replitali

Final RepliTali model estimating relative cumulative replicative history from methylation in common partially methylated domains; it was fitted to normalized population doublings across serially cultured primary human cells.

Predicts	replicative history
Species	Homo sapiens
Tissue	cultured primary human cells
Data type	DNA methylation
Model type	elastic net regression
Year	2022

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["replitali"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Endicott, J.L., Nolte, P.A., Shen, H. & Laird, P.W. Cell division drives DNA methylation loss in late-replicating domains in primary human cells. Nature Communications 13, 6659 (2022).

https://doi.org/10.1038/s41467-022-34268-8