senmortalityage

Senescence-enriched elastic-net Cox predictor of mortality, restricted to direction-concordant senescence/age/mortality CpGs and trained in the Framingham Heart Study.

Predicts	mortality risk
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	elastic net Cox regression
Year	2026

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["senmortalityage"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Kasamoto, K., Gibson, J., Moqri, M., Smith, R. & Higgins-Chen, A.T. DNA methylation signatures of cellular senescence are not reversed by senolytic treatment. Aging Cell 25, e70430 (2026).

https://doi.org/10.1111/acel.70430