations - can yield a useful fixed subword vocabulary. We propose a new information-driven subword tokeniser, ByteSpan, that uses an external byte-level LM during training to identify contiguous predictable byte sequences and group them into subwords. Experiments show that ByteSpan yields efficient vocabularies with higher morphological alignment scores than BPE for English. Multilingual experiments show similar compression and R\'enyi efficiency for 25 languages.

With the rapid advancements in multimodal generative technology, Affective Computing research has provoked discussion about the potential consequences of AI systems equipped with emotional intelligence. Affective Computing involves the design, evaluation, and implementation of Emotion AI and related technologies aimed at improving people's lives. Designing a computational model in affective computing requires vast amounts of multimodal data, including RGB images, video, audio, text, and physiological signals. Moreover, Affective Computing research is deeply engaged with ethical considerations at various stages-from training emotionally intelligent models on large-scale human data to deploying these models in specific applications. Fundamentally, the development of any AI system must prioritize its impact on humans, aiming to augment and enhance human abilities rather than replace them, while drawing inspiration from human intelligence in a safe and responsible manner. The MRAC 2024 Track 1 workshop seeks to extend these principles from controlled, small-scale lab environments to real-world, large-scale contexts, emphasizing responsible development. The workshop also aims to highlight the potential implications of generative technology, along with the ethical consequences of its use, to researchers and industry professionals. To the best of our knowledge, this is the first workshop series to comprehensively address the full spectrum of multimodal, generative affective computing from a responsible AI perspective, and this is the second iteration of this workshop. Webpage: https://react-ws.github.io/2024/

What is the computational model behind a Transformer? Where recurrent neural networks have direct parallels in finite state machines, allowing clear discussion and thought around architecture variants or trained models, Transformers have no such familiar parallel. In this paper we aim to change that, proposing a computational model for the transformer-encoder in the form of a programming language. We map the basic components of a transformer-encoder -- attention and feed-forward computation -- into simple primitives, around which we form a programming language: the Restricted Access Sequence Processing Language (RASP). We show how RASP can be used to program solutions to tasks that could conceivably be learned by a Transformer, and how a Transformer can be trained to mimic a RASP solution. In particular, we provide RASP programs for histograms, sorting, and Dyck-languages. We further use our model to relate their difficulty in terms of the number of required layers and attention heads: analyzing a RASP program implies a maximum number of heads and layers necessary to encode a task in a transformer. Finally, we see how insights gained from our abstraction might be used to explain phenomena seen in recent works.

Bone degradation, especially for astronauts in microgravity conditions, is crucial for space exploration missions since the lower applied external forces accelerate the diminution in bone stiffness and strength substantially. Although existing computational models help us understand this phenomenon and possibly restrict its effect in the future, they are time-consuming to simulate the changes in the bones, not just the bone microstructures, of each individual in detail. In this study, a robust yet fast computational method to predict and visualize bone degradation has been developed. Our deep-learning method, TransVNet, can take in different 3D voxelized images and predict their evolution throughout months utilizing a hybrid 3D-CNN-VisionTransformer autoencoder architecture. Because of limited available experimental data and challenges of obtaining new samples, a digital twin dataset of diverse and initial bone-like microstructures was generated to train our TransVNet on the evolution of the 3D images through a previously developed degradation model for microgravity.

Large Language Models (LLMs) are computational models capable of performing complex natural language processing tasks. Leveraging these capabilities, LLMs hold the potential to transform the entire hardware design stack, with predictions suggesting that front-end and back-end tasks could be fully automated in the near future. Currently, LLMs show great promise in streamlining Register Transfer Level (RTL) generation, enhancing efficiency, and accelerating innovation. However, their probabilistic nature makes them prone to inaccuracies - a significant drawback in RTL design, where reliability and precision are essential. To address these challenges, this paper introduces AIvril, an advanced framework designed to enhance the accuracy and reliability of RTL-aware LLMs. AIvril employs a multi-agent, LLM-agnostic system for automatic syntax correction and functional verification, significantly reducing - and in many cases, completely eliminating - instances of erroneous code generation. Experimental results conducted on the VerilogEval-Human dataset show that our framework improves code quality by nearly 2x when compared to previous works, while achieving an 88.46% success rate in meeting verification objectives. This represents a critical step toward automating and optimizing hardware design workflows, offering a more dependable methodology for AI-driven RTL design.

Instructional videos provide detailed how-to guides for various tasks, with viewers often posing questions regarding the content. Addressing these questions is vital for comprehending the content, yet receiving immediate answers is difficult. While numerous computational models have been developed for Video Question Answering (Video QA) tasks, they are primarily trained on questions generated based on video content, aiming to produce answers from within the content. However, in real-world situations, users may pose questions that go beyond the video's informational boundaries, highlighting the necessity to determine if a video can provide the answer. Discerning whether a question can be answered by video content is challenging due to the multi-modal nature of videos, where visual and verbal information are intertwined. To bridge this gap, we present the YTCommentQA dataset, which contains naturally-generated questions from YouTube, categorized by their answerability and required modality to answer -- visual, script, or both. Experiments with answerability classification tasks demonstrate the complexity of YTCommentQA and emphasize the need to comprehend the combined role of visual and script information in video reasoning. The dataset is available at https://github.com/lgresearch/YTCommentQA.

Readability assessment is the task of evaluating the reading difficulty of a given piece of text. Although research on computational approaches to readability assessment is now two decades old, there is not much work on synthesizing this research. This article is a brief survey of contemporary research on developing computational models for readability assessment. We identify the common approaches, discuss their shortcomings, and identify some challenges for the future. Where possible, we also connect computational research with insights from related work in other disciplines such as education and psychology.

The field of machine learning has taken a dramatic twist in recent times, with the rise of the Artificial Neural Network (ANN). These biologically inspired computational models are able to far exceed the performance of previous forms of artificial intelligence in common machine learning tasks. One of the most impressive forms of ANN architecture is that of the Convolutional Neural Network (CNN). CNNs are primarily used to solve difficult image-driven pattern recognition tasks and with their precise yet simple architecture, offers a simplified method of getting started with ANNs. This document provides a brief introduction to CNNs, discussing recently published papers and newly formed techniques in developing these brilliantly fantastic image recognition models. This introduction assumes you are familiar with the fundamentals of ANNs and machine learning.

The model-based estimation of 3D animal pose and shape from images enables computational modeling of animal behavior. Training models for this purpose requires large amounts of labeled image data with precise pose and shape annotations. However, capturing such data requires the use of multi-view or marker-based motion-capture systems, which are impractical to adapt to wild animals in situ and impossible to scale across a comprehensive set of animal species. Some have attempted to address the challenge of procuring training data by pseudo-labeling individual real-world images through manual 2D annotation, followed by 3D-parameter optimization to those labels. While this approach may produce silhouette-aligned samples, the obtained pose and shape parameters are often implausible due to the ill-posed nature of the monocular fitting problem. Sidestepping real-world ambiguity, others have designed complex synthetic-data-generation pipelines leveraging video-game engines and collections of artist-designed 3D assets. Such engines yield perfect ground-truth annotations but are often lacking in visual realism and require considerable manual effort to adapt to new species or environments. Motivated by these shortcomings, we propose an alternative approach to synthetic-data generation: rendering with a conditional image-generation model. We introduce a pipeline that samples a diverse set of poses and shapes for a variety of mammalian quadrupeds and generates realistic images with corresponding ground-truth pose and shape parameters. To demonstrate the scalability of our approach, we introduce GenZoo, a synthetic dataset containing one million images of distinct subjects. We train a 3D pose and shape regressor on GenZoo, which achieves state-of-the-art performance on a real-world animal pose and shape estimation benchmark, despite being trained solely on synthetic data. https://genzoo.is.tue.mpg.de

Computing in the life sciences has undergone a transformative evolution, from early computational models in the 1950s to the applications of artificial intelligence (AI) and machine learning (ML) seen today. This paper highlights key milestones and technological advancements through the historical development of computing in the life sciences. The discussion includes the inception of computational models for biological processes, the advent of bioinformatics tools, and the integration of AI/ML in modern life sciences research. Attention is given to AI-enabled tools used in the life sciences, such as scientific large language models and bio-AI tools, examining their capabilities, limitations, and impact to biological risk. This paper seeks to clarify and establish essential terminology and concepts to ensure informed decision-making and effective communication across disciplines.

The efficient coding hypothesis proposes that the response properties of sensory systems are adapted to the statistics of their inputs such that they capture maximal information about the environment, subject to biological constraints. While elegant, information theoretic properties are notoriously difficult to measure in practical settings or to employ as objective functions in optimization. This difficulty has necessitated that computational models designed to test the hypothesis employ several different information metrics ranging from approximations and lower bounds to proxy measures like reconstruction error. Recent theoretical advances have characterized a novel and ecologically relevant efficiency metric, the manifold capacity, which is the number of object categories that may be represented in a linearly separable fashion. However, calculating manifold capacity is a computationally intensive iterative procedure that until now has precluded its use as an objective. Here we outline the simplifying assumptions that allow manifold capacity to be optimized directly, yielding Maximum Manifold Capacity Representations (MMCR). The resulting method is closely related to and inspired by advances in the field of self supervised learning (SSL), and we demonstrate that MMCRs are competitive with state of the art results on standard SSL benchmarks. Empirical analyses reveal differences between MMCRs and representations learned by other SSL frameworks, and suggest a mechanism by which manifold compression gives rise to class separability. Finally we evaluate a set of SSL methods on a suite of neural predictivity benchmarks, and find MMCRs are higly competitive as models of the ventral stream.

Protolanguage reconstruction is central to historical linguistics. The comparative method, one of the most influential theoretical and methodological frameworks in the history of the language sciences, allows linguists to infer protoforms (reconstructed ancestral words) from their reflexes (related modern words) based on the assumption of regular sound change. Not surprisingly, numerous computational linguists have attempted to operationalize comparative reconstruction through various computational models, the most successful of which have been supervised encoder-decoder models, which treat the problem of predicting protoforms given sets of reflexes as a sequence-to-sequence problem. We argue that this framework ignores one of the most important aspects of the comparative method: not only should protoforms be inferable from cognate sets (sets of related reflexes) but the reflexes should also be inferable from the protoforms. Leveraging another line of research -- reflex prediction -- we propose a system in which candidate protoforms from a reconstruction model are reranked by a reflex prediction model. We show that this more complete implementation of the comparative method allows us to surpass state-of-the-art protoform reconstruction methods on three of four Chinese and Romance datasets.

Transferring latent structure from one environment or problem to another is a mechanism by which humans and animals generalize with very little data. Inspired by cognitive and neurobiological insights, we propose graph schemas as a mechanism of abstraction for transfer learning. Graph schemas start with latent graph learning where perceptually aliased observations are disambiguated in the latent space using contextual information. Latent graph learning is also emerging as a new computational model of the hippocampus to explain map learning and transitive inference. Our insight is that a latent graph can be treated as a flexible template -- a schema -- that models concepts and behaviors, with slots that bind groups of latent nodes to the specific observations or groundings. By treating learned latent graphs (schemas) as prior knowledge, new environments can be quickly learned as compositions of schemas and their newly learned bindings. We evaluate graph schemas on two previously published challenging tasks: the memory & planning game and one-shot StreetLearn, which are designed to test rapid task solving in novel environments. Graph schemas can be learned in far fewer episodes than previous baselines, and can model and plan in a few steps in novel variations of these tasks. We also demonstrate learning, matching, and reusing graph schemas in more challenging 2D and 3D environments with extensive perceptual aliasing and size variations, and show how different schemas can be composed to model larger and more complex environments. To summarize, our main contribution is a unified system, inspired and grounded in cognitive science, that facilitates rapid transfer learning of new environments using schemas via map-induction and composition that handles perceptual aliasing.

The widespread online communication in a modern multilingual world has provided opportunities to blend more than one language (aka code-mixed language) in a single utterance. This has resulted a formidable challenge for the computational models due to the scarcity of annotated data and presence of noise. A potential solution to mitigate the data scarcity problem in low-resource setup is to leverage existing data in resource-rich language through translation. In this paper, we tackle the problem of code-mixed (Hinglish and Bengalish) to English machine translation. First, we synthetically develop HINMIX, a parallel corpus of Hinglish to English, with ~4.2M sentence pairs. Subsequently, we propose RCMT, a robust perturbation based joint-training model that learns to handle noise in the real-world code-mixed text by parameter sharing across clean and noisy words. Further, we show the adaptability of RCMT in a zero-shot setup for Bengalish to English translation. Our evaluation and comprehensive analyses qualitatively and quantitatively demonstrate the superiority of RCMT over state-of-the-art code-mixed and robust translation methods.

Central to our understanding of chemical reactivity is the principle of mass conservation, which is fundamental for ensuring physical consistency, balancing equations, and guiding reaction design. However, data-driven computational models for tasks such as reaction product prediction rarely abide by this most basic constraint. In this work, we recast the problem of reaction prediction as a problem of electron redistribution using the modern deep generative framework of flow matching. Our model, FlowER, overcomes limitations inherent in previous approaches by enforcing exact mass conservation, thereby resolving hallucinatory failure modes, recovering mechanistic reaction sequences for unseen substrate scaffolds, and generalizing effectively to out-of-domain reaction classes with extremely data-efficient fine-tuning. FlowER additionally enables estimation of thermodynamic or kinetic feasibility and manifests a degree of chemical intuition in reaction prediction tasks. This inherently interpretable framework represents a significant step in bridging the gap between predictive accuracy and mechanistic understanding in data-driven reaction outcome prediction.

Code-mixing is a well-studied linguistic phenomenon when two or more languages are mixed in text or speech. Several datasets have been build with the goal of training computational models for code-mixing. Although it is very common to observe code-mixing with multiple languages, most datasets available contain code-mixed between only two languages. In this paper, we introduce SentMix-3L, a novel dataset for sentiment analysis containing code-mixed data between three languages Bangla, English, and Hindi. We carry out a comprehensive evaluation using SentMix-3L. We show that zero-shot prompting with GPT-3.5 outperforms all transformer-based models on SentMix-3L.

Bionic vision uses neuroprostheses to restore useful vision to people living with incurable blindness. However, a major outstanding challenge is predicting what people 'see' when they use their devices. The limited field of view of current devices necessitates head movements to scan the scene, which is difficult to simulate on a computer screen. In addition, many computational models of bionic vision lack biological realism. To address these challenges, we present VR-SPV, an open-source virtual reality toolbox for simulated prosthetic vision that uses a psychophysically validated computational model to allow sighted participants to 'see through the eyes' of a bionic eye user. To demonstrate its utility, we systematically evaluated how clinically reported visual distortions affect performance in a letter recognition and an immersive obstacle avoidance task. Our results highlight the importance of using an appropriate phosphene model when predicting visual outcomes for bionic vision.

This paper discusses a simple and explicit toy-model example of the categorical Hopfield equations introduced in previous work of Manin and the author. These describe dynamical assignments of resources to networks, where resources are objects in unital symmetric monoidal categories and assignments are realized by summing functors. The special case discussed here is based on computational resources (computational models of neurons) as objects in a category of DNNs, with a simple choice of the endofunctors defining the Hopfield equations that reproduce the usual updating of the weights in DNNs by gradient descent.

As offensive language has become a rising issue for online communities and social media platforms, researchers have been investigating ways of coping with abusive content and developing systems to detect its different types: cyberbullying, hate speech, aggression, etc. With a few notable exceptions, most research on this topic so far has dealt with English. This is mostly due to the availability of language resources for English. To address this shortcoming, this paper presents the first Greek annotated dataset for offensive language identification: the Offensive Greek Tweet Dataset (OGTD). OGTD is a manually annotated dataset containing 4,779 posts from Twitter annotated as offensive and not offensive. Along with a detailed description of the dataset, we evaluate several computational models trained and tested on this data.

We introduce MilkQA, a question answering dataset from the dairy domain dedicated to the study of consumer questions. The dataset contains 2,657 pairs of questions and answers, written in the Portuguese language and originally collected by the Brazilian Agricultural Research Corporation (Embrapa). All questions were motivated by real situations and written by thousands of authors with very different backgrounds and levels of literacy, while answers were elaborated by specialists from Embrapa's customer service. Our dataset was filtered and anonymized by three human annotators. Consumer questions are a challenging kind of question that is usually employed as a form of seeking information. Although several question answering datasets are available, most of such resources are not suitable for research on answer selection models for consumer questions. We aim to fill this gap by making MilkQA publicly available. We study the behavior of four answer selection models on MilkQA: two baseline models and two convolutional neural network archictetures. Our results show that MilkQA poses real challenges to computational models, particularly due to linguistic characteristics of its questions and to their unusually longer lengths. Only one of the experimented models gives reasonable results, at the cost of high computational requirements.

We introduce LAMBADA, a dataset to evaluate the capabilities of computational models for text understanding by means of a word prediction task. LAMBADA is a collection of narrative passages sharing the characteristic that human subjects are able to guess their last word if they are exposed to the whole passage, but not if they only see the last sentence preceding the target word. To succeed on LAMBADA, computational models cannot simply rely on local context, but must be able to keep track of information in the broader discourse. We show that LAMBADA exemplifies a wide range of linguistic phenomena, and that none of several state-of-the-art language models reaches accuracy above 1% on this novel benchmark. We thus propose LAMBADA as a challenging test set, meant to encourage the development of new models capable of genuine understanding of broad context in natural language text.

Social norms -- the unspoken commonsense rules about acceptable social behavior -- are crucial in understanding the underlying causes and intents of people's actions in narratives. For example, underlying an action such as "wanting to call cops on my neighbors" are social norms that inform our conduct, such as "It is expected that you report crimes." We present Social Chemistry, a new conceptual formalism to study people's everyday social norms and moral judgments over a rich spectrum of real life situations described in natural language. We introduce Social-Chem-101, a large-scale corpus that catalogs 292k rules-of-thumb such as "it is rude to run a blender at 5am" as the basic conceptual units. Each rule-of-thumb is further broken down with 12 different dimensions of people's judgments, including social judgments of good and bad, moral foundations, expected cultural pressure, and assumed legality, which together amount to over 4.5 million annotations of categorical labels and free-text descriptions. Comprehensive empirical results based on state-of-the-art neural models demonstrate that computational modeling of social norms is a promising research direction. Our model framework, Neural Norm Transformer, learns and generalizes Social-Chem-101 to successfully reason about previously unseen situations, generating relevant (and potentially novel) attribute-aware social rules-of-thumb.

Triggered by limitations of graph-based deep learning methods in terms of computational expressivity and model flexibility, recent years have seen a surge of interest in computational models that operate on higher-order topological domains such as hypergraphs and simplicial complexes. While the increased expressivity of these models can indeed lead to a better classification performance and a more faithful representation of the underlying system, the computational cost of these higher-order models can increase dramatically. To this end, we here explore a simplicial complex neural network learning architecture based on random walks and fast 1D convolutions (SCRaWl), in which we can adjust the increase in computational cost by varying the length and number of random walks considered while accounting for higher-order relationships. Importantly, due to the random walk-based design, the expressivity of the proposed architecture is provably incomparable to that of existing message-passing simplicial neural networks. We empirically evaluate SCRaWl on real-world datasets and show that it outperforms other simplicial neural networks.

In this paper, we consider a novel research problem: music-to-text synaesthesia. Different from the classical music tagging problem that classifies a music recording into pre-defined categories, music-to-text synaesthesia aims to generate descriptive texts from music recordings with the same sentiment for further understanding. As existing music-related datasets do not contain the semantic descriptions on music recordings, we collect a new dataset that contains 1,955 aligned pairs of classical music recordings and text descriptions. Based on this, we build a computational model to generate sentences that can describe the content of the music recording. To tackle the highly non-discriminative classical music, we design a group topology-preservation loss, which considers more samples as a group reference and preserves the relative topology among different samples. Extensive experimental results qualitatively and quantitatively demonstrate the effectiveness of our proposed model over five heuristics or pre-trained competitive methods and their variants on our collected dataset.

Automated rationale generation is an approach for real-time explanation generation whereby a computational model learns to translate an autonomous agent's internal state and action data representations into natural language. Training on human explanation data can enable agents to learn to generate human-like explanations for their behavior. In this paper, using the context of an agent that plays Frogger, we describe (a) how to collect a corpus of explanations, (b) how to train a neural rationale generator to produce different styles of rationales, and (c) how people perceive these rationales. We conducted two user studies. The first study establishes the plausibility of each type of generated rationale and situates their user perceptions along the dimensions of confidence, humanlike-ness, adequate justification, and understandability. The second study further explores user preferences between the generated rationales with regard to confidence in the autonomous agent, communicating failure and unexpected behavior. Overall, we find alignment between the intended differences in features of the generated rationales and the perceived differences by users. Moreover, context permitting, participants preferred detailed rationales to form a stable mental model of the agent's behavior.

DeepSeek-R1 has demonstrated remarkable effectiveness in incentivizing reasoning and generalization capabilities of large language models (LLMs) through reinforcement learning. Nevertheless, the potential of reasoning-induced computational modeling has not been thoroughly explored in the context of image quality assessment (IQA), a task critically dependent on visual reasoning. In this paper, we introduce VisualQuality-R1, a reasoning-induced no-reference IQA (NR-IQA) model, and we train it with reinforcement learning to rank, a learning algorithm tailored to the intrinsically relative nature of visual quality. Specifically, for a pair of images, we employ group relative policy optimization to generate multiple quality scores for each image. These estimates are then used to compute comparative probabilities of one image having higher quality than the other under the Thurstone model. Rewards for each quality estimate are defined using continuous fidelity measures rather than discretized binary labels. Extensive experiments show that the proposed VisualQuality-R1 consistently outperforms discriminative deep learning-based NR-IQA models as well as a recent reasoning-induced quality regression method. Moreover, VisualQuality-R1 is capable of generating contextually rich, human-aligned quality descriptions, and supports multi-dataset training without requiring perceptual scale realignment. These features make VisualQuality-R1 especially well-suited for reliably measuring progress in a wide range of image processing tasks like super-resolution and image generation.

There is a growing interest in the ability of neural networks to execute algorithmic tasks (e.g., arithmetic, summary statistics, and sorting). The goal of this work is to better understand the role of attention in Transformers for algorithmic execution. Its importance for algorithmic execution has been studied theoretically and empirically using parallel computational models. Notably, many parallel algorithms communicate between processors solely using positional information. Inspired by this observation, we investigate how Transformers can execute algorithms using positional attention, where attention weights depend exclusively on positional encodings. We prove that Transformers with positional attention (positional Transformers) maintain the same expressivity of parallel computational models, incurring a logarithmic depth cost relative to the input length. We analyze their in-distribution learnability and explore how parameter norms in positional attention affect sample complexity. Our results show that positional Transformers introduce a learning trade-off: while they exhibit better theoretical dependence on parameter norms, certain tasks may require more layers, which can, in turn, increase sample complexity. Finally, we empirically explore the out-of-distribution performance of positional Transformers and find that they perform well in tasks where their underlying algorithmic solution relies on positional information.

Large participatory biomedical studies, studies that recruit individuals to join a dataset, are gaining popularity and investment, especially for analysis by modern AI methods. Because they purposively recruit participants, these studies are uniquely able to address a lack of historical representation, an issue that has affected many biomedical datasets. In this work, we define representativeness as the similarity to a target population distribution of a set of attributes and our goal is to mirror the U.S. population across distributions of age, gender, race, and ethnicity. Many participatory studies recruit at several institutions, so we introduce a computational approach to adaptively allocate recruitment resources among sites to improve representativeness. In simulated recruitment of 10,000-participant cohorts from medical centers in the STAR Clinical Research Network, we show that our approach yields a more representative cohort than existing baselines. Thus, we highlight the value of computational modeling in guiding recruitment efforts.

The advancement of visual intelligence is intrinsically tethered to the availability of large-scale data. In parallel, generative Artificial Intelligence (AI) has unlocked the potential to create synthetic images that closely resemble real-world photographs. This prompts a compelling inquiry: how much visual intelligence could benefit from the advance of generative AI? This paper explores the innovative concept of harnessing these AI-generated images as new data sources, reshaping traditional modeling paradigms in visual intelligence. In contrast to real data, AI-generated data exhibit remarkable advantages, including unmatched abundance and scalability, the rapid generation of vast datasets, and the effortless simulation of edge cases. Built on the success of generative AI models, we examine the potential of their generated data in a range of applications, from training machine learning models to simulating scenarios for computational modeling, testing, and validation. We probe the technological foundations that support this groundbreaking use of generative AI, engaging in an in-depth discussion on the ethical, legal, and practical considerations that accompany this transformative paradigm shift. Through an exhaustive survey of current technologies and applications, this paper presents a comprehensive view of the synthetic era in visual intelligence. A project associated with this paper can be found at https://github.com/mwxely/AIGS .

Over the past decade, machine learning has revolutionized computers' ability to analyze text through flexible computational models. Due to their structural similarity to written language, transformer-based architectures have also shown promise as tools to make sense of a range of multi-variate sequences from protein-structures, music, electronic health records to weather-forecasts. We can also represent human lives in a way that shares this structural similarity to language. From one perspective, lives are simply sequences of events: People are born, visit the pediatrician, start school, move to a new location, get married, and so on. Here, we exploit this similarity to adapt innovations from natural language processing to examine the evolution and predictability of human lives based on detailed event sequences. We do this by drawing on arguably the most comprehensive registry data in existence, available for an entire nation of more than six million individuals across decades. Our data include information about life-events related to health, education, occupation, income, address, and working hours, recorded with day-to-day resolution. We create embeddings of life-events in a single vector space showing that this embedding space is robust and highly structured. Our models allow us to predict diverse outcomes ranging from early mortality to personality nuances, outperforming state-of-the-art models by a wide margin. Using methods for interpreting deep learning models, we probe the algorithm to understand the factors that enable our predictions. Our framework allows researchers to identify new potential mechanisms that impact life outcomes and associated possibilities for personalized interventions.

Postprandial hyperglycemia, marked by the blood glucose level exceeding the normal range after meals, is a critical indicator of progression toward type 2 diabetes in prediabetic and healthy individuals. A key metric for understanding blood glucose dynamics after eating is the postprandial area under the curve (PAUC). Predicting PAUC in advance based on a person's diet and activity level and explaining what affects postprandial blood glucose could allow an individual to adjust their lifestyle accordingly to maintain normal glucose levels. In this paper, we propose GlucoLens, an explainable machine learning approach to predict PAUC and hyperglycemia from diet, activity, and recent glucose patterns. We conducted a five-week user study with 10 full-time working individuals to develop and evaluate the computational model. Our machine learning model takes multimodal data including fasting glucose, recent glucose, recent activity, and macronutrient amounts, and provides an interpretable prediction of the postprandial glucose pattern. Our extensive analyses of the collected data revealed that the trained model achieves a normalized root mean squared error (NRMSE) of 0.123. On average, GlucoLense with a Random Forest backbone provides a 16% better result than the baseline models. Additionally, GlucoLens predicts hyperglycemia with an accuracy of 74% and recommends different options to help avoid hyperglycemia through diverse counterfactual explanations. Code available: https://github.com/ab9mamun/GlucoLens.

