cpgptgrimage3

CpGPTGrimAge3 implementation combining chronological age, GrimAge2 DNAm proxies, and CpGPT-predicted plasma-protein proxies in a Cox linear predictor that is calibrated to years.

Predicts	biological age, mortality risk
Species	Homo sapiens
Tissue	whole blood
Data type	DNA methylation
Model type	Cox proportional hazards regression
Year	2024

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["cpgptgrimage3"])

Browse every clock in the pyaging Clock Catalogue.

Citation

de Lima Camillo, L. P., Sehgal, R., Armstrong, J., Higgins-Chen, A. T., Horvath, S., & Wang, B. CpGPT: a foundation model for DNA methylation. bioRxiv 2024.10.24.619766 (2024).

https://doi.org/10.1101/2024.10.24.619766