MedNeXt-L โ€” BraTS 2026 Brain Metastasis Segmentation

MedNeXt-L kernel5 checkpoint trained on the BraTS 2026 Brain Metastasis Segmentation training set (fold 0, model_best). Part of a three-model ensemble; see the full pipeline at the GitHub repository.

Model Details

  • Architecture: MedNeXt-L with 5ร—5ร—5 depthwise convolutions
  • Input: 4 MRI modalities โ€” T1n, T1c, T2w, T2f
  • Output: 5-class segmentation (background, NETC, SNFH, ET, RC)
  • Trainer: nnUNetTrainerV2_MedNeXt_L_kernel5_BraTS
  • Checkpoint: model_best.model + model_best.model.pkl (both files required)

Label Convention

Label Region
0 Background
1 NETC (Non-Enhancing Tumor Core)
2 SNFH (Surrounding Non-Enhancing FLAIR Hyperintensity)
3 ET (Enhancing Tumor)
4 RC (Resection Cavity)

Usage

Inference code and full ensemble pipeline: GitHub repository

Install MedNeXt following the instructions at MIC-DKFZ/MedNeXt.

Note: both model_best.model and model_best.model.pkl must be present in the same folder for inference.

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