Autonomous edge computing in robotics, smart cities, and autonomous vehicles relies on the seamless integration of sensing, processing, and actuation for real-time decision-making in dynamic environments. At its core is the sensing-to-action loop, which iteratively aligns sensor inputs with computational models to drive adaptive control strategies. These loops can adapt to hyper-local conditions, enhancing resource efficiency and responsiveness, but also face challenges such as resource constraints, synchronization delays in multi-modal data fusion, and the risk of cascading errors in feedback loops. This article explores how proactive, context-aware sensing-to-action and action-to-sensing adaptations can enhance efficiency by dynamically adjusting sensing and computation based on task demands, such as sensing a very limited part of the environment and predicting the rest. By guiding sensing through control actions, action-to-sensing pathways can improve task relevance and resource use, but they also require robust monitoring to prevent cascading errors and maintain reliability. Multi-agent sensing-action loops further extend these capabilities through coordinated sensing and actions across distributed agents, optimizing resource use via collaboration. Additionally, neuromorphic computing, inspired by biological systems, provides an efficient framework for spike-based, event-driven processing that conserves energy, reduces latency, and supports hierarchical control--making it ideal for multi-agent optimization. This article highlights the importance of end-to-end co-design strategies that align algorithmic models with hardware and environmental dynamics and improve cross-layer interdependencies to improve throughput, precision, and adaptability for energy-efficient edge autonomy in complex environments.

The objective of personalized medicine is to tailor interventions to an individual patient's unique characteristics. A key technology for this purpose involves medical digital twins, computational models of human biology that can be personalized and dynamically updated to incorporate patient-specific data collected over time. Certain aspects of human biology, such as the immune system, are not easily captured with physics-based models, such as differential equations. Instead, they are often multi-scale, stochastic, and hybrid. This poses a challenge to existing model-based control and optimization approaches that cannot be readily applied to such models. Recent advances in automatic differentiation and neural-network control methods hold promise in addressing complex control problems. However, the application of these approaches to biomedical systems is still in its early stages. This work introduces dynamics-informed neural-network controllers as an alternative approach to control of medical digital twins. As a first use case for this method, the focus is on agent-based models, a versatile and increasingly common modeling platform in biomedicine. The effectiveness of the proposed neural-network control method is illustrated and benchmarked against other methods with two widely-used agent-based model types. The relevance of the method introduced here extends beyond medical digital twins to other complex dynamical systems.

The Abstraction and Reasoning Corpus (ARC) is a general artificial intelligence benchmark that poses difficulties for pure machine learning methods due to its requirement for fluid intelligence with a focus on reasoning and abstraction. In this work, we introduce an ARC solver, Generalized Planning for Abstract Reasoning (GPAR). It casts an ARC problem as a generalized planning (GP) problem, where a solution is formalized as a planning program with pointers. We express each ARC problem using the standard Planning Domain Definition Language (PDDL) coupled with external functions representing object-centric abstractions. We show how to scale up GP solvers via domain knowledge specific to ARC in the form of restrictions over the actions model, predicates, arguments and valid structure of planning programs. Our experiments demonstrate that GPAR outperforms the state-of-the-art solvers on the object-centric tasks of the ARC, showing the effectiveness of GP and the expressiveness of PDDL to model ARC problems. The challenges provided by the ARC benchmark motivate research to advance existing GP solvers and understand new relations with other planning computational models. Code is available at github.com/you68681/GPAR.

Communication via natural language is a crucial aspect of intelligence, and it requires computational models to learn and reason about world concepts, with varying levels of supervision. While there has been significant progress made on fully-supervised non-interactive tasks, such as question-answering and procedural text understanding, much of the community has turned to various sequential interactive tasks, as in semi-Markov text-based games, which have revealed limitations of existing approaches in terms of coherence, contextual awareness, and their ability to learn effectively from the environment. In this paper, we propose a framework for enabling improved functional grounding of agents in text-based games. Specifically, we consider two forms of domain knowledge that we inject into learning-based agents: memory of previous correct actions and affordances of relevant objects in the environment. Our framework supports three representative model classes: `pure' reinforcement learning (RL) agents, RL agents enhanced with knowledge graphs, and agents equipped with language models. Furthermore, we devise multiple injection strategies for the above domain knowledge types and agent architectures, including injection via knowledge graphs and augmentation of the existing input encoding strategies. We perform all experiments on the ScienceWorld text-based game environment, to illustrate the performance of various model configurations in challenging science-related instruction-following tasks. Our findings provide crucial insights on the development of effective natural language processing systems for interactive contexts.

Writing is, by nature, a strategic, adaptive, and more importantly, an iterative process. A crucial part of writing is editing and revising the text. Previous works on text revision have focused on defining edit intention taxonomies within a single domain or developing computational models with a single level of edit granularity, such as sentence-level edits, which differ from human's revision cycles. This work describes IteraTeR: the first large-scale, multi-domain, edit-intention annotated corpus of iteratively revised text. In particular, IteraTeR is collected based on a new framework to comprehensively model the iterative text revisions that generalize to various domains of formal writing, edit intentions, revision depths, and granularities. When we incorporate our annotated edit intentions, both generative and edit-based text revision models significantly improve automatic evaluations. Through our work, we better understand the text revision process, making vital connections between edit intentions and writing quality, enabling the creation of diverse corpora to support computational modeling of iterative text revisions.

Large language models exhibit surprising emergent generalization properties, yet also struggle on many simple reasoning tasks such as arithmetic and parity. This raises the question of if and when Transformer models can learn the true algorithm for solving a task. We study the scope of Transformers' abilities in the specific setting of length generalization on algorithmic tasks. Here, we propose a unifying framework to understand when and how Transformers can exhibit strong length generalization on a given task. Specifically, we leverage RASP (Weiss et al., 2021) -- a programming language designed for the computational model of a Transformer -- and introduce the RASP-Generalization Conjecture: Transformers tend to length generalize on a task if the task can be solved by a short RASP program which works for all input lengths. This simple conjecture remarkably captures most known instances of length generalization on algorithmic tasks. Moreover, we leverage our insights to drastically improve generalization performance on traditionally hard tasks (such as parity and addition). On the theoretical side, we give a simple example where the "min-degree-interpolator" model of learning from Abbe et al. (2023) does not correctly predict Transformers' out-of-distribution behavior, but our conjecture does. Overall, our work provides a novel perspective on the mechanisms of compositional generalization and the algorithmic capabilities of Transformers.

In this paper, we consider the problem of generalised visual object counting, with the goal of developing a computational model for counting the number of objects from arbitrary semantic categories, using arbitrary number of "exemplars", i.e. zero-shot or few-shot counting. To this end, we make the following four contributions: (1) We introduce a novel transformer-based architecture for generalised visual object counting, termed as Counting Transformer (CounTR), which explicitly capture the similarity between image patches or with given "exemplars" with the attention mechanism;(2) We adopt a two-stage training regime, that first pre-trains the model with self-supervised learning, and followed by supervised fine-tuning;(3) We propose a simple, scalable pipeline for synthesizing training images with a large number of instances or that from different semantic categories, explicitly forcing the model to make use of the given "exemplars";(4) We conduct thorough ablation studies on the large-scale counting benchmark, e.g. FSC-147, and demonstrate state-of-the-art performance on both zero and few-shot settings.

Energy consumption in solving computational problems has been gaining growing attention as a part of the performance measures of computers. Quantum computation is known to offer advantages over classical computation in terms of various computational resources; however, its advantage in energy consumption has been challenging to analyze due to the lack of a theoretical foundation to relate the physical notion of energy and the computer-scientific notion of complexity for quantum computation with finite computational resources. To bridge this gap, we introduce a general framework for studying the energy consumption of quantum and classical computation based on a computational model that has been conventionally used for studying query complexity in computational complexity theory. With this framework, we derive an upper bound for the achievable energy consumption of quantum computation. We also develop techniques for proving a nonzero lower bound of energy consumption of classical computation based on the energy-conservation law and Landauer's principle. With these general bounds, we rigorously prove that quantum computation achieves an exponential energy-consumption advantage over classical computation for solving a specific computational problem, Simon's problem. Furthermore, we clarify how to demonstrate this energy-consumption advantage of quantum computation in an experimental setting. These results provide a fundamental framework and techniques to explore the physical meaning of quantum advantage in the query-complexity setting based on energy consumption, opening an alternative way to study the advantages of quantum computation.

More than a decade has passed since the development of FearNot!, an application designed to help children deal with bullying through role-playing with virtual characters. It was also the application that led to the creation of FAtiMA, an affective agent architecture for creating autonomous characters that can evoke empathic responses. In this paper, we describe FAtiMA Toolkit, a collection of open-source tools that is designed to help researchers, game developers and roboticists incorporate a computational model of emotion and decision-making in their work. The toolkit was developed with the goal of making FAtiMA more accessible, easier to incorporate into different projects and more flexible in its capabilities for human-agent interaction, based upon the experience gathered over the years across different virtual environments and human-robot interaction scenarios. As a result, this work makes several different contributions to the field of Agent-Based Architectures. More precisely, FAtiMA Toolkit's library based design allows developers to easily integrate it with other frameworks, its meta-cognitive model affords different internal reasoners and affective components and its explicit dialogue structure gives control to the author even within highly complex scenarios. To demonstrate the use of FAtiMA Toolkit, several different use cases where the toolkit was successfully applied are described and discussed.

Iterative text revision improves text quality by fixing grammatical errors, rephrasing for better readability or contextual appropriateness, or reorganizing sentence structures throughout a document. Most recent research has focused on understanding and classifying different types of edits in the iterative revision process from human-written text instead of building accurate and robust systems for iterative text revision. In this work, we aim to build an end-to-end text revision system that can iteratively generate helpful edits by explicitly detecting editable spans (where-to-edit) with their corresponding edit intents and then instructing a revision model to revise the detected edit spans. Leveraging datasets from other related text editing NLP tasks, combined with the specification of editable spans, leads our system to more accurately model the process of iterative text refinement, as evidenced by empirical results and human evaluations. Our system significantly outperforms previous baselines on our text revision tasks and other standard text revision tasks, including grammatical error correction, text simplification, sentence fusion, and style transfer. Through extensive qualitative and quantitative analysis, we make vital connections between edit intentions and writing quality, and better computational modeling of iterative text revisions.

Anxiety is a common mental health condition characterised by excessive worry, fear and apprehension about everyday situations. Even with significant progress over the past few years, predicting anxiety from electroencephalographic (EEG) signals, specifically using error-related negativity (ERN), still remains challenging. Following the PRISMA protocol, this paper systematically reviews 54 research papers on using EEG and ERN markers for anxiety detection published in the last 10 years (2013 -- 2023). Our analysis highlights the wide usage of traditional machine learning, such as support vector machines and random forests, as well as deep learning models, such as convolutional neural networks and recurrent neural networks across different data types. Our analysis reveals that the development of a robust and generic anxiety prediction method still needs to address real-world challenges, such as task-specific setup, feature selection and computational modelling. We conclude this review by offering potential future direction for non-invasive, objective anxiety diagnostics, deployed across diverse populations and anxiety sub-types.

Users of social platforms often perceive these sites as supportive spaces to post about their mental health issues. Those conversations contain important traces about individuals' health risks. Recently, researchers have exploited this online information to construct mental health detection models, which aim to identify users at risk on platforms like Twitter, Reddit or Facebook. Most of these models are centred on achieving good classification results, ignoring the explainability and interpretability of the decisions. Recent research has pointed out the importance of using clinical markers, such as the use of symptoms, to improve trust in the computational models by health professionals. In this paper, we propose using transformer-based architectures to detect and explain the appearance of depressive symptom markers in the users' writings. We present two approaches: i) train a model to classify, and another one to explain the classifier's decision separately and ii) unify the two tasks simultaneously using a single model. Additionally, for this latter manner, we also investigated the performance of recent conversational LLMs when using in-context learning. Our natural language explanations enable clinicians to interpret the models' decisions based on validated symptoms, enhancing trust in the automated process. We evaluate our approach using recent symptom-based datasets, employing both offline and expert-in-the-loop metrics to assess the quality of the explanations generated by our models. The experimental results show that it is possible to achieve good classification results while generating interpretable symptom-based explanations.

Understanding the origin(s) of life (OoL) is a fundamental challenge for science in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, mathematics and philosophy. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniques, data, and software in OoL studies. This has made communication between the disciplines relevant to the OoL extremely difficult because the interpretation of data, analyses, or standards of evidence can vary dramatically. Here, we hope to bridge this wide field of study by providing common ground via the consolidation of tools and techniques rather than positing a unifying view on how life emerges. We review the common tools and techniques that have been used significantly in OoL studies in recent years. In particular, we aim to identify which information is most relevant for comparing and integrating the results of experimental analyses into mathematical and computational models. This review aims to provide a baseline expectation and understanding of technical aspects of origins research, rather than being a primer on any particular topic. As such, it spans broadly -- from analytical chemistry to mathematical models -- and highlights areas of future work that will benefit from a multidisciplinary approach to tackling the mystery of life's origin. Ultimately, we hope to empower a new generation of OoL scientists by reviewing how they can investigate life's origin, rather than dictating how to think about the problem.

The science of fractography revolves around the correlation between topographic characteristics of the fracture surface and the mechanisms and external conditions leading to their creation. While being a topic of investigation for centuries, it has remained mostly qualitative to date. A quantitative analysis of fracture surfaces is of prime interest for both the scientific community and the industrial sector, bearing the potential for improved understanding on the mechanisms controlling the fracture process and at the same time assessing the reliability of computational models currently being used for material design. With new advances in the field of image analysis, and specifically with machine learning tools becoming more accessible and reliable, it is now feasible to automate the process of extracting meaningful information from fracture surface images. Here, we propose a method of identifying and quantifying the relative appearance of intergranular and transgranular fracture events from scanning electron microscope images. The newly proposed method is based on a convolutional neural network algorithm for semantic segmentation. The proposed method is extensively tested and evaluated against two ceramic material systems (Al_2O_3,MgAl_2O_4) and shows high prediction accuracy, despite being trained on only one material system (MgAl_2O_4). While here attention is focused on brittle fracture characteristics, the method can be easily extended to account for other fracture morphologies, such as dimples, fatigue striations, etc.

Machine learning programs, such as those performing inference, fine-tuning, and training of LLMs, are commonly delegated to untrusted compute providers. To provide correctness guarantees for the client, we propose adapting the cryptographic notion of refereed delegation to the machine learning setting. This approach enables a computationally limited client to delegate a program to multiple untrusted compute providers, with a guarantee of obtaining the correct result if at least one of them is honest. Refereed delegation of ML programs poses two technical hurdles: (1) an arbitration protocol to resolve disputes when compute providers disagree on the output, and (2) the ability to bitwise reproduce ML programs across different hardware setups, For (1), we design Verde, a dispute arbitration protocol that efficiently handles the large scale and graph-based computational model of modern ML programs. For (2), we build RepOps (Reproducible Operators), a library that eliminates hardware "non-determinism" by controlling the order of floating point operations performed on all hardware. Our implementation shows that refereed delegation achieves both strong guarantees for clients and practical overheads for compute providers.

Language models are not accurate in numerical problems. Their architecture does not allow for anything less than a probabilistic next word. This paper introduces ComputeGPT: an approach of creating a chat model able to answer computational problems through running on-demand code. ComputeGPT converts each question to relevant code, runs the code, and returns the computed answer as part of the chat. We combine this approach with a local browser-based Python interpretation and fine-tuned prompts in order to achieve state-of-the-art efficiency on numerical problems and provide a suitable front-end and safe environment for the code to be executed in.

The brain has computational capabilities that surpass those of modern systems, being able to solve complex problems efficiently in a simple way. Neuromorphic engineering aims to mimic biology in order to develop new systems capable of incorporating such capabilities. Bio-inspired learning systems continue to be a challenge that must be solved, and much work needs to be done in this regard. Among all brain regions, the hippocampus stands out as an autoassociative short-term memory with the capacity to learn and recall memories from any fragment of them. These characteristics make the hippocampus an ideal candidate for developing bio-inspired learning systems that, in addition, resemble content-addressable memories. Therefore, in this work we propose a bio-inspired spiking content-addressable memory model based on the CA3 region of the hippocampus with the ability to learn, forget and recall memories, both orthogonal and non-orthogonal, from any fragment of them. The model was implemented on the SpiNNaker hardware platform using Spiking Neural Networks. A set of experiments based on functional, stress and applicability tests were performed to demonstrate its correct functioning. This work presents the first hardware implementation of a fully-functional bio-inspired spiking hippocampal content-addressable memory model, paving the way for the development of future more complex neuromorphic systems.

Although large pre-trained models of code have delivered significant advancements in various code processing tasks, there is an impediment to the wide and fluent adoption of these powerful models in software developers' daily workflow: these large models consume hundreds of megabytes of memory and run slowly on personal devices, which causes problems in model deployment and greatly degrades the user experience. It motivates us to propose Compressor, a novel approach that can compress the pre-trained models of code into extremely small models with negligible performance sacrifice. Our proposed method formulates the design of tiny models as simplifying the pre-trained model architecture: searching for a significantly smaller model that follows an architectural design similar to the original pre-trained model. Compressor proposes a genetic algorithm (GA)-based strategy to guide the simplification process. Prior studies found that a model with higher computational cost tends to be more powerful. Inspired by this insight, the GA algorithm is designed to maximize a model's Giga floating-point operations (GFLOPs), an indicator of the model computational cost, to satisfy the constraint of the target model size. Then, we use the knowledge distillation technique to train the small model: unlabelled data is fed into the large model and the outputs are used as labels to train the small model. We evaluate Compressor with two state-of-the-art pre-trained models, i.e., CodeBERT and GraphCodeBERT, on two important tasks, i.e., vulnerability prediction and clone detection. We use our method to compress pre-trained models to a size (3 MB), which is 160times smaller than the original size. The results show that compressed CodeBERT and GraphCodeBERT are 4.31times and 4.15times faster than the original model at inference, respectively. More importantly, ...

Although Large Vision Language Models (LVLMs) have demonstrated remarkable performance in image understanding tasks, their computational efficiency remains a significant challenge, particularly on resource-constrained devices due to the high cost of processing large numbers of visual tokens. Recently, training-free visual token pruning methods have gained popularity as a low-cost solution to this issue. However, existing approaches suffer from two key limitations: semantic saliency-based strategies primarily focus on high cross-attention visual tokens, often neglecting visual diversity, whereas visual diversity-based methods risk inadvertently discarding semantically important tokens, especially under high compression ratios. In this paper, we introduce GreedyPrune, a training-free plug-and-play visual token pruning algorithm designed to jointly optimize semantic saliency and visual diversity. We formalize the token pruning process as a combinatorial optimization problem and demonstrate that greedy algorithms effectively balance computational efficiency with model accuracy. Extensive experiments validate the effectiveness of our approach, showing that GreedyPrune achieves state-of-the-art accuracy across various multimodal tasks and models while significantly reducing end-to-end inference latency.

Recent generations of language models have introduced Large Reasoning Models (LRMs) that generate detailed thinking processes before providing answers. While these models demonstrate improved performance on reasoning benchmarks, their fundamental capabilities, scaling properties, and limitations remain insufficiently understood. Current evaluations primarily focus on established math and coding benchmarks, emphasizing final answer accuracy. However, this evaluation paradigm often suffers from contamination and does not provide insights into the reasoning traces. In this work, we systematically investigate these gaps with the help of controllable puzzle environments that allow precise manipulation of complexity while maintaining consistent logical structures. This setup enables the analysis of not only final answers but also the internal reasoning traces, offering insights into how LRMs think. Through extensive experiments, we show that LRMs face a complete accuracy collapse beyond certain complexities. Moreover, they exhibit a counterintuitive scaling limit: their reasoning effort increases with problem complexity up to a point, then declines despite having remaining token budget. By comparing LRMs with their standard LLM counterparts under same inference compute, we identify three performance regimes: (1) low-complexity tasks where standard models outperform LRMs, (2) medium-complexity tasks where LRMs demonstrates advantage, and (3) high-complexity tasks where both models face complete collapse. We found that LRMs have limitations in exact computation: they fail to use explicit algorithms and reason inconsistently across scales. We also investigate the reasoning traces in more depth, studying the patterns of explored solutions and analyzing the models' computational behavior, shedding light on their strengths, limitations, and raising questions about their reasoning capabilities.

Voxel-based methods have achieved state-of-the-art performance for 3D object detection in autonomous driving. However, their significant computational and memory costs pose a challenge for their application to resource-constrained vehicles. One reason for this high resource consumption is the presence of a large number of redundant background points in Lidar point clouds, resulting in spatial redundancy in both 3D voxel and dense BEV map representations. To address this issue, we propose an adaptive inference framework called Ada3D, which focuses on exploiting the input-level spatial redundancy. Ada3D adaptively filters the redundant input, guided by a lightweight importance predictor and the unique properties of the Lidar point cloud. Additionally, we utilize the BEV features' intrinsic sparsity by introducing the Sparsity Preserving Batch Normalization. With Ada3D, we achieve 40% reduction for 3D voxels and decrease the density of 2D BEV feature maps from 100% to 20% without sacrificing accuracy. Ada3D reduces the model computational and memory cost by 5x, and achieves 1.52x/1.45x end-to-end GPU latency and 1.5x/4.5x GPU peak memory optimization for the 3D and 2D backbone respectively.

Artificial Neural Networks are computational network models inspired by signal processing in the brain. These models have dramatically improved the performance of many learning tasks, including speech and object recognition. However, today's computing hardware is inefficient at implementing neural networks, in large part because much of it was designed for von Neumann computing schemes. Significant effort has been made to develop electronic architectures tuned to implement artificial neural networks that improve upon both computational speed and energy efficiency. Here, we propose a new architecture for a fully-optical neural network that, using unique advantages of optics, promises a computational speed enhancement of at least two orders of magnitude over the state-of-the-art and three orders of magnitude in power efficiency for conventional learning tasks. We experimentally demonstrate essential parts of our architecture using a programmable nanophotonic processor.

Digital twin technology has is anticipated to transform healthcare, enabling personalized medicines and support, earlier diagnoses, simulated treatment outcomes, and optimized surgical plans. Digital twins are readily gaining traction in industries like manufacturing, supply chain logistics, and civil infrastructure. Not in patient care, however. The challenge of modeling complex diseases with multimodal patient data and the computational complexities of analyzing it have stifled digital twin adoption in the biomedical vertical. Yet, these major obstacles can potentially be handled by approaching these models in a different way. This paper proposes a novel framework for addressing the barriers to clinical twin modeling created by computational costs and modeling complexities. We propose structuring patient health data as a knowledge graph and using closed-form continuous-time liquid neural networks, for real-time analytics. By synthesizing multimodal patient data and leveraging the flexibility and efficiency of closed form continuous time networks and knowledge graph ontologies, our approach enables real time insights, personalized medicine, early diagnosis and intervention, and optimal surgical planning. This novel approach provides a comprehensive and adaptable view of patient health along with real-time analytics, paving the way for digital twin simulations and other anticipated benefits in healthcare.

In the domain of medical imaging, many supervised learning based methods for segmentation face several challenges such as high variability in annotations from multiple experts, paucity of labelled data and class imbalanced datasets. These issues may result in segmentations that lack the requisite precision for clinical analysis and can be misleadingly overconfident without associated uncertainty quantification. We propose the PULASki for biomedical image segmentation that accurately captures variability in expert annotations, even in small datasets. Our approach makes use of an improved loss function based on statistical distances in a conditional variational autoencoder structure (Probabilistic UNet), which improves learning of the conditional decoder compared to the standard cross-entropy particularly in class imbalanced problems. We analyse our method for two structurally different segmentation tasks (intracranial vessel and multiple sclerosis (MS) lesion) and compare our results to four well-established baselines in terms of quantitative metrics and qualitative output. Empirical results demonstrate the PULASKi method outperforms all baselines at the 5\% significance level. The generated segmentations are shown to be much more anatomically plausible than in the 2D case, particularly for the vessel task. Our method can also be applied to a wide range of multi-label segmentation tasks and and is useful for downstream tasks such as hemodynamic modelling (computational fluid dynamics and data assimilation), clinical decision making, and treatment planning.

The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their development demands large-scale datasets, considerable storage capacity, and substantial computational resources. Furthermore, ensuring their clinical applicability and generalizability requires rigorous validation across a broad spectrum of clinical tasks. Here, we present PathOrchestra, a versatile pathology foundation model trained via self-supervised learning on a dataset comprising 300K pathological slides from 20 tissue and organ types across multiple centers. The model was rigorously evaluated on 112 clinical tasks using a combination of 61 private and 51 public datasets. These tasks encompass digital slide preprocessing, pan-cancer classification, lesion identification, multi-cancer subtype classification, biomarker assessment, gene expression prediction, and the generation of structured reports. PathOrchestra demonstrated exceptional performance across 27,755 WSIs and 9,415,729 ROIs, achieving over 0.950 accuracy in 47 tasks, including pan-cancer classification across various organs, lymphoma subtype diagnosis, and bladder cancer screening. Notably, it is the first model to generate structured reports for high-incidence colorectal cancer and diagnostically complex lymphoma-areas that are infrequently addressed by foundational models but hold immense clinical potential. Overall, PathOrchestra exemplifies the feasibility and efficacy of a large-scale, self-supervised pathology foundation model, validated across a broad range of clinical-grade tasks. Its high accuracy and reduced reliance on extensive data annotation underline its potential for clinical integration, offering a pathway toward more efficient and high-quality medical services.

Deep learning models have shown promise in histopathology image analysis, but their opaque decision-making process poses challenges in high-risk medical scenarios. Here we introduce HIPPO, an explainable AI method that interrogates attention-based multiple instance learning (ABMIL) models in computational pathology by generating counterfactual examples through tissue patch modifications in whole slide images. Applying HIPPO to ABMIL models trained to detect breast cancer metastasis reveals that they may overlook small tumors and can be misled by non-tumor tissue, while attention mapsx2014widely used for interpretationx2014often highlight regions that do not directly influence predictions. By interpreting ABMIL models trained on a prognostic prediction task, HIPPO identified tissue areas with stronger prognostic effects than high-attention regions, which sometimes showed counterintuitive influences on risk scores. These findings demonstrate HIPPO's capacity for comprehensive model evaluation, bias detection, and quantitative hypothesis testing. HIPPO greatly expands the capabilities of explainable AI tools to assess the trustworthy and reliable development, deployment, and regulation of weakly-supervised models in computational pathology.

Most existing learning-based methods for solving imaging inverse problems can be roughly divided into two classes: iterative algorithms, such as plug-and-play and diffusion methods, that leverage pretrained denoisers, and unrolled architectures that are trained end-to-end for specific imaging problems. Iterative methods in the first class are computationally costly and often provide suboptimal reconstruction performance, whereas unrolled architectures are generally specific to a single inverse problem and require expensive training. In this work, we propose a novel non-iterative, lightweight architecture that incorporates knowledge about the forward operator (acquisition physics and noise parameters) without relying on unrolling. Our model is trained to solve a wide range of inverse problems beyond denoising, including deblurring, magnetic resonance imaging, computed tomography, inpainting, and super-resolution. The proposed model can be easily adapted to unseen inverse problems or datasets with a few fine-tuning steps (up to a few images) in a self-supervised way, without ground-truth references. Throughout a series of experiments, we demonstrate state-of-the-art performance from medical imaging to low-photon imaging and microscopy.

Large Language Models (LLMs) like ChatGPT are capable of successfully performing many language processing tasks zero-shot (without the need for training data). If this capacity also applies to the coding of social phenomena like persuasiveness and political ideology, then LLMs could effectively transform Computational Social Science (CSS). This work provides a road map for using LLMs as CSS tools. Towards this end, we contribute a set of prompting best practices and an extensive evaluation pipeline to measure the zero-shot performance of 13 language models on 24 representative CSS benchmarks. On taxonomic labeling tasks (classification), LLMs fail to outperform the best fine-tuned models but still achieve fair levels of agreement with humans. On free-form coding tasks (generation), LLMs produce explanations that often exceed the quality of crowdworkers' gold references. We conclude that today's LLMs can radically augment the CSS research pipeline in two ways: (1) serving as zero-shot data annotators on human annotation teams, and (2) bootstrapping challenging creative generation tasks (e.g., explaining the hidden meaning behind text). In summary, LLMs can significantly reduce costs and increase efficiency of social science analysis in partnership with humans.

