corticalclock

Cortex-specific DNA-methylation chronological-age estimator trained by elastic net on 1,047 post-mortem cortical samples; its 347-CpG weighted score is back-transformed to years.

Predicts	chronological age
Species	Homo sapiens
Tissue	brain cortex
Data type	DNA methylation
Model type	elastic net regression
Year	2020

Use with pyaging

import pyaging as pya

pya.pred.predict_age(adata, ["corticalclock"])

Browse every clock in the pyaging Clock Catalogue.

Citation

Shireby, G. L., et al. "Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex." Brain 143.12 (2020): 3763-3775.

https://doi.org/10.1093/brain/awaa334