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0000cd74db884c08fe20
Leukemoid Reaction in Association with Bone Marrow Necrosis due to Metastatic Prostate Cancer
Leukemoid reaction is defined as a reactive leukocytosis in excess of 7.5×10 3 / l. It is caused by an exaggerated myeloid response to several stimuli including infections, allergies, burns, intoxications, acute hemorrhage, malignant neoplasms and certain drugs including corticosteroids and lithium. In the absence of l...
0004970cf2fe7f80e66a
Varying temporal criteria for generalized anxiety disorder: prevalence and clinical characteristics in a young age cohort.
1984) . The Zurich study involved a sample of 4547 subjects (2201 males, 2346 females) representative of the canton of Zurich in Switzerland, who were screened in 1978 with the Symptom Checklist 90-R (SCL-90-R ; Derogatis, 1977) , a comprehensive self-report questionnaire of 90 questions that has been validated as a ...
00064724899a9eb24b3e
Distinct right ventricle remodeling in response to pressure overload in the rat
PVR was derived from ESP and CO, and cardiac index (CI) was derived from CO and body surface area. ESP-and EDP-volume slopes [end-systolic and enddiastolic elastance (Ees and Eed), respectively] were also determined. Ventriculoarterial coupling was determined by dividing Ees by Ea. The mass-to-volume (M/V) ratio was de...
00072139d3e5c9ee838c
Flap Complications and Thrombophilia: An Evidence-Based Model and Cost Analysis for Preoperative Screening*
Our institutional laboratory cost for a complete thrombophilia screening panel was $1206 per patient, while a limited panel of the 5 thrombophilias predicted to cause 87% of complications was $572 per patient. The limited panel includes activated protein C resistance, lupus anticoagulant, hyperhomocysteinemia, protein ...
00080c2ec8830197e2a9
The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis?
The peptides generated by specific protein degradation by MMPs or other proteases involved in a specific disease provide a unique fingerprint for a particular disease [117] . This approach is called protein fingerprint (Figure 2a ). Compared to measurement of the intact/whole protein, the measurement of such modified '...
000b924d6d453ba14f23
Effect of an educational booklet for prevention and treatment of foot musculoskeletal dysfunctions in people with diabetic neuropathy: the FOotCAre (FOCA) trial II, a study protocol of a randomized controlled trial
A systematic review [68] of self-care education programs in people with DM showed that this kind of strategy is favorable for all biopsychosocial and economic outcomes, but the authors reinforced the need for further studies due to the wide variety of methodologies and study variables. The booklet proposed for this R...
0013d5d8128d935b21fa
Leptin and the brain: then and now
The discovery of the adipocyte hormone leptin and the demonstration that severe obesity in ob/ob and db/db mice results from mutation of genes encoding leptin and its receptor, respectively, ushered in a new era of obesity research. Our investigation into mechanisms mediating CNS actions of insulin led us to ask whethe...
001432e1b178c5827409
Living high-training low ” altitude training improves sea level performance in male and female elite runners
Cross-sectional studies in the Peruvian Andes (19, 28, 32) as well as in the Colorado Rockies (36) have demonstrated clearly that there is an elevated red cell mass in natives of high altitude that is proportional to the oxyhemoglobin saturation (19, 36) . Moreover, when sea level natives ascend acutely to altitude, ...
001e0e9f29fa46522199
Subclinical rheumatic heart disease: A single center experience
Thus, it has been emphasized in children that irregular focal thickening of the mitral valve, especially the excessive mobility of the anterior leaflet in systole and its prolapse together with the eccentric insufficiency jet accompanying the restricted mobility of the posterior leaflet, should be evaluated in favor of...
0022e6d14dd4139ea95c
The Brachial Ankle Pulse Wave Velocity is Associated with the Presence of Significant Coronary Artery Disease but Not the Extent
; furthermore, arterial stiffness is increased in patients with atherosclerotic disease. 2) Although arterial stiffness can be evaluated by various parameters, there is no consistent method. Among these methods, pulse wave velocity (PWV) has been becoming a widely adopted as an index of arterial stiffness because of ...
