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Fig. 6. A schematic mechanism of AFAP1-AS1 in hepatocarcinoma progression. AFAP1-AS1 upregulation positively correlates with CRKL overexpression through Ras/MEK/c-Jun signaling transduction and EMT process of hepatocarcinoma cells and aggravate the tumor malignancy of hepatocarcinoma patients. | ["As schemed in Fig. 6, current work disclosed the role of AFAP1-AS1 together with interaction with CRKL and underlying mechanism in hepatocarcinoma malignancy. AFAP1-AS1 together with its interaction with CRKL promotes the proliferation, migration and invasion of cancer cells through CRKL-mediated Ras/MEK/c-Jun-EMT an... | Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.03.010 | https://linkinghub.elsevier.com/retrieve/pii/S209012322030059X | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 4 (a) CCII based KHN filter using two elements of different orders, (b) simulation results for the KHN filter at different values of a and b for xh = 1 kHz, (c) CCII based TT filter using two fractional elements of different orders, and (d) circuit simulation at different values for a and b. | ["And by substituting in (15), the required circuit elements will be determined and used in the simulations of the circuit shown in Fig. 4a for different values of a and b. The simulation results of the CCII based KHN filter is presented in Fig. 4b for different values of a and b.", "Then by using (9) to calculate the v... | CCII based fractional filters of different orders | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.01.007 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213000088 | [{"legend": "(a)", "type": "figure", "bbox": [0.0, 0, 0.5456, 0.4955]}, {"legend": "(b)", "type": "chart", "bbox": [0.5719, 0.0545, 0.987, 0.4323]}, {"legend": "(c)", "type": "figure", "bbox": [0.0278, 0.5699, 0.5075, 0.8833]}, {"legend": "(d)", "type": "chart", "bbox": [0.5715, 0.5656, 1.0, 0.9522]}] | |
Fig. 5 Average best fitness curves of the ADE algorithm for selected benchmark functions for D = 50 and population size = 50. | [] | An alternative differential evolution algorithm for global optimization | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.06.004 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211000786 | [{"type": "chart", "bbox": [0.0074, 0, 0.9917, 0.162]}, {"type": "chart", "bbox": [0.0042, 0.1667, 0.9917, 0.3315]}, {"type": "chart", "bbox": [0.0001, 0.3371, 0.9959, 0.5013]}, {"type": "chart", "bbox": [0.0116, 0.5099, 1, 0.6754]}, {"type": "chart", "bbox": [0.0074, 0.681, 1, 0.8451]}, {"type": "chart", "bbox": [0.00... | |
Fig. 1 Cavities indicated to be included in the study. A (Si/Sta 1.2); B (Si/Sta 1.3) | ["The study population comprised students from 4 (2 for boys and 2 for girls) local governmental preparatory schools in Giza governorate, Cairo, Egypt, who had a comparable low to moderate socioeconomic status. These schools were selected as there was a dental clinic nearby that belonged to the government health insura... | Survival of occlusal ART restorations using high-viscosity glass-ionomer with and without chlorhexidine: A 2-year split-mouth quadruple-blind randomized controlled clinical trial | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.01.015 | https://linkinghub.elsevier.com/retrieve/pii/S2090123219300153 | [{"legend": "A", "type": "figure", "bbox": [0, 0.0001, 0.5289, 1]}, {"legend": "B", "type": "figure", "bbox": [0.5305, 0.0001, 0.9999, 1]}] | |
Fig. 2. A-G. Best genes in the training set. Workflow of selecting differentially expressed genes (A). The best performing genes linked to NPM1 mutations in the training set (B-G). Hazard rates with 95% confidence intervals are shown. | [] | Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survival | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.05.006 | https://linkinghub.elsevier.com/retrieve/pii/S2090123219301080 | [{"legend": "A", "type": "figure", "bbox": [0.2412, 0.0241, 0.7952, 0.3586]}, {"legend": "B", "item": [{"type": "chart", "bbox": [0.0001, 0.3913, 0.2319, 0.5729]}, {"type": "chart", "bbox": [0.2534, 0.3877, 0.4576, 0.5626]}]}, {"legend": "C", "item": [{"type": "chart", "bbox": [0.5276, 0.3928, 0.7597, 0.5715]}, {"type"... | |
Fig. 2a XRD patterns of samples calcined at 1100 C. | [] | Effect of strontium on Nd doped Ba 1− x Sr x Ce 0.65 Zr 0.25 Nd 0.1 O 3− δ proton conductor as an electrolyte for solid oxide fuel cells | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2016.12.006 | https://linkinghub.elsevier.com/retrieve/pii/S2090123217300024 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 6. Summary of P300 components induced by samples with different grating widths. | ["The P300 is an ERP component elicited in the process of decision making. It usually happens after approximately 300 ms in the ERP waveform. In this section, the peak amplitude and peak latency of P300 are discussed. Fig. 6 and Fig. 7 summarize the P300 compo- nents induced by samples with different grating widths and... | From finger friction to brain activation: Tactile perception of the roughness of gratings | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.11.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123219301791 | [{"legend": "(a) Group 3", "item": [{"type": "chart", "bbox": [0.0, 0, 0.4938, 0.2904]}, {"type": "chart", "bbox": [0.5163, 0.0042, 0.9966, 0.2927]}]}, {"legend": "(b) Group 3", "item": [{"type": "chart", "bbox": [0.0024, 0.3433, 0.495, 0.6371]}, {"type": "chart", "bbox": [0.5142, 0.353, 0.9941, 0.6399]}, {"type": "cha... | |
Fig. 2 Temperature distribution (K) for cylindrical buffer-target and (a) cylindrical nozzle, (b) conical nozzle, (c) spherical nozzle, with different radius (R), and height (H) for nozzle. The viscosity of water as a function of temperature is considered to these simulations [11]. The buffer thickness is assumed 0.5 m... | ["For all investigations in this part, energy was assumed 50 keV which is put onto the target surface versus W/cm2. The operating current was 300 lA. Firstly, various nozzle geometries such as cylindrical, spheri- cal, and conical shapes for cylindrical buffer shape were inves- tigated. The buffer thickness was assumed... | Anode optimization for miniature electronic brachytherapy X-ray sources using Monte Carlo and computational fluid dynamic codes | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2015.04.006 | https://linkinghub.elsevier.com/retrieve/pii/S2090123215000557 | [{"legend": "(a)", "type": "figure", "bbox": [0, 0.0983, 0.2613, 0.9842]}, {"legend": "(b)", "type": "figure", "bbox": [0.2836, 0.1012, 0.5323, 0.9999]}, {"legend": "(c)", "type": "chart", "bbox": [0.5682, 0.0703, 1, 0.9891]}] | |