The advent of foundation models (FMs) as an emerging suite of AI techniques has struck a wave of opportunities in computational healthcare. The interactive nature of these models, guided by pre-training data and human instructions, has ignited a data-centric AI paradigm that emphasizes better data characterization, quality, and scale. In healthcare AI, obtaining and processing high-quality clinical data records has been a longstanding challenge, ranging from data quantity, annotation, patient privacy, and ethics. In this survey, we investigate a wide range of data-centric approaches in the FM era (from model pre-training to inference) towards improving the healthcare workflow. We discuss key perspectives in AI security, assessment, and alignment with human values. Finally, we offer a promising outlook of FM-based analytics to enhance the performance of patient outcome and clinical workflow in the evolving landscape of healthcare and medicine. We provide an up-to-date list of healthcare-related foundation models and datasets at https://github.com/Yunkun-Zhang/Data-Centric-FM-Healthcare .

Tissue phenotyping is a fundamental computational pathology (CPath) task in learning objective characterizations of histopathologic biomarkers in anatomic pathology. However, whole-slide imaging (WSI) poses a complex computer vision problem in which the large-scale image resolutions of WSIs and the enormous diversity of morphological phenotypes preclude large-scale data annotation. Current efforts have proposed using pretrained image encoders with either transfer learning from natural image datasets or self-supervised pretraining on publicly-available histopathology datasets, but have not been extensively developed and evaluated across diverse tissue types at scale. We introduce UNI, a general-purpose self-supervised model for pathology, pretrained using over 100 million tissue patches from over 100,000 diagnostic haematoxylin and eosin-stained WSIs across 20 major tissue types, and evaluated on 33 representative CPath clinical tasks in CPath of varying diagnostic difficulties. In addition to outperforming previous state-of-the-art models, we demonstrate new modeling capabilities in CPath such as resolution-agnostic tissue classification, slide classification using few-shot class prototypes, and disease subtyping generalization in classifying up to 108 cancer types in the OncoTree code classification system. UNI advances unsupervised representation learning at scale in CPath in terms of both pretraining data and downstream evaluation, enabling data-efficient AI models that can generalize and transfer to a gamut of diagnostically-challenging tasks and clinical workflows in anatomic pathology.

The accelerated adoption of digital pathology and advances in deep learning have enabled the development of powerful models for various pathology tasks across a diverse array of diseases and patient cohorts. However, model training is often difficult due to label scarcity in the medical domain and the model's usage is limited by the specific task and disease for which it is trained. Additionally, most models in histopathology leverage only image data, a stark contrast to how humans teach each other and reason about histopathologic entities. We introduce CONtrastive learning from Captions for Histopathology (CONCH), a visual-language foundation model developed using diverse sources of histopathology images, biomedical text, and notably over 1.17 million image-caption pairs via task-agnostic pretraining. Evaluated on a suite of 13 diverse benchmarks, CONCH can be transferred to a wide range of downstream tasks involving either or both histopathology images and text, achieving state-of-the-art performance on histology image classification, segmentation, captioning, text-to-image and image-to-text retrieval. CONCH represents a substantial leap over concurrent visual-language pretrained systems for histopathology, with the potential to directly facilitate a wide array of machine learning-based workflows requiring minimal or no further supervised fine-tuning.

Contrastive language-audio pretraining (CLAP) has recently emerged as a method for making audio analysis more generalisable. Specifically, CLAP-style models are able to `answer' a diverse set of language queries, extending the capabilities of audio models beyond a closed set of labels. However, CLAP relies on a large set of (audio, query) pairs for pretraining. While such sets are available for general audio tasks, like captioning or sound event detection, there are no datasets with matched audio and text queries for computational paralinguistic (CP) tasks. As a result, the community relies on generic CLAP models trained for general audio with limited success. In the present study, we explore training considerations for ParaCLAP, a CLAP-style model suited to CP, including a novel process for creating audio-language queries. We demonstrate its effectiveness on a set of computational paralinguistic tasks, where it is shown to surpass the performance of open-source state-of-the-art models.

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.

While various models and computational tools have been proposed for structure and property analysis of molecules, generating molecules that conform to all desired structures and properties remains a challenge. Here, we introduce a multi-constraint molecular generation large language model, TSMMG, which, akin to a student, incorporates knowledge from various small models and tools, namely, the 'teachers'. To train TSMMG, we construct a large set of text-molecule pairs by extracting molecular knowledge from these 'teachers', enabling it to generate novel molecules that conform to the descriptions through various text prompts. We experimentally show that TSMMG remarkably performs in generating molecules meeting complex, natural language-described property requirements across two-, three-, and four-constraint tasks, with an average molecular validity of over 99% and success ratio of 82.58%, 68.03%, and 67.48%, respectively. The model also exhibits adaptability through zero-shot testing, creating molecules that satisfy combinations of properties that have not been encountered. It can comprehend text inputs with various language styles, extending beyond the confines of outlined prompts, as confirmed through empirical validation. Additionally, the knowledge distillation feature of TSMMG contributes to the continuous enhancement of small models, while the innovative approach to dataset construction effectively addresses the issues of data scarcity and quality, which positions TSMMG as a promising tool in the domains of drug discovery and materials science.

Foundation models have triggered a paradigm shift in computer vision and are increasingly being adopted in remote sensing, particularly for multispectral imagery. Yet, their potential in hyperspectral imaging (HSI) remains untapped due to the absence of comprehensive and globally representative hyperspectral datasets. To close this gap, we introduce SpectralEarth, a large-scale multi-temporal dataset designed to pretrain hyperspectral foundation models leveraging data from the Environmental Mapping and Analysis Program (EnMAP). SpectralEarth comprises 538,974 image patches covering 415,153 unique locations from more than 11,636 globally distributed EnMAP scenes spanning two years of archive. Additionally, 17.5% of these locations include multiple timestamps, enabling multi-temporal HSI analysis. Utilizing state-of-the-art self-supervised learning (SSL) algorithms, we pretrain a series of foundation models on SpectralEarth. We integrate a spectral adapter into classical vision backbones to accommodate the unique characteristics of HSI. In tandem, we construct four downstream datasets for land-cover and crop-type mapping, providing benchmarks for model evaluation. Experimental results support the versatility of our models, showcasing their generalizability across different tasks and sensors. We also highlight computational efficiency during model fine-tuning. The dataset, models, and source code will be made publicly available.

Deploying large scale language models on edge devices faces inherent challenges such as high computational demands, energy consumption, and potential data privacy risks. This paper introduces the Shakti Small Language Models (SLMs) Shakti-100M, Shakti-250M, and Shakti-500M which target these constraints headon. By combining efficient architectures, quantization techniques, and responsible AI principles, the Shakti series enables on-device intelligence for smartphones, smart appliances, IoT systems, and beyond. We provide comprehensive insights into their design philosophy, training pipelines, and benchmark performance on both general tasks (e.g., MMLU, Hellaswag) and specialized domains (healthcare, finance, and legal). Our findings illustrate that compact models, when carefully engineered and fine-tuned, can meet and often exceed expectations in real-world edge-AI scenarios.

Transformer models have revolutionized natural language processing with their unparalleled ability to grasp complex contextual relationships. However, the vast number of parameters in these models has raised concerns regarding computational efficiency, environmental impact, and deployability on resource-limited platforms. To address these challenges, this paper investigates the application of weight pruning-a strategic reduction of model parameters based on their significance-as an optimization strategy for Transformer architectures. Through extensive experimentation, we explore various pruning methodologies, highlighting their impact on model performance, size, and computational demands. Our findings suggest that with judicious selection of pruning hyperparameters, significant reductions in model size are attainable without considerable compromise on performance. Moreover, when coupled with post-pruning fine-tuning strategies, some pruned models even exhibit enhanced generalization capabilities. This work seeks to bridge the gap between model efficiency and performance, paving the way for more scalable and environmentally responsible deep learning applications.

Mixture of Experts (MoE) offers remarkable performance and computational efficiency by selectively activating subsets of model parameters. Traditionally, MoE models use homogeneous experts, each with identical capacity. However, varying complexity in input data necessitates experts with diverse capabilities, while homogeneous MoE hinders effective expert specialization and efficient parameter utilization. In this study, we propose a novel Heterogeneous Mixture of Experts (HMoE), where experts differ in size and thus possess diverse capacities. This heterogeneity allows for more specialized experts to handle varying token complexities more effectively. To address the imbalance in expert activation, we propose a novel training objective that encourages the frequent activation of smaller experts, enhancing computational efficiency and parameter utilization. Extensive experiments demonstrate that HMoE achieves lower loss with fewer activated parameters and outperforms conventional homogeneous MoE models on various pre-training evaluation benchmarks. Codes will be released upon acceptance.

We present SwD, a scale-wise distillation framework for diffusion models (DMs), which effectively employs next-scale prediction ideas for diffusion-based few-step generators. In more detail, SwD is inspired by the recent insights relating diffusion processes to the implicit spectral autoregression. We suppose that DMs can initiate generation at lower data resolutions and gradually upscale the samples at each denoising step without loss in performance while significantly reducing computational costs. SwD naturally integrates this idea into existing diffusion distillation methods based on distribution matching. Also, we enrich the family of distribution matching approaches by introducing a novel patch loss enforcing finer-grained similarity to the target distribution. When applied to state-of-the-art text-to-image diffusion models, SwD approaches the inference times of two full resolution steps and significantly outperforms the counterparts under the same computation budget, as evidenced by automated metrics and human preference studies.

Video frame interpolation (VFI) aims to synthesize intermediate frames in between existing frames to enhance visual smoothness and quality. Beyond the conventional methods based on the reconstruction loss, recent works employ the high quality generative models for perceptual quality. However, they require complex training and large computational cost for modeling on the pixel space. In this paper, we introduce disentangled Motion Modeling (MoMo), a diffusion-based approach for VFI that enhances visual quality by focusing on intermediate motion modeling. We propose disentangled two-stage training process, initially training a frame synthesis model to generate frames from input pairs and their optical flows. Subsequently, we propose a motion diffusion model, equipped with our novel diffusion U-Net architecture designed for optical flow, to produce bi-directional flows between frames. This method, by leveraging the simpler low-frequency representation of motions, achieves superior perceptual quality with reduced computational demands compared to generative modeling methods on the pixel space. Our method surpasses state-of-the-art methods in perceptual metrics across various benchmarks, demonstrating its efficacy and efficiency in VFI. Our code is available at: https://github.com/JHLew/MoMo

We study the problem of modeling a population of agents pursuing unknown goals subject to unknown computational constraints. In standard models of bounded rationality, sub-optimal decision-making is simulated by adding homoscedastic noise to optimal decisions rather than explicitly simulating constrained inference. In this work, we introduce a latent inference budget model (L-IBM) that models agents' computational constraints explicitly, via a latent variable (inferred jointly with a model of agents' goals) that controls the runtime of an iterative inference algorithm. L-IBMs make it possible to learn agent models using data from diverse populations of suboptimal actors. In three modeling tasks -- inferring navigation goals from routes, inferring communicative intents from human utterances, and predicting next moves in human chess games -- we show that L-IBMs match or outperform Boltzmann models of decision-making under uncertainty. Inferred inference budgets are themselves meaningful, efficient to compute, and correlated with measures of player skill, partner skill and task difficulty.

Training large models from scratch usually costs a substantial amount of resources. Towards this problem, recent studies such as bert2BERT and LiGO have reused small pretrained models to initialize a large model (termed the ``target model''), leading to a considerable acceleration in training. Despite the successes of these previous studies, they grew pretrained models by mapping partial weights only, ignoring potential correlations across the entire model. As we show in this paper, there are inter- and intra-interactions among the weights of both the pretrained and the target models. As a result, the partial mapping may not capture the complete information and lead to inadequate growth. In this paper, we propose a method that linearly correlates each weight of the target model to all the weights of the pretrained model to further enhance acceleration ability. We utilize multi-linear operators to reduce computational and spacial complexity, enabling acceptable resource requirements. Experiments demonstrate that our method can save 76\% computational costs on DeiT-base transferred from DeiT-small, which outperforms bert2BERT by +12.0\% and LiGO by +20.7\%, respectively.

Self-supervised pre-training of language models usually consists in predicting probability distributions over extensive token vocabularies. In this study, we propose an innovative method that shifts away from probability prediction and instead focuses on reconstructing input embeddings in a contrastive fashion via Constrastive Weight Tying (CWT). We apply this approach to pretrain Headless Language Models in both monolingual and multilingual contexts. Our method offers practical advantages, substantially reducing training computational requirements by up to 20 times, while simultaneously enhancing downstream performance and data efficiency. We observe a significant +1.6 GLUE score increase and a notable +2.7 LAMBADA accuracy improvement compared to classical LMs within similar compute budgets.

Tokenization is fundamental to pretrained language models (PLMs). Existing tokenization methods for Chinese PLMs typically treat each character as an indivisible token. However, they ignore the unique feature of the Chinese writing system where additional linguistic information exists below the character level, i.e., at the sub-character level. To utilize such information, we propose sub-character (SubChar for short) tokenization. Specifically, we first encode the input text by converting each Chinese character into a short sequence based on its glyph or pronunciation, and then construct the vocabulary based on the encoded text with sub-word segmentation. Experimental results show that SubChar tokenizers have two main advantages over existing tokenizers: 1) They can tokenize inputs into much shorter sequences, thus improving the computational efficiency. 2) Pronunciation-based SubChar tokenizers can encode Chinese homophones into the same transliteration sequences and produce the same tokenization output, hence being robust to homophone typos. At the same time, models trained with SubChar tokenizers perform competitively on downstream tasks. We release our code and models at https://github.com/thunlp/SubCharTokenization to facilitate future work.

Large Language Models (LLMs) have shown great promise in integrating diverse expert models to tackle intricate language and vision tasks. Despite their significance in advancing the field of Artificial Intelligence Generated Content (AIGC), their potential in intelligent audio content creation remains unexplored. In this work, we tackle the problem of creating audio content with storylines encompassing speech, music, and sound effects, guided by text instructions. We present WavJourney, a system that leverages LLMs to connect various audio models for audio content generation. Given a text description of an auditory scene, WavJourney first prompts LLMs to generate a structured script dedicated to audio storytelling. The audio script incorporates diverse audio elements, organized based on their spatio-temporal relationships. As a conceptual representation of audio, the audio script provides an interactive and interpretable rationale for human engagement. Afterward, the audio script is fed into a script compiler, converting it into a computer program. Each line of the program calls a task-specific audio generation model or computational operation function (e.g., concatenate, mix). The computer program is then executed to obtain an explainable solution for audio generation. We demonstrate the practicality of WavJourney across diverse real-world scenarios, including science fiction, education, and radio play. The explainable and interactive design of WavJourney fosters human-machine co-creation in multi-round dialogues, enhancing creative control and adaptability in audio production. WavJourney audiolizes the human imagination, opening up new avenues for creativity in multimedia content creation.

Time series models face significant challenges in scaling to handle large and complex datasets, akin to the scaling achieved by large language models (LLMs). The unique characteristics of time series data and the computational demands of model scaling necessitate innovative approaches. While researchers have explored various architectures such as Transformers, LSTMs, and GRUs to address these challenges, we propose a novel solution using RWKV-7, which incorporates meta-learning into its state update mechanism. By integrating RWKV-7's time mix and channel mix components into the transformer-based time series model Timer, we achieve a substantial performance improvement of approximately 1.13 to 43.3x and a 4.5x reduction in training time with 1/23 parameters, all while utilizing fewer parameters. Our code and model weights are publicly available for further research and development at https://github.com/Alic-Li/BlackGoose_Rimer.

Recently, Large Language Models (LLMs) have achieved amazing zero-shot learning performance over a variety of Natural Language Processing (NLP) tasks, especially for text generative tasks. Yet, the large size of LLMs often leads to the high computational cost of model training and online deployment. In our work, we present ALTER, a system that effectively builds the multi-tAsk Learners with mixTure-of-task-adaptERs upon small language models (with <1B parameters) to address multiple NLP tasks simultaneously, capturing the commonalities and differences between tasks, in order to support domain-specific applications. Specifically, in ALTER, we propose the Mixture-of-Task-Adapters (MTA) module as an extension to the transformer architecture for the underlying model to capture the intra-task and inter-task knowledge. A two-stage training method is further proposed to optimize the collaboration between adapters at a small computational cost. Experimental results over a mixture of NLP tasks show that our proposed MTA architecture and the two-stage training method achieve good performance. Based on ALTER, we have also produced MTA-equipped language models for various domains.

Mixture-of-Experts (MoE), a conditional computation architecture, achieved promising performance by scaling local module (i.e. feed-forward network) of transformer. However, scaling the cross-token module (i.e. self-attention) is challenging due to the unstable training. This work proposes Sparse-MLP, an all-MLP model which applies sparsely-activated MLPs to cross-token modeling. Specifically, in each Sparse block of our all-MLP model, we apply two stages of MoE layers: one with MLP experts mixing information within channels along image patch dimension, the other with MLP experts mixing information within patches along the channel dimension. In addition, by proposing importance-score routing strategy for MoE and redesigning the image representation shape, we further improve our model's computational efficiency. Experimentally, we are more computation-efficient than Vision Transformers with comparable accuracy. Also, our models can outperform MLP-Mixer by 2.5\% on ImageNet Top-1 accuracy with fewer parameters and computational cost. On downstream tasks, i.e. Cifar10 and Cifar100, our models can still achieve better performance than baselines.

We propose a novel approach to addressing two fundamental challenges in Model-based Reinforcement Learning (MBRL): the computational expense of repeatedly finding a good policy in the learned model, and the objective mismatch between model fitting and policy computation. Our "lazy" method leverages a novel unified objective, Performance Difference via Advantage in Model, to capture the performance difference between the learned policy and expert policy under the true dynamics. This objective demonstrates that optimizing the expected policy advantage in the learned model under an exploration distribution is sufficient for policy computation, resulting in a significant boost in computational efficiency compared to traditional planning methods. Additionally, the unified objective uses a value moment matching term for model fitting, which is aligned with the model's usage during policy computation. We present two no-regret algorithms to optimize the proposed objective, and demonstrate their statistical and computational gains compared to existing MBRL methods through simulated benchmarks.

Advances in foundation modeling have reshaped computational pathology. However, the increasing number of available models and lack of standardized benchmarks make it increasingly complex to assess their strengths, limitations, and potential for further development. To address these challenges, we introduce a new suite of software tools for whole-slide image processing, foundation model benchmarking, and curated publicly available tasks. We anticipate that these resources will promote transparency, reproducibility, and continued progress in the field.

In this paper, we introduce a novel dynamic expert selection framework for Mixture of Experts (MoE) models, aiming to enhance computational efficiency and model performance by adjusting the number of activated experts based on input difficulty. Unlike traditional MoE approaches that rely on fixed Top-K routing, which activates a predetermined number of experts regardless of the input's complexity, our method dynamically selects experts based on the confidence level in expert selection for each input. This allows for a more efficient utilization of computational resources, activating more experts for complex tasks requiring advanced reasoning and fewer for simpler tasks. Through extensive evaluations, our dynamic routing method demonstrates substantial improvements over conventional Top-2 routing across various benchmarks, achieving an average improvement of 0.7% with less than 90% activated parameters. Further analysis shows our model dispatches more experts to tasks requiring complex reasoning skills, like BBH, confirming its ability to dynamically allocate computational resources in alignment with the input's complexity. Our findings also highlight a variation in the number of experts needed across different layers of the transformer model, offering insights into the potential for designing heterogeneous MoE frameworks. The code and models are available at https://github.com/ZhenweiAn/Dynamic_MoE.

Language modeling has witnessed remarkable advancements in recent years, with Large Language Models (LLMs) like ChatGPT setting unparalleled benchmarks in human-like text generation. However, a prevailing limitation is the underrepresentation of languages like Tamil in these cutting-edge models, leading to suboptimal performance in diverse linguistic contexts. This paper addresses this lacuna, enhancing the open-source LLaMA model with an addition of 16,000 Tamil tokens, aiming to achieve superior text generation and comprehension in the Tamil language. We strategically employ the LoRA methodology for efficient model training on a comprehensive Tamil corpus, ensuring computational feasibility and model robustness. Moreover, we introduce a Tamil-translated version of the Alpaca dataset and a subset of the OpenOrca dataset tailored for instruction fine-tuning. Our results showcase significant performance improvements in Tamil text generation, with potential implications for the broader landscape of LLMs in Indian languages. We further underscore our commitment to open research by making our models, datasets, and code publicly accessible, fostering further innovations in language modeling.

Active inference is a first principles approach for understanding the brain in particular, and sentient agents in general, with the single imperative of minimizing free energy. As such, it provides a computational account for modelling artificial intelligent agents, by defining the agent's generative model and inferring the model parameters, actions and hidden state beliefs. However, the exact specification of the generative model and the hidden state space structure is left to the experimenter, whose design choices influence the resulting behaviour of the agent. Recently, deep learning methods have been proposed to learn a hidden state space structure purely from data, alleviating the experimenter from this tedious design task, but resulting in an entangled, non-interpreteable state space. In this paper, we hypothesize that such a learnt, entangled state space does not necessarily yield the best model in terms of free energy, and that enforcing different factors in the state space can yield a lower model complexity. In particular, we consider the problem of 3D object representation, and focus on different instances of the ShapeNet dataset. We propose a model that factorizes object shape, pose and category, while still learning a representation for each factor using a deep neural network. We show that models, with best disentanglement properties, perform best when adopted by an active agent in reaching preferred observations.

Vision-and-Language Navigation (VLN) in real-world settings requires agents to process continuous visual streams and generate actions with low latency grounded in language instructions. While Video-based Large Language Models (Video-LLMs) have driven recent progress, current VLN methods based on Video-LLM often face trade-offs among fine-grained visual understanding, long-term context modeling and computational efficiency. We introduce StreamVLN, a streaming VLN framework that employs a hybrid slow-fast context modeling strategy to support multi-modal reasoning over interleaved vision, language and action inputs. The fast-streaming dialogue context facilitates responsive action generation through a sliding-window of active dialogues, while the slow-updating memory context compresses historical visual states using a 3D-aware token pruning strategy. With this slow-fast design, StreamVLN achieves coherent multi-turn dialogue through efficient KV cache reuse, supporting long video streams with bounded context size and inference cost. Experiments on VLN-CE benchmarks demonstrate state-of-the-art performance with stable low latency, ensuring robustness and efficiency in real-world deployment. The project page is: https://streamvln.github.io/{https://streamvln.github.io/}.

Mixture-of-Experts (MoE) language models can reduce computational costs by 2-4times compared to dense models without sacrificing performance, making them more efficient in computation-bounded scenarios. However, MoE models generally require 2-4times times more parameters to achieve comparable performance to a dense model, which incurs larger GPU memory requirements and makes MoE models less efficient in I/O-bounded scenarios like autoregressive generation. In this work, we propose a hybrid dense training and sparse inference framework for MoE models (DS-MoE) which achieves strong computation and parameter efficiency by employing dense computation across all experts during training and sparse computation during inference. Our experiments on training LLMs demonstrate that our DS-MoE models are more parameter-efficient than standard sparse MoEs and are on par with dense models in terms of total parameter size and performance while being computationally cheaper (activating 30-40% of the model's parameters). Performance tests using vLLM show that our DS-MoE-6B model runs up to 1.86times faster than similar dense models like Mistral-7B, and between 1.50times and 1.71times faster than comparable MoEs, such as DeepSeekMoE-16B and Qwen1.5-MoE-A2.7B.

We investigate the potential of large language models (LLMs) to distill text: to remove the textual traces of an undesired forbidden variable. We employ a range of LLMs with varying architectures and training approaches to distill text by identifying and removing information about the target variable while preserving other relevant signals. Our findings shed light on the strengths and limitations of LLMs in addressing the distillation and provide insights into the strategies for leveraging these models in computational social science investigations involving text data. In particular, we show that in the strong test of removing sentiment, the statistical association between the processed text and sentiment is still clearly detectable to machine learning classifiers post-LLM-distillation. Furthermore, we find that human annotators also struggle to distill sentiment while preserving other semantic content. This suggests there may be limited separability between concept variables in some text contexts, highlighting limitations of methods relying on text-level transformations and also raising questions about the robustness of distillation methods that achieve statistical independence in representation space if this is difficult for human coders operating on raw text to attain.

Large Language Models are becoming an increasingly popular tool for software development. Their ability to model and generate source code has been demonstrated in a variety of contexts, including code completion, summarization, translation, and lookup. However, they often struggle to generate code for more complex tasks. In this paper, we explore the ability of state-of-the-art language models to generate parallel code. We propose a benchmark, PCGBench, consisting of a set of 420 tasks for evaluating the ability of language models to generate parallel code, and we evaluate the performance of several state-of-the-art open- and closed-source language models on these tasks. We introduce novel metrics for comparing parallel code generation performance and use them to explore how well each LLM performs on various parallel programming models and computational problem types.

Training large language models with data collected from various domains can improve their performance on downstream tasks. However, given a fixed training budget, the sampling proportions of these different domains significantly impact the model's performance. How can we determine the domain weights across different data domains to train the best-performing model within constrained computational resources? In this paper, we provide a comprehensive overview of existing data mixture methods. First, we propose a fine-grained categorization of existing methods, extending beyond the previous offline and online classification. Offline methods are further grouped into heuristic-based, algorithm-based, and function fitting-based methods. For online methods, we categorize them into three groups: online min-max optimization, online mixing law, and other approaches by drawing connections with the optimization frameworks underlying offline methods. Second, we summarize the problem formulations, representative algorithms for each subtype of offline and online methods, and clarify the relationships and distinctions among them. Finally, we discuss the advantages and disadvantages of each method and highlight key challenges in the field of data mixture.

Recent advancements in sequence modeling have led to the emergence of Structured State Space Models (SSMs) as an efficient alternative to Recurrent Neural Networks (RNNs) and Transformers, addressing challenges in long-range dependency modeling and computational efficiency. While RNNs suffer from vanishing gradients and sequential inefficiencies, and Transformers face quadratic complexity, SSMs leverage structured recurrence and state-space representations to achieve superior long-sequence processing with linear or near-linear complexity. This survey provides a comprehensive review of SSMs, tracing their evolution from the foundational S4 model to its successors like Mamba, Simplified Structured State Space Sequence Model (S5), and Jamba, highlighting their improvements in computational efficiency, memory optimization, and inference speed. By comparing SSMs with traditional sequence models across domains such as natural language processing (NLP), speech recognition, vision, and time-series forecasting, we demonstrate their advantages in handling long-range dependencies while reducing computational overhead. Despite their potential, challenges remain in areas such as training optimization, hybrid modeling, and interpretability. This survey serves as a structured guide for researchers and practitioners, detailing the advancements, trade-offs, and future directions of SSM-based architectures in AI and deep learning.

Diffusion models have achieved remarkable success in image generation, with applications broadening across various domains. Inpainting is one such application that can benefit significantly from diffusion models. Existing methods either hijack the reverse process of a pretrained diffusion model or cast the problem into a larger framework, \ie, conditioned generation. However, these approaches often require nested loops in the generation process or additional components for conditioning. In this paper, we present region-aware diffusion models (RAD) for inpainting with a simple yet effective reformulation of the vanilla diffusion models. RAD utilizes a different noise schedule for each pixel, which allows local regions to be generated asynchronously while considering the global image context. A plain reverse process requires no additional components, enabling RAD to achieve inference time up to 100 times faster than the state-of-the-art approaches. Moreover, we employ low-rank adaptation (LoRA) to fine-tune RAD based on other pretrained diffusion models, reducing computational burdens in training as well. Experiments demonstrated that RAD provides state-of-the-art results both qualitatively and quantitatively, on the FFHQ, LSUN Bedroom, and ImageNet datasets.