002333f5448d7d779b97
Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke The DIAS-4 Trial ( Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke )
In the pooled population, these rates were 10 of 385 (2.6%) and 12 of 382 (3.1%), respectively. Because of early termination, DIAS-4 was underpowered with only 270 patients randomized and did not meet its primary efficacy end point; outcomes in the desmoteplase group were similar to the anticipated outcomes based on ...
002364141e329e5ad01e
Canadian 24-hour movement guidelines for the early years (0–4 years): exploring the perceptions of stakeholders and end users regarding their acceptability, barriers to uptake, and dissemination
Such a module could also be useful for ongoing professional development of teachers as well as license renewal for ECEs. Non-electronic formats to disseminate the Movement Guidelines included printed pamphlets, posters, magnets, professional conference presentations and booths, peer-reviewed journal articles (and the...
00275a38891c8db2ac22
Metabolic syndrome in Iranian elderly
In addition, 60.4% of women and 39.6% of men over 60 years were diagnosed with metabolic syndrome. table 1 compares the mean levels of components of metabolic syndrome in subjects over 60 years with individuals under 60 years. According to table 1, significant differences were observed in the mean of height, BMI, abdom...
00282d6f9c54c94e910c
The importance of selenium to human health
Selenium enters the food chain through plants, which take it up from the soil. Selenium deficiency has therefore been identified in parts of the world notable for their low soil content of selenium, such as volcanic regions. 10 Acid soils and complexation, frequently with iron or aluminium, also reduce the uptake of se...
0028e4af7f9799d3c9e6
Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells?
Enhancing plasticity by enhancing cytoskeletal rearrangement provides another potential target for increasing the likelihood of integration and survival of newborn neurons. While a multitude of factors have effects on cytoskeletal rearrangement, most of these converge on the family of small Rho GTPases, RhoA, Rac1, a...
002ac6def6ef2dfcf377
Detection of residual disc hernia material and confirmation of nerve root decompression at lumbar disc herniation surgery by intraoperative ultrasound.
Therefore, after inspection of the dural sac on sagittal section, the echo probe should be tilted and rotated to accommodate the long axis of the nerve root. As the 8 echogenicity of oozing blood pooling in the epidural space is equivalent to HDM, inspection of the nerve root is compromised. Sufficient hemostasis and a...
002c0bb8d8cd6dd67708
Sjögren's syndrome: studying the disease in mice
Subsequently, infl ammation in the exocrine glands, concomitant with production of anti-Ro autoantibodies, anti-La autoantibodies and anti-DNA autoantibodies, were observed in these mice without, however, assessing exocrine gland function [133] . Th e overall phenotype of this strain, in addition, is characterized by i...
002c441144d00c501c51
Changing Tobacco Control's policy on tobacco industry-funded research.
Changing Tobacco Control's policy on tobacco industryfunded research For several years, the senior editors and editorial board of Tobacco Control have discussed changing our formal stance on the publication of research funded by the tobacco industry. It is simple enough to say, as most journals do, that regardless of...
002e220032a5bdd1f279
General Anesthesia Affecting on Developing Brain: Evidence from Animal to Clinical Research
A recent review by integrating more than 440 pre-clinical studies with exceed 30 clinical studies up to date, demonstrated no clear exposure duration threshold below which no structural injury or subsequent cognitive abnormalities icity of early-life anaesthesia on animals. First is the developmental stage at which ani...
0033e31a5f5c78a00f84
What Patients Expect From Complementary Therapy: A Qualitative Study
This issue requires further investigation, particularly in regard to the chronic nature of the problem and length of illness and comorbidity of patients treated privately versus those treated through NHS funding. Seven distinct but overlapping themes regarding patients' expectations emerged from data analysis: relief...
