SmileyLlama-1B-GGUF

GGUF quantizations of kysun63/smileyllama-1b-reproduced, a finetune of Llama-3.2-1B-Instruct.

Available quants

Quant File
Q2_K SmileyLlama-1B-Q2_K.gguf
Q4_K_M SmileyLlama-1B-Q4_K_M.gguf
Q6_K SmileyLlama-1B-Q6_K.gguf
Q8_0 SmileyLlama-1B-Q8_0.gguf
f16 SmileyLlama-1B-f16.gguf

SmileyLlama Prompt Template

Without properties,

### Instruction:
You love and excel at generating SMILES strings of drug-like molecules

### Input:
Output a SMILES string for a drug like molecule:

### Response:

With properties, where PROPERTY_LIST is a comma-space (", ".join()) separated list of the following options:

  • ( <= 3, <= 4, <= 5, <= 7, > 7) H-bond donors
  • ( <= 3, <= 4, <= 5, <= 10, <= 15) H-bond acceptors
  • ( <= 300, <= 400, <= 500, <= 600, > 600) Molecular weight
  • ( <= 3, <= 4, <= 5, <= 10, <= 15, > 15) logP
  • ( <= 7, <= 10, > 10) Rotatable bonds
  • ( < 0.4, > 0.4, > 0.5, > 0.6) Fraction sp3
  • ( <= 90, <= 140, <= 200, > 200) TPSA
  • (a macrocycle, no macrocycles)
  • (has, lacks) bad SMARTS
  • lacks covalent warheads
  • has covalent warheads: (sulfonyl fluorides, acrylamides, ...)
  • A substructure of {SMILES_STRING}
  • A chemical of {CHEMICAL_FORMULA}

List of possible warheads:

  • sulfonyl fluorides: [#16](=[#8])(=[#8])-[#9]
  • chloroacetamides: [#8]=[#6](-[#6]-[#17])-[#7]
  • cyanoacrylamides: [#7]-[#6](=[#8])-[#6](-[#6]#[#7])=[#6]
  • epoxides: [#6]1-[#6]-[#8]-1
  • aziridines: [#6]1-[#6]-[#7]-1
  • disulfides: [#16]-[#16]
  • aldehydes: [#6](=[#8])-[#1]
  • vinyl sulfones: [#6]=[#6]-[#16](=[#8])(=[#8])-[#7]
  • boronic acids/esters: [#6]-[#5](-[#8])-[#8]
  • acrylamides: [#6]=[#6]-[#6](=[#8])-[#7]
  • cyanamides: [#6]-[#7](-[#6]#[#7])-[#6]
  • chloroFluoroAcetamides: [#7]-[#6](=[#8])-[#6](-[#9])-[#17]
  • butynamides: [#6]#[#6]-[#6](=[#8])-[#7]-[#6]
  • chloropropionamides: [#7]-[#6](=[#8])-[#6](-[#6])-[#17]
  • fluorosulfates: [#8]=[#16](=[#8])(-[#9])-[#8]
  • beta lactams: [#7]1-[#6]-[#6]-[#6]-1=[#8]
### Instruction:
You love and excel at generating SMILES strings of drug-like molecules

### Input:
Output a SMILES string for a drug like molecule with the following properties: {PROPERTY_LIST}:

### Response:
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