Large Language Models (LLMs) have shown remarkable capabilities, but their development has primarily focused on English and other high-resource languages, leaving many languages underserved. We present our latest Hindi-English bi-lingual LLM Mantra-14B with ~3\% average improvement in benchmark scores over both languages, outperforming models twice its size. Using a curated dataset composed of English and Hindi instruction data of 485K samples, we instruction tuned models such as Qwen-2.5-14B-Instruct and Phi-4 to improve performance over both English and Hindi. Our experiments encompassing seven different LLMs of varying parameter sizes and over 140 training attempts with varying English-Hindi training data ratios demonstrated that it is possible to significantly improve multilingual performance without compromising native performance. Further, our approach avoids resource-intensive techniques like vocabulary expansion or architectural modifications, thus keeping the model size small. Our results indicate that modest fine-tuning with culturally and locally informed data can bridge performance gaps without incurring significant computational overhead. We release our training code, datasets, and models under mit and apache licenses to aid further research towards under-represented and low-resource languages.

Biophysical modeling, particularly involving partial differential equations (PDEs), offers significant potential for tailoring disease treatment protocols to individual patients. However, the inverse problem-solving aspect of these models presents a substantial challenge, either due to the high computational requirements of model-based approaches or the limited robustness of deep learning (DL) methods. We propose a novel framework that leverages the unique strengths of both approaches in a synergistic manner. Our method incorporates a DL ensemble for initial parameter estimation, facilitating efficient downstream evolutionary sampling initialized with this DL-based prior. We showcase the effectiveness of integrating a rapid deep-learning algorithm with a high-precision evolution strategy in estimating brain tumor cell concentrations from magnetic resonance images. The DL-Prior plays a pivotal role, significantly constraining the effective sampling-parameter space. This reduction results in a fivefold convergence acceleration and a Dice-score of 95%

In this paper, we introduce Flash-VL 2B, a novel approach to optimizing Vision-Language Models (VLMs) for real-time applications, targeting ultra-low latency and high throughput without sacrificing accuracy. Leveraging advanced architectural enhancements and efficient computational strategies, Flash-VL 2B is designed to maximize throughput by reducing processing time while maintaining competitive performance across multiple vision-language benchmarks. Our approach includes tailored architectural choices, token compression mechanisms, data curation, training schemes, and a novel image processing technique called implicit semantic stitching that effectively balances computational load and model performance. Through extensive evaluations on 11 standard VLM benchmarks, we demonstrate that Flash-VL 2B achieves state-of-the-art results in both speed and accuracy, making it a promising solution for deployment in resource-constrained environments and large-scale real-time applications.

While many EDA tasks already involve graph-based data, existing LLMs in EDA primarily either represent graphs as sequential text, or simply ignore graph-structured data that might be beneficial like dataflow graphs of RTL code. Recent studies have found that LLM performance suffers when graphs are represented as sequential text, and using additional graph information significantly boosts performance. To address these challenges, we introduce BRIDGES, a framework designed to incorporate graph modality into LLMs for EDA tasks. BRIDGES integrates an automated data generation workflow, a solution that combines graph modality with LLM, and a comprehensive evaluation suite. First, we establish an LLM-driven workflow to generate RTL and netlist-level data, converting them into dataflow and netlist graphs with function descriptions. This workflow yields a large-scale dataset comprising over 500,000 graph instances and more than 1.5 billion tokens. Second, we propose a lightweight cross-modal projector that encodes graph representations into text-compatible prompts, enabling LLMs to effectively utilize graph data without architectural modifications. Experimental results demonstrate 2x to 10x improvements across multiple tasks compared to text-only baselines, including accuracy in design retrieval, type prediction and perplexity in function description, with negligible computational overhead (<1% model weights increase and <30% additional runtime overhead). Even without additional LLM finetuning, our results outperform text-only by a large margin. We plan to release BRIDGES, including the dataset, models, and training flow.

Human-produced emissions are growing at an alarming rate, causing already observable changes in the climate and environment in general. Each year global carbon dioxide emissions hit a new record, and it is reported that 0.5% of total US greenhouse gas emissions are attributed to data centres as of 2021. The release of ChatGPT in late 2022 sparked social interest in Large Language Models (LLMs), the new generation of Language Models with a large number of parameters and trained on massive amounts of data. Currently, numerous companies are releasing products featuring various LLMs, with many more models in development and awaiting release. Deep Learning research is a competitive field, with only models that reach top performance attracting attention and being utilized. Hence, achieving better accuracy and results is often the first priority, while the model's efficiency and the environmental impact of the study are neglected. However, LLMs demand substantial computational resources and are very costly to train, both financially and environmentally. It becomes essential to raise awareness and promote conscious decisions about algorithmic and hardware choices. Providing information on training time, the approximate carbon dioxide emissions and power consumption would assist future studies in making necessary adjustments and determining the compatibility of available computational resources with model requirements. In this study, we infused T5 LLM with external knowledge and fine-tuned the model for Question-Answering task. Furthermore, we calculated and reported the approximate environmental impact for both steps. The findings demonstrate that the smaller models may not always be sustainable options, and increased training does not always imply better performance. The most optimal outcome is achieved by carefully considering both performance and efficiency factors.

The use of artificial intelligence to enable precision medicine and decision support systems through the analysis of pathology images has the potential to revolutionize the diagnosis and treatment of cancer. Such applications will depend on models' abilities to capture the diverse patterns observed in pathology images. To address this challenge, we present Virchow, a foundation model for computational pathology. Using self-supervised learning empowered by the DINOv2 algorithm, Virchow is a vision transformer model with 632 million parameters trained on 1.5 million hematoxylin and eosin stained whole slide images from diverse tissue and specimen types, which is orders of magnitude more data than previous works. The Virchow model enables the development of a pan-cancer detection system with 0.949 overall specimen-level AUC across 17 different cancer types, while also achieving 0.937 AUC on 7 rare cancer types. The Virchow model sets the state-of-the-art on the internal and external image tile level benchmarks and slide level biomarker prediction tasks. The gains in performance highlight the importance of training on massive pathology image datasets, suggesting scaling up the data and network architecture can improve the accuracy for many high-impact computational pathology applications where limited amounts of training data are available.

The industrial application motivating this work is the fatigue computation of aircraft engines' high-pressure turbine blades. The material model involves nonlinear elastoviscoplastic behavior laws, for which the parameters depend on the temperature. For this application, the temperature loading is not accurately known and can reach values relatively close to the creep temperature: important nonlinear effects occur and the solution strongly depends on the used thermal loading. We consider a nonlinear reduced order model able to compute, in the exploitation phase, the behavior of the blade for a new temperature field loading. The sensitivity of the solution to the temperature makes {the classical unenriched proper orthogonal decomposition method} fail. In this work, we propose a new error indicator, quantifying the error made by the reduced order model in computational complexity independent of the size of the high-fidelity reference model. In our framework, when the {error indicator} becomes larger than a given tolerance, the reduced order model is updated using one time step solution of the high-fidelity reference model. The approach is illustrated on a series of academic test cases and applied on a setting of industrial complexity involving 5 million degrees of freedom, where the whole procedure is computed in parallel with distributed memory.

Application of deep learning on histopathological whole slide images (WSIs) holds promise of improving diagnostic efficiency and reproducibility but is largely dependent on the ability to write computer code or purchase commercial solutions. We present a code-free pipeline utilizing free-to-use, open-source software (QuPath, DeepMIB, and FastPathology) for creating and deploying deep learning-based segmentation models for computational pathology. We demonstrate the pipeline on a use case of separating epithelium from stroma in colonic mucosa. A dataset of 251 annotated WSIs, comprising 140 hematoxylin-eosin (HE)-stained and 111 CD3 immunostained colon biopsy WSIs, were developed through active learning using the pipeline. On a hold-out test set of 36 HE and 21 CD3-stained WSIs a mean intersection over union score of 96.6% and 95.3% was achieved on epithelium segmentation. We demonstrate pathologist-level segmentation accuracy and clinical acceptable runtime performance and show that pathologists without programming experience can create near state-of-the-art segmentation solutions for histopathological WSIs using only free-to-use software. The study further demonstrates the strength of open-source solutions in its ability to create generalizable, open pipelines, of which trained models and predictions can seamlessly be exported in open formats and thereby used in external solutions. All scripts, trained models, a video tutorial, and the full dataset of 251 WSIs with ~31k epithelium annotations are made openly available at https://github.com/andreped/NoCodeSeg to accelerate research in the field.

With the widespread application of Large Language Models (LLMs), it has become a significant concern to ensure their safety and prevent harmful responses. While current safe-alignment methods based on instruction fine-tuning and Reinforcement Learning from Human Feedback (RLHF) can effectively reduce harmful responses from LLMs, they often require high-quality datasets and heavy computational overhead during model training. Another way to align language models is to modify the logit of tokens in model outputs without heavy training. Recent studies have shown that contrastive decoding can enhance the performance of language models by reducing the likelihood of confused tokens. However, these methods require the manual selection of contrastive models or instruction templates. To this end, we propose Adversarial Contrastive Decoding (ACD), an optimization-based framework to generate two opposite system prompts for prompt-based contrastive decoding. ACD only needs to apply a lightweight prompt tuning on a rather small anchor dataset (< 3 min for each model) without training the target model. Experiments conducted on extensive models and benchmarks demonstrate that the proposed method achieves much better safety performance than previous model training-free decoding methods without sacrificing its original generation ability.

Large Vision Language Models (LVLMs) have achieved significant success across multi-modal tasks. However, the computational cost of processing long visual tokens can be prohibitively expensive on resource-limited devices. Previous methods have identified redundancy in visual tokens within the Large Language Model (LLM) decoder layers and have mitigated this by pruning tokens using a pre-defined or fixed ratio, thereby reducing computational overhead. Nonetheless, we observe that the impact of pruning ratio varies across different LLM layers and instances (image-prompt pairs). Therefore, it is essential to develop a layer-wise and instance-wise vision token pruning strategy to balance computational cost and model performance effectively. We propose ATP-LLaVA, a novel approach that adaptively determines instance-specific token pruning ratios for each LLM layer. Specifically, we introduce an Adaptive Token Pruning (ATP) module, which computes the importance score and pruning threshold based on input instance adaptively. The ATP module can be seamlessly integrated between any two LLM layers with negligible computational overhead. Additionally, we develop a Spatial Augmented Pruning (SAP) strategy that prunes visual tokens with both token redundancy and spatial modeling perspectives. Our approach reduces the average token count by 75% while maintaining performance, with only a minimal 1.9% degradation across seven widely used benchmarks. The project page can be accessed via https://yxxxb.github.io/ATP-LLaVA-page/.

Mixture of Experts (MoE) models have emerged as a primary solution for reducing the computational cost of Large Language Models. In this work, we analyze their scaling properties, incorporating an expanded range of variables. Specifically, we introduce a new hyperparameter, granularity, whose adjustment enables precise control over the size of the experts. Building on this, we establish scaling laws for fine-grained MoE, taking into account the number of training tokens, model size, and granularity. Leveraging these laws, we derive the optimal training configuration for a given computational budget. Our findings not only show that MoE models consistently outperform dense Transformers but also highlight that the efficiency gap between dense and MoE models widens as we scale up the model size and training budget. Furthermore, we demonstrate that the common practice of setting the size of experts in MoE to mirror the feed-forward layer is not optimal at almost any computational budget.

Despite their remarkable performance, modern Diffusion Transformers are hindered by substantial resource requirements during inference, stemming from the fixed and large amount of compute needed for each denoising step. In this work, we revisit the conventional static paradigm that allocates a fixed compute budget per denoising iteration and propose a dynamic strategy instead. Our simple and sample-efficient framework enables pre-trained DiT models to be converted into flexible ones -- dubbed FlexiDiT -- allowing them to process inputs at varying compute budgets. We demonstrate how a single flexible model can generate images without any drop in quality, while reducing the required FLOPs by more than 40\% compared to their static counterparts, for both class-conditioned and text-conditioned image generation. Our method is general and agnostic to input and conditioning modalities. We show how our approach can be readily extended for video generation, where FlexiDiT models generate samples with up to 75\% less compute without compromising performance.

Video diffusion models have achieved impressive realism and controllability but are limited by high computational demands, restricting their use on mobile devices. This paper introduces the first mobile-optimized video diffusion model. Starting from a spatio-temporal UNet from Stable Video Diffusion (SVD), we reduce memory and computational cost by reducing the frame resolution, incorporating multi-scale temporal representations, and introducing two novel pruning schema to reduce the number of channels and temporal blocks. Furthermore, we employ adversarial finetuning to reduce the denoising to a single step. Our model, coined as MobileVD, is 523x more efficient (1817.2 vs. 4.34 TFLOPs) with a slight quality drop (FVD 149 vs. 171), generating latents for a 14x512x256 px clip in 1.7 seconds on a Xiaomi-14 Pro. Our results are available at https://qualcomm-ai-research.github.io/mobile-video-diffusion/

Encoder-free multimodal large language models(MLLMs) eliminate the need for a well-trained vision encoder by directly processing image tokens before the language model. While this approach reduces computational overhead and model complexity, it often requires large amounts of training data to effectively capture the visual knowledge typically encoded by vision models like CLIP. The absence of a vision encoder implies that the model is likely to rely on substantial data to learn the necessary visual-semantic alignments. In this work, we present BREEN, a data-efficient encoder-free multimodal architecture that mitigates this issue. BREEN leverages a learnable query and image experts to achieve comparable performance with significantly less training data. The learnable query, positioned between image and text tokens, is supervised by the output of a pretrained CLIP model to distill visual knowledge, bridging the gap between visual and textual modalities. Additionally, the image expert processes image tokens and learnable queries independently, improving efficiency and reducing interference with the LLM's textual capabilities. BREEN achieves comparable performance to prior encoder-free state-of-the-art models like Mono-InternVL, using only 13 million text-image pairs in training about one percent of the data required by existing methods. Our work highlights a promising direction for data-efficient encoder-free multimodal learning, offering an alternative to traditional encoder-based approaches.

Believable proxies of human behavior can empower interactive applications ranging from immersive environments to rehearsal spaces for interpersonal communication to prototyping tools. In this paper, we introduce generative agents--computational software agents that simulate believable human behavior. Generative agents wake up, cook breakfast, and head to work; artists paint, while authors write; they form opinions, notice each other, and initiate conversations; they remember and reflect on days past as they plan the next day. To enable generative agents, we describe an architecture that extends a large language model to store a complete record of the agent's experiences using natural language, synthesize those memories over time into higher-level reflections, and retrieve them dynamically to plan behavior. We instantiate generative agents to populate an interactive sandbox environment inspired by The Sims, where end users can interact with a small town of twenty five agents using natural language. In an evaluation, these generative agents produce believable individual and emergent social behaviors: for example, starting with only a single user-specified notion that one agent wants to throw a Valentine's Day party, the agents autonomously spread invitations to the party over the next two days, make new acquaintances, ask each other out on dates to the party, and coordinate to show up for the party together at the right time. We demonstrate through ablation that the components of our agent architecture--observation, planning, and reflection--each contribute critically to the believability of agent behavior. By fusing large language models with computational, interactive agents, this work introduces architectural and interaction patterns for enabling believable simulations of human behavior.

Transformer model architectures have garnered immense interest lately due to their effectiveness across a range of domains like language, vision and reinforcement learning. In the field of natural language processing for example, Transformers have become an indispensable staple in the modern deep learning stack. Recently, a dizzying number of "X-former" models have been proposed - Reformer, Linformer, Performer, Longformer, to name a few - which improve upon the original Transformer architecture, many of which make improvements around computational and memory efficiency. With the aim of helping the avid researcher navigate this flurry, this paper characterizes a large and thoughtful selection of recent efficiency-flavored "X-former" models, providing an organized and comprehensive overview of existing work and models across multiple domains.

Although large language models (LLMs) have achieved remarkable success across various domains, their considerable scale necessitates substantial computational resources, posing significant challenges for deployment in resource-constrained environments. Layer pruning, as a simple yet effective compression method, removes layers of a model directly, reducing computational overhead. However, what are the best practices for layer pruning in LLMs? Are sophisticated layer selection metrics truly effective? Does the LoRA (Low-Rank Approximation) family, widely regarded as a leading method for pruned model fine-tuning, truly meet expectations when applied to post-pruning fine-tuning? To answer these questions, we dedicate thousands of GPU hours to benchmarking layer pruning in LLMs and gaining insights across multiple dimensions. Our results demonstrate that a simple approach, i.e., pruning the final 25\% of layers followed by fine-tuning the lm\_head and the remaining last three layer, yields remarkably strong performance. Following this guide, we prune Llama-3.1-8B-It and obtain a model that outperforms many popular LLMs of similar size, such as ChatGLM2-6B, Vicuna-7B-v1.5, Qwen1.5-7B and Baichuan2-7B. We release the optimal model weights on Huggingface, and the code is available on GitHub.

Scaling laws for large language models (LLMs) predict model performance based on parameters like size and training data. However, differences in training configurations and data processing across model families lead to significant variations in benchmark performance, making it difficult for a single scaling law to generalize across all LLMs. On the other hand, training family-specific scaling laws requires training models of varying sizes for every family. In this work, we propose Skills Scaling Laws (SSLaws, pronounced as Sloth), a novel scaling law that leverages publicly available benchmark data and assumes LLM performance is driven by low-dimensional latent skills, such as reasoning and instruction following. These latent skills are influenced by computational resources like model size and training tokens but with varying efficiencies across model families. Sloth exploits correlations across benchmarks to provide more accurate and interpretable predictions while alleviating the need to train multiple LLMs per family. We present both theoretical results on parameter identification and empirical evaluations on 12 prominent benchmarks, from Open LLM Leaderboard v1/v2, demonstrating that Sloth predicts LLM performance efficiently and offers insights into scaling behaviors for complex downstream tasks and increased test-time compute.

Large-scale foundation models have demonstrated exceptional performance in language and vision tasks. However, the numerous dense matrix-vector operations involved in these large networks pose significant computational challenges during inference. To address these challenges, we introduce the Block-Level Adaptive STructured (BLAST) matrix, designed to learn and leverage efficient structures prevalent in the weight matrices of linear layers within deep learning models. Compared to existing structured matrices, the BLAST matrix offers substantial flexibility, as it can represent various types of structures that are either learned from data or computed from pre-existing weight matrices. We demonstrate the efficiency of using the BLAST matrix for compressing both language and vision tasks, showing that (i) for medium-sized models such as ViT and GPT-2, training with BLAST weights boosts performance while reducing complexity by 70% and 40%, respectively; and (ii) for large foundation models such as Llama-7B and DiT-XL, the BLAST matrix achieves a 2x compression while exhibiting the lowest performance degradation among all tested structured matrices. Our code is available at https://github.com/changwoolee/BLAST.

Pruning eliminates unnecessary parameters in neural networks; it offers a promising solution to the growing computational demands of large language models (LLMs). While many focus on post-training pruning, sparse pre-training--which combines pruning and pre-training into a single phase--provides a simpler alternative. In this work, we present the first systematic exploration of optimal sparse pre-training configurations for LLMs through an examination of 80 unique pruning schedules across different sparsity levels and training durations. We find that initiating pruning at 25% of total training compute and concluding at 75% achieves near-optimal final evaluation loss. These findings provide valuable insights for efficient and effective sparse pre-training of LLMs. Furthermore, we propose a new scaling law that modifies the Chinchilla scaling law to use the average parameter count over pre-training. Through empirical and theoretical validation, we demonstrate that this modified scaling law accurately models evaluation loss for both sparsely and densely pre-trained LLMs, unifying scaling laws across pre-training paradigms. Our findings indicate that while sparse pre-training achieves the same final model quality as dense pre-training for equivalent compute budgets, it provides substantial benefits through reduced model size, enabling significant potential computational savings during inference.

Image-language learning has made unprecedented progress in visual understanding. These developments have come at high costs, as contemporary vision-language models require large model scales and amounts of data. We here propose a much easier recipe for image-language learning, which produces effective models, outperforming bigger and more expensive ones, often trained on orders of magnitude larger datasets. Our key finding is the joint learning of a compact vision and language representation, which adaptively and iteratively fuses the multi-modal features. This results in a more effective image-language learning, greatly lowering the FLOPs by combining and reducing the number of tokens for both text and images, e.g. a 33\% reduction in FLOPs is achieved, compared to baseline fusion techniques used by popular image-language models, while improving performance. This also allows the model to scale without a large increase in FLOPs or memory. In addition, we propose adaptive pre-training data sampling which improves the data efficiency. The proposed approach achieves competitive performance compared to much larger models, and does so with significantly less data and FLOPs. With only 40M training examples and with 39 GFLOPs our lightweight model outperforms many times larger state-of-the-art models of 2-20x more FLOPs and using bigger datasets some of which with close to 1B training examples.

Video matting aims to predict the alpha mattes for each frame from a given input video sequence. Recent solutions to video matting have been dominated by deep convolutional neural networks (CNN) for the past few years, which have become the de-facto standard for both academia and industry. However, they have inbuilt inductive bias of locality and do not capture global characteristics of an image due to the CNN-based architectures. They also lack long-range temporal modeling considering computational costs when dealing with feature maps of multiple frames. In this paper, we propose VMFormer: a transformer-based end-to-end method for video matting. It makes predictions on alpha mattes of each frame from learnable queries given a video input sequence. Specifically, it leverages self-attention layers to build global integration of feature sequences with short-range temporal modeling on successive frames. We further apply queries to learn global representations through cross-attention in the transformer decoder with long-range temporal modeling upon all queries. In the prediction stage, both queries and corresponding feature maps are used to make the final prediction of alpha matte. Experiments show that VMFormer outperforms previous CNN-based video matting methods on the composited benchmarks. To our best knowledge, it is the first end-to-end video matting solution built upon a full vision transformer with predictions on the learnable queries. The project is open-sourced at https://chrisjuniorli.github.io/project/VMFormer/

With the advent of deep generative models in computational chemistry, in silico anticancer drug design has undergone an unprecedented transformation. While state-of-the-art deep learning approaches have shown potential in generating compounds with desired chemical properties, they disregard the genetic profile and properties of the target disease. Here, we introduce the first generative model capable of tailoring anticancer compounds for a specific biomolecular profile. Using a RL framework, the transcriptomic profiles of cancer cells are used as a context for the generation of candidate molecules. Our molecule generator combines two separately pretrained variational autoencoders (VAEs) - the first VAE encodes transcriptomic profiles into a smooth, latent space which in turn is used to condition a second VAE to generate novel molecular structures on the given transcriptomic profile. The generative process is optimized through PaccMann, a previously developed drug sensitivity prediction model to obtain effective anticancer compounds for the given context (i.e., transcriptomic profile). We demonstrate how the molecule generation can be biased towards compounds with high predicted inhibitory effect against individual cell lines or specific cancer sites. We verify our approach by investigating candidate drugs generated against specific cancer types and find the highest structural similarity to existing compounds with known efficacy against these cancer types. We envision our approach to transform in silico anticancer drug design by leveraging the biomolecular characteristics of the disease in order to increase success rates in lead compound discovery.

The Vision Transformer (ViT) has made significant strides in the field of computer vision. However, as the depth of the model and the resolution of the input images increase, the computational cost associated with training and running ViT models has surged dramatically. This paper proposes a hybrid model based on CNN and Vision Transformer, named CI2P-ViT. The model incorporates a module called CI2P, which utilizes the CompressAI encoder to compress images and subsequently generates a sequence of patches through a series of convolutions. CI2P can replace the Patch Embedding component in the ViT model, enabling seamless integration into existing ViT models. Compared to ViT-B/16, CI2P-ViT has the number of patches input to the self-attention layer reduced to a quarter of the original. This design not only significantly reduces the computational cost of the ViT model but also effectively enhances the model's accuracy by introducing the inductive bias properties of CNN. The ViT model's precision is markedly enhanced. When trained from the ground up on the Animals-10 dataset, CI2P-ViT achieved an accuracy rate of 92.37%, representing a 3.3% improvement over the ViT-B/16 baseline. Additionally, the model's computational operations, measured in floating-point operations per second (FLOPs), were diminished by 63.35%, and it exhibited a 2-fold increase in training velocity on identical hardware configurations.

Global channel pruning (GCP) aims to remove a subset of channels (filters) across different layers from a deep model without hurting the performance. Previous works focus on either single task model pruning or simply adapting it to multitask scenario, and still face the following problems when handling multitask pruning: 1) Due to the task mismatch, a well-pruned backbone for classification task focuses on preserving filters that can extract category-sensitive information, causing filters that may be useful for other tasks to be pruned during the backbone pruning stage; 2) For multitask predictions, different filters within or between layers are more closely related and interacted than that for single task prediction, making multitask pruning more difficult. Therefore, aiming at multitask model compression, we propose a Performance-Aware Global Channel Pruning (PAGCP) framework. We first theoretically present the objective for achieving superior GCP, by considering the joint saliency of filters from intra- and inter-layers. Then a sequentially greedy pruning strategy is proposed to optimize the objective, where a performance-aware oracle criterion is developed to evaluate sensitivity of filters to each task and preserve the globally most task-related filters. Experiments on several multitask datasets show that the proposed PAGCP can reduce the FLOPs and parameters by over 60% with minor performance drop, and achieves 1.2xsim3.3x acceleration on both cloud and mobile platforms.

Image tokenization plays a critical role in reducing the computational demands of modeling high-resolution images, significantly improving the efficiency of image and multimodal understanding and generation. Recent advances in 1D latent spaces have reduced the number of tokens required by eliminating the need for a 2D grid structure. In this paper, we further advance compact discrete image representation by introducing 1D binary image latents. By representing each image as a sequence of binary vectors, rather than using traditional one-hot codebook tokens, our approach preserves high-resolution details while maintaining the compactness of 1D latents. To the best of our knowledge, our text-to-image models are the first to achieve competitive performance in both diffusion and auto-regressive generation using just 128 discrete tokens for images up to 1024x1024, demonstrating up to a 32-fold reduction in token numbers compared to standard VQ-VAEs. The proposed 1D binary latent space, coupled with simple model architectures, achieves marked improvements in speed training and inference speed. Our text-to-image models allow for a global batch size of 4096 on a single GPU node with 8 AMD MI300X GPUs, and the training can be completed within 200 GPU days. Our models achieve competitive performance compared to modern image generation models without any in-house private training data or post-training refinements, offering a scalable and efficient alternative to conventional tokenization methods.

Pairwise re-ranking models predict which of two documents is more relevant to a query and then aggregate a final ranking from such preferences. This is often more effective than pointwise re-ranking models that directly predict a relevance value for each document. However, the high inference overhead of pairwise models limits their practical application: usually, for a set of k documents to be re-ranked, preferences for all k^2-k comparison pairs excluding self-comparisons are aggregated. We investigate whether the efficiency of pairwise re-ranking can be improved by sampling from all pairs. In an exploratory study, we evaluate three sampling methods and five preference aggregation methods. The best combination allows for an order of magnitude fewer comparisons at an acceptable loss of retrieval effectiveness, while competitive effectiveness is already achieved with about one third of the comparisons.

We study self-rewarding reasoning large language models (LLMs), which can simultaneously generate step-by-step reasoning and evaluate the correctness of their outputs during the inference time-without external feedback. This integrated approach allows a single model to independently guide its reasoning process, offering computational advantages for model deployment. We particularly focus on the representative task of self-correction, where models autonomously detect errors in their responses, revise outputs, and decide when to terminate iterative refinement loops. To enable this, we propose a two-staged algorithmic framework for constructing self-rewarding reasoning models using only self-generated data. In the first stage, we employ sequential rejection sampling to synthesize long chain-of-thought trajectories that incorporate both self-rewarding and self-correction mechanisms. Fine-tuning models on these curated data allows them to learn the patterns of self-rewarding and self-correction. In the second stage, we further enhance the models' ability to assess response accuracy and refine outputs through reinforcement learning with rule-based signals. Experiments with Llama-3 and Qwen-2.5 demonstrate that our approach surpasses intrinsic self-correction capabilities and achieves performance comparable to systems that rely on external reward models.