00366ccf6dbdba324b84
The bevacizumab experience in advanced renal cell carcinoma
The doses were de-escalated to bevacizumab 5 mg IV, everolimus 5 mg orally daily, and erlotinib 75 mg orally daily with no dose-limiting toxicities. A phase 2 study of bevacizumab and everolimus has demonstrated efficacy in both treatment-naïve and treatmentrefractory (prior sunitinib and/or sorafenib) patients. 46 O...
0037e0a0a12a58b83b8e
The role of psychosocial factors in irritable bowel syndrome
29 Psychosocial factors and physiology (motility and sensation) interact reciprocally through the central nervous system/enteric nervous system axis. Psychosocial stressors affect colonic motility in both normals and patients 30 , and patients with functional gastrointestinal disorders have increased motor rea...
003af1588a3754f1e5e9
A Century of Optocardiography
4 ) [32] . In the late 1980s, optical action potentials were used to measure conduction velocity in papillary muscle [33] . Later in the early 1990s, the recording of optical action potentials was validated by comparison with computer simulations. This study showed that the maximum of the first and second derivatives...
003e553f41c3c8cb4f84
Efficacy and safety of combined directly acting antivirals for treatment of Chinese chronic hepatitis C patients in a real-world setting
BUN level at the end of treatment had no significant changes compared with baseline level, while an increased BUN level was observed at 24 wk after the end of treatment (5.17 ± 1.50 vs 5.65 ± 1.80, P02 = 0.009) (Figure 2 ). DAAs regimens and time points had no interactive effects on the changes of hepatorenal function ...
003f8a5a90fad03d937b
IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study
[13, 14, 27, 30] In addition, the IL-1 blocking agent ameliorated the pancreatic homeostasis, as demonstrated by the improvement in functions of beta-cells and alpha-cells. The improvement in insulin sensitivity and the restored pancreatic regulation may result in a positive synergy, leading to an overall reduction of ...
0040d0fe27ee2d39a8b0
The efficacy of XP-endo SHAPER (XPS) in cleaning the apical third of the root canal
Complex anatomy of the root canal system and inadequate cleaning using the existing instruments and techniques are still significant and current problems of endodontic treatment [1, 2] . It has been confirmed that even after careful selection of hand or rotary files, almost 30-50% of the wall surface remains untouched ...
00419be0220836dc9227
Do not resuscitate, brain death, and organ transplantation: Islamic perspective
[20] The opponents argue that organ procurement is performed in the operating room with no general anesthesia because donors are presumed dead. [33] In fact, most surgeons require general anesthesia to procure organs from brain-dead individuals to avoid spinal reflexes. Others have rejected the diagnosis of brain dea...
0042ee7d193aff14684b
Stem cell therapy for heart diseases.
Ischaemic heart disease (IHD) is the most common cause of death in the world accounting for 7.2 million deaths per year ( 12% of all reported deaths). 1 Acute myocardial infarction (AMI) affects 250 000 people each year in the UK 2 and subsequent heart failure with left ventricular systolic dysfunction (LVSD) is common...
0044f84fb444e66a2f75
Recent Progress in Preclinical HIV-1 Vaccine Research
Since isolation in humans in 1983 [1, 2] , HIV-1 has developed into a global pandemic. But an effective HIV-1 vaccine has not been succeeded despite multiple human vaccine trials performed [3, 4] . Challenges to an effective vaccine arise from intrinsic virological and immunological features of HIV-1 [3] [4] [5] [6] [7...
00458558f2859b525b02
Interventional CMR: Clinical Applications and Future Directions
Pre-clinical examples include direct closed chest beating-heart transthoracic access to the right and left ventricles to deliver large devices [17, 18] , transcatheter extra-anatomic Bbidirectional cavopulmonary^shunt (Ratnayaka et al. 2015 , under review), and closed chest transthoracic VSD repair [19] . The followi...
00462649539e586247b6
A Review of the Urban Development and Transport Impacts on Public Health with Particular Reference to Australia: Trans-Disciplinary Research Teams and Some Research Gaps
