intrinclock370

Author-demo IntrinClock at lambda.1se: 370 nonzero CpGs from the original serialized cv.glmnet fit. Predicts chronological age resistant to immune-cell-composition changes. This is a separately fitted regularization column, not the existing 380-CpG lambda.min model with ten sites removed. Returns years using the author's inverse Horvath transform.

Model weights retain the original authors' terms; the pyaging software license does not relicense them.

Predicts	chronological age
Species	Homo sapiens
Tissue	multi-tissue
Data type	DNA methylation
Model type	two-stage elastic net regression
Year	2024

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["intrinclock370"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Tomusiak, A., et al. “Development of an epigenetic clock resistant to changes in immune cell composition.” Communications Biology 7, 934 (2024).

https://doi.org/10.1038/s42003-024-06609-4