Fig. 2 Ultrasound scan of liver of a goat with hepatic lipidosis showing areas of increased echogenicity distributed in hepatic parenchyma (black arrows). R = shadow of rib, white arrow- s = hepatic veins, V = visceral surface of the liver, A = abdom- inal wall. | ["Ultrasonographic-hepatic changes were recorded in 21 (90.4%) out of 23 goats with lipidosis associated with cobalt and cyanocobalamin deficiency. All cases with severe hepatic lipidosis (n = 9) showed increased diffuse echogenicity of the liver parenchyma, which appeared in the form of hyperechoic dots distributed in ... | Ultrasonographic evaluation to diagnose hepatic lipidosis in Egyptian Zaraibi goats with vitamin B12 deficiency | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2010.09.004 | https://linkinghub.elsevier.com/retrieve/pii/S2090123210001116 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 6 The solution of Eq. (2) for a given frequency and boundary conditions and effect of misalignment. | ["Another effect of misalignment is frequency shifting. We cannot use a lumped model, like that in Fig. 2, for considering the misalignment because the resonance frequency is more re- lated to shape mode and structure width than that of anchor location. By solving the Eq. (2) with the related boundary con- ditions, the... | Crossed ring anchored disk resonator for self-alignment of the anchor | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.01.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213000027 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 3: Urology system - X-ray and ultrasound stone localization for radiolucent (uric acid calculi). | [] | Epidemiology, pathophysiology, and management of uric acid urolithiasis: A narrative review | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2017.04.005 | https://linkinghub.elsevier.com/retrieve/pii/S2090123217300504 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 2 Reachable Workspace (WS) compared with Constrained Reachable Workspace (CWS). | ["Fig. 2 shows the Reachable Workspace (WS) and Con- strained Reachable Workspace (CWS) for a simple planar two-link manipulator as an illustrative example."] | Task based synthesis of serial manipulators | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2014.12.006 | https://linkinghub.elsevier.com/retrieve/pii/S2090123214001532 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1 SEM images of (A) IBS loaded nanofibres at 10,000 , (B) IBS loaded nanofibres at 30,000 and (C) IBS loaded solvent-cast films at 10,000 . | ["SEM was used in order to confirm formation of nanofibres (Fig. 1). SEM images revealed formation of discrete IBS loaded PVP nanofibres having size in the range of 60–80 nm. Since the images did not show the presence of the drug crystals and/or aggregates it is postulated that the drug was encapsu- lated and molecularly ... | Fabrication of electrospun nanofibres of BCS II drug for enhanced dissolution and permeation across skin | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2016.03.009 | https://linkinghub.elsevier.com/retrieve/pii/S209012321630011X | [{"legend": "A", "type": "figure", "bbox": [0, 0.0058, 0.3302, 1]}, {"legend": "B", "type": "figure", "bbox": [0.3404, 0.0058, 0.6647, 1]}, {"legend": "C", "type": "figure", "bbox": [0.6752, 0, 1.0, 0.9882]}] | |
Fig. 1. Biochemical measurements in RRMS (n = 72) and healthy controls (n = 28) (A) Plasma levels of ApoA1, HDL-cholesterol, LDL-cholesterol, IFN-c and IL17 (B) Long noncoding RNAs expressions (Fold Change). (C) Expression of sphingosine kinases (SPHKs) and sphingosine 1-phosphate receptors (S1PRs) (Fold Change). Box p... | ["As shown in Fig. 1A, RRMS patients showed significantly lower levels of plasma ApoA1 and HDL-cholesterol along with higher LDL-cholesterol compared to control values (Fig. 1A). Whereas, their APOA1-AS expression was dramatically upregulated reaching six fold of healthy control values (Fig. 1B).", "In MS patients, both... | Long noncoding RNAs APOA1-AS, IFNG-AS1, RMRP and their related biomolecules in Egyptian patients with relapsing-remitting multiple sclerosis: Relation to disease activity and patient disability | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.10.012 | https://linkinghub.elsevier.com/retrieve/pii/S209012321930178X | [{"legend": "A", "type": "chart", "bbox": [0.0, 0, 0.4076, 1]}, {"legend": "B", "type": "chart", "bbox": [0.4969, 0.0063, 0.9944, 0.3846]}, {"legend": "C", "item": [{"type": "chart", "bbox": [0.466, 0.4115, 0.8558, 0.7048]}, {"type": "chart", "bbox": [0.472, 0.7152, 1, 0.9944]}]}] | |
Fig. 5 DSSS - Node c2 - Number of CTS packets heard by innocent node for two other nodes - one of them is an attacker (a1 represented by the blue line). | ["In Fig. 4 for the FHSS case and Fig. 5 for the DSSS case, an innocent node in Area C is listening to the CTS packets sent in the medium and finds that one node in Area A is exceeding the threshold calculated for the channel in this area divided by the number of nodes in this area. The blue line is for the at- tacker a... | DoS detection in IEEE 802.11 with the presence of hidden nodes | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.11.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213001379 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 15 Biotransformation pathways of resibufogenin and cinobufagin by Pseudomonas aeruginosa. | ["Thus, biotransformation has played a role in generating new and more active derivatives. Microbial hydrolysis can achieve very high yield. For instance, cinobufagin (133) and resibufog- enin (135) could be completely metabolized by Alternaria alter- nata AS 3.4578 to generate their 12b-hydroxylated products in greate... | Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2014.11.009 | https://linkinghub.elsevier.com/retrieve/pii/S2090123214001428 | [{"type": "molecule", "bbox": [0.0036, 0.7181, 0.4404, 0.9882]}, {"type": "molecule", "bbox": [0.006, 0.2584, 0.4442, 0.5269]}, {"type": "molecule", "bbox": [0.0089, 0.0142, 0.4472, 0.2803]}, {"type": "molecule", "bbox": [0.5688, 0.7186, 0.9932, 0.9851]}, {"type": "molecule", "bbox": [0.5748, 0.0051, 0.9983, 0.2712]}, ... | |
Fig.4. In vitro drug release profile of rutin and various formulations of rutin-loaded nanospheres in gradually pH-changing buffer at 37 °C up to 24 hrs. Each data point represents mean ± SD (n=3). | ["The in vitro drug release was performed to evaluate the potential of the pH- sensitive nanospheres to target rutin to the colon. Rutin-loaded Eudragit S100 nanospheres formulations, namely F1-F5 were selected for in vitro drug release study as they possessed the highest EE% as well as smallest particle size diameter.... | Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2017.10.003 | https://linkinghub.elsevier.com/retrieve/pii/S2090123217301078 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 5 Langmuir plot of different adsorbents for copper and zinc removal at 27 ± 2 C. | [] | A study of the removal characteristics of heavy metals from wastewater by low-cost adsorbents | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.01.008 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211000269 | [{"legend": "(a) Cu", "type": "chart", "bbox": [0.0, 0.145, 0.4944, 0.9908]}, {"legend": "(b) Zn", "type": "chart", "bbox": [0.5362, 0.1541, 1.0, 0.9999]}] | |
Fig. 6 Butterfly diagram (top) of the frequency of sunspots forming at different solar latitudes. Since 1874, normally these patterns nest so that during solar minimum, sunspots are appearing from both the old and the new cycles at low and high latitudes, respectively. The average sunspot area over the visible hemisphe... | ["Fig. 6 shows a butterfly diagram for sunspot locations as well as the sunspot area index. Besides the fact that sunspot cycle 24 is now underway in both hemispheres, this plot shows that the sunspot area has not built up to historic values for this phase of the solar cycle. This appears to be a result of the weakness ... | How unprecedented a solar minimum was it? | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2012.08.011 | https://linkinghub.elsevier.com/retrieve/pii/S2090123212000690 | [{"type": "chart", "bbox": [0, 0.0001, 0.9999, 0.4908]}, {"type": "chart", "bbox": [0.0071, 0.5338, 0.9989, 0.9999]}] | |