In the Special Edition of the New South Wales Public Health Bulletin on 'Cities, Sustainability and Health' an example of this approach is proposed with a ten-point checklist for the planning and development of healthy and sustainable communities has been proposed [179] . Developing these sector inter-connections a bit...
0046cf4aaca503985af0
The potential for measles transmission in England
Measles vaccination was introduced in the UK in 1968 for children in the second year of life [1] . Coverage gradually improved from approximately 50% during the 1970s to 86% when MMR vaccine replaced single antigen vaccine in 1988, and reached 92% in 1995. As a result, measles epidemics, which had occurred biennially i...
004748f26969e4350966
Patients, pharmacists, and the placebo in France: From iatrogenic to ethical risks
The person is trying to avoid giving a real pharmaceutical to a family member when he/she thinks that this is not necessary or that the symptom is not serious, when the aim is to avoid a pointless consumption of medicines. Or the person gives a different medicine from that with the corresponding indications for the aff...
0049661254b11e516ecb
Adenovirus expressing Fas ligand gene decreases airway hyper-responsiveness and eosinophilia in a murine model of asthma
32, 35 Taken together, these data suggest that the induction of Fasmediated apoptosis of the infiltrated eosinophils in the airway could be a novel therapeutic strategy for asthma. We and others demonstrated that stimulation of purified eosinophils in vitro with a monoclonal anti-Fas antibody induced apoptosis in a d...
004a78ced2078ef5a1c4
Insulin resistance, blood glucose and inflammatory cytokine levels are risk factors for cardiovascular events in diabetic patients complicated with coronary heart disease
Elevated blood glucose, insulin resistance and inflammation marker lnt of simple coronary heart disease (CHD) or diabetes mellitus type 2 (T2DM) (1) , which, in turn, also affect the body's fat metabolism, blood pressure regulation and glucose metabolism process (2) . T2DM and CHD are associated with decreased sensitiv...
004c8818fa3ab247c804
Neuropsychological aspects of benign childhood epilepsy with centrotemporal spikes
19, 20 Moreover, at the extreme end, BECTS can occasionally deteriorate into syndromes with electrical status epilepticus in slow wave sleep (ESES) or continuous spike wave during slow-wave sleep (CSWS) characterized by severe cognitive and behavioral abnormalities. 19, 20 The findings of our study indicate that the le...
004e8d51f63c13babe43
Pemphigus: a disease stamped in the skin
The term pemphigus, from the greek pemphix (blister), describes a group of autoimmune blistering diseases involving the skin and mucous membranes, the histologically characteristic is the formation of acantholytic intraepidermal blister and the deposition of IgG autoantibodies on the surface of epidermal keratinocytes....
00510fbd8104341f5b7d
Sprinkle Formulations—A Review of Commercially Available Products
The agency recommends a target bead size up to 2.5 mm with less than 10% variation and a maximum size of 2.8 mm to avoid inadvertent chewing. The For example, a burst or an early release of the drug may occur for the ER or DR beads, respectively, and the unpleasant taste of released drug may lead to poor compliance wit...
00556434de6e0053f0df
1854. Effective Antimicrobial Stewardship for Outpatient Parenteral Antimicrobial Therapy (OPAT): Nationwide Experience in Infectious Disease Physician Infusion Centers
No reported disclosures. Background. Antimicrobial therapy for asymptomatic bacteriuria (ASB) is often unnecessary and is a common reason for inappropriate antimicrobial use in hospitalized patients. ASB treatment leads to development of resistance, drug toxicities and increased risk of Clostridium difficile infections...
00564cd2894412d9c160
Spinal Tuberculosis: Diagnosis and Management
According to different reports, considering the following factors could be helpful in order to select the approach [26, 27, 55, 59, 60, 63, 67, [73] [74] [75] [77] [78] [79] [80] [81] [82] 88] . 1-Patient's age 2-Presence of medical co-morbidities 3-Location of bony destruction (anterior, posterior or both) 4-Locatio...
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MIRIAD — Training, unified schema