Recently, there has been tremendous progress in visual synthesis and the underlying generative models. Here, diffusion models (DMs) stand out particularly, but lately, flow matching (FM) has also garnered considerable interest. While DMs excel in providing diverse images, they suffer from long training and slow generation. With latent diffusion, these issues are only partially alleviated. Conversely, FM offers faster training and inference but exhibits less diversity in synthesis. We demonstrate that introducing FM between the Diffusion model and the convolutional decoder offers high-resolution image synthesis with reduced computational cost and model size. Diffusion can then efficiently provide the necessary generation diversity. FM compensates for the lower resolution, mapping the small latent space to a high-dimensional one. Subsequently, the convolutional decoder of the LDM maps these latents to high-resolution images. By combining the diversity of DMs, the efficiency of FMs, and the effectiveness of convolutional decoders, we achieve state-of-the-art high-resolution image synthesis at 1024^2 with minimal computational cost. Importantly, our approach is orthogonal to recent approximation and speed-up strategies for the underlying DMs, making it easily integrable into various DM frameworks.

Diffusion Models (DM) have revolutionized the text-to-image visual generation process. However, the large computational cost and model footprint of DMs hinders practical deployment, especially on edge devices. Post-training quantization (PTQ) is a lightweight method to alleviate these burdens without the need for training or fine-tuning. While recent DM PTQ methods achieve W4A8 on integer-based PTQ, two key limitations remain: First, while most existing DM PTQ methods evaluate on classical DMs like Stable Diffusion XL, 1.5 or earlier, which use convolutional U-Nets, newer Diffusion Transformer (DiT) models like the PixArt series, Hunyuan and others adopt fundamentally different transformer backbones to achieve superior image synthesis. Second, integer (INT) quantization is prevailing in DM PTQ but doesn't align well with the network weight and activation distribution, while Floating-Point Quantization (FPQ) is still under-investigated, yet it holds the potential to better align the weight and activation distributions in low-bit settings for DiT. In response, we introduce FP4DiT, a PTQ method that leverages FPQ to achieve W4A6 quantization. Specifically, we extend and generalize the Adaptive Rounding PTQ technique to adequately calibrate weight quantization for FPQ and demonstrate that DiT activations depend on input patch data, necessitating robust online activation quantization techniques. Experimental results demonstrate that FP4DiT outperforms integer-based PTQ at W4A6 and W4A8 precision and generates convincing visual content on PixArt-alpha, PixArt-Sigma and Hunyuan in terms of several T2I metrics such as HPSv2 and CLIP.

A new generation of AI models generates step-by-step reasoning text before producing an answer. This text appears to offer a human-readable window into their computation process, and is increasingly relied upon for transparency and interpretability. However, it is unclear whether human understanding of this text matches the model's actual computational process. In this paper, we investigate a necessary condition for correspondence: the ability of humans to identify which steps in a reasoning text causally influence later steps. We evaluated humans on this ability by composing questions based on counterfactual measurements and found a significant discrepancy: participant accuracy was only 29.3%, barely above chance (25%), and remained low (42%) even when evaluating the majority vote on questions with high agreement. Our results reveal a fundamental gap between how humans interpret reasoning texts and how models use it, challenging its utility as a simple interpretability tool. We argue that reasoning texts should be treated as an artifact to be investigated, not taken at face value, and that understanding the non-human ways these models use language is a critical research direction.

Pre-training large language models (LLMs) necessitates enormous diverse textual corpora, making effective data selection a key challenge for balancing computational resources and model performance. Current methodologies primarily emphasize data quality metrics and mixing proportions, yet they fail to adequately capture the underlying semantic connections between training samples and quality disparities within individual domains. We introduce ToReMi (Topic-based Reweighting for Model improvement), a novel two-stage framework that dynamically adjusts training sample weights according to their topical associations and observed learning patterns. Our comprehensive experiments reveal that ToReMi variants consistently achieve superior performance over conventional pre-training approaches, demonstrating accelerated perplexity reduction across multiple domains and enhanced capabilities on downstream evaluation tasks. Code is available at https://github.com/zxx000728/ToReMi.

Medical image segmentation remains a formidable challenge due to the label scarcity. Pre-training Vision Transformer (ViT) through masked image modeling (MIM) on large-scale unlabeled medical datasets presents a promising solution, providing both computational efficiency and model generalization for various downstream tasks. However, current ViT-based MIM pre-training frameworks predominantly emphasize local aggregation representations in output layers and fail to exploit the rich representations across different ViT layers that better capture fine-grained semantic information needed for more precise medical downstream tasks. To fill the above gap, we hereby present Hierarchical Encoder-driven MAE (Hi-End-MAE), a simple yet effective ViT-based pre-training solution, which centers on two key innovations: (1) Encoder-driven reconstruction, which encourages the encoder to learn more informative features to guide the reconstruction of masked patches; and (2) Hierarchical dense decoding, which implements a hierarchical decoding structure to capture rich representations across different layers. We pre-train Hi-End-MAE on a large-scale dataset of 10K CT scans and evaluated its performance across seven public medical image segmentation benchmarks. Extensive experiments demonstrate that Hi-End-MAE achieves superior transfer learning capabilities across various downstream tasks, revealing the potential of ViT in medical imaging applications. The code is available at: https://github.com/FengheTan9/Hi-End-MAE

Large-scale multi-modal deep learning models have revolutionized domains such as healthcare, highlighting the importance of computational power. However, in resource-constrained regions like Low and Middle-Income Countries (LMICs), limited access to GPUs and data poses significant challenges, often leaving CPUs as the sole resource. To address this, we advocate for leveraging vector embeddings to enable flexible and efficient computational methodologies, democratizing multimodal deep learning across diverse contexts. Our paper investigates the efficiency and effectiveness of using vector embeddings from single-modal foundation models and multi-modal Vision-Language Models (VLMs) for multimodal deep learning in low-resource environments, particularly in healthcare. Additionally, we propose a simple yet effective inference-time method to enhance performance by aligning image-text embeddings. Comparing these approaches with traditional methods, we assess their impact on computational efficiency and model performance using metrics like accuracy, F1-score, inference time, training time, and memory usage across three medical modalities: BRSET (ophthalmology), HAM10000 (dermatology), and SatelliteBench (public health). Our findings show that embeddings reduce computational demands without compromising model performance. Furthermore, our alignment method improves performance in medical tasks. This research promotes sustainable AI practices by optimizing resources in constrained environments, highlighting the potential of embedding-based approaches for efficient multimodal learning. Vector embeddings democratize multimodal deep learning in LMICs, particularly in healthcare, enhancing AI adaptability in varied use cases.

As machine learning tasks continue to evolve, the trend has been to gather larger datasets and train increasingly larger models. While this has led to advancements in accuracy, it has also escalated computational costs to unsustainable levels. Addressing this, our work aims to strike a delicate balance between computational efficiency and model accuracy, a persisting challenge in the field. We introduce a novel method that employs core subset selection for reweighting, effectively optimizing both computational time and model performance. By focusing on a strategically selected coreset, our approach offers a robust representation, as it efficiently minimizes the influence of outliers. The re-calibrated weights are then mapped back to and propagated across the entire dataset. Our experimental results substantiate the effectiveness of this approach, underscoring its potential as a scalable and precise solution for model training.

Incrementally fine-tuning foundational models on new tasks or domains is now the de facto approach in NLP. A known pitfall of this approach is the catastrophic forgetting of prior knowledge that happens during fine-tuning. A common approach to alleviate such forgetting is to rehearse samples from prior tasks during fine-tuning. Several existing works assume a fixed memory buffer to store prior task examples, while relying on inferences (forward passes) with the model at hand for choosing examples for rehearsal from the buffer. However, given the increasing computational cost of model inference, and decreasing cost of data storage, we focus on the setting to rehearse samples with a fixed computational budget instead of a fixed memory budget. We propose a sampling scheme, \bf mix-cd, that prioritizes rehearsal of ``collateral damage'' samples, which are samples predicted correctly by the prior model but forgotten by the incrementally tuned one. The crux of our scheme is a procedure to efficiently estimate the density of collateral damage samples without incurring additional model inferences. Our approach is computationally efficient, easy to implement, and outperforms several leading continual learning methods in compute-constrained settings. All the code will be publicly available at https://github.com/jybai/mix-cd-rehearsal.

The quadratic computational complexity in the self-attention mechanism of popular transformer architectures poses significant challenges for training and inference, particularly in terms of efficiency and memory requirements. Towards addressing these challenges, this paper introduces a novel fast computation method for gradient calculation in multi-layer transformer models. Our approach enables the computation of gradients for the entire multi-layer transformer model in almost linear time n^{1+o(1)}, where n is the input sequence length. This breakthrough significantly reduces the computational bottleneck associated with the traditional quadratic time complexity. Our theory holds for any loss function and maintains a bounded approximation error across the entire model. Furthermore, our analysis can hold when the multi-layer transformer model contains many practical sub-modules, such as residual connection, casual mask, and multi-head attention. By improving the efficiency of gradient computation in large language models, we hope that our work will facilitate the more effective training and deployment of long-context language models based on our theoretical results.

In this work, we reveal the limitations of visual tokenizers and VAEs in preserving fine-grained features, and propose a benchmark to evaluate reconstruction performance for two challenging visual contents: text and face. Visual tokenizers and VAEs have significantly advanced visual generation and multimodal modeling by providing more efficient compressed or quantized image representations. However, while helping production models reduce computational burdens, the information loss from image compression fundamentally limits the upper bound of visual generation quality. To evaluate this upper bound, we focus on assessing reconstructed text and facial features since they typically: 1) exist at smaller scales, 2) contain dense and rich textures, 3) are prone to collapse, and 4) are highly sensitive to human vision. We first collect and curate a diverse set of clear text and face images from existing datasets. Unlike approaches using VLM models, we employ established OCR and face recognition models for evaluation, ensuring accuracy while maintaining an exceptionally lightweight assessment process <span style="font-weight: bold; color: rgb(214, 21, 21);">requiring just 2GB memory and 4 minutes</span> to complete. Using our benchmark, we analyze text and face reconstruction quality across various scales for different image tokenizers and VAEs. Our results show modern visual tokenizers still struggle to preserve fine-grained features, especially at smaller scales. We further extend this evaluation framework to video, conducting comprehensive analysis of video tokenizers. Additionally, we demonstrate that traditional metrics fail to accurately reflect reconstruction performance for faces and text, while our proposed metrics serve as an effective complement.

Explaining deep learning models is essential for clinical integration of medical image analysis systems. A good explanation highlights if a model depends on spurious features that undermines generalization and harms a subset of patients or, conversely, may present novel biological insights. Although techniques like GradCAM can identify influential features, they are measurement tools that do not themselves form an explanation. We propose a human-machine-VLM interaction system tailored to explaining classifiers in computational pathology, including multi-instance learning for whole-slide images. Our proof of concept comprises (1) an AI-integrated slide viewer to run sliding-window experiments to test claims of an explanation, and (2) quantification of an explanation's predictiveness using general-purpose vision-language models. The results demonstrate that this allows us to qualitatively test claims of explanations and can quantifiably distinguish competing explanations. This offers a practical path from explainable AI to explained AI in digital pathology and beyond. Code and prompts are available at https://github.com/nki-ai/x2x.

Recent advancements in fine-tuning Vision-Language Foundation Models (VLMs) have garnered significant attention for their effectiveness in downstream few-shot learning tasks.While these recent approaches exhibits some performance improvements, they often suffer from excessive training parameters and high computational costs. To address these challenges, we propose a novel Block matrix-based low-rank adaptation framework, called Block-LoRA, for fine-tuning VLMs on downstream few-shot tasks. Inspired by recent work on Low-Rank Adaptation (LoRA), Block-LoRA partitions the original low-rank decomposition matrix of LoRA into a series of sub-matrices while sharing all down-projection sub-matrices. This structure not only reduces the number of training parameters, but also transforms certain complex matrix multiplication operations into simpler matrix addition, significantly lowering the computational cost of fine-tuning. Notably, Block-LoRA enables fine-tuning CLIP on the ImageNet few-shot benchmark using a single 24GB GPU. We also show that Block-LoRA has the more tighter bound of generalization error than vanilla LoRA. Without bells and whistles, extensive experiments demonstrate that Block-LoRA achieves competitive performance compared to state-of-the-art CLIP-based few-shot methods, while maintaining a low training parameters count and reduced computational overhead.

Despite its importance for federated learning, continuous learning and many other applications, on-device training remains an open problem for EdgeAI. The problem stems from the large number of operations (e.g., floating point multiplications and additions) and memory consumption required during training by the back-propagation algorithm. Consequently, in this paper, we propose a new gradient filtering approach which enables on-device CNN model training. More precisely, our approach creates a special structure with fewer unique elements in the gradient map, thus significantly reducing the computational complexity and memory consumption of back propagation during training. Extensive experiments on image classification and semantic segmentation with multiple CNN models (e.g., MobileNet, DeepLabV3, UPerNet) and devices (e.g., Raspberry Pi and Jetson Nano) demonstrate the effectiveness and wide applicability of our approach. For example, compared to SOTA, we achieve up to 19times speedup and 77.1% memory savings on ImageNet classification with only 0.1% accuracy loss. Finally, our method is easy to implement and deploy; over 20times speedup and 90% energy savings have been observed compared to highly optimized baselines in MKLDNN and CUDNN on NVIDIA Jetson Nano. Consequently, our approach opens up a new direction of research with a huge potential for on-device training.

Transformers have revolutionized almost all natural language processing (NLP) tasks but suffer from memory and computational complexity that scales quadratically with sequence length. In contrast, recurrent neural networks (RNNs) exhibit linear scaling in memory and computational requirements but struggle to match the same performance as Transformers due to limitations in parallelization and scalability. We propose a novel model architecture, Receptance Weighted Key Value (RWKV), that combines the efficient parallelizable training of Transformers with the efficient inference of RNNs. Our approach leverages a linear attention mechanism and allows us to formulate the model as either a Transformer or an RNN, which parallelizes computations during training and maintains constant computational and memory complexity during inference, leading to the first non-transformer architecture to be scaled to tens of billions of parameters. Our experiments reveal that RWKV performs on par with similarly sized Transformers, suggesting that future work can leverage this architecture to create more efficient models. This work presents a significant step towards reconciling the trade-offs between computational efficiency and model performance in sequence processing tasks.

The label scarcity problem is the main challenge that hinders the wide application of deep learning systems in automatic cardiovascular diseases (CVDs) detection using electrocardiography (ECG). Tuning pre-trained models alleviates this problem by transferring knowledge learned from large datasets to downstream small datasets. However, bottlenecks in computational efficiency and detection performance limit its clinical applications. It is difficult to improve the detection performance without significantly sacrificing the computational efficiency during model training. Here, we propose a computation-efficient semi-supervised learning paradigm (CE-SSL) for robust and computation-efficient CVDs detection using ECG. It enables a robust adaptation of pre-trained models on downstream datasets with limited supervision and high computational efficiency. First, a random-deactivation technique is developed to achieve robust and fast low-rank adaptation of pre-trained weights. Subsequently, we propose a one-shot rank allocation module to determine the optimal ranks for the update matrices of the pre-trained weights. Finally, a lightweight semi-supervised learning pipeline is introduced to enhance model performance by leveraging labeled and unlabeled data with high computational efficiency. Extensive experiments on four downstream datasets demonstrate that CE-SSL not only outperforms the state-of-the-art methods in multi-label CVDs detection but also consumes fewer GPU footprints, training time, and parameter storage space. As such, this paradigm provides an effective solution for achieving high computational efficiency and robust detection performance in the clinical applications of pre-trained models under limited supervision. Code and Supplementary Materials are available at https://github.com/KAZABANA/CE-SSL

Scaling sequence length has become a critical demand in the era of large language models. However, existing methods struggle with either computational complexity or model expressivity, rendering the maximum sequence length restricted. In this work, we introduce LongNet, a Transformer variant that can scale sequence length to more than 1 billion tokens, without sacrificing the performance on shorter sequences. Specifically, we propose dilated attention, which expands the attentive field exponentially as the distance grows. LongNet has significant advantages: 1) it has a linear computation complexity and a logarithm dependency between tokens; 2) it can be served as a distributed trainer for extremely long sequences; 3) its dilated attention is a drop-in replacement for standard attention, which can be seamlessly integrated with the existing Transformer-based optimization. Experiments results demonstrate that LongNet yields strong performance on both long-sequence modeling and general language tasks. Our work opens up new possibilities for modeling very long sequences, e.g., treating a whole corpus or even the entire Internet as a sequence.

The development of efficient machine learning models for molecular systems representation is becoming crucial in scientific research. We introduce TensorNet, an innovative O(3)-equivariant message-passing neural network architecture that leverages Cartesian tensor representations. By using Cartesian tensor atomic embeddings, feature mixing is simplified through matrix product operations. Furthermore, the cost-effective decomposition of these tensors into rotation group irreducible representations allows for the separate processing of scalars, vectors, and tensors when necessary. Compared to higher-rank spherical tensor models, TensorNet demonstrates state-of-the-art performance with significantly fewer parameters. For small molecule potential energies, this can be achieved even with a single interaction layer. As a result of all these properties, the model's computational cost is substantially decreased. Moreover, the accurate prediction of vector and tensor molecular quantities on top of potential energies and forces is possible. In summary, TensorNet's framework opens up a new space for the design of state-of-the-art equivariant models.

Climate-economic modeling under uncertainty presents significant computational challenges that may limit policymakers' ability to address climate change effectively. This paper explores neural network-based approaches for solving high-dimensional optimal control problems arising from models that incorporate ambiguity aversion in climate mitigation decisions. We develop a continuous-time endogenous-growth economic model that accounts for multiple mitigation pathways, including emission-free capital and carbon intensity reductions. Given the inherent complexity and high dimensionality of these models, traditional numerical methods become computationally intractable. We benchmark several neural network architectures against finite-difference generated solutions, evaluating their ability to capture the dynamic interactions between uncertainty, technology transitions, and optimal climate policy. Our findings demonstrate that appropriate neural architecture selection significantly impacts both solution accuracy and computational efficiency when modeling climate-economic systems under uncertainty. These methodological advances enable more sophisticated modeling of climate policy decisions, allowing for better representation of technology transitions and uncertainty-critical elements for developing effective mitigation strategies in the face of climate change.

Through considerable effort and intuition, several recent works have reverse-engineered nontrivial behaviors of transformer models. This paper systematizes the mechanistic interpretability process they followed. First, researchers choose a metric and dataset that elicit the desired model behavior. Then, they apply activation patching to find which abstract neural network units are involved in the behavior. By varying the dataset, metric, and units under investigation, researchers can understand the functionality of each component. We automate one of the process' steps: to identify the circuit that implements the specified behavior in the model's computational graph. We propose several algorithms and reproduce previous interpretability results to validate them. For example, the ACDC algorithm rediscovered 5/5 of the component types in a circuit in GPT-2 Small that computes the Greater-Than operation. ACDC selected 68 of the 32,000 edges in GPT-2 Small, all of which were manually found by previous work. Our code is available at https://github.com/ArthurConmy/Automatic-Circuit-Discovery.

State-of-the-art language models are becoming increasingly large in an effort to achieve the highest performance on large corpora of available textual data. However, the sheer size of the Transformer architectures makes it difficult to deploy models within computational, environmental or device-specific constraints. We explore data-driven compression of existing pretrained models as an alternative to training smaller models from scratch. To do so, we scale Kronecker-factored curvature approximations of the target loss landscape to large language models. In doing so, we can compute both the dynamic allocation of structures that can be removed as well as updates of remaining weights that account for the removal. We provide a general framework for unstructured, semi-structured and structured pruning and improve upon weight updates to capture more correlations between weights, while remaining computationally efficient. Experimentally, our method can prune rows and columns from a range of OPT models and Llamav2-7B by 20%-30%, with a negligible loss in performance, and achieve state-of-the-art results in unstructured and semi-structured pruning of large language models.

The success of deep learning in vision can be attributed to: (a) models with high capacity; (b) increased computational power; and (c) availability of large-scale labeled data. Since 2012, there have been significant advances in representation capabilities of the models and computational capabilities of GPUs. But the size of the biggest dataset has surprisingly remained constant. What will happen if we increase the dataset size by 10x or 100x? This paper takes a step towards clearing the clouds of mystery surrounding the relationship between `enormous data' and visual deep learning. By exploiting the JFT-300M dataset which has more than 375M noisy labels for 300M images, we investigate how the performance of current vision tasks would change if this data was used for representation learning. Our paper delivers some surprising (and some expected) findings. First, we find that the performance on vision tasks increases logarithmically based on volume of training data size. Second, we show that representation learning (or pre-training) still holds a lot of promise. One can improve performance on many vision tasks by just training a better base model. Finally, as expected, we present new state-of-the-art results for different vision tasks including image classification, object detection, semantic segmentation and human pose estimation. Our sincere hope is that this inspires vision community to not undervalue the data and develop collective efforts in building larger datasets.

The attention mechanism, a cornerstone of state-of-the-art neural models, faces computational hurdles in processing long sequences due to its quadratic complexity. Consequently, research efforts in the last few years focused on finding more efficient alternatives. Among them, Hyena (Poli et al., 2023) stands out for achieving competitive results in both language modeling and image classification, while offering sub-quadratic memory and computational complexity. Building on these promising results, we propose ConfHyena, a Conformer whose encoder self-attentions are replaced with an adaptation of Hyena for speech processing, where the long input sequences cause high computational costs. Through experiments in automatic speech recognition (for English) and translation (from English into 8 target languages), we show that our best ConfHyena model significantly reduces the training time by 27%, at the cost of minimal quality degradation (~1%), which, in most cases, is not statistically significant.

Despite their many successes, transformer-based large language models (LLMs) continue to struggle with tasks that require complex reasoning over large parts of their input. We argue that these failures arise due to capacity limits on the accurate flow of information within LLMs. To formalize this issue, we introduce the bounded attention prefix oracle (BAPO) model, a new computational framework that models bandwidth constraints on attention heads, the mechanism for internal communication in LLMs. We show that several important reasoning problems like graph reachability require high communication bandwidth for BAPOs to solve; we call these problems BAPO-hard. Our experiments corroborate our theoretical predictions: GPT-4o, Claude, and Gemini succeed on BAPO-easy tasks and fail even on relatively small BAPO-hard tasks. BAPOs also reveal another benefit of chain of thought (CoT): we prove that breaking down a task using CoT can turn any BAPO-hard problem into a BAPO-easy one. Our results offer principled explanations for key LLM failures and suggest directions for architectures and inference methods that mitigate bandwidth limits.

Currently, one main research line in designing a more efficient vision transformer is reducing the computational cost of self attention modules by adopting sparse attention or using local attention windows. In contrast, we propose a different approach that aims to improve the performance of transformer-based architectures by densifying the attention pattern. Specifically, we proposed forward cross attention for hybrid vision transformer (FcaFormer), where tokens from previous blocks in the same stage are secondary used. To achieve this, the FcaFormer leverages two innovative components: learnable scale factors (LSFs) and a token merge and enhancement module (TME). The LSFs enable efficient processing of cross tokens, while the TME generates representative cross tokens. By integrating these components, the proposed FcaFormer enhances the interactions of tokens across blocks with potentially different semantics, and encourages more information flows to the lower levels. Based on the forward cross attention (Fca), we have designed a series of FcaFormer models that achieve the best trade-off between model size, computational cost, memory cost, and accuracy. For example, without the need for knowledge distillation to strengthen training, our FcaFormer achieves 83.1% top-1 accuracy on Imagenet with only 16.3 million parameters and about 3.6 billion MACs. This saves almost half of the parameters and a few computational costs while achieving 0.7% higher accuracy compared to distilled EfficientFormer.

Existing video-language studies mainly focus on learning short video clips, leaving long-term temporal dependencies rarely explored due to over-high computational cost of modeling long videos. To address this issue, one feasible solution is learning the correspondence between video clips and captions, which however inevitably encounters the multi-granularity noisy correspondence (MNC) problem. To be specific, MNC refers to the clip-caption misalignment (coarse-grained) and frame-word misalignment (fine-grained), hindering temporal learning and video understanding. In this paper, we propose NOise Robust Temporal Optimal traNsport (Norton) that addresses MNC in a unified optimal transport (OT) framework. In brief, Norton employs video-paragraph and clip-caption contrastive losses to capture long-term dependencies based on OT. To address coarse-grained misalignment in video-paragraph contrast, Norton filters out the irrelevant clips and captions through an alignable prompt bucket and realigns asynchronous clip-caption pairs based on transport distance. To address the fine-grained misalignment, Norton incorporates a soft-maximum operator to identify crucial words and key frames. Additionally, Norton exploits the potential faulty negative samples in clip-caption contrast by rectifying the alignment target with OT assignment to ensure precise temporal modeling. Extensive experiments on video retrieval, videoQA, and action segmentation verify the effectiveness of our method. Code is available at https://lin-yijie.github.io/projects/Norton.

Despite the tantalizing success in a broad of vision tasks, transformers have not yet demonstrated on-par ability as ConvNets in high-resolution image generative modeling. In this paper, we seek to explore using pure transformers to build a generative adversarial network for high-resolution image synthesis. To this end, we believe that local attention is crucial to strike the balance between computational efficiency and modeling capacity. Hence, the proposed generator adopts Swin transformer in a style-based architecture. To achieve a larger receptive field, we propose double attention which simultaneously leverages the context of the local and the shifted windows, leading to improved generation quality. Moreover, we show that offering the knowledge of the absolute position that has been lost in window-based transformers greatly benefits the generation quality. The proposed StyleSwin is scalable to high resolutions, with both the coarse geometry and fine structures benefit from the strong expressivity of transformers. However, blocking artifacts occur during high-resolution synthesis because performing the local attention in a block-wise manner may break the spatial coherency. To solve this, we empirically investigate various solutions, among which we find that employing a wavelet discriminator to examine the spectral discrepancy effectively suppresses the artifacts. Extensive experiments show the superiority over prior transformer-based GANs, especially on high resolutions, e.g., 1024x1024. The StyleSwin, without complex training strategies, excels over StyleGAN on CelebA-HQ 1024, and achieves on-par performance on FFHQ-1024, proving the promise of using transformers for high-resolution image generation. The code and models will be available at https://github.com/microsoft/StyleSwin.

We introduce LLaVA-MoD, a novel framework designed to enable the efficient training of small-scale Multimodal Language Models (s-MLLM) by distilling knowledge from large-scale MLLM (l-MLLM). Our approach tackles two fundamental challenges in MLLM distillation. First, we optimize the network structure of s-MLLM by integrating a sparse Mixture of Experts (MoE) architecture into the language model, striking a balance between computational efficiency and model expressiveness. Second, we propose a progressive knowledge transfer strategy to ensure comprehensive knowledge migration. This strategy begins with mimic distillation, where we minimize the Kullback-Leibler (KL) divergence between output distributions to enable the student model to emulate the teacher network's understanding. Following this, we introduce preference distillation via Direct Preference Optimization (DPO), where the key lies in treating l-MLLM as the reference model. During this phase, the s-MLLM's ability to discriminate between superior and inferior examples is significantly enhanced beyond l-MLLM, leading to a better student that surpasses its teacher, particularly in hallucination benchmarks. Extensive experiments demonstrate that LLaVA-MoD outperforms existing models across various multimodal benchmarks while maintaining a minimal number of activated parameters and low computational costs. Remarkably, LLaVA-MoD, with only 2B activated parameters, surpasses Qwen-VL-Chat-7B by an average of 8.8% across benchmarks, using merely 0.3% of the training data and 23% trainable parameters. These results underscore LLaVA-MoD's ability to effectively distill comprehensive knowledge from its teacher model, paving the way for the development of more efficient MLLMs. The code will be available on: https://github.com/shufangxun/LLaVA-MoD.