Figure 2: Interaction between Htra1 and amyloid fibrils. The trimer of HtrA1 (PDB code: 3NZI) interact with the amyloid fibril (PDB code: 2MXU). The PDZ domain of HtrA1 (PDB code: 2YTW) (cyan) is responsible for the interaction with the amyloid fibrils by binding to specific sequence along the fibril. The exact binding... | ["HtrA1 is a serine protease that consists of a flexible N terminal (a signal peptide and a partial insulin-like growth factor binding protein-70) domain, a protease domain and a C-terminal PDZ domain. HtrA1 is an ATP-independent protein disaggregase found abundantly in the human brain where it has been reported to dis... | Molecular mechanisms of amyloid disaggregation | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2021.05.007 | https://linkinghub.elsevier.com/retrieve/pii/S209012322100093X | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 4 Effect of the type of inner vessel on % removal of pollutants. Coagulant = 60 mg/l and feed flow rate = 0.7 l/min. | ["The results of the study of the geometrical shape effect for the inner vessel on the removal efficiency are illustrated in Fig. 4. It can be easily noticed that using of cone (1) results in the best treatment of the sewage. Results indicated that the removal efficiencies for TSS, COD, BOD and total phosphorous are 83%,... | Combined coagulation flocculation pre treatment unit for municipal wastewater | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.10.004 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211001214 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 10 Step responsecurves ranging from 50% to +50% for Ta. | ["The robustness of the proposed controller is also investi- gated by changing the time constants (Ta, Te, Tg, and Ts) of the four AVR system components separately [32]. The range of change is selected to be ±50% of the nominal time constant values with a step size of 25%. The robustness step response curves are presen... | A new multiobjective performance criterion used in PID tuning optimization algorithms | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2015.03.004 | https://linkinghub.elsevier.com/retrieve/pii/S209012321500034X | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1 Alignment of amino acid sequences of RBP encoding gene of camel PPV-Bikaner with other parapoxviruses using the software BioEdit Version 7.0.9. Star indicates the position of myristylation motif in camel PPVs. Triangle denotes the position of asn-glycosylation motif in camel PPVs. Arrow denotes the position of a... | ["The complete nucleotide sequences of RBP encoding gene of camel PPVs from three different geographical areas of Rajasthan state (Bikaner, Pali and Udaipur), India were ana- lysed for the first time. These sequences of RBP encoding gene and their comparison to corresponding amino acid sequences from seventeen other PPV... | Comparative sequence analysis of double stranded RNA binding protein encoding gene of parapoxviruses from Indian camels | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.05.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213000647 | [{"type": "figure", "bbox": [0, 0.0, 0.9926, 0.3221]}, {"type": "figure", "bbox": [0, 0.3401, 0.9901, 0.6624]}, {"type": "figure", "bbox": [0, 0.6786, 1.0, 1.0]}] | |
Fig. 2 Dependence of 100% modulus of the blends on HDPE and CR. | ["Fig. 2 shows the modulus of the MW filled NBR/HDPE blends. It can be observed that the modulus of the blends increases with increasing HDPE content. At higher HDPE content, the elastomer phase remains as dispersed particles. The HDPE phase contributes to the higher modulus of NBR/HDPE blends. It was found that increas... | An investigation on chloroprene-compatibilized acrylonitrile butadiene rubber/high density polyethylene blends | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2014.06.003 | https://linkinghub.elsevier.com/retrieve/pii/S2090123214000770 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 3 Load displacement curve for rough vertical and batter piles in loose sand, L/d = 15.00 and Rd = 25%. | ["2 shows typical load versus normalized displacement ratio (S/d) for rough pile under axial pull that constructed in dense sand (u = 43.5 ). It is clear that, the ultimate pullout capacity of batter rough pile constructed in dense sand increases with the increase of batter angle attains maximum value and then decrease... | Pullout capacity of batter pile in sand | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2012.04.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123212000276 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 5. Normalized responses of the damping power potentiality, sprung-mass acceleration, dynamic tire force and the suspension deflection with respect to the 30% SD randomized damping rate. | ["Fig. 5 presents the normalized trends of the energy-harvesting content and suspension dynamics to reveal both the amplitude and frequency bandwidth sensitivities and the sensitivity change of the resonant frequencies of these responses against a 30% SD randomly sampled spring stiffness. It is inferred from Fig. 5a–d ... | Monte Carlo sensitivity analysis of vehicle suspension energy harvesting in frequency domain | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.02.012 | https://linkinghub.elsevier.com/retrieve/pii/S2090123220300369 | [{"legend": "(a)", "type": "chart", "bbox": [0.0004, 0.0, 0.5015, 0.4984]}, {"legend": "(b)", "type": "chart", "bbox": [0.5008, 0.0042, 0.9969, 0.492]}, {"legend": "(c)", "type": "chart", "bbox": [0.0, 0.5064, 0.4972, 0.9904]}, {"legend": "(d)", "type": "chart", "bbox": [0.5012, 0.508, 1, 1]}] | |
Fig. 2 Effect of the number of hidden neurons and number of cycles during training on the MSE, in the prediction of the separation factor (a), combination II. (a) 3D surface plot and (b) 3D contour plot. | [] | Application of artificial neural networks for response surface modelling in HPLC method development | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.04.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211000415 | [{"legend": "a", "type": "chart", "bbox": [0.1715, 0.0199, 1, 0.4654]}, {"legend": "b", "type": "chart", "bbox": [0, 0.5644, 0.9968, 0.9999]}] | |
Fig. 10 (a) Oil removal efficiency for 30 (NRG-0.5) or 15 (CM) adsorption-desorption cycles and (b) physical characteristics of NRG-0.5 and CM sorbents before and after 30 (NRG- 0.5) or 15 (CM) adsorption-desorption cycles. | ["As well as the oil removal efficiency, the sorbent reusability is a crucial criterium in an oil spill cleanup. The reusability of sorbents minimizes the total amount of the waste generation for landfills and reduces the costs of oil spill removals. The oil recovery efficiencies of the NRG-0.5 and CM sorbents during 3... | Natural rubber/reduced-graphene oxide composite materials: Morphological and oil adsorption properties for treatment of oil spills | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.05.007 | https://linkinghub.elsevier.com/retrieve/pii/S2090123219301171 | [{"legend": "(a)", "type": "chart", "bbox": [0.0, 0, 0.9893, 0.4529]}, {"legend": "=0", "type": "figure", "bbox": [0.0162, 0.4539, 1, 0.6993]}, {"legend": "b)", "type": "figure", "bbox": [0.195, 0.7197, 0.7452, 1]}] | |