A seeded sample of miriad/miriad-4.4M, made into retrieval training pairs and reshaped into the strict schema shared by every dataset in this collection. One of the 15 domain sources (code, medical, science, finance, legal) added to the collection's general sources.

Source miriad/miriad-4.4M @ ba958e430c08
Task medical question → paper passage
Domain · languages medical · eng
Queries / documents / qrels 60,000 / 35,729 / 60,000
Qrels per query min 1 · mean 1.0 · max 1
Score values 2 ×60,000 (2: the first positive, 1: any other)
Layout queries · corpus · qrels · hard-negatives · teacher-scores, split train
Splits corpus: train · hard-negatives: train · judgments: train · qrels: train · queries: train · teacher-scores: train
Hard negatives sources: dense · 5,941,717 rows
Teacher scores jinaai/jina-reranker-v3.5 · 6,001,717 rows (positives included)
Judgments judgments: typesafe/jev-1.13.0 · 943,032 rows
Ids sha1(text)[:20]; identical texts collapse to one document / query
License unspecified

Schema

config columns rules
queries id: string, text: string ids unique and non-empty; every query has ≥ 1 qrel
corpus id: string, title: string, text: string title is always present ("" when the source has none)
qrels query-id: string, corpus-id: string, score: int32 referential integrity to both tables; no duplicate pairs; no floats
hard-negatives query-id: string, corpus-id: string, rank: int32, source: string one row per negative; (query-id, corpus-id, source) unique; never a labelled positive of the same query
teacher-scores query-id: string, corpus-id: string, teacher: string, score: float32 one row per scored pair (positives included); a row means scored — never a placeholder
judgments query-id: string, corpus-id: string, judge: string, role: string, p_yes: float64, round: int32 one row per judged pair; role is positive (the training positive) or candidate (a mined candidate, never a labelled positive or a labelled negative); p_yes in [0, 1]; round 0 the first request, 1.. the top-ups

Files are Parquet, sorted by id, zstd-compressed, sharded at 500 MB. Every rule above is checked before publishing; provenance.json records the source revision, what changed, and the output file hashes.

What changed from the source

  • sampled: a seeded random sample (seed 1) of up to 60,000 pairs, streamed through a shuffle buffer of 50,000
  • reshaped: the question is the query, the paper passage (passage_text) the document, with the paper title (paper_title) as its title
  • filtered: papers whose title is a test-corpus title, or that are SciFact documents, were left out
  • decontaminated (exact): a pair was dropped when its normalised query equals any evaluation query, or a positive equals a document of a test or dev corpus; a repeated query keeps its first pair
  • decontaminated (near-duplicates): 0 passages and 0 queries that nearly copy a text of an evaluation set (word 13-grams for passages, 8-grams for queries; at least half shared with one text of the 23 test corpora (BEIR, RTEB, LitSearch) and the 3 dev corpora) were removed, and with them 0 queries in total
  • text: leading and trailing whitespace stripped; otherwise as converted above
  • ids re-keyed to sha1(text)[:20]: 0 documents and 0 queries collapsed into identical texts

Hard negatives and teacher scores

Filled by the owner's annotation pipeline (annotation=jina35-u2) for the train split of the query set(s) below; queries without a labelled positive are left out.

  • Candidates: dense retrieval with jinaai/jina-embeddings-v5-text-small over the full corpus to depth 1,000; 100 candidates per query drawn from the rank windows 1–30 (30), 31–100 (30), 101–300 (20), 301–1000 (20), the query's labelled positives excluded. rank is the dense rank; source is dense for a mined row and dataset for a negative the source labels itself (those are kept for every query of the split, sampled or not).
  • Teacher: jinaai/jina-reranker-v3.5, listwise: a query's positive and all of its candidates are scored together in one context of up to 32,768 tokens. score is the raw cosine score, one row per (query, positive) and per (query, candidate); a labelled negative that was also mined is scored once. Every document was cut to its first 1,024 reranker tokens before scoring (max_doc_tokens=1024). No filtering is applied to the tables.
configs queries hard negatives teacher scores
hard-negatives · teacher-scores 60,000 (all) 5,941,717 (5,941,717 dense) 6,001,717
from datasets import load_dataset
negatives = load_dataset("Hyukkyu/train-miriad", "hard-negatives", split="train")
scores    = load_dataset("Hyukkyu/train-miriad", "teacher-scores", split="train")

