cvdwesterman

Whole-blood DNA-methylation score for cardiovascular risk. The paper's final cross-study learner stacks cohort-specific elastic-net Cox models; the packaged pyaging implementation is a 235-CpG linear score followed by a sigmoid.

Predicts	cardiovascular disease risk
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	elastic net Cox ensemble
Year	2020

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["cvdwesterman"])

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Citation

Westerman, K. et al. Epigenomic assessment of cardiovascular disease risk and interactions with traditional risk metrics. Journal of the American Heart Association 9, e015299 (2020).

https://doi.org/10.1161/jaha.119.015299