Fig. 2 Effect of oxine concentration on the recovery factor. Conditions: pH:11, 100 lg L 1 Cd2+, 70 lL ([Omim][PF6]), extraction time 6 min. | ["Fig. 2, and show that the absorbance increased by increasing the oxine concentration up to 1.35 · 10 4 mol L 1 and then re- mained constant afterwards. A concentration of 1.35 · 10 4 mol L 1 of oxine was chosen for subsequent determinations."] | Vortex-assisted ionic liquid microextraction coupled to flame atomic absorption spectrometry for determination of trace levels of cadmium in real samples | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.12.002 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211001263 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1. Crosslinking time and compressibility of the bio-ink. (A) Crosslinking times of filaments with different diameters under different UV light intensities. (B) Compressibility of the bio-ink. (C) Stress-strain curves of the bio-ink. The compression strains in various cycles were 15%, 20%, 25%, and 30%, respectivel... | ["The photopolymerizable bio-ink was mainly composed of methacrylated gelatin (GelMA), sodium alginate, and polyethylene glycol diacrylate (PEGDA). GelMA deriving from partially hydro- lyzed collagen from animal tissues could provide essential bio- chemical cues [23] and enhance the mechanical strength of the crosslink... | Robotic in situ 3D bio-printing technology for repairing large segmental bone defects | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.11.011 | https://linkinghub.elsevier.com/retrieve/pii/S209012322030237X | [{"legend": "A", "type": "chart", "bbox": [0.0077, 0.038, 0.3026, 0.5018]}, {"legend": "B", "type": "chart", "bbox": [0.3251, 0.0486, 0.6273, 0.4915]}, {"legend": "C", "type": "chart", "bbox": [0.6702, 0.0362, 0.9762, 0.4897]}, {"legend": "D", "type": "chart", "bbox": [0, 0.5762, 0.2941, 0.9808]}, {"legend": "E", "type... | |
Fig. 2 (a) In vitro release profiles of TiM from transfersomes from formulae (1T-8T) using T80. (b) In vitro release profiles of TiM from transfersomes from formulae (1S-8S) using S80. | ["Fig. 2 represents the in vitro release profile of the drug from the formulations which followed a biphasic release. This could be attributed to the presence of free drug together with the entrapped one, which is due to the limited capacity of the lipid to accommodate large amounts of the drug leading to disposi- tion ... | Improved bioavailability of timolol maleate via transdermal transfersomal gel: Statistical optimization, characterization, and pharmacokinetic assessment | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2016.07.003 | https://linkinghub.elsevier.com/retrieve/pii/S2090123216300510 | [{"legend": "(a)", "type": "chart", "bbox": [0.0041, 0.0041, 0.8985, 0.4541]}, {"legend": "(b)", "type": "chart", "bbox": [0.0016, 0.4796, 0.9999, 0.9999]}] | |
Fig. 10. Size and size distribution by DLS of C. albicans (A), H. pylori (B) and (Ca + Hp)BF (C). | ["Size and size distribution by DLS are shown in Fig. 10. It can be seen that alike to results obtained by SEM and TEM, the mean size of C. albicans is higher than mean size of H. pylori. By DLS, size changes from 1.7 to 4.8 mm for C. albicans and from 0.71 to 4.1 mm for H. pylori were obtained. For H. pylori, substanc... | Multiple surface interaction mechanisms direct the anchoring, co-aggregation and formation of dual-species biofilm between Candida albicans and Helicobacter pylori | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2021.03.013 | https://linkinghub.elsevier.com/retrieve/pii/S209012322100062X | [{"legend": "(A)", "type": "chart", "bbox": [0.005, 0.0035, 0.999, 0.3222]}, {"legend": "(B)", "type": "chart", "bbox": [0.0079, 0.3438, 0.999, 0.6647]}, {"legend": "(C)", "type": "chart", "bbox": [0.007, 0.6841, 1.0, 0.9999]}] | |
Fig 6(a). Dimensions of a tensile testing sample (All dimensions in mm) | ["The tensile tests were conducted on the test specimens according to ASTM E08-8 standards. Prior to their loading, the specimens were first polished with silicon carbide abrasive papers in grit size ranges from 220-800 in order to remove the surface defects on the sample. The universal testing machine (UTM-INSTRON 400... | Comparative study on the mechanical and microstructural characterisation of AA 7075 nano and hybrid nanocomposites produced by stir and squeeze casting | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2017.02.005 | https://linkinghub.elsevier.com/retrieve/pii/S2090123217300310 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1 Hop a/b bitter acids composition in comparison to its cytotoxic effect. (A) Chemical structures of humulones (a-bitter acids) and lupulones (b-bitter acids) series detected in hop resin. (B) Hierarchical cluster analysis (HCA) of hop cultivars based on group average cluster analysis of its biochemical profile as... | ["All rights reserved. is used in brewing, baking and as cattle feed for its bacteriostatic action and preservative qualities [1]. In addition, it is used in pharmaceutical applications. The resin is used as a mild seda- tive in European phytotherapy, and hop has been investigated for its potent estrogenic and, more re... | Cytotoxic effect of commercial Humulus lupulus L. (hop) preparations – In comparison to its metabolomic fingerprint | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2012.07.006 | https://linkinghub.elsevier.com/retrieve/pii/S2090123212000550 | [{"legend": "(A)", "item": [{"type": "molecule", "bbox": [0.0128, 0.0293, 0.3524, 0.2089]}, {"type": "expression", "bbox": [0.0034, 0.0226, 0.9975, 0.214]}]}, {"legend": "(B)", "item": [{"type": "molecule", "bbox": [0.65, 0.0281, 0.9999, 0.2116]}, {"type": "chart", "bbox": [0.0854, 0.2509, 0.8623, 0.6414]}]}, {"legend"... | |
Fig. 1. Percentage of haemoglobin released on exposure to different AS-48 concentrations using whole blood (dark blue) and defibrinated erythrocytes (light blue). The results are shown as means ± SD of twenty independent samples. | ["The haemolytic potential of purified AS-48 was determined by the percentage of lysed red cells using whole blood and defibrinated human erythrocytes. According to the data obtained, the haemolytic potential of purified AS-48 varied with assay and concentration used. When tested on whole blood, hemolysis produced by t... | Preclinical studies of toxicity and safety of the AS-48 bacteriocin | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.06.003 | https://linkinghub.elsevier.com/retrieve/pii/S209012321930133X | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 7 Results of 10 PSO trials with the proposed objective function. | ["The response of the AVR system with PID controller shown in Fig. 6, exhibits Mp ¼ 12% at tp = 0.28 s, tr = 0.14 s, and ts = 0.78 s. These values are comparable to the corresponding mean values of the Pareto front sets shown in Fig. 5. This con- firms the ability of the