Forensic pathology is critical in determining the cause and manner of death through post-mortem examinations, both macroscopic and microscopic. The field, however, grapples with issues such as outcome variability, laborious processes, and a scarcity of trained professionals. This paper presents SongCi, an innovative visual-language model (VLM) designed specifically for forensic pathology. SongCi utilizes advanced prototypical cross-modal self-supervised contrastive learning to enhance the accuracy, efficiency, and generalizability of forensic analyses. It was pre-trained and evaluated on a comprehensive multi-center dataset, which includes over 16 million high-resolution image patches, 2,228 vision-language pairs of post-mortem whole slide images (WSIs), and corresponding gross key findings, along with 471 distinct diagnostic outcomes. Our findings indicate that SongCi surpasses existing multi-modal AI models in many forensic pathology tasks, performs comparably to experienced forensic pathologists and significantly better than less experienced ones, and provides detailed multi-modal explainability, offering critical assistance in forensic investigations. To the best of our knowledge, SongCi is the first VLM specifically developed for forensic pathological analysis and the first large-vocabulary computational pathology (CPath) model that directly processes gigapixel WSIs in forensic science.

Mixture-of-Expert (MoE) models have obtained state-of-the-art performance in Neural Machine Translation (NMT) tasks. Existing works in MoE mostly consider a homogeneous design where the same number of experts of the same size are placed uniformly throughout the network. Furthermore, existing MoE works do not consider computational constraints (e.g., FLOPs, latency) to guide their design. To this end, we develop AutoMoE -- a framework for designing heterogeneous MoE's under computational constraints. AutoMoE leverages Neural Architecture Search (NAS) to obtain efficient sparse MoE sub-transformers with 4x inference speedup (CPU) and FLOPs reduction over manually designed Transformers, with parity in BLEU score over dense Transformer and within 1 BLEU point of MoE SwitchTransformer, on aggregate over benchmark datasets for NMT. Heterogeneous search space with dense and sparsely activated Transformer modules (e.g., how many experts? where to place them? what should be their sizes?) allows for adaptive compute -- where different amounts of computations are used for different tokens in the input. Adaptivity comes naturally from routing decisions which send tokens to experts of different sizes. AutoMoE code, data, and trained models are available at https://aka.ms/AutoMoE.

Imposing known physical constraints, such as conservation laws, during neural network training introduces an inductive bias that can improve accuracy, reliability, convergence, and data efficiency for modeling physical dynamics. While such constraints can be softly imposed via loss function penalties, recent advancements in differentiable physics and optimization improve performance by incorporating PDE-constrained optimization as individual layers in neural networks. This enables a stricter adherence to physical constraints. However, imposing hard constraints significantly increases computational and memory costs, especially for complex dynamical systems. This is because it requires solving an optimization problem over a large number of points in a mesh, representing spatial and temporal discretizations, which greatly increases the complexity of the constraint. To address this challenge, we develop a scalable approach to enforce hard physical constraints using Mixture-of-Experts (MoE), which can be used with any neural network architecture. Our approach imposes the constraint over smaller decomposed domains, each of which is solved by an "expert" through differentiable optimization. During training, each expert independently performs a localized backpropagation step by leveraging the implicit function theorem; the independence of each expert allows for parallelization across multiple GPUs. Compared to standard differentiable optimization, our scalable approach achieves greater accuracy in the neural PDE solver setting for predicting the dynamics of challenging non-linear systems. We also improve training stability and require significantly less computation time during both training and inference stages.

Programming-by-example is the task of synthesizing a program that is consistent with a set of user-provided input-output examples. As examples are often an under-specification of one's intent, a good synthesizer must choose the intended program from the many that are consistent with the given set of examples. Prior work frames program synthesis as a cooperative game between a listener (that synthesizes programs) and a speaker (a user choosing examples), and shows that models of computational pragmatic inference are effective in choosing the user intended programs. However, these models require counterfactual reasoning over a large set of programs and examples, which is infeasible in realistic program spaces. In this paper, we propose a novel way to amortize this search with neural networks. We sample pairs of programs and examples via self-play between listener and speaker models, and use pragmatic inference to choose informative training examples from this sample.We then use the informative dataset to train models to improve the synthesizer's ability to disambiguate user-provided examples without human supervision. We validate our method on the challenging task of synthesizing regular expressions from example strings, and find that our method (1) outperforms models trained without choosing pragmatic examples by 23% (a 51% relative increase) (2) matches the performance of supervised learning on a dataset of pragmatic examples provided by humans, despite using no human data in training.

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational pathology (CPath). However, automatic recognition of different nuclei is faced with a major challenge in that there are several different types of nuclei, some of them exhibiting large intraclass variability. In this work, we propose an approach that combine Separable-HoverNet and Instance-YOLOv5 to indentify colon nuclei small and unbalanced. Our approach can achieve mPQ+ 0.389 on the Segmentation and Classification-Preliminary Test Dataset and r2 0.599 on the Cellular Composition-Preliminary Test Dataset on ISBI 2022 CoNIC Challenge.

While large language models (LLMs) dominate the AI landscape, Small-scale large Language Models (SLMs) are gaining attention due to cost and efficiency demands from consumers. However, there is limited research on the training behavior and computational requirements of SLMs. In this study, we explore the computational bottlenecks of training SLMs (up to 2B parameters) by examining the effects of various hyperparameters and configurations, including GPU type, batch size, model size, communication protocol, attention type, and the number of GPUs. We assess these factors on popular cloud services using metrics such as loss per dollar and tokens per second. Our findings aim to support the broader adoption and optimization of language model training for low-resource AI research institutes.

Chaining language model (LM) calls as composable modules is fueling a new powerful way of programming. However, ensuring that LMs adhere to important constraints remains a key challenge, one often addressed with heuristic "prompt engineering". We introduce LM Assertions, a new programming construct for expressing computational constraints that LMs should satisfy. We integrate our constructs into the recent DSPy programming model for LMs, and present new strategies that allow DSPy to compile programs with arbitrary LM Assertions into systems that are more reliable and more accurate. In DSPy, LM Assertions can be integrated at compile time, via automatic prompt optimization, and/or at inference time, via automatic selfrefinement and backtracking. We report on two early case studies for complex question answering (QA), in which the LM program must iteratively retrieve information in multiple hops and synthesize a long-form answer with citations. We find that LM Assertions improve not only compliance with imposed rules and guidelines but also enhance downstream task performance, delivering intrinsic and extrinsic gains up to 35.7% and 13.3%, respectively. Our reference implementation of LM Assertions is integrated into DSPy at https://github.com/stanfordnlp/dspy

Recently, Visual Autoregressive (VAR) Models introduced a groundbreaking advancement in the field of image generation, offering a scalable approach through a coarse-to-fine "next-scale prediction" paradigm. However, the state-of-the-art algorithm of VAR models in [Tian, Jiang, Yuan, Peng and Wang, NeurIPS 2024] takes O(n^4) time, which is computationally inefficient. In this work, we analyze the computational limits and efficiency criteria of VAR Models through a fine-grained complexity lens. Our key contribution is identifying the conditions under which VAR computations can achieve sub-quadratic time complexity. Specifically, we establish a critical threshold for the norm of input matrices used in VAR attention mechanisms. Above this threshold, assuming the Strong Exponential Time Hypothesis (SETH) from fine-grained complexity theory, a sub-quartic time algorithm for VAR models is impossible. To substantiate our theoretical findings, we present efficient constructions leveraging low-rank approximations that align with the derived criteria. This work initiates the study of the computational efficiency of the VAR model from a theoretical perspective. Our technique will shed light on advancing scalable and efficient image generation in VAR frameworks.

We study the computational limits of Low-Rank Adaptation (LoRA) update for finetuning transformer-based models using fine-grained complexity theory. Our key observation is that the existence of low-rank decompositions within the gradient computation of LoRA adaptation leads to possible algorithmic speedup. This allows us to (i) identify a phase transition behavior and (ii) prove the existence of nearly linear algorithms by controlling the LoRA update computation term by term, assuming the Strong Exponential Time Hypothesis (SETH). For the former, we identify a sharp transition in the efficiency of all possible rank-r LoRA update algorithms for transformers, based on specific norms resulting from the multiplications of the input sequence X, pretrained weights W^star, and adapter matrices alpha B A / r. Specifically, we derive a shared upper bound threshold for such norms and show that efficient (sub-quadratic) approximation algorithms of LoRA exist only below this threshold. For the latter, we prove the existence of nearly linear approximation algorithms for LoRA adaptation by utilizing the hierarchical low-rank structures of LoRA gradients and approximating the gradients with a series of chained low-rank approximations. To showcase our theory, we consider two practical scenarios: partial (e.g., only W_V and W_Q) and full adaptations (e.g., W_Q, W_V, and W_K) of weights in attention heads.

Text analysis of social media for sentiment, topic analysis, and other analysis depends initially on the selection of keywords and phrases that will be used to create the research corpora. However, keywords that researchers choose may occur infrequently, leading to errors that arise from using small samples. In this paper, we use the capacity for memorization, interpolation, and extrapolation of Transformer Language Models such as the GPT series to learn the linguistic behaviors of a subgroup within larger corpora of Yelp reviews. We then use prompt-based queries to generate synthetic text that can be analyzed to produce insights into specific opinions held by the populations that the models were trained on. Once learned, more specific sentiment queries can be made of the model with high levels of accuracy when compared to traditional keyword searches. We show that even in cases where a specific keyphrase is limited or not present at all in the training corpora, the GPT is able to accurately generate large volumes of text that have the correct sentiment.

Practical identifiability is a critical concern in data-driven modeling of mathematical systems. In this paper, we propose a novel framework for practical identifiability analysis to evaluate parameter identifiability in mathematical models of biological systems. Starting with a rigorous mathematical definition of practical identifiability, we demonstrate its equivalence to the invertibility of the Fisher Information Matrix. Our framework establishes the relationship between practical identifiability and coordinate identifiability, introducing a novel metric that simplifies and accelerates the evaluation of parameter identifiability compared to the profile likelihood method. Additionally, we introduce new regularization terms to address non-identifiable parameters, enabling uncertainty quantification and improving model reliability. To guide experimental design, we present an optimal data collection algorithm that ensures all model parameters are practically identifiable. Applications to Hill functions, neural networks, and dynamic biological models demonstrate the feasibility and efficiency of the proposed computational framework in uncovering critical biological processes and identifying key observable variables.

Multiple Instance Learning (MIL) has emerged as a dominant paradigm to extract discriminative feature representations within Whole Slide Images (WSIs) in computational pathology. Despite driving notable progress, existing MIL approaches suffer from limitations in facilitating comprehensive and efficient interactions among instances, as well as challenges related to time-consuming computations and overfitting. In this paper, we incorporate the Selective Scan Space State Sequential Model (Mamba) in Multiple Instance Learning (MIL) for long sequence modeling with linear complexity, termed as MambaMIL. By inheriting the capability of vanilla Mamba, MambaMIL demonstrates the ability to comprehensively understand and perceive long sequences of instances. Furthermore, we propose the Sequence Reordering Mamba (SR-Mamba) aware of the order and distribution of instances, which exploits the inherent valuable information embedded within the long sequences. With the SR-Mamba as the core component, MambaMIL can effectively capture more discriminative features and mitigate the challenges associated with overfitting and high computational overhead. Extensive experiments on two public challenging tasks across nine diverse datasets demonstrate that our proposed framework performs favorably against state-of-the-art MIL methods. The code is released at https://github.com/isyangshu/MambaMIL.

Classification algorithms have recently found applications in computational physics for the selection of numerical methods or models adapted to the environment and the state of the physical system. For such classification tasks, labeled training data come from numerical simulations and generally correspond to physical fields discretized on a mesh. Three challenging difficulties arise: the lack of training data, their high dimensionality, and the non-applicability of common data augmentation techniques to physics data. This article introduces two algorithms to address these issues, one for dimensionality reduction via feature selection, and one for data augmentation. These algorithms are combined with a wide variety of classifiers for their evaluation. When combined with a stacking ensemble made of six multilayer perceptrons and a ridge logistic regression, they enable reaching an accuracy of 90% on our classification problem for nonlinear structural mechanics.

Real-world applications of large language models (LLMs) in computational social science (CSS) tasks primarily depend on the effectiveness of instruction tuning (IT) or in-context learning (ICL). While IT has shown highly effective at fine-tuning LLMs for various tasks, ICL offers a rapid alternative for task adaptation by learning from examples without explicit gradient updates. In this paper, we evaluate the classification performance of LLMs using IT versus ICL in few-shot CSS tasks. The experimental results indicate that ICL consistently outperforms IT in most CSS tasks. Additionally, we investigate the relationship between the increasing number of training samples and LLM performance. Our findings show that simply increasing the number of samples without considering their quality does not consistently enhance the performance of LLMs with either ICL or IT and can sometimes even result in a performance decline. Finally, we compare three prompting strategies, demonstrating that ICL is more effective than zero-shot and Chain-of-Thought (CoT). Our research highlights the significant advantages of ICL in handling CSS tasks in few-shot settings and emphasizes the importance of optimizing sample quality and prompting strategies to improve LLM classification performance. The code will be made available.

Extracting semantic representations from mobile user interfaces (UI) and using the representations for designers' decision-making processes have shown the potential to be effective computational design support tools. Current approaches rely on machine learning models trained on small-sized mobile UI datasets to extract semantic vectors and use screenshot-to-screenshot comparison to retrieve similar-looking UIs given query screenshots. However, the usability of these methods is limited because they are often not open-sourced and have complex training pipelines for practitioners to follow, and are unable to perform screenshot set-to-set (i.e., app-to-app) retrieval. To this end, we (1) employ visual models trained with large web-scale images and test whether they could extract a UI representation in a zero-shot way and outperform existing specialized models, and (2) use mathematically founded methods to enable app-to-app retrieval and design consistency analysis. Our experiments show that our methods not only improve upon previous retrieval models but also enable multiple new applications.

Digital cameras transform sensor RAW readings into RGB images by means of their Image Signal Processor (ISP). Computational photography tasks such as image denoising and colour constancy are commonly performed in the RAW domain, in part due to the inherent hardware design, but also due to the appealing simplicity of noise statistics that result from the direct sensor readings. Despite this, the availability of RAW images is limited in comparison with the abundance and diversity of available RGB data. Recent approaches have attempted to bridge this gap by estimating the RGB to RAW mapping: handcrafted model-based methods that are interpretable and controllable usually require manual parameter fine-tuning, while end-to-end learnable neural networks require large amounts of training data, at times with complex training procedures, and generally lack interpretability and parametric control. Towards addressing these existing limitations, we present a novel hybrid model-based and data-driven ISP that builds on canonical ISP operations and is both learnable and interpretable. Our proposed invertible model, capable of bidirectional mapping between RAW and RGB domains, employs end-to-end learning of rich parameter representations, i.e. dictionaries, that are free from direct parametric supervision and additionally enable simple and plausible data augmentation. We evidence the value of our data generation process by extensive experiments under both RAW image reconstruction and RAW image denoising tasks, obtaining state-of-the-art performance in both. Additionally, we show that our ISP can learn meaningful mappings from few data samples, and that denoising models trained with our dictionary-based data augmentation are competitive despite having only few or zero ground-truth labels.

Machine learning for time-series forecasting remains a key area of research. Despite successful application of many machine learning techniques, relating computational efficiency to forecast error remains an under-explored domain. This paper addresses this topic through a series of real-time experiments to quantify the relationship between computational cost and forecast error using meteorological nowcasting as an example use-case. We employ a variety of popular regression techniques (XGBoost, FC-MLP, Transformer, and LSTM) for multi-horizon, short-term forecasting of three variables (temperature, wind speed, and cloud cover) for multiple locations. During a 5-day live experiment, 4000 data sources were streamed for training and inferencing 144 models per hour. These models were parameterized to explore forecast error for two computational cost minimization methods: a novel auto-adaptive data reduction technique (Variance Horizon) and a performance-based concept drift-detection mechanism. Forecast error of all model variations were benchmarked in real-time against a state-of-the-art numerical weather prediction model. Performance was assessed using classical and novel evaluation metrics. Results indicate that using the Variance Horizon reduced computational usage by more than 50\%, while increasing between 0-15\% in error. Meanwhile, performance-based retraining reduced computational usage by up to 90\% while also improving forecast error by up to 10\%. Finally, the combination of both the Variance Horizon and performance-based retraining outperformed other model configurations by up to 99.7\% when considering error normalized to computational usage.

Deep learning yields great results across many fields, from speech recognition, image classification, to translation. But for each problem, getting a deep model to work well involves research into the architecture and a long period of tuning. We present a single model that yields good results on a number of problems spanning multiple domains. In particular, this single model is trained concurrently on ImageNet, multiple translation tasks, image captioning (COCO dataset), a speech recognition corpus, and an English parsing task. Our model architecture incorporates building blocks from multiple domains. It contains convolutional layers, an attention mechanism, and sparsely-gated layers. Each of these computational blocks is crucial for a subset of the tasks we train on. Interestingly, even if a block is not crucial for a task, we observe that adding it never hurts performance and in most cases improves it on all tasks. We also show that tasks with less data benefit largely from joint training with other tasks, while performance on large tasks degrades only slightly if at all.

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances, foundation models are still limited in their ability to encode the entire gigapixel whole-slide images without additional training and often lack complementary multimodal data. Here, we introduce Threads, a slide-level foundation model capable of generating universal representations of whole-slide images of any size. Threads was pre-trained using a multimodal learning approach on a diverse cohort of 47,171 hematoxylin and eosin (H&E)-stained tissue sections, paired with corresponding genomic and transcriptomic profiles - the largest such paired dataset to be used for foundation model development to date. This unique training paradigm enables Threads to capture the tissue's underlying molecular composition, yielding powerful representations applicable to a wide array of downstream tasks. In extensive benchmarking across 54 oncology tasks, including clinical subtyping, grading, mutation prediction, immunohistochemistry status determination, treatment response prediction, and survival prediction, Threads outperformed all baselines while demonstrating remarkable generalizability and label efficiency. It is particularly well suited for predicting rare events, further emphasizing its clinical utility. We intend to make the model publicly available for the broader community.

Antibodies comprise the most versatile class of binding molecules, with numerous applications in biomedicine. Computational design of antibodies involves generating novel and diverse sequences, while maintaining structural consistency. Unique to antibodies, designing the complementarity-determining region (CDR), which determines the antigen binding affinity and specificity, creates its own unique challenges. Recent deep learning models have shown impressive results, however the limited number of known antibody sequence/structure pairs frequently leads to degraded performance, particularly lacking diversity in the generated sequences. In our work we address this challenge by leveraging Model Reprogramming (MR), which repurposes pretrained models on a source language to adapt to the tasks that are in a different language and have scarce data - where it may be difficult to train a high-performing model from scratch or effectively fine-tune an existing pre-trained model on the specific task. Specifically, we introduce ReprogBert in which a pretrained English language model is repurposed for protein sequence infilling - thus considers cross-language adaptation using less data. Results on antibody design benchmarks show that our model on low-resourced antibody sequence dataset provides highly diverse CDR sequences, up to more than a two-fold increase of diversity over the baselines, without losing structural integrity and naturalness. The generated sequences also demonstrate enhanced antigen binding specificity and virus neutralization ability. Code is available at https://github.com/IBM/ReprogBERT

Surrogate models are necessary to optimize meaningful quantities in physical dynamics as their recursive numerical resolutions are often prohibitively expensive. It is mainly the case for fluid dynamics and the resolution of Navier-Stokes equations. However, despite the fast-growing field of data-driven models for physical systems, reference datasets representing real-world phenomena are lacking. In this work, we develop AirfRANS, a dataset for studying the two-dimensional incompressible steady-state Reynolds-Averaged Navier-Stokes equations over airfoils at a subsonic regime and for different angles of attacks. We also introduce metrics on the stress forces at the surface of geometries and visualization of boundary layers to assess the capabilities of models to accurately predict the meaningful information of the problem. Finally, we propose deep learning baselines on four machine learning tasks to study AirfRANS under different constraints for generalization considerations: big and scarce data regime, Reynolds number, and angle of attack extrapolation.

Empathy requires perspective-taking: empathetic responses require a person to reason about what another has experienced and communicate that understanding in language. However, most NLP approaches to empathy do not explicitly model this alignment process. Here, we introduce a new approach to recognizing alignment in empathetic speech, grounded in Appraisal Theory. We introduce a new dataset of over 9.2K span-level annotations of different types of appraisals of a person's experience and over 3K empathetic alignments between a speaker's and observer's speech. Through computational experiments, we show that these appraisals and alignments can be accurately recognized. In experiments in over 9.2M Reddit conversations, we find that appraisals capture meaningful groupings of behavior but that most responses have minimal alignment. However, we find that mental health professionals engage with substantially more empathetic alignment.

As the most public component of the Supreme Court's decision-making process, oral argument receives an out-sized share of attention in the popular media. Despite its prominence, however, the basic function and operation of oral argument as an institution remains poorly understood, as political scientists and legal scholars continue to debate even the most fundamental questions about its role. Past study of oral argument has tended to focus on discrete, quantifiable attributes of oral argument, such as the number of questions asked to each advocate, the party of the Justices' appointing president, or the ideological implications of the case on appeal. Such studies allow broad generalizations about oral argument and judicial decision making: Justices tend to vote in accordance with their ideological preferences, and they tend to ask more questions when they are skeptical of a party's position. But they tell us little about the actual goings on at oral argument -- the running dialog between Justice and advocate that is the heart of the institution. This Article fills that void, using machine learning techniques to, for the first time, construct predictive models of judicial decision making based not on oral argument's superficial features or on factors external to oral argument, such as where the case falls on a liberal-conservative spectrum, but on the actual content of the oral argument itself -- the Justices' questions to each side. The resultant models offer an important new window into aspects of oral argument that have long resisted empirical study, including the Justices' individual questioning styles, how each expresses skepticism, and which of the Justices' questions are most central to oral argument dialog.

Efficiently capturing the long-range patterns in sequential data sources salient to a given task -- such as classification and generative modeling -- poses a fundamental challenge. Popular approaches in the space tradeoff between the memory burden of brute-force enumeration and comparison, as in transformers, the computational burden of complicated sequential dependencies, as in recurrent neural networks, or the parameter burden of convolutional networks with many or large filters. We instead take inspiration from wavelet-based multiresolution analysis to define a new building block for sequence modeling, which we call a MultiresLayer. The key component of our model is the multiresolution convolution, capturing multiscale trends in the input sequence. Our MultiresConv can be implemented with shared filters across a dilated causal convolution tree. Thus it garners the computational advantages of convolutional networks and the principled theoretical motivation of wavelet decompositions. Our MultiresLayer is straightforward to implement, requires significantly fewer parameters, and maintains at most a O(Nlog N) memory footprint for a length N sequence. Yet, by stacking such layers, our model yields state-of-the-art performance on a number of sequence classification and autoregressive density estimation tasks using CIFAR-10, ListOps, and PTB-XL datasets.

The ML community is rapidly exploring techniques for prompting language models (LMs) and for stacking them into pipelines that solve complex tasks. Unfortunately, existing LM pipelines are typically implemented using hard-coded "prompt templates", i.e. lengthy strings discovered via trial and error. Toward a more systematic approach for developing and optimizing LM pipelines, we introduce DSPy, a programming model that abstracts LM pipelines as text transformation graphs, i.e. imperative computational graphs where LMs are invoked through declarative modules. DSPy modules are parameterized, meaning they can learn (by creating and collecting demonstrations) how to apply compositions of prompting, finetuning, augmentation, and reasoning techniques. We design a compiler that will optimize any DSPy pipeline to maximize a given metric. We conduct two case studies, showing that succinct DSPy programs can express and optimize sophisticated LM pipelines that reason about math word problems, tackle multi-hop retrieval, answer complex questions, and control agent loops. Within minutes of compiling, a few lines of DSPy allow GPT-3.5 and llama2-13b-chat to self-bootstrap pipelines that outperform standard few-shot prompting (generally by over 25% and 65%, respectively) and pipelines with expert-created demonstrations (by up to 5-46% and 16-40%, respectively). On top of that, DSPy programs compiled to open and relatively small LMs like 770M-parameter T5 and llama2-13b-chat are competitive with approaches that rely on expert-written prompt chains for proprietary GPT-3.5. DSPy is available at https://github.com/stanfordnlp/dspy

A major challenge in computational research in 3D medical imaging is the lack of comprehensive datasets. Addressing this issue, our study introduces CT-RATE, the first 3D medical imaging dataset that pairs images with textual reports. CT-RATE consists of 25,692 non-contrast chest CT volumes, expanded to 50,188 through various reconstructions, from 21,304 unique patients, along with corresponding radiology text reports. Leveraging CT-RATE, we developed CT-CLIP, a CT-focused contrastive language-image pre-training framework. As a versatile, self-supervised model, CT-CLIP is designed for broad application and does not require task-specific training. Remarkably, CT-CLIP outperforms state-of-the-art, fully supervised methods in multi-abnormality detection across all key metrics, thus eliminating the need for manual annotation. We also demonstrate its utility in case retrieval, whether using imagery or textual queries, thereby advancing knowledge dissemination. The open-source release of CT-RATE and CT-CLIP marks a significant advancement in medical AI, enhancing 3D imaging analysis and fostering innovation in healthcare.

Modern Natural Language Processing (NLP) models based on Transformer structures represent the state of the art in terms of performance on very diverse tasks. However, these models are complex and represent several hundred million parameters for the smallest of them. This may hinder their adoption at the industrial level, making it difficult to scale up to a reasonable infrastructure and/or to comply with societal and environmental responsibilities. To this end, we present in this paper a model that drastically reduces the computational cost of a well-known French model (CamemBERT), while preserving good performance.

In the fields of computational mathematics and artificial intelligence, the need for precise data modeling is crucial, especially for predictive machine learning tasks. This paper explores further XNet, a novel algorithm that employs the complex-valued Cauchy integral formula, offering a superior network architecture that surpasses traditional Multi-Layer Perceptrons (MLPs) and Kolmogorov-Arnold Networks (KANs). XNet significant improves speed and accuracy across various tasks in both low and high-dimensional spaces, redefining the scope of data-driven model development and providing substantial improvements over established time series models like LSTMs.

Image-to-Image translation (I2I) is a subtype of Machine Learning (ML) that has tremendous potential in applications where two domains of images and the need for translation between the two exist, such as the removal of fog. For example, this could be useful for autonomous vehicles, which currently struggle with adverse weather conditions like fog. However, datasets for I2I tasks are not abundant and typically hard to acquire. Here, we introduce STEREOFOG, a dataset comprised of 10,067 paired fogged and clear images, captured using a custom-built device, with the purpose of exploring I2I's potential in this domain. It is the only real-world dataset of this kind to the best of our knowledge. Furthermore, we apply and optimize the pix2pix I2I ML framework to this dataset. With the final model achieving an average Complex Wavelet-Structural Similarity (CW-SSIM) score of 0.76, we prove the technique's suitability for the problem.

