downsyndrome

Implementation-derived Down-syndrome-associated methylation projection score: pyaging computes a zero-intercept weighted sum of 652 neonatal blood-spot beta values using the paper's autosomal EWAS beta_overall effect estimates. The paper presents an EWAS, not a trained or validated Down syndrome classifier.

Predicts	Down syndrome methylation score
Species	Homo sapiens
Tissue	neonatal blood spots
Data type	DNA methylation
Model type	weighted linear score
Year	2021

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["downsyndrome"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Muskens, Ivo S., et al. "The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis." Nature Communications 12 (2021): 821.

https://doi.org/10.1038/s41467-021-21064-z