systemsage

Composite Systems Age integrates the 11 mortality-associated physiological-system scores plus a DNAm chronological-age prediction through PCA and Cox elastic-net regression, then rescales the result to an age-like value.

Predicts	multisystem biological age
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	PCA + elastic net regression
Year	2025

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["systemsage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Sehgal, R., Markov, Y., Qin, C., et al. (2025). Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems. Nature Aging, 5, 1880–1896.

https://doi.org/10.1038/s43587-025-00958-3