twelvecelldeconvolutebloodepicbas

Reference-based constrained deconvolution returning the basophil proportion from EPIC-array blood methylation. The published EPIC IDOL-Ext library used 1,200 CpGs selected to optimize recovery of known artificial-mixture cell-type proportions; pyaging instead inherits Biolearn’s undocumented 240-CpG replacement, whose rows reproducibly comprise 10 positive and 10 negative maximal cell-versus-other methylation contrasts per subtype and are not a subset of the published 1,200 probes.

Predicts	basophil proportion
Species	Homo sapiens
Tissue	purified blood leukocytes
Data type	DNA methylation
Model type	reference-based constrained deconvolution
Year	2022

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["twelvecelldeconvolutebloodepicbas"])

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Citation

Salas, L.A., Zhang, Z., Koestler, D.C. et al. Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling. Nature Communications 13, 761 (2022).

https://doi.org/10.1038/s41467-021-27864-7