proposed objective function in produc- ing optimi... | A new multiobjective performance criterion used in PID tuning optimization algorithms | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2015.03.004 | https://linkinghub.elsevier.com/retrieve/pii/S209012321500034X | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 3 Relation between the absorption coefficient (ln a) and the photon energy (hm) (a) and the Urbach's energy Eu (b) for pristine and Makrofol samples irradiated with different doses of gamma rays. | ["The variation in the logarithm of the absorption coefficient a as a function of the photon energy hm was observed by Urbach and is given by relation [29]: where ao is a constant, E is the photon energy and Eu is Urbach’s energy, which represents the inverse logarithmic slope of the absorption coefficient. Fig. 3a shows... | Modifications induced by gamma irradiation to Makrofol polymer nuclear track detector | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2014.01.005 | https://linkinghub.elsevier.com/retrieve/pii/S209012321400006X | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1 A diagram of the solar dryer (dimensions in mm - the bold arrows refer to air streamlines). | ["Drying experiments were carried out using direct and indirect prototype solar dryers. The two prototypes are constructed from wood frames and have the same dimensions as shown in Figs. 1 and 2. The direct proto- type solar dryer was covered by transparent polyethylene film; while black polyethylene film was used to cov... | Solar drying of whole mint plant under natural and forced convection | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.12.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213001458 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Figure 7: Complete circuit of Jerk chaotic system with 9-scroll attractors. | ["The main circuit implementation of the Jerk system is depicted in Fig. 7 using OPAs and RC chain type fractances. In order to generate the sgn(·) function in F(x), the OPAs in the circuit are required to have high slew rates. Here, choosing TL081/TL084 (slew rate is 16 V/µs, output voltage swing is ±13.5 V when load ... | Analysis and implementation of fractional-order chaotic system with standard components | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.05.008 | https://linkinghub.elsevier.com/retrieve/pii/S2090123220300916 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 1 Thermo gravimetric (TGA) curve of marble sludge powder. | ["Fig. 1 shows the thermo gravimetric curve discloses one dis- tinctive weight loss stage for MS sample (Fig. 1). Weight loss of 42.56% has been observed due to the evolution of carbon dioxide which signifies the presence of metal carbonates. The chemical analysis, XRF and TGA, show that marble sludge powder is mainly c... | Reinforcement of natural rubber hybrid composites based on marble sludge/Silica and marble sludge/rice husk derived silica | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.01.008 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213000258 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 2. (a) Entrapment efficiency of basic fuchsin and bromophenol blue in the vesicles and (b) time course (months) of the amount of entrapped dye. Data are means ± SE (n = 5, n = individual vesicles extraction with individual entrapment assay). Asterisk (*) indicates significant differences (P < 0.05, student's t-tes... | ["The statistical analyses were carried out using R version 3.4.3. The student0s t-test at P < 0.05 was chosen to determine significant differences, between the total amount and the amount entrapped (Fig. 2a) and between time 0 and 1 year (Fig. 6b). Tukey0s HSD test at P < 0.05 was used to determine significant differenc... | Plant plasma membrane vesicles interaction with keratinocytes reveals their potential as carriers | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.02.004 | https://linkinghub.elsevier.com/retrieve/pii/S209012322030028X | [{"legend": "a", "type": "chart", "bbox": [0.0024, 0.0496, 0.492, 0.9858]}, {"legend": "b", "type": "chart", "bbox": [0.5044, 0.0509, 1, 1.0]}] | |
Fig. 4 Output x- and y-components of the proposed HNN resulting from a rotating unit value input (k = 0.48/d and kc = 0.3). | ["There is no doubt that if the input is restricted to vary along a single direction, output behavior will be as shown in Fig. 2. The far-reaching capabilities of the proposed four-node hybrid HNN, however, may be demonstrated when vector input–out- put variations are considered. For instance, consider output component... | Efficient modeling of vector hysteresis using a novel Hopfield neural network implementation of Stoner–Wohlfarth-like operators | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2012.07.009 | https://linkinghub.elsevier.com/retrieve/pii/S2090123212000586 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 4. Activated CD4+ and CD8+ T cells evidently contributed to the improved survival in the treatment of 25 mg CpG plus NAP-UVA Vax. (a) IHC staining of selected tumor tissues after treatment, including PBS group, 25 mg CpG alone and 25 mg CpG plus NAP-UVA with delayed growth; (b) scheme of in vitro apoptosis study o... | ["Our analysis indicated that high proliferating tumor cells (Ki67 positive) in the PBS and increased CpG alone groups were highly correlated with the expression of FOXP3, the immune suppressive Treg cells marker that was also CD4 positive (Fig. 4a). No signifi- cant positive staining of CD8+ T cells or only weakly dist... | In vitro naphthylquinoxaline thymidine conjugate and UVA treated cancer cells are effective therapeutic vaccines for tumors in vivo with CpG as the adjuvant | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2021.03.003 | https://linkinghub.elsevier.com/retrieve/pii/S2090123221000382 | [{"legend": "(a)", "type": "figure", "bbox": [0.0, 0.0052, 1.0, 0.5948]}, {"legend": "(b)", "item": [{"type": "molecule", "bbox": [0.0379, 0.6434, 0.1297, 0.7356]}, {"type": "figure", "bbox": [0.0369, 0.6416, 0.507, 0.7791]}]}, {"legend": "(c)", "type": "chart", "bbox": [0.5925, 0.633, 0.9883, 0.8121]}, {"legend": "(d)... | |
Fig. 3 Spatial changes in the populations of bacterial indicators of pollution along the course of the canal. (a) Population changes in bacterial indicators of pollution (MPN/100 ml); (b) percentage decreases in bacterial load by distance; (c) correlation matrix; (d) cumulative total bacterial load by distance. | ["(Fig. 3a). Irrespective of the seasons and sites, the indicators of pollution did present with population ranged from >0 to 550, >0 to 70, and >0 to 550 MPN/100 ml of total coliforms, fecal coliforms, and fecal streptococci respectively. This is an indica- tion of the suitability of the water for irrigation not for d... | El-Salam canal is a potential project reusing the Nile Delta drainage water for Sinai desert agriculture: Microbial and chemical water quality | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2011.04.003 | https://linkinghub.elsevier.com/retrieve/pii/S2090123211000439 | [{"legend": "a", "type": "chart", "bbox": [0, 0.0348, 0.44, 0.6203]}, {"legend": "c", "type": "chart", "bbox": [0.0418, 0.7533, 0.4845, 0.9507]}, {"legend": "b", "type": "chart", "bbox": [0.5, 0.0729, 0.9912, 0.5116]}, {"legend": "d", "type": "chart", "bbox": [0.5234, 0.5931, 1, 1]}] | |
