target_id string | target_sha256 string | wave1_total int64 | megadock_max_cohort_n int64 | megadock_checkpoint_cutoffs list | megadock_stratified_prefix_n int64 | megadock_population_complete bool | hdock_confirmatory_n int64 | hdock_pool string | hdock_stratum_counts dict | cohort_sha256 string | selected_before_conventional_docking bool | uses_megadock_results bool | uses_hdock_results bool | megadock_selection_design string | megadock_wave_order_design string | hdock_selection_design string | hdock_order_design string | protocol_amendment string | interpretation string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
target_003 | 845eaf183dc3336d1ca30975e738e441b85827f5e8675979e500a2cf1cee2767 | 200 | 200 | [
30,
45,
60
] | 60 | true | 15 | frozen MEGADOCK validation orders 1-30 only | {
"0": 4,
"1": 4,
"2": 4,
"3": 3
} | 4337dce5e086d2a8c98965749c84c688e0588fd7801425bfd4e625908a89dafa | true | false | false | Boltz stability stratification + alternating Boltz-contact-map and antibody-sequence maximin diversity | orders 1-60 preserve the prospectively stratified/interleaved design; orders 61-200 append the remaining frozen Wave-1 population | within frozen MEGADOCK orders 1-30: proportional stability-stratum allocation, then sequence-novelty seed + alternating Boltz-contact-map and antibody-sequence maximin diversity | interleaved across stability strata | After the five-candidate engineering pilot demonstrated low MEGADOCK-GPU runtime, MEGADOCK coverage was expanded prospectively from max 60 to the complete frozen Wave-1 cohort before population hotspot analysis. | MEGADOCK N=200 covers the complete frozen Wave-1 population and can support population-level contact frequencies. Orders 1-60 remain a deliberately diversity/stability-enriched prefix for sample-efficiency analysis only. |
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