Jev judgments

judgments holds, for every query of the training sample (the queries with teacher scores), whether TypeSafe's Jev (jev-1.13.0) judged its training positive and its mined candidates relevant: p_yes is Jev's P(yes) for the source's question (e.g. does the passage answer the query?). They locate the false negatives among the mined candidates and the mislabelled positives.

  • Requests. One request per query (round 0): its training positive, its candidates whose teacher score taken as (cos + 1) / 2 is at least 0.85 × the positive's (at most 12, the highest scores) and 4 random candidates below that, shuffled under neutral ids, one yes/no question per passage. Queries left with fewer than 10 candidates under their source's cutoff got their next hardest unjudged candidates in rounds 1–8 (8 per request), those still under 10 in rounds 9–10 (24 per request). The dataset's own labelled negatives were never sent. Texts were cut to 512 (query) and 512 (passage) tokens of the jina-embeddings-v5 small tokenizer. Jev answers a request's passages in one context, so P(yes) is calibrated to these groups: the thresholds below apply to this table, not to single-pair calls.
  • Accuracy (an audit of 1237 pairs from the pilot's first requests (100 queries per source; the five long-query sources re-piloted at 512-token queries), labelled blind by an LLM (Claude), at the pilot's fixed thresholds 0.35 and 0.15): a candidate at P(yes) ≥ 0.35 was relevant 67% of the time inside the band (n = 350) and 45% below it (n = 87); one under 0.35 was relevant 6% (band, n = 387) and 1% (below the band, n = 210) of the time. A positive under 0.15 was mislabelled 100% of the time (n = 20) in the sources that keep the check; in dom-casehold, dom-clerc, dom-cornstack-py, dom-finqa10k, dom-gerlayqa, dom-investopedia, dom-lawse, dom-magicoder, dom-medmcqa, dom-pubmedqa, dom-s2orc, dom-tatqa, Jev's flags were right less often (0%–57% in this audit), under the 70% the check needs, so their positives are not checked.
  • Use (the SPARSE loader, annotation.filter.judge): a candidate at P(yes) ≥ its source's cutoff (below; fitted on 1,521 labelled pairs) is never a negative; a positive under 0.15 is replaced by the candidate Jev scores highest if that is ≥ 0.8, else the query is dropped; a candidate at ≥ 0.9 can become an extra positive. Compare p_yes as a float64 (it is stored as one).
config queries rows candidates per query top-up rows candidate cutoff positive check
judgments 60,000 943,032 14.7 462,138 0.34 < 0.15

Load it

from datasets import load_dataset
queries   = load_dataset("Hyukkyu/train-miriad", "queries", split="train")
corpus    = load_dataset("Hyukkyu/train-miriad", "corpus", split="train")
qrels     = load_dataset("Hyukkyu/train-miriad", "qrels", split="train")
negatives = load_dataset("Hyukkyu/train-miriad", "hard-negatives", split="train")
scores    = load_dataset("Hyukkyu/train-miriad", "teacher-scores", split="train")
judgments = load_dataset("Hyukkyu/train-miriad", "judgments", split="train")

License and attribution

The data is redistributed under the source's terms — unspecified. All credit belongs to the original authors; see the source repository (https://huggingface.co/datasets/miriad/miriad-4.4M). This repository is an independent repackaging.

No license declared upstream. The source repository states no redistribution terms. This copy is published for the reproducibility of our training data only; check with the original authors before any other use.

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