Fig. 4. Therapeutic efficacy of DOX@MTP/HA-EGCG NPs in GL261 cells via chemotherapy and CDT. (A) Cytotoxicity of GL261 cells treated with EGCG and HA-EGCG conjugates, as determined by MTT assay. (B) Cytotoxicity and IC50 (C) of GL261 cells treated with DOX, DOX/HA-EGCG, DOX@MTP, and DOX@MTP/HA-EGCG NPs. (D, E) Apoptosi... | ["The antitumor activity of EGCG and HA-EGCG was measured in GL261 cells. The HA-EGCG carrier was able to maintain its antitu- mor effect compared with that of EGCG at the same concentration (Fig. 4A). Subsequently, we detected the cytotoxicity of DOX, DOX/HA-EGCG, DOX@MTP, and DOX@MTP/HA-EGCG in GL261 cells (Fig. 4B),... | A Tumor-Specific Ferric-Coordinated Epigallocatechin-3-gallate cascade nanoreactor for glioblastoma therapy | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2021.07.010 | https://linkinghub.elsevier.com/retrieve/pii/S2090123221001442 | [{"legend": "A", "type": "chart", "bbox": [0.0223, 0.0482, 0.3439, 0.3571]}, {"legend": "B", "type": "chart", "bbox": [0.364, 0.0273, 0.7087, 0.3605]}, {"legend": "C", "type": "chart", "bbox": [0.7519, 0.0323, 0.988, 0.3687]}, {"legend": "D", "type": "chart", "bbox": [0.0032, 0.3759, 0.6603, 1.0]}, {"legend": "E", "typ... | |
Fig. 5. Effects of LRRK2 on autophagy in cardiomyocytes. a-d: NRCMs were transfected with Ad-LRRK2. a and b. The protein levels of Atg5, Atg7, and P62 in NRCMs (n = 6). c and d. NRCMs were transfected with Ad-LC3-mCherry-GFP. c: Representative images (n = 5). d: Red puncta number, green puncta number, red-green puncta/... | ["Cell autophagy was analysed because LRRK2 was reported to function in autophagy regulation. The autophagy-associated pro- teins Atg5 and Atg7 were downregulated, while P62 accumulated in PE-stimulated cells (Fig. 5a, b). We observed a robust reduction in Atg5 and Atg7 and a robust increase in P62 accumulation in LRRK... | Leucine-rich repeat kinase-2 deficiency protected against cardiac remodelling in mice via regulating autophagy formation and degradation | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2021.07.004 | https://linkinghub.elsevier.com/retrieve/pii/S2090123221001387 | [{"legend": "A", "type": "figure", "bbox": [0.0001, 0.0547, 0.3076, 0.263]}, {"legend": "B", "type": "chart", "bbox": [0.3292, 0.0957, 0.629, 0.2764]}, {"legend": "C", "type": "figure", "bbox": [0.6546, 0, 0.9623, 0.2872]}, {"legend": "D", "item": [{"type": "chart", "bbox": [0.0387, 0.316, 0.1765, 0.4801]}, {"type": "c... | |
Fig. 3. Effect of exercise training on proteins involved in extrinsic apoptosis. (A) Representative Western blots show the changes in the protein levels of Fas-L, FADD and Caspase-8 in the left ventricle tissue in from different groups (Control and Exercise: rats under exercise training, induced-aging: D-galactose indu... | ["To determine the changes in the cardiac Fas receptor-involved apoptosis mechanism in the aging model after exercise training, Fas ligand (Fas-L), FADD and active caspase-8 levels were checked by Western blot analysis. The results reveal that Fas-L and FADD increased significantly in the aging rats (Fig. 3) and thereby... | Exercise training restores IGFIR survival signaling in d-galactose induced-aging rats to suppress cardiac apoptosis | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2020.06.015 | https://linkinghub.elsevier.com/retrieve/pii/S2090123220301247 | [{"legend": "(A)", "type": "figure", "bbox": [0.0852, 0.0398, 0.9153, 0.492]}, {"legend": "(B)", "item": [{"type": "chart", "bbox": [0, 0.6457, 0.3319, 0.9964]}, {"type": "chart", "bbox": [0.3393, 0.6457, 0.6696, 1]}, {"type": "chart", "bbox": [0.6884, 0.6131, 0.9999, 0.9927]}]}] | |
Fig. 17 Five different subjects all diagnosed with tumor in the brain. Contrast enhanced T1-weighted MRI images are shown in (a) (oligodendroglioma), in (c) (brain metastases), in (e) (anaplas- tic oligodendroglioma), in (g) (glioblastoma) and in (i) (tumor with intraventricular extension). The signal resilient to inte... | ["Generally, the choice of the technical characteristics of the MRI modalities such as: T1-weighted MRI with or without contrast agent, T2-weighted MRI, FLAIR pulse sequence; has been made with the specific intention to image the brain tumors at best. In reference to the metastases this manuscript reports: (i) a coronal... | Intensity-Curvature Measurement Approaches for the Diagnosis of Magnetic Resonance Imaging Brain Tumors | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2015.01.001 | https://linkinghub.elsevier.com/retrieve/pii/S2090123215000028 | [{"legend": "(a)", "type": "figure", "bbox": [0.0001, 0.0, 0.4897, 0.1951]}, {"legend": "(b)", "type": "figure", "bbox": [0.5475, 0.0116, 0.9267, 0.1958]}, {"legend": "(c)", "type": "figure", "bbox": [0.0001, 0.2007, 0.4904, 0.3963]}, {"legend": "(d)", "type": "figure", "bbox": [0.5102, 0.2016, 0.9998, 0.3999]}, {"lege... | |
Fig. 1e General view of test setup of test unit SP-H1. | ["Great care was given to leveling of the specimens to ensure that it was correctly aligned during testing. Fig. 1e shows the general setup for test unit (SP-H1) of group A."] | Behavior of concentrically loaded CFT braces connections | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2013.03.005 | https://linkinghub.elsevier.com/retrieve/pii/S2090123213000362 | [{"type": "figure", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig. 3. Quantitative analysis of the binding ability was determined by isothermal titration calorimetry (ITC). Each tandem-domain protein was titrated with HPTM peptides. The titration in the same group was conducted under the same experimental parameters. A). TRIM24-PB titrated with H3K4me3K9ac; B) TRIM24-PB titrated ... | ["To quantify the binding affinities, we carried out ITC assays between the peptides containing combinatorial modifications and tandem-domain proteins based on the MS screening results (Fig 3). The tandem-domain proteins used in ITC were digested by thrombin proteases to remove the GST tag and the digestion was verifie... | Identification of dual histone modification-binding protein interaction by combining mass spectrometry and isothermal titration calorimetric analysis | Others | ["Multidisciplinary Journals"] | Journal of Advanced Research | 10.1016/j.jare.2019.11.003 | https://linkinghub.elsevier.com/retrieve/pii/S209012321930181X | [{"legend": "J", "type": "chart", "bbox": [0.0093, 0.0022, 0.3259, 0.3286]}, {"legend": "K", "type": "chart", "bbox": [0.3521, 0.0026, 0.6648, 0.3294]}, {"legend": "L", "type": "chart", "bbox": [0.6874, 0.0015, 1, 0.3274]}, {"legend": "M", "type": "chart", "bbox": [0.0127, 0.3414, 0.3203, 0.6617]}, {"legend": "N", "typ... | |
