epicmithypo

Hypomethylation component of epiCMIT: a 1,164-CpG score ranging from 0 to 1 that tracks low-to-high relative proliferative history in normal and neoplastic B cells.

Predicts	mitotic age
Species	Homo sapiens
Tissue	B cells
Data type	DNA methylation
Model type	complement of mean methylation
Year	2020

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["epicmithypo"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Duran-Ferrer, M., et al. "The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome." Nature Cancer 1 (2020): 1066-1081.

https://doi.org/10.1038/s43018-020-00131-2