When faced with novel situations, people are able to marshal relevant considerations from a wide range of background knowledge and put these to use in inferences and predictions. What permits us to draw in globally relevant information and reason over it coherently? Here, we explore the hypothesis that people use a combination of distributed and symbolic representations to construct bespoke mental models tailored to novel situations. We propose a computational implementation of this idea -- a ``Model Synthesis Architecture'' (MSA) -- using language models to implement global relevance-based retrieval and model synthesis and probabilistic programs to implement bespoke, coherent world models. We evaluate our MSA as a model of human judgments on a novel reasoning dataset. The dataset -- built around a `Model Olympics` domain of sports vignettes -- tests models' capacity for human-like, open-ended reasoning by requiring (i) judgments about novel causal structures described in language; (ii) drawing on large bodies of background knowledge; and (iii) doing both in light of observations that introduce arbitrary novel variables. Our MSA approach captures human judgments better than language model-only baselines, under both direct and chain-of-thought generations from the LM that supports model synthesis. These results suggest that MSAs can be implemented in a way that mirrors people's ability to deliver locally coherent reasoning over globally relevant variables, offering a path to understanding and replicating human reasoning in open-ended domains.

Recent advances in diffusion models have demonstrated remarkable capabilities in video generation. However, the computational intensity remains a significant challenge for practical applications. While feature caching has been proposed to reduce the computational burden of diffusion models, existing methods typically overlook the heterogeneous significance of individual blocks, resulting in suboptimal reuse and degraded output quality. To this end, we address this gap by introducing ProfilingDiT, a novel adaptive caching strategy that explicitly disentangles foreground and background-focused blocks. Through a systematic analysis of attention distributions in diffusion models, we reveal a key observation: 1) Most layers exhibit a consistent preference for either foreground or background regions. 2) Predicted noise shows low inter-step similarity initially, which stabilizes as denoising progresses. This finding inspires us to formulate a selective caching strategy that preserves full computation for dynamic foreground elements while efficiently caching static background features. Our approach substantially reduces computational overhead while preserving visual fidelity. Extensive experiments demonstrate that our framework achieves significant acceleration (e.g., 2.01 times speedup for Wan2.1) while maintaining visual fidelity across comprehensive quality metrics, establishing a viable method for efficient video generation.

This study explores the relationship between textual features and Information Engagement (IE) on digital platforms. It highlights the impact of computational linguistics and analytics on user interaction. The READ model is introduced to quantify key predictors like representativeness, ease of use, affect, and distribution, which forecast engagement levels. The model's effectiveness is validated through AB testing and randomized trials, showing strong predictive performance in participation (accuracy: 0.94), perception (accuracy: 0.85), perseverance (accuracy: 0.81), and overall IE (accuracy: 0.97). While participation metrics are strong, perception and perseverance show slightly lower recall and F1-scores, indicating some challenges. The study demonstrates that modifying text based on the READ model's insights leads to significant improvements. For example, increasing representativeness and positive affect boosts selection rates by 11 percent, raises evaluation averages from 3.98 to 4.46, and improves retention rates by 11 percent. These findings highlight the importance of linguistic factors in IE, providing a framework for enhancing digital text engagement. The research offers practical strategies applicable to fields like education, health, and media.

This paper presents a novel technique for accelerating inference in large, pre-trained language models (LLMs) by introducing early exits during inference. The computational demands of these models, used across a wide range of applications, can be substantial. By capitalizing on the inherent variability in token complexity, our approach enables selective acceleration of the inference process. Specifically, we propose the integration of early exit ''heads'' atop existing transformer layers, which facilitate conditional terminations based on a confidence metric. These heads are trained in a self-supervised manner using the model's own predictions as training data, thereby eliminating the need for additional annotated data. The confidence metric, established using a calibration set, ensures a desired level of accuracy while enabling early termination when confidence exceeds a predetermined threshold. Notably, our method preserves the original accuracy and reduces computational time on certain tasks, leveraging the existing knowledge of pre-trained LLMs without requiring extensive retraining. This lightweight, modular modification has the potential to greatly enhance the practical usability of LLMs, particularly in applications like real-time language processing in resource-constrained environments.

How to efficiently serve Large Language Models (LLMs) has become a pressing issue because of their huge computational cost in their autoregressive generation process. To mitigate computational costs, LLMs often employ the KV Cache technique to improve the generation speed. While improving the computational efficiency, the storage requirements of the KV cache are substantial, particularly in long-context scenarios, leading to significant memory consumption. Existing KV cache eviction methods often degrade the performance of LLMs in long-context scenarios due to the information loss introduced by eviction. In this paper, we propose a novel KV cache merging approach, called KVMerger, to achieve adaptive KV cache compression for long-context tasks without significant performance degradation under constrained memory budgets. Our approach is inspired by the intriguing observation that key states exhibit high similarity at the token level within a single sequence. To facilitate merging, we develop an effective yet straightforward merging set identification algorithm to identify suitable KV states for merging. Our merging set identification algorithm stimulates the second observation that KV cache sparsity, from similarity perspective, is independent of the dataset and remains persistent at the model level. Subsequently, we propose a Gaussian kernel weighted merging algorithm to selectively merge all states within each merging set. We conduct extensive experiments to demonstrate the effectiveness of KVMerger for long-context tasks under constrained memory budgets, applying it to models including Llama2-7B-chat and Llama2-13B-chat. Using the LongBench and ZeroScroll benchmarks, we compare our method with other KV cache compression techniques, including H2O and CaM, showing that our method achieves superior performance across tasks with both 50% and 35% KV cache budgets.

The development of domain-specific language models has significantly advanced natural language processing applications in various specialized fields, particularly in biomedicine. However, the focus has largely been on English-language models, leaving a gap for less-resourced languages such as Italian. This paper introduces Igea, the first decoder-only language model designed explicitly for biomedical text generation in Italian. Built on the Minerva model and continually pretrained on a diverse corpus of Italian medical texts, Igea is available in three model sizes: 350 million, 1 billion, and 3 billion parameters. The models aim to balance computational efficiency and performance, addressing the challenges of managing the peculiarities of medical terminology in Italian. We evaluate Igea using a mix of in-domain biomedical corpora and general-purpose benchmarks, highlighting its efficacy and retention of general knowledge even after the domain-specific training. This paper discusses the model's development and evaluation, providing a foundation for future advancements in Italian biomedical NLP.

We first adopt a human-guided machine learning framework to develop a new dataset for hyperpartisan news title detection with 2,200 manually labeled and 1.8 million machine-labeled titles that were posted from 2014 to the present by nine representative media organizations across three media bias groups - Left, Central, and Right in an active learning manner. The fine-tuned transformer-based language model achieves an overall accuracy of 0.84 and an F1 score of 0.78 on an external validation set. Next, we conduct a computational analysis to quantify the extent and dynamics of partisanship in news titles. While some aspects are as expected, our study reveals new or nuanced differences between the three media groups. We find that overall the Right media tends to use proportionally more hyperpartisan titles. Roughly around the 2016 Presidential Election, the proportions of hyperpartisan titles increased in all media bias groups where the relative increase in the proportion of hyperpartisan titles of the Left media was the most. We identify three major topics including foreign issues, political systems, and societal issues that are suggestive of hyperpartisanship in news titles using logistic regression models and the Shapley values. Through an analysis of the topic distribution, we find that societal issues gradually receive more attention from all media groups. We further apply a lexicon-based language analysis tool to the titles of each topic and quantify the linguistic distance between any pairs of the three media groups. Three distinct patterns are discovered. The Left media is linguistically more different from Central and Right in terms of foreign issues. The linguistic distance between the three media groups becomes smaller over recent years. In addition, a seasonal pattern where linguistic difference is associated with elections is observed for societal issues.

Differentially private (DP) optimization is the standard paradigm to learn large neural networks that are accurate and privacy-preserving. The computational cost for DP deep learning, however, is notoriously heavy due to the per-sample gradient clipping. Existing DP implementations are 2-1000times more costly in time and space complexity than the standard (non-private) training. In this work, we develop a novel Book-Keeping (BK) technique that implements existing DP optimizers (thus achieving the same accuracy), with a substantial improvement on the computational cost. Specifically, BK enables DP training on large models and high dimensional data to be roughly as efficient as the standard training, whereas previous DP algorithms can be inefficient or incapable of training due to memory error. The computational advantage of BK is supported by the complexity analysis as well as extensive experiments on vision and language tasks. Our implementation achieves state-of-the-art (SOTA) accuracy with very small extra cost: on GPT2 and at the same memory cost, BK has 1.0times the time complexity of the standard training (0.75times training speed in practice), and 0.6times the time complexity of the most efficient DP implementation (1.24times training speed in practice). We will open-source the codebase for the BK algorithm.

We introduce Kanana, a series of bilingual language models that demonstrate exceeding performance in Korean and competitive performance in English. The computational cost of Kanana is significantly lower than that of state-of-the-art models of similar size. The report details the techniques employed during pre-training to achieve compute-efficient yet competitive models, including high quality data filtering, staged pre-training, depth up-scaling, and pruning and distillation. Furthermore, the report outlines the methodologies utilized during the post-training of the Kanana models, encompassing supervised fine-tuning and preference optimization, aimed at enhancing their capability for seamless interaction with users. Lastly, the report elaborates on plausible approaches used for language model adaptation to specific scenarios, such as embedding, retrieval augmented generation, and function calling. The Kanana model series spans from 2.1B to 32.5B parameters with 2.1B models (base, instruct, embedding) publicly released to promote research on Korean language models.

Due to the substantial scale of Large Language Models (LLMs), the direct application of conventional compression methodologies proves impractical. The computational demands associated with even minimal gradient updates present challenges, particularly on consumer-grade hardware. This paper introduces an innovative approach for the parametric and practical compression of LLMs based on reduced order modelling, which entails low-rank decomposition within the feature space and re-parameterization in the weight space. Notably, this compression technique operates in a layer-wise manner, obviating the need for a GPU device and enabling the compression of billion-scale models within stringent constraints of both memory and time. Our method represents a significant advancement in model compression by leveraging matrix decomposition, demonstrating superior efficacy compared to the prevailing state-of-the-art structured pruning method.

We introduce Einstein Fields, a neural representation that is designed to compress computationally intensive four-dimensional numerical relativity simulations into compact implicit neural network weights. By modeling the metric, which is the core tensor field of general relativity, Einstein Fields enable the derivation of physical quantities via automatic differentiation. However, unlike conventional neural fields (e.g., signed distance, occupancy, or radiance fields), Einstein Fields are Neural Tensor Fields with the key difference that when encoding the spacetime geometry of general relativity into neural field representations, dynamics emerge naturally as a byproduct. Einstein Fields show remarkable potential, including continuum modeling of 4D spacetime, mesh-agnosticity, storage efficiency, derivative accuracy, and ease of use. We address these challenges across several canonical test beds of general relativity and release an open source JAX-based library, paving the way for more scalable and expressive approaches to numerical relativity. Code is made available at https://github.com/AndreiB137/EinFields

Metalenses offer significant potential for ultra-compact computational imaging but face challenges from complex optical degradation and computational restoration difficulties. Existing methods typically rely on precise optical calibration or massive paired datasets, which are non-trivial for real-world imaging systems. Furthermore, a lack of control over the inference process often results in undesirable hallucinated artifacts. We introduce Degradation-Modeled Multipath Diffusion for tunable metalens photography, leveraging powerful natural image priors from pretrained models instead of large datasets. Our framework uses positive, neutral, and negative-prompt paths to balance high-frequency detail generation, structural fidelity, and suppression of metalens-specific degradation, alongside pseudo data augmentation. A tunable decoder enables controlled trade-offs between fidelity and perceptual quality. Additionally, a spatially varying degradation-aware attention (SVDA) module adaptively models complex optical and sensor-induced degradation. Finally, we design and build a millimeter-scale MetaCamera for real-world validation. Extensive results show that our approach outperforms state-of-the-art methods, achieving high-fidelity and sharp image reconstruction. More materials: https://dmdiff.github.io/.

In this paper, we introduce a novel class of fast, beam search-based adversarial attack (BEAST) for Language Models (LMs). BEAST employs interpretable parameters, enabling attackers to balance between attack speed, success rate, and the readability of adversarial prompts. The computational efficiency of BEAST facilitates us to investigate its applications on LMs for jailbreaking, eliciting hallucinations, and privacy attacks. Our gradient-free targeted attack can jailbreak aligned LMs with high attack success rates within one minute. For instance, BEAST can jailbreak Vicuna-7B-v1.5 under one minute with a success rate of 89% when compared to a gradient-based baseline that takes over an hour to achieve 70% success rate using a single Nvidia RTX A6000 48GB GPU. Additionally, we discover a unique outcome wherein our untargeted attack induces hallucinations in LM chatbots. Through human evaluations, we find that our untargeted attack causes Vicuna-7B-v1.5 to produce ~15% more incorrect outputs when compared to LM outputs in the absence of our attack. We also learn that 22% of the time, BEAST causes Vicuna to generate outputs that are not relevant to the original prompt. Further, we use BEAST to generate adversarial prompts in a few seconds that can boost the performance of existing membership inference attacks for LMs. We believe that our fast attack, BEAST, has the potential to accelerate research in LM security and privacy. Our codebase is publicly available at https://github.com/vinusankars/BEAST.

We present a novel family of language model (LM) estimation techniques named Sparse Non-negative Matrix (SNM) estimation. A first set of experiments empirically evaluating it on the One Billion Word Benchmark shows that SNM n-gram LMs perform almost as well as the well-established Kneser-Ney (KN) models. When using skip-gram features the models are able to match the state-of-the-art recurrent neural network (RNN) LMs; combining the two modeling techniques yields the best known result on the benchmark. The computational advantages of SNM over both maximum entropy and RNN LM estimation are probably its main strength, promising an approach that has the same flexibility in combining arbitrary features effectively and yet should scale to very large amounts of data as gracefully as n-gram LMs do.

Large language models(LLMs) have shown its outperforming ability on various tasks and question answering. However, LLMs require high computation cost and large memory cost. At the same time, LLMs may cause privacy leakage when training or prediction procedure contains sensitive information. In this paper, we propose SPA(Side Plugin Adaption), a lightweight architecture for fast on-devices inference and privacy retaining on the constraints of strict on-devices computation and memory constraints. Compared with other on-devices seq2seq generation, SPA could make a fast and stable inference on low-resource constraints, allowing it to obtain cost effiency. Our method establish an interaction between a pretrained LLMs on-cloud and additive parameters on-devices, which could provide the knowledge on both pretrained LLMs and private personal feature.Further more, SPA provides a framework to keep feature-base parameters on private guaranteed but low computational devices while leave the parameters containing general information on the high computational devices.

In this paper, we provide two case studies to demonstrate how artificial intelligence can empower civil engineering. In the first case, a machine learning-assisted framework, BRAILS, is proposed for city-scale building information modeling. Building information modeling (BIM) is an efficient way of describing buildings, which is essential to architecture, engineering, and construction. Our proposed framework employs deep learning technique to extract visual information of buildings from satellite/street view images. Further, a novel machine learning (ML)-based statistical tool, SURF, is proposed to discover the spatial patterns in building metadata. The second case focuses on the task of soft-story building classification. Soft-story buildings are a type of buildings prone to collapse during a moderate or severe earthquake. Hence, identifying and retrofitting such buildings is vital in the current earthquake preparedness efforts. For this task, we propose an automated deep learning-based procedure for identifying soft-story buildings from street view images at a regional scale. We also create a large-scale building image database and a semi-automated image labeling approach that effectively annotates new database entries. Through extensive computational experiments, we demonstrate the effectiveness of the proposed method.

This paper explores the use of large language models (LLMs) as research tools in the history, philosophy, and sociology of science (HPSS). LLMs are remarkably effective at processing unstructured text and inferring meaning from context, offering new affordances that challenge long-standing divides between computational and interpretive methods. This raises both opportunities and challenges for HPSS, which emphasizes interpretive methodologies and understands meaning as context-dependent, ambiguous, and historically situated. We argue that HPSS is uniquely positioned not only to benefit from LLMs' capabilities but also to interrogate their epistemic assumptions and infrastructural implications. To this end, we first offer a concise primer on LLM architectures and training paradigms tailored to non-technical readers. We frame LLMs not as neutral tools but as epistemic infrastructures that encode assumptions about meaning, context, and similarity, conditioned by their training data, architecture, and patterns of use. We then examine how computational techniques enhanced by LLMs, such as structuring data, detecting patterns, and modeling dynamic processes, can be applied to support interpretive research in HPSS. Our analysis compares full-context and generative models, outlines strategies for domain and task adaptation (e.g., continued pretraining, fine-tuning, and retrieval-augmented generation), and evaluates their respective strengths and limitations for interpretive inquiry in HPSS. We conclude with four lessons for integrating LLMs into HPSS: (1) model selection involves interpretive trade-offs; (2) LLM literacy is foundational; (3) HPSS must define its own benchmarks and corpora; and (4) LLMs should enhance, not replace, interpretive methods.

We introduce nested diffusion models, an efficient and powerful hierarchical generative framework that substantially enhances the generation quality of diffusion models, particularly for images of complex scenes. Our approach employs a series of diffusion models to progressively generate latent variables at different semantic levels. Each model in this series is conditioned on the output of the preceding higher-level models, culminating in image generation. Hierarchical latent variables guide the generation process along predefined semantic pathways, allowing our approach to capture intricate structural details while significantly improving image quality. To construct these latent variables, we leverage a pre-trained visual encoder, which learns strong semantic visual representations, and modulate its capacity via dimensionality reduction and noise injection. Across multiple datasets, our system demonstrates significant enhancements in image quality for both unconditional and class/text conditional generation. Moreover, our unconditional generation system substantially outperforms the baseline conditional system. These advancements incur minimal computational overhead as the more abstract levels of our hierarchy work with lower-dimensional representations.

Diffusion models are emerging models that generate images by iteratively denoising random Gaussian noise using deep neural networks. These models typically exhibit high computational and memory demands, necessitating effective post-training quantization for high-performance inference. Recent works propose low-bitwidth (e.g., 8-bit or 4-bit) quantization for diffusion models, however 4-bit integer quantization typically results in low-quality images. We observe that on several widely used hardware platforms, there is little or no difference in compute capability between floating-point and integer arithmetic operations of the same bitwidth (e.g., 8-bit or 4-bit). Therefore, we propose an effective floating-point quantization method for diffusion models that provides better image quality compared to integer quantization methods. We employ a floating-point quantization method that was effective for other processing tasks, specifically computer vision and natural language tasks, and tailor it for diffusion models by integrating weight rounding learning during the mapping of the full-precision values to the quantized values in the quantization process. We comprehensively study integer and floating-point quantization methods in state-of-the-art diffusion models. Our floating-point quantization method not only generates higher-quality images than that of integer quantization methods, but also shows no noticeable degradation compared to full-precision models (32-bit floating-point), when both weights and activations are quantized to 8-bit floating-point values, while has minimal degradation with 4-bit weights and 8-bit activations.

Foundation models are rapidly being developed for computational pathology applications. However, it remains an open question which factors are most important for downstream performance with data scale and diversity, model size, and training algorithm all playing a role. In this work, we present the result of scaling both data and model size, surpassing previous studies in both dimensions, and introduce two new models: Virchow 2, a 632M parameter vision transformer, and Virchow 2G, a 1.85B parameter vision transformer, each trained with 3.1M histopathology whole slide images. To support this scale, we propose domain-inspired adaptations to the DINOv2 training algorithm, which is quickly becoming the default method in self-supervised learning for computational pathology. We achieve state of the art performance on twelve tile-level tasks, as compared to the top performing competing models. Our results suggest that data diversity and domain-specific training can outperform models that only scale in the number of parameters, but, on average, performance benefits from domain-tailoring, data scale, and model scale.

We present a computational framework that transforms single images into 3D physical objects. The visual geometry of a physical object in an image is determined by three orthogonal attributes: mechanical properties, external forces, and rest-shape geometry. Existing single-view 3D reconstruction methods often overlook this underlying composition, presuming rigidity or neglecting external forces. Consequently, the reconstructed objects fail to withstand real-world physical forces, resulting in instability or undesirable deformation -- diverging from their intended designs as depicted in the image. Our optimization framework addresses this by embedding physical compatibility into the reconstruction process. We explicitly decompose the three physical attributes and link them through static equilibrium, which serves as a hard constraint, ensuring that the optimized physical shapes exhibit desired physical behaviors. Evaluations on a dataset collected from Objaverse demonstrate that our framework consistently enhances the physical realism of 3D models over existing methods. The utility of our framework extends to practical applications in dynamic simulations and 3D printing, where adherence to physical compatibility is paramount.

Visual motion processing is essential for humans to perceive and interact with dynamic environments. Despite extensive research in cognitive neuroscience, image-computable models that can extract informative motion flow from natural scenes in a manner consistent with human visual processing have yet to be established. Meanwhile, recent advancements in computer vision (CV), propelled by deep learning, have led to significant progress in optical flow estimation, a task closely related to motion perception. Here we propose an image-computable model of human motion perception by bridging the gap between biological and CV models. Specifically, we introduce a novel two-stages approach that combines trainable motion energy sensing with a recurrent self-attention network for adaptive motion integration and segregation. This model architecture aims to capture the computations in V1-MT, the core structure for motion perception in the biological visual system, while providing the ability to derive informative motion flow for a wide range of stimuli, including complex natural scenes. In silico neurophysiology reveals that our model's unit responses are similar to mammalian neural recordings regarding motion pooling and speed tuning. The proposed model can also replicate human responses to a range of stimuli examined in past psychophysical studies. The experimental results on the Sintel benchmark demonstrate that our model predicts human responses better than the ground truth, whereas the state-of-the-art CV models show the opposite. Our study provides a computational architecture consistent with human visual motion processing, although the physiological correspondence may not be exact.

Differentially Private (DP) learning has seen limited success for building large deep learning models of text, and straightforward attempts at applying Differentially Private Stochastic Gradient Descent (DP-SGD) to NLP tasks have resulted in large performance drops and high computational overhead. We show that this performance drop can be mitigated with (1) the use of large pretrained language models; (2) non-standard hyperparameters that suit DP optimization; and (3) fine-tuning objectives which are aligned with the pretraining procedure. With the above, we obtain NLP models that outperform state-of-the-art DP-trained models under the same privacy budget and strong non-private baselines -- by directly fine-tuning pretrained models with DP optimization on moderately-sized corpora. To address the computational challenge of running DP-SGD with large Transformers, we propose a memory saving technique that allows clipping in DP-SGD to run without instantiating per-example gradients for any linear layer in the model. The technique enables privately training Transformers with almost the same memory cost as non-private training at a modest run-time overhead. Contrary to conventional wisdom that DP optimization fails at learning high-dimensional models (due to noise that scales with dimension) empirical results reveal that private learning with pretrained language models doesn't tend to suffer from dimension-dependent performance degradation. Code to reproduce results can be found at https://github.com/lxuechen/private-transformers.

We introduce MiniMax-01 series, including MiniMax-Text-01 and MiniMax-VL-01, which are comparable to top-tier models while offering superior capabilities in processing longer contexts. The core lies in lightning attention and its efficient scaling. To maximize computational capacity, we integrate it with Mixture of Experts (MoE), creating a model with 32 experts and 456 billion total parameters, of which 45.9 billion are activated for each token. We develop an optimized parallel strategy and highly efficient computation-communication overlap techniques for MoE and lightning attention. This approach enables us to conduct efficient training and inference on models with hundreds of billions of parameters across contexts spanning millions of tokens. The context window of MiniMax-Text-01 can reach up to 1 million tokens during training and extrapolate to 4 million tokens during inference at an affordable cost. Our vision-language model, MiniMax-VL-01 is built through continued training with 512 billion vision-language tokens. Experiments on both standard and in-house benchmarks show that our models match the performance of state-of-the-art models like GPT-4o and Claude-3.5-Sonnet while offering 20-32 times longer context window. We publicly release MiniMax-01 at https://github.com/MiniMax-AI.

The growing computational demands of training large language models (LLMs) necessitate more efficient methods. Quantized training presents a promising solution by enabling low-bit arithmetic operations to reduce these costs. While FP8 precision has demonstrated feasibility, leveraging FP4 remains a challenge due to significant quantization errors and limited representational capacity. This work introduces the first FP4 training framework for LLMs, addressing these challenges with two key innovations: a differentiable quantization estimator for precise weight updates and an outlier clamping and compensation strategy to prevent activation collapse. To ensure stability, the framework integrates a mixed-precision training scheme and vector-wise quantization. Experimental results demonstrate that our FP4 framework achieves accuracy comparable to BF16 and FP8, with minimal degradation, scaling effectively to 13B-parameter LLMs trained on up to 100B tokens. With the emergence of next-generation hardware supporting FP4, our framework sets a foundation for efficient ultra-low precision training.

How does language inform our downstream thinking? In particular, how do humans make meaning from language -- and how can we leverage a theory of linguistic meaning to build machines that think in more human-like ways? In this paper, we propose rational meaning construction, a computational framework for language-informed thinking that combines neural models of language with probabilistic models for rational inference. We frame linguistic meaning as a context-sensitive mapping from natural language into a probabilistic language of thought (PLoT) -- a general-purpose symbolic substrate for probabilistic, generative world modeling. Our architecture integrates two powerful computational tools that have not previously come together: we model thinking with probabilistic programs, an expressive representation for flexible commonsense reasoning; and we model meaning construction with large language models (LLMs), which support broad-coverage translation from natural language utterances to code expressions in a probabilistic programming language. We illustrate our framework in action through examples covering four core domains from cognitive science: probabilistic reasoning, logical and relational reasoning, visual and physical reasoning, and social reasoning about agents and their plans. In each, we show that LLMs can generate context-sensitive translations that capture pragmatically-appropriate linguistic meanings, while Bayesian inference with the generated programs supports coherent and robust commonsense reasoning. We extend our framework to integrate cognitively-motivated symbolic modules to provide a unified commonsense thinking interface from language. Finally, we explore how language can drive the construction of world models themselves.

Recent advancements in unified multimodal understanding and visual generation (or multimodal generation) models have been hindered by their quadratic computational complexity and dependence on large-scale training data. We present OmniMamba, the first linear-architecture-based multimodal generation model that generates both text and images through a unified next-token prediction paradigm. The model fully leverages Mamba-2's high computational and memory efficiency, extending its capabilities from text generation to multimodal generation. To address the data inefficiency of existing unified models, we propose two key innovations: (1) decoupled vocabularies to guide modality-specific generation, and (2) task-specific LoRA for parameter-efficient adaptation. Furthermore, we introduce a decoupled two-stage training strategy to mitigate data imbalance between two tasks. Equipped with these techniques, OmniMamba achieves competitive performance with JanusFlow while surpassing Show-o across benchmarks, despite being trained on merely 2M image-text pairs, which is 1,000 times fewer than Show-o. Notably, OmniMamba stands out with outstanding inference efficiency, achieving up to a 119.2 times speedup and 63% GPU memory reduction for long-sequence generation compared to Transformer-based counterparts. Code and models are released at https://github.com/hustvl/OmniMamba

This work aims to improve the efficiency of text-to-image diffusion models. While diffusion models use computationally expensive UNet-based denoising operations in every generation step, we identify that not all operations are equally relevant for the final output quality. In particular, we observe that UNet layers operating on high-res feature maps are relatively sensitive to small perturbations. In contrast, low-res feature maps influence the semantic layout of the final image and can often be perturbed with no noticeable change in the output. Based on this observation, we propose Clockwork Diffusion, a method that periodically reuses computation from preceding denoising steps to approximate low-res feature maps at one or more subsequent steps. For multiple baselines, and for both text-to-image generation and image editing, we demonstrate that Clockwork leads to comparable or improved perceptual scores with drastically reduced computational complexity. As an example, for Stable Diffusion v1.5 with 8 DPM++ steps we save 32% of FLOPs with negligible FID and CLIP change.

