systemsageliver

Liver-system component of Systems Age: a whole-blood DNAm score built from hepatic-system biomarkers and mortality training, returned on an age-like scale.

Predicts	hepatic-system biological age
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	PCA + elastic net regression
Year	2025

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["systemsageliver"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.

https://doi.org/10.1038/s43587-025-00958-3