deconvolutebloodepiccd4tcell

Reference-based constrained deconvolution returning the CD4+ T cell proportion from EPIC-array blood methylation. Pyaging uses the paper's automatic 600-CpG top-hypermethylated/top-hypomethylated reference, not the paper's preferred 450-CpG EPIC IDOL library.

Predicts	CD4+ T cell proportion
Species	Homo sapiens
Tissue	purified blood leukocytes
Data type	DNA methylation
Model type	reference-based constrained deconvolution
Year	2018

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["deconvolutebloodepiccd4tcell"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Salas, L.A., Koestler, D.C., Butler, R.A. et al. An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray. Genome Biology 19, 64 (2018).

https://doi.org/10.1186/s13059-018-1448-7