When applied to question answering and other text generation tasks, language models (LMs) may be queried generatively (by sampling answers from their output distribution) or discriminatively (by using them to score or rank a set of candidate outputs). These procedures sometimes yield very different predictions. How do we reconcile mutually incompatible scoring procedures to obtain coherent LM predictions? We introduce a new, a training-free, game-theoretic procedure for language model decoding. Our approach casts language model decoding as a regularized imperfect-information sequential signaling game - which we term the CONSENSUS GAME - in which a GENERATOR seeks to communicate an abstract correctness parameter using natural language sentences to a DISCRIMINATOR. We develop computational procedures for finding approximate equilibria of this game, resulting in a decoding algorithm we call EQUILIBRIUM-RANKING. Applied to a large number of tasks (including reading comprehension, commonsense reasoning, mathematical problem-solving, and dialog), EQUILIBRIUM-RANKING consistently, and sometimes substantially, improves performance over existing LM decoding procedures - on multiple benchmarks, we observe that applying EQUILIBRIUM-RANKING to LLaMA-7B outperforms the much larger LLaMA-65B and PaLM-540B models. These results highlight the promise of game-theoretic tools for addressing fundamental challenges of truthfulness and consistency in LMs.

The high computational costs of large language models (LLMs) have led to a flurry of research on LLM compression, via methods such as quantization, sparsification, or structured pruning. A new frontier in this area is given by dynamic, non-uniform compression methods, which adjust the compression levels (e.g., sparsity) per-block or even per-layer in order to minimize accuracy loss, while guaranteeing a global compression threshold. Yet, current methods rely on heuristics for identifying the "importance" of a given layer towards the loss, based on assumptions such as error monotonicity, i.e. that the end-to-end model compression error is proportional to the sum of layer-wise errors. In this paper, we revisit this area, and propose a new and general approach for dynamic compression that is provably optimal in a given input range. We begin from the motivating observation that, in general, error monotonicity does not hold for LLMs: compressed models with lower sum of per-layer errors can perform worse than models with higher error sums. To address this, we propose a new general evolutionary framework for dynamic LLM compression called EvoPress, which has provable convergence, and low sample and evaluation complexity. We show that these theoretical guarantees lead to highly competitive practical performance for dynamic compression of Llama, Mistral and Phi models. Via EvoPress, we set new state-of-the-art results across all compression approaches: structural pruning (block/layer dropping), unstructured sparsity, as well as quantization with dynamic bitwidths. Our code is available at https://github.com/IST-DASLab/EvoPress.

The computational and energy costs of Large Language Models (LLMs) have increased exponentially driven by the growing model sizes and the massive adoption of LLMs by hundreds of millions of users. The unit cost of an LLM is the computation of a token. Therefore, the tokenizer plays an important role in the efficiency of a model, and they are carefully optimized to minimize the number of tokens for the text in their training corpus. One of the most popular applications of LLMs are chatbots that interact with users. A key observation is that, for those chatbots, what is important is the performance of the tokenizer in the user text input and the chatbot responses. Those are most likely different from the text in the training corpus. So, a question that immediately arises is whether there is a potential benefit in optimizing tokenizers for chatbot conversations. In this paper, this idea is explored for different tokenizers by using a publicly available corpus of chatbot conversations to redesign their vocabularies and evaluate their performance in this domain. The results show that conversation-optimized tokenizers consistently reduce the number of tokens in chatbot dialogues, which can lead to meaningful energy savings, in the range of 5% to 10% while having minimal or even slightly positive impact on tokenization efficiency for the original training corpus.

Text-to-Video (T2V) generation has attracted significant attention for its ability to synthesize realistic videos from textual descriptions. However, existing models struggle to balance computational efficiency and high visual quality, particularly on resource-limited devices, e.g.,iGPUs and mobile phones. Most prior work prioritizes visual fidelity while overlooking the need for smaller, more efficient models suitable for real-world deployment. To address this challenge, we propose a lightweight T2V framework, termed Hummingbird, which prunes existing models and enhances visual quality through visual feedback learning. Our approach reduces the size of the U-Net from 1.4 billion to 0.7 billion parameters, significantly improving efficiency while preserving high-quality video generation. Additionally, we introduce a novel data processing pipeline that leverages Large Language Models (LLMs) and Video Quality Assessment (VQA) models to enhance the quality of both text prompts and video data. To support user-driven training and style customization, we publicly release the full training code, including data processing and model training. Extensive experiments show that our method achieves a 31X speedup compared to state-of-the-art models such as VideoCrafter2, while also attaining the highest overall score on VBench. Moreover, our method supports the generation of videos with up to 26 frames, addressing the limitations of existing U-Net-based methods in long video generation. Notably, the entire training process requires only four GPUs, yet delivers performance competitive with existing leading methods. Hummingbird presents a practical and efficient solution for T2V generation, combining high performance, scalability, and flexibility for real-world applications.

Mixture-of-Experts (MoE) models have become a key approach for scaling large language models efficiently by activating only a subset of experts during training and inference. Typically, the number of activated experts presents a trade-off: fewer experts reduce computational costs, while more experts improve performance. Recent studies reveal that not all activated experts contribute equally to model performance, with some providing minimal utility, particularly when finetuning pretrained MoE models for specialized downstream tasks. The co-existence of significant and redundant parameters in experts provides us an opportunity to reduce the number of activated experts while maintaining model performance. In this work, we propose the concept of compressed experts, lightweight modules that serve as compact representations of full experts. Our approach preserves the most important experts while replacing other auxiliary activated experts with compressed experts. The reduction of active parameters significantly lowers inference costs while achieving comparable performance. Extensive experiments on models including Phi-MoE and OLMoE demonstrate that compressed experts recover over 90% of full expert performance across various tasks while reducing more than 30% active parameters and saving 20% in inference costs. This approach enables efficient deployment of MoE models in resource-constrained settings and facilitates scaling to larger models with manageable overhead. Our code is available at https://github.com/yifei-he/Compressed-Experts.

Diffusion models have shown promising results for a wide range of generative tasks with continuous data, such as image and audio synthesis. However, little progress has been made on using diffusion models to generate discrete symbolic music because this new class of generative models are not well suited for discrete data while its iterative sampling process is computationally expensive. In this work, we propose a diffusion model combined with a Generative Adversarial Network, aiming to (i) alleviate one of the remaining challenges in algorithmic music generation which is the control of generation towards a target emotion, and (ii) mitigate the slow sampling drawback of diffusion models applied to symbolic music generation. We first used a trained Variational Autoencoder to obtain embeddings of a symbolic music dataset with emotion labels and then used those to train a diffusion model. Our results demonstrate the successful control of our diffusion model to generate symbolic music with a desired emotion. Our model achieves several orders of magnitude improvement in computational cost, requiring merely four time steps to denoise while the steps required by current state-of-the-art diffusion models for symbolic music generation is in the order of thousands.

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation.

Recent advancements in personalized image generation using diffusion models have been noteworthy. However, existing methods suffer from inefficiencies due to the requirement for subject-specific fine-tuning. This computationally intensive process hinders efficient deployment, limiting practical usability. Moreover, these methods often grapple with identity distortion and limited expression diversity. In light of these challenges, we propose PortraitBooth, an innovative approach designed for high efficiency, robust identity preservation, and expression-editable text-to-image generation, without the need for fine-tuning. PortraitBooth leverages subject embeddings from a face recognition model for personalized image generation without fine-tuning. It eliminates computational overhead and mitigates identity distortion. The introduced dynamic identity preservation strategy further ensures close resemblance to the original image identity. Moreover, PortraitBooth incorporates emotion-aware cross-attention control for diverse facial expressions in generated images, supporting text-driven expression editing. Its scalability enables efficient and high-quality image creation, including multi-subject generation. Extensive results demonstrate superior performance over other state-of-the-art methods in both single and multiple image generation scenarios.

The transformer model is known to be computationally demanding, and prohibitively costly for long sequences, as the self-attention module uses a quadratic time and space complexity with respect to sequence length. Many researchers have focused on designing new forms of self-attention or introducing new parameters to overcome this limitation, however a large portion of them prohibits the model to inherit weights from large pretrained models. In this work, the transformer's inefficiency has been taken care of from another perspective. We propose Fourier Transformer, a simple yet effective approach by progressively removing redundancies in hidden sequence using the ready-made Fast Fourier Transform (FFT) operator to perform Discrete Cosine Transformation (DCT). Fourier Transformer is able to significantly reduce computational costs while retain the ability to inherit from various large pretrained models. Experiments show that our model achieves state-of-the-art performances among all transformer-based models on the long-range modeling benchmark LRA with significant improvement in both speed and space. For generative seq-to-seq tasks including CNN/DailyMail and ELI5, by inheriting the BART weights our model outperforms the standard BART and other efficient models. Our code is publicly available at \url{https://github.com/LUMIA-Group/FourierTransformer}

Despite the recent visually-pleasing results achieved, the massive computational cost has been a long-standing flaw for diffusion probabilistic models (DPMs), which, in turn, greatly limits their applications on resource-limited platforms. Prior methods towards efficient DPM, however, have largely focused on accelerating the testing yet overlooked their huge complexity and sizes. In this paper, we make a dedicated attempt to lighten DPM while striving to preserve its favourable performance. We start by training a small-sized latent diffusion model (LDM) from scratch, but observe a significant fidelity drop in the synthetic images. Through a thorough assessment, we find that DPM is intrinsically biased against high-frequency generation, and learns to recover different frequency components at different time-steps. These properties make compact networks unable to represent frequency dynamics with accurate high-frequency estimation. Towards this end, we introduce a customized design for slim DPM, which we term as Spectral Diffusion (SD), for light-weight image synthesis. SD incorporates wavelet gating in its architecture to enable frequency dynamic feature extraction at every reverse steps, and conducts spectrum-aware distillation to promote high-frequency recovery by inverse weighting the objective based on spectrum magni tudes. Experimental results demonstrate that, SD achieves 8-18x computational complexity reduction as compared to the latent diffusion models on a series of conditional and unconditional image generation tasks while retaining competitive image fidelity.

As Large Language Models (LLMs) gain widespread practical application, providing the model family of different parameter sizes has become standard practice to address diverse computational requirements. Conventionally, each model in a family is trained independently, resulting in computational costs that scale additively with the number of models. We propose an efficient method for constructing the model family through progressive training, where smaller models are incrementally expanded to larger sizes to create a complete model family. Through extensive experiments with a model family ranging from 1B to 8B parameters, we demonstrate that our method reduces computational costs by approximately 25% while maintaining comparable performance to independently trained models. Furthermore, by strategically adjusting maximum learning rates based on model size, our method outperforms the independent training across various metrics. Beyond performance gains, our approach offers an additional advantage: models in our family tend to yield more consistent behavior across different model sizes.

Video understanding models often struggle with high computational requirements, extensive parameter counts, and slow inference speed, making them inefficient for practical use. To tackle these challenges, we propose Mobile-VideoGPT, an efficient multimodal framework designed to operate with fewer than a billion parameters. Unlike traditional video large multimodal models (LMMs), Mobile-VideoGPT consists of lightweight dual visual encoders, efficient projectors, and a small language model (SLM), enabling real-time throughput. To further improve efficiency, we present an Attention-Based Frame Scoring mechanism to select the key-frames, along with an efficient token projector that prunes redundant visual tokens and preserves essential contextual cues. We evaluate our model across well-established six video understanding benchmarks (e.g., MVBench, EgoSchema, NextQA, and PercepTest). Our results show that Mobile-VideoGPT-0.5B can generate up to 46 tokens per second while outperforming existing state-of-the-art 0.5B-parameter models by 6 points on average with 40% fewer parameters and more than 2x higher throughput. Our code and models are publicly available at: https://github.com/Amshaker/Mobile-VideoGPT.

Vision-Language-Action (VLA) model can process instructions and visual perception to directly generate actions as output in an end-to-end fashion due to its strong multi-modal reasoning capabilities. While the performance of VLA models is promising, their computational cost can be substantial. This raises challenge for applying them on robotics tasks, which requires real-time decision-making to respond quickly to environmental changes. Since robotic control involves sequential decision-making, the visual input often exhibits minimal variation between successive steps. A natural idea is to reuse the computational results of unchanged visual tokens from the last step. Motivated by this idea, we propose VLA-Cache, an efficient vision-language-action model. VLA-Cache incorporates a token-selection mechanism that compares the visual input at each step with the input from the previous step, adaptively identifying visual tokens with minimal changes. The computational results for these unchanged tokens are then reused in subsequent steps via KV-cache, thereby significantly improving the efficiency of the VLA-Cache model. Experimental results on both simulation (e.g., LIBERO benchmark and SIMPLER) and real-world robot valid VLA-Cache can achieve practical acceleration with minimal sacrifice in success rate.

Benefiting from the powerful capabilities of Large Language Models (LLMs), pre-trained visual encoder models connected to LLMs form Vision Language Models (VLMs). However, recent research shows that the visual modality in VLMs is highly vulnerable, allowing attackers to bypass safety alignment in LLMs through visually transmitted content, launching harmful attacks. To address this challenge, we propose a progressive concept-based alignment strategy, PSA-VLM, which incorporates safety modules as concept bottlenecks to enhance visual modality safety alignment. By aligning model predictions with specific safety concepts, we improve defenses against risky images, enhancing explainability and controllability while minimally impacting general performance. Our method is obtained through two-stage training. The low computational cost of the first stage brings very effective performance improvement, and the fine-tuning of the language model in the second stage further improves the safety performance. Our method achieves state-of-the-art results on popular VLM safety benchmark.

Large Language Models (LLMs) have revolutionized natural language processing by achieving state-of-the-art results across a variety of tasks. However, the computational demands of LLM inference, including high memory consumption and slow processing speeds, pose significant challenges for real-world applications, particularly on resource-constrained devices. Efficient inference is crucial for scaling the deployment of LLMs to a broader range of platforms, including mobile and edge devices. This survey explores contemporary techniques in model compression that address these challenges by reducing the size and computational requirements of LLMs while maintaining their performance. We focus on model-level compression methods, including quantization, knowledge distillation, and pruning, as well as system-level optimizations like KV cache efficient design. Each of these methodologies offers a unique approach to optimizing LLMs, from reducing numerical precision to transferring knowledge between models and structurally simplifying neural networks. Additionally, we discuss emerging trends in system-level design that further enhance the efficiency of LLM inference. This survey aims to provide a comprehensive overview of current advancements in model compression and their potential to make LLMs more accessible and practical for diverse applications.

Guardrails have emerged as an alternative to safety alignment for content moderation of large language models (LLMs). Existing model-based guardrails have not been designed for resource-constrained computational portable devices, such as mobile phones, more and more of which are running LLM-based applications locally. We introduce LoRA-Guard, a parameter-efficient guardrail adaptation method that relies on knowledge sharing between LLMs and guardrail models. LoRA-Guard extracts language features from the LLMs and adapts them for the content moderation task using low-rank adapters, while a dual-path design prevents any performance degradation on the generative task. We show that LoRA-Guard outperforms existing approaches with 100-1000x lower parameter overhead while maintaining accuracy, enabling on-device content moderation.

Existing Multimodal Large Language Models (MLLMs) follow the paradigm that perceives visual information by aligning visual features with the input space of Large Language Models (LLMs), and concatenating visual tokens with text tokens to form a unified sequence input for LLMs. These methods demonstrate promising results on various vision-language tasks but are limited by the high computational effort due to the extended input sequence resulting from the involvement of visual tokens. In this paper, instead of input space alignment, we propose a novel parameter space alignment paradigm that represents visual information as model weights. For each input image, we use a vision encoder to extract visual features, convert features into perceptual weights, and merge the perceptual weights with LLM's weights. In this way, the input of LLM does not require visual tokens, which reduces the length of the input sequence and greatly improves efficiency. Following this paradigm, we propose VLoRA with the perceptual weights generator. The perceptual weights generator is designed to convert visual features to perceptual weights with low-rank property, exhibiting a form similar to LoRA. The experimental results show that our VLoRA achieves comparable performance on various benchmarks for MLLMs, while significantly reducing the computational costs for both training and inference. The code and models will be made open-source.

The high computational cost associated with pretraining large language models limits their research. Two strategies have emerged to address this issue: domain specialization and pretraining with high-quality data. To explore these strategies, we specialized the Sabi\'a-2 Small model with 1.9 billion unique tokens from reputable Brazilian legal sources and conducted few-shot evaluations on legal and general knowledge exams. Our model, Juru, demonstrates the benefits of domain specialization with a reduced amount of pretraining data. However, this specialization comes at the expense of degrading performance in other knowledge areas within the same language. This study contributes to the growing body of scientific evidence showing that pretraining data selection may enhance the performance of large language models, enabling the exploration of these models at a lower cost.

Limited by the encoder-decoder architecture, learning-based edge detectors usually have difficulty predicting edge maps that satisfy both correctness and crispness. With the recent success of the diffusion probabilistic model (DPM), we found it is especially suitable for accurate and crisp edge detection since the denoising process is directly applied to the original image size. Therefore, we propose the first diffusion model for the task of general edge detection, which we call DiffusionEdge. To avoid expensive computational resources while retaining the final performance, we apply DPM in the latent space and enable the classic cross-entropy loss which is uncertainty-aware in pixel level to directly optimize the parameters in latent space in a distillation manner. We also adopt a decoupled architecture to speed up the denoising process and propose a corresponding adaptive Fourier filter to adjust the latent features of specific frequencies. With all the technical designs, DiffusionEdge can be stably trained with limited resources, predicting crisp and accurate edge maps with much fewer augmentation strategies. Extensive experiments on four edge detection benchmarks demonstrate the superiority of DiffusionEdge both in correctness and crispness. On the NYUDv2 dataset, compared to the second best, we increase the ODS, OIS (without post-processing) and AC by 30.2%, 28.1% and 65.1%, respectively. Code: https://github.com/GuHuangAI/DiffusionEdge.

Scaling of deep neural networks, especially Transformers, is pivotal for their surging performance and has further led to the emergence of sophisticated reasoning capabilities in foundation models. Such scaling generally requires training large models from scratch with random initialization, failing to leverage the knowledge acquired by their smaller counterparts, which are already resource-intensive to obtain. To tackle this inefficiency, we present LosslEss MOdel ExpansioN (LEMON), a recipe to initialize scaled models using the weights of their smaller but pre-trained counterparts. This is followed by model training with an optimized learning rate scheduler tailored explicitly for the scaled models, substantially reducing the training time compared to training from scratch. Notably, LEMON is versatile, ensuring compatibility with various network structures, including models like Vision Transformers and BERT. Our empirical results demonstrate that LEMON reduces computational costs by 56.7% for Vision Transformers and 33.2% for BERT when compared to training from scratch.

Image denoising is a fundamental problem in computational photography, where achieving high perception with low distortion is highly demanding. Current methods either struggle with perceptual quality or suffer from significant distortion. Recently, the emerging diffusion model has achieved state-of-the-art performance in various tasks and demonstrates great potential for image denoising. However, stimulating diffusion models for image denoising is not straightforward and requires solving several critical problems. For one thing, the input inconsistency hinders the connection between diffusion models and image denoising. For another, the content inconsistency between the generated image and the desired denoised image introduces distortion. To tackle these problems, we present a novel strategy called the Diffusion Model for Image Denoising (DMID) by understanding and rethinking the diffusion model from a denoising perspective. Our DMID strategy includes an adaptive embedding method that embeds the noisy image into a pre-trained unconditional diffusion model and an adaptive ensembling method that reduces distortion in the denoised image. Our DMID strategy achieves state-of-the-art performance on both distortion-based and perception-based metrics, for both Gaussian and real-world image denoising.The code is available at https://github.com/Li-Tong-621/DMID.

This paper presents a 3D generative model that uses diffusion models to automatically generate 3D digital avatars represented as neural radiance fields. A significant challenge in generating such avatars is that the memory and processing costs in 3D are prohibitive for producing the rich details required for high-quality avatars. To tackle this problem we propose the roll-out diffusion network (Rodin), which represents a neural radiance field as multiple 2D feature maps and rolls out these maps into a single 2D feature plane within which we perform 3D-aware diffusion. The Rodin model brings the much-needed computational efficiency while preserving the integrity of diffusion in 3D by using 3D-aware convolution that attends to projected features in the 2D feature plane according to their original relationship in 3D. We also use latent conditioning to orchestrate the feature generation for global coherence, leading to high-fidelity avatars and enabling their semantic editing based on text prompts. Finally, we use hierarchical synthesis to further enhance details. The 3D avatars generated by our model compare favorably with those produced by existing generative techniques. We can generate highly detailed avatars with realistic hairstyles and facial hair like beards. We also demonstrate 3D avatar generation from image or text as well as text-guided editability.

Large-scale commercial platforms usually involve numerous business domains for diverse business strategies and expect their recommendation systems to provide click-through rate (CTR) predictions for multiple domains simultaneously. Existing promising and widely-used multi-domain models discover domain relationships by explicitly constructing domain-specific networks, but the computation and memory boost significantly with the increase of domains. To reduce computational complexity, manually grouping domains with particular business strategies is common in industrial applications. However, this pre-defined data partitioning way heavily relies on prior knowledge, and it may neglect the underlying data distribution of each domain, hence limiting the model's representation capability. Regarding the above issues, we propose an elegant and flexible multi-distribution modeling paradigm, named Adaptive Distribution Hierarchical Model (AdaptDHM), which is an end-to-end optimization hierarchical structure consisting of a clustering process and classification process. Specifically, we design a distribution adaptation module with a customized dynamic routing mechanism. Instead of introducing prior knowledge for pre-defined data allocation, this routing algorithm adaptively provides a distribution coefficient for each sample to determine which cluster it belongs to. Each cluster corresponds to a particular distribution so that the model can sufficiently capture the commonalities and distinctions between these distinct clusters. Extensive experiments on both public and large-scale Alibaba industrial datasets verify the effectiveness and efficiency of AdaptDHM: Our model achieves impressive prediction accuracy and its time cost during the training stage is more than 50% less than that of other models.

The assumption that response and predictor belong to the same statistical unit may be violated in practice. Unbiased estimation and recovery of true label ordering based on unlabeled data are challenging tasks and have attracted increasing attentions in the recent literature. In this paper, we present a relatively complete analysis of label permutation problem for the generalized linear model with multivariate responses. The theory is established under different scenarios, with knowledge of true parameters, with partial knowledge of underlying label permutation matrix and without any knowledge. Our results remove the stringent conditions required by the current literature and are further extended to the missing observation setting which has never been considered in the field of label permutation problem. On computational side, we propose two methods, "maximum likelihood estimation" algorithm and "two-step estimation" algorithm, to accommodate for different settings. When the proportion of permuted labels is moderate, both methods work effectively. Multiple numerical experiments are provided and corroborate our theoretical findings.

Recent improvements in KG-to-text generation are due to additional auxiliary pre-training tasks designed to give the fine-tune task a boost in performance. These tasks require extensive computational resources while only suggesting marginal improvements. Here, we demonstrate that by fusing graph-aware elements into existing pre-trained language models, we are able to outperform state-of-the-art models and close the gap imposed by additional pre-training tasks. We do so by proposing a mask structure to capture neighborhood information and a novel type encoder that adds a bias to the graph-attention weights depending on the connection type. Experiments on two KG-to-text benchmark datasets show our models are competitive while involving fewer parameters and no additional pre-training tasks. By formulating the problem as a framework, we can interchange the various proposed components and begin interpreting KG-to-text generative models based on the topological and type information found in a graph.

Transformer-based language models spread FLOPs uniformly across input sequences. In this work we demonstrate that transformers can instead learn to dynamically allocate FLOPs (or compute) to specific positions in a sequence, optimising the allocation along the sequence for different layers across the model depth. Our method enforces a total compute budget by capping the number of tokens (k) that can participate in the self-attention and MLP computations at a given layer. The tokens to be processed are determined by the network using a top-k routing mechanism. Since k is defined a priori, this simple procedure uses a static computation graph with known tensor sizes, unlike other conditional computation techniques. Nevertheless, since the identities of the k tokens are fluid, this method can expend FLOPs non-uniformly across the time and model depth dimensions. Thus, compute expenditure is entirely predictable in sum total, but dynamic and context-sensitive at the token-level. Not only do models trained in this way learn to dynamically allocate compute, they do so efficiently. These models match baseline performance for equivalent FLOPS and wall-clock times to train, but require a fraction of the FLOPs per forward pass, and can be upwards of 50\% faster to step during post-training sampling.

Small-scale models offer various computational advantages, and yet to which extent size is critical for problem-solving abilities remains an open question. Specifically for solving grade school math, the smallest model size so far required to break the 80\% barrier on the GSM8K benchmark remains to be 34B. Our work studies how high-quality datasets may be the key for small language models to acquire mathematical reasoning. We introduce TinyGSM, a synthetic dataset of 12.3M grade school math problems paired with Python solutions, generated fully by GPT-3.5. After finetuning on TinyGSM, we find that a duo of a 1.3B generation model and a 1.3B verifier model can achieve 81.5\% accuracy, outperforming existing models that are orders of magnitude larger. This also rivals the performance of the GPT-3.5 ``teacher'' model (77.4\%), from which our model's training data is generated. Our approach is simple and has two key components: 1) the high-quality dataset TinyGSM, 2) the use of a verifier, which selects the final outputs from multiple candidate generations.

In this paper, we introduce a novel low-latency inference framework for large language models (LLMs) inference which enables LLMs to perform inferences with incomplete prompts. By reallocating computational processes to prompt input phase, we achieve a substantial reduction in latency, thereby significantly enhancing the interactive experience for users of LLMs. The framework adeptly manages the visibility of the streaming prompt to the model, allowing it to infer from incomplete prompts or await additional prompts. Compared with traditional inference methods that utilize complete prompts, our approach demonstrates an average reduction of 59% in response latency on the MMLU-Pro dataset, while maintaining comparable accuracy. Additionally, our framework facilitates collaborative inference and output across different models. By employing an LLM for inference and a small language model (SLM) for output, we achieve an average 68% reduction in response latency, alongside a 5.5% improvement in accuracy on the MMLU-Pro dataset compared with the SLM baseline. For long prompts exceeding 20 sentences, the response latency can be reduced by up to 93%.

In social sciences, researchers often face challenges when conducting large-scale experiments, particularly due to the simulations' complexity and the lack of technical expertise required to develop such frameworks. Agent-Based Modeling (ABM) is a computational approach that simulates agents' actions and interactions to evaluate how their behaviors influence the outcomes. However, the traditional implementation of ABM can be demanding and complex. Generative Agent-Based Modeling (GABM) offers a solution by enabling scholars to create simulations where AI-driven agents can generate complex behaviors based on underlying rules and interactions. This paper introduces a framework for designing reliable experiments using GABM, making sophisticated simulation techniques more accessible to researchers across various fields. We provide a step-by-step guide for selecting appropriate tools, designing the model, establishing experimentation protocols, and validating results.

Scaling model size and training data has led to great advances in the performance of Large Language Models (LLMs). However, the diminishing returns of this approach necessitate alternative methods to improve model capabilities, particularly in tasks requiring advanced reasoning. Large reasoning models, which leverage long chain-of-thoughts, bring unprecedented breakthroughs in problem-solving capabilities but at a substantial deployment cost associated to longer generations. Reducing inference costs is crucial for the economic feasibility, user experience, and environmental sustainability of these models. In this work, we propose to train large reasoning models to reason efficiently. More precisely, we use reinforcement learning (RL) to train reasoning models to dynamically allocate inference-time compute based on task complexity. Our method incentivizes models to minimize unnecessary computational overhead while maintaining accuracy, thereby achieving substantial efficiency gains. It enables the derivation of a family of reasoning models with varying efficiency levels, controlled via a single hyperparameter. Experiments on two open-weight large reasoning models demonstrate significant reductions in inference cost while preserving most of the accuracy.