Fig 3. Scale and direction of dispersal. Dispersal kernels indicating the scale of dispersal observed in the dataset of parentage assignments (grey) and the consistent model simulations (blue). Shaded regions indicate 95% confidence bounds of uncertainty, resulting from sampling variation (adults and juveniles) and unc... | ["To measure the distance scale of recruitment predicted by the consistent biophysical model and observed in the parentage assignments, we fit isotropic larval dispersal kernels to both [26]. The two kernels broadly agree, although the consistent model simulations were best fit by a shorter dispersal kernel than the ob... | Successful validation of a larval dispersal model using genetic parentage data | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.3000380 | https://dx.plos.org/10.1371/journal.pbio.3000380 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig 2. Queuosine modification alters features of tRNA anticodons. (A) The sequence of D. melanogaster tRNATyr (after Suter and colleagues [62]) shows modification of guanosine (G) to queuosine (Q) in the anticodon position corresponding to the third-position (wobble) base of the codon. Positions of cis-diol moieties ar... | ["1. The original Fig 2 is missing a double bond in the three cyclopentyl moieties. A corrected Fig 2 is provided here. This new Fig 2 also adds stereochemistry to that moiety."] | Correction: A Nutrient-Driven tRNA Modification Alters Translational Fidelity and Genome-wide Protein Coding across an Animal Genus | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.1002150 | https://dx.plos.org/10.1371/journal.pbio.1002150 | [{"legend": "A", "item": [{"type": "molecule", "bbox": [0, 0.0698, 0.3677, 0.9109]}, {"type": "molecule", "bbox": [0.4117, 0.4452, 0.6052, 0.9302]}, {"type": "molecule", "bbox": [0.4151, 0.0707, 0.6086, 0.2953]}, {"type": "molecule", "bbox": [0.6631, 0.5086, 0.9948, 0.9994]}, {"type": "molecule", "bbox": [0.6635, 0, 0.... | |
Fig 5. Glucose-induced proliferation of gastrointestinal cancer cells relies on ROS/AMPK/EP300/β-catenin signaling. See related results in S5 Fig. (A) Scheme of the axis evaluated with indicated blockade at each level: ROS were blocked by CoQ10; AMPK by Compound C or CRISPR/Cas9 deletion of α1 and α2 subunits; EP300 by... | ["In support of a ROS/AMPK/EP300/β-catenin axis mediating glucose-induced proliferation of colon cancer cells, blockade at each level (Fig 5A) abolished the effects of glucose on prolif- eration. First, counteracting ROS accumulation with CoQ10 reduced the proliferative response of gastrointestinal cancer cells to high... | Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.3000732 | https://dx.plos.org/10.1371/journal.pbio.3000732 | [{"legend": "A", "type": "figure", "bbox": [0.0152, 0.0111, 0.9999, 0.1377]}, {"legend": "B", "type": "chart", "bbox": [0.0348, 0.1656, 0.3071, 0.4311]}, {"legend": "C", "type": "chart", "bbox": [0.3858, 0.165, 0.6609, 0.4357]}, {"legend": "D", "type": "chart", "bbox": [0.7293, 0.1648, 0.9938, 0.4357]}, {"legend": "E",... | |
Fig 1. Developing long bones accurately maintain their body proportions during more than a 5-fold increase in length in a cost-optimal manner by regulating the balance between the growth rates at their two ends. Image credit: Tomer Stern. | ["To determine whether scaling during bone growth is isometric or allometric, Stern and col- leagues assembled a large database containing 3-D micro-CT images of mouse long bones at different stages of development from embryo to adult. Comparing the position of symmetry- breaking elements for each bone revealed that, w... | Make No Bones about It: Long Bones Scale Isometrically | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.1002211 | https://dx.plos.org/10.1371/journal.pbio.1002211 | [{"type": "chart", "bbox": [0, 0, 1, 1], "legend": "", "caption": ""}] | |
Fig 4. Bromodomain inhibition is reversible and "memory" of the active ES is retained. (A) Flow cytometry measuring the amount of anti-VSG antibody bound to the cell surface as well as surface levels of EP1 following treatment with I-BET151 for the indicated number of days. (B) Flow cytometry measuring surface levels o... | ["In agreement with this notion, the effects of I-BET151 treatment are reversible. Longer treatments (5 d) with I-BET151 lead to very low levels of anti- VSG antibody bound to the cell surface (Fig 4A), but memory of the active ES appears to be retained, as the VSG associated with this same ES is expressed on the surfa... | Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.1002316 | https://dx.plos.org/10.1371/journal.pbio.1002316 | [{"legend": "A", "type": "chart", "bbox": [0.0033, 0.0197, 0.9951, 0.4564]}, {"legend": "B", "item": [{"type": "chart", "bbox": [0.0067, 0.5092, 0.4958, 0.7047]}, {"type": "chart", "bbox": [0.5396, 0.5045, 0.9935, 0.7028]}, {"type": "chart", "bbox": [0.0075, 0.7442, 1, 0.9999]}]}] | |
Fig 7. Deletion of rif1 rescues cell cycles to Cdc7-depleted embryos. (A) Cell cycle-regulated recruitment of Cdc7 to the nucleus during early interphase shown by time-lapse microscopy of Cdc7-GFP, His2Av-RFP during nuclear cycle 12 using a 100× objective. (B) Live imaging of Cdc7-GFP embryos during cycles 10-14 reveal... | ["To address this issue, we first tagged endogenous cdc7 with GFP using CRISPR-Cas9. The resulting cdc7-GFP stock was healthy and fertile, indicating that the tag did not disrupt the essential function of Cdc7. Time-lapse imaging of Cdc7-GFP embryos during syncytial devel- opment revealed that Cdc7 localization was cel... | Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.2005687 | https://dx.plos.org/10.1371/journal.pbio.2005687 | [{"legend": "A", "type": "figure", "bbox": [0.1228, 0.0001, 0.9899, 0.1818]}, {"legend": "B", "type": "figure", "bbox": [0.0123, 0.1915, 1, 0.4647]}, {"legend": "C", "type": "figure", "bbox": [0, 0.4829, 0.9372, 0.6527]}, {"legend": "D", "type": "figure", "bbox": [0.0437, 0.6646, 0.9791, 0.8911]}, {"legend": "E", "type... | |
Fig 7. RMH-1 and SMC-5 cooperate to prevent accumulation of aberrant interhomolog connections. (A) In smc-5(ok2421), RMH-1 foci increase in mid pachytene nuclei (MP) (green square), while in late pachytene (LP) (yellow square), a zone with fewer foci is still present, as in WT. (B) Quantification of RMH-1 foci in MP nu... | ["First, we observed a significant increase in RMH-1 foci in mid pachytene nuclei in the smc-5 mutant; 29.1% of nuclei contained more than 25 foci, never seen in wild type (Fig 7A and 7B). However, late pachytene nuclei in the smc-5 mutant had an average of six foci per nucleus, as in wild type (Fig 7C), suggesting tha... | Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.1002412 | https://dx.plos.org/10.1371/journal.pbio.1002412 | [{"legend": "A", "type": "figure", "bbox": [0, 0, 0.9972, 0.1397]}, {"legend": "B", "type": "chart", "bbox": [0.0726, 0.1551, 0.4553, 0.326]}, {"legend": "C", "type": "chart", "bbox": [0.6164, 0.1451, 0.9387, 0.3294]}, {"legend": "D", "type": "chart", "bbox": [0.0263, 0.3494, 0.3261, 0.5572]}, {"legend": "E", "type": "... | |
Fig 3. Expression of Wnt genes with anterior ectodermal localizations. Whole mount in situ hybridization of Wnt genes with ectodermal localization in the more anterior domain of the embryo. All data are presented as optical sagittal or frontal sections following clearing in Murray Clear. Developmental staging is from b... | ["As has been described in other species, many Wnt ligands are expressed around the forming blastopore; wnt1 and wnt4 (Fig 2Cii and 2Dii) are both expressed around the inside of the blastopore lip at the boundary of ectoderm and endomeso- derm, whereas wnt3, wnt6, and wnt16 (Fig 2Bii, 2Eii and 2Fii) are expressed furth... | Anteroposterior axis patterning by early canonical Wnt signaling during hemichordate development | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.2003698 | https://dx.plos.org/10.1371/journal.pbio.2003698 | [{"legend": "Ai", "type": "figure", "bbox": [0.0017, 0.0004, 0.1978, 0.1411]}, {"legend": "Ali", "type": "figure", "bbox": [0.2012, 0.0004, 0.3996, 0.1418]}, {"legend": "Al", "type": "figure", "bbox": [0.4011, 0, 0.5985, 0.1414]}, {"legend": "Aiv", "type": "figure", "bbox": [0.6023, 0.0004, 0.7987, 0.1418]}, {"legend":... | |
