Beyond MAE: Ancestry-Stratified Warfarin Dose Prediction
Collection
Reproducible ML pipeline for warfarin dosing. Best MAE 8.55mg/wk, R2=0.475. Reveals a per-ancestry calibration gap masked in aggregate. • 5 items • Updated • 1
warfarisk-catboost-6256
CatBoost regressor (clinical + genetic features) for stable weekly warfarin dose, trained on the IWPC-6256 cohort (n_train=4830, n_test=1207, split seed 20260725). This is the model served by the WarfaRisk prototype app.
| MAE (mg/week) | R2 | PW20 |
|---|---|---|
| 8.875 | 0.446 | 0.455 |
Files: catboost_iwpc6256_combined.cbm (model), catboost_iwpc6256_combined.json (feature columns, defaults, test metrics,
conformal half-width), metrics.json.
Code and reproduction: https://github.com/HasanBGit/WarfaRisk (see docs/REPRODUCIBILITY.md).
Research use only; not a clinical decision tool.