depressionbarbu

Blood methylation risk score for major depressive disorder built with penalised regression on genome-wide EPIC-array CpGs, trained on over 1,200 cases and 1,800 controls. Discriminates prevalent from incident MDD independently of polygenic risk, with a smoking-independent variant also derived.

Predicts	major depressive disorder
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	elastic net regression
Year	2021

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["depressionbarbu"])

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Citation

Barbu, Miruna C., et al. "Epigenetic prediction of major depressive disorder." Molecular Psychiatry 26.9 (2021): 5112-5123.

https://doi.org/10.1038/s41380-020-0808-3