Fig 2. The spinal hemicords are preferentially connected to the contralateral cerebral cortex at rest. The left column shows the location of spinal ROIs, and on the right their associated brain functional connectivity maps are presented. As shown, the left (top row) and right (bottom row) spinal ROIs are mostly correla... | ["001). Specifically, with respect to the left spinal cord, the right cerebral hemisphere revealed significantly larger volume of activation than the left hemisphere (Fig 2 top bar plot; paired-sample t test, left ROI: t23 = 3.44, p = 0.002). The laterality index was signif- icantly less than zero (mean value: −10.97; ... | Resting-state brain and spinal cord networks in humans are functionally integrated | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.3000789 | https://dx.plos.org/10.1371/journal.pbio.3000789 | [{"legend": "R", "item": [{"type": "figure", "bbox": [0.0046, 0.72, 0.1532, 0.842]}, {"type": "figure", "bbox": [0.1579, 0.0, 0.8391, 0.4995]}, {"type": "chart", "bbox": [0.8318, 0.0138, 0.9986, 0.486]}, {"type": "figure", "bbox": [0.1042, 0.5068, 0.9869, 1.0]}, {"type": "chart", "bbox": [0.8318, 0.519, 1.0, 0.994]}]},... | |
Fig 3. Navigation preference correlates with the place field assembly distribution. (A) Spatial distribution of the spikes (colored dots) from the reward loop cells (represented by different colors) recorded from 3 preference group animals and (B) from 3 nonpreference group animals. The straight red line denotes the we... | ["To evaluate whether the spatial distribution of the place field assemblies reflects the navigation preference of each animal, we analyzed the COM from all place cells’ spikes recorded from a single animal using a spatial population vector (SPV). This parameter estimates the Cartesian distribution of the spikes from m... | Place field assembly distribution encodes preferred locations | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.2002365 | https://dx.plos.org/10.1371/journal.pbio.2002365 | [{"legend": "A", "type": "figure", "bbox": [0.0047, 0, 0.5721, 0.1933]}, {"legend": "E", "item": [{"type": "chart", "bbox": [0.6188, 0.0233, 0.791, 0.2219]}, {"type": "chart", "bbox": [0.7934, 0.0241, 0.954, 0.2227]}]}, {"legend": "B", "type": "figure", "bbox": [0.0047, 0.2003, 0.5736, 0.3694]}, {"legend": "F", "item":... | |
Fig 3. zipt-7.1 controls sperm activation. (A) DIC photomicrographs of wild-type spermatids in standard SM medium (left) or SM medium supplemented with zinc (middle) or Pronase (right). Activation (or spermiogenesis) results in the extension of pseudopods, which are indicated with dotted white lines. (B,C) Using these ... | ["Nematode spermatids remain round and immotile until they receive an activating signal, which causes them to extend a pseudopod and begin to crawl (Fig 3A) [4]. Sperm isolated by dissection from wild-type hermaphrodites displayed the extended pseudopods characteristic of in vivo activation. By contrast, those isolated... | The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.2005069 | https://dx.plos.org/10.1371/journal.pbio.2005069 | [{"legend": "A", "type": "figure", "bbox": [0, 0, 0.994, 0.3033]}, {"legend": "B", "type": "chart", "bbox": [0.1019, 0.3167, 0.994, 0.6526]}, {"legend": "Q", "type": "chart", "bbox": [0.1036, 0.6669, 1, 1.0]}] | |
Fig 2. DSP1 is required for snRNA 30 end maturation. (A) The accumulation of various pre-snRNAs detected by qRT-PCR. The levels of pre-snRNAs in dsp1-1 were normalized to those of UBQ5 and compared with Col. Error bars indicate SD of three technical replications (**p < 0.01). Black arrowheads: primers used for RT-PCR; ... | ["Because the structures of Pol II-dependent snRNA genes share considerable similarities [30], we hypothesized that DSP1 might have a general effect on pre-snRNA levels. To test this hypothesis, we randomly selected several Pol II-dependent pre-snRNAs from the U1, U4, and U5 gene families and examined their abundance i... | snRNA 3′ End Processing by a CPSF73-Containing Complex Essential for Development in Arabidopsis | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.1002571 | https://dx.plos.org/10.1371/journal.pbio.1002571 | [{"legend": "A", "type": "chart", "bbox": [0.0289, 0.0106, 0.4981, 0.2085]}, {"legend": "B", "type": "figure", "bbox": [0.5731, 0.014, 0.8077, 0.1987]}, {"legend": "C", "type": "figure", "bbox": [0.0145, 0.2266, 0.7247, 0.4207]}, {"legend": "D", "type": "chart", "bbox": [0.7629, 0.2208, 0.9895, 0.4159]}, {"legend": "E"... | |
Fig 3. The effect of mevastatin and lovastatin on MACC1 expression. (A-B) HCT116 cells were treated with increasing concentrations of mevastatin (p < 0.01, p < 0.001) (A) and lovastatin (p < 0.05, p < 0.001) (B) for 24 h. MACC1 mRNA expression and protein expression were determined by quantitative real-time reverse-tra... | ["To determine the effect of the identified inhibitors on MACC1 expression, HCT116 cells were treated with increasing concentrations of rottlerin, mevastatin, and lovastatin for 24 h. At a concentration of 2.5 μM, rottlerin showed more than 60% reduction in the endogenous MACC1 mRNA (p < 0.001) and protein level compar... | Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1 | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.2000784 | https://dx.plos.org/10.1371/journal.pbio.2000784 | [{"legend": "A", "type": "chart", "bbox": [0.1638, 0.0324, 0.4975, 0.3215]}, {"legend": "B", "type": "chart", "bbox": [0.5038, 0.0304, 0.8332, 0.3222]}, {"legend": "C", "type": "chart", "bbox": [0.1632, 0.3663, 0.4994, 0.6581]}, {"legend": "D", "type": "chart", "bbox": [0.4961, 0.3655, 0.8316, 0.6793]}, {"legend": "E",... | |
Fig 3. Regressions of all samples, Method 2: Relationships between the 95th percentile of expressed genes in ancient tissues (x-axis) versus control samples (y-axis). Values are calculated based on per-tissue scores (see Methods), having removed duplicate reads from mapping data. Black data points and trend line refer ... | ["Like our observations from Method 1, we found that the historical Skin 2 and the ancient Tumat liver tissues showed significantly more similarity to their modern control counterparts than the other historical/ancient tissues (Fig 2; S4 Data; S5 Data). Of the 14,300-year-old Tumat samples, we found virtually no correl... | Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival | Biology | ["Biology"] | PLOS Biology | 10.1371/journal.pbio.3000166 | https://dx.plos.org/10.1371/journal.pbio.3000166 | [{"legend": "A", "type": "chart", "bbox": [0, 0.0001, 0.4639, 0.3085]}, {"legend": "B", "type": "chart", "bbox": [0.5373, 0.0001, 1, 0.3087]}, {"legend": "C", "type": "chart", "bbox": [0, 0.3479, 0.4652, 0.6545]}, {"legend": "D", "type": "chart", "bbox": [0.5388, 0.3476, 0.9986, 0.6552]}, {"legend": "E", "type": "chart... |
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