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p0 | Hereditary Cancer Syndromes, including Hereditary Breast and Ovarian Cancer (HBOC) and Lynch Syndrome (LS), can result in various forms of cancer due to germline mutations in cancer predisposition genes. While the major contributory genes for these syndromes have been identified and well-studied (BRCA1/ BRCA2 for HBOC ... |
p1 | Hybrid F1 mice were injected with urethane (300 mg/kg) at 8 days of age. A group was then put on a MAK-supplemented diet, another group was fed a standard pellet diet. At 36 weeks of age the mice were sacrificed and the livers examined for the presence of tumors mouse (Panel A) and for the number of nodules per mouse (... |
p2 | Decompressive craniectomy is a valid neurosurgical strategy now a day as an alternative to control an elevated intracranial pressure (ICP) and controlling the risk of uncal and/or subfalcine herniation, in refractory cases to the postural, ventilator, and pharmacological measures to control it. The neurocritical care a... |
p3 | disease. Early diagnosis ensures early management of the breast cancer and decreases the mortality associated with the disease. Male breast cancers occur in patients experiencing gynecomastia due to hormonal problems and overabundance of estrogen precursors. These are usually due to side effects of therapeutic drugs, h... |
p4 | The cellular prion protein (PrP C ) is expressed as a cell surface protein mainly in the central and peripheral nervous system, as well as in some cells and organs of the immune system (leukocytes and the spleen), the reproductive system (the testes and ovaries), and others, such as Peyer's patches in the intestinal tr... |
p5 | FMF is considered as an autosomal recessive hereditary disease, associated with a single gene named MEFV [1] . However, about one-third of FMF patients bear a single mutation on one allele, suggesting that the disease might be transferred as an autosomal dominant trait with partial penetration. Alternatively, an additi... |
p6 | The percentage of hypochromic red cells also showed a significant negative correlation with the CHr (Figure 4 ).
In 16 patients, the response of iron and haematology parameters to the administration of iron and recombin- uration >15% (n=6), CHr was >26 pg and hypochromic red cells were <2.5%, whereas the CHr was <26 ... |
p7 | There is also a need for further evidence supporting the doseeresponse relationships for many of these adverse effects. EFSA also reported that the provisional tolerable weekly intake (PTWI) of 15 mg/kg b.w. established by JECFA was no longer appropriate as adverse effects had been reported at exposures lower than thos... |
p8 | I t is unequivocal that peristomal complications are one of the most challenging aspects of living with ostomies. These skin complications and associated symptoms (eg, pain, irritation, and odor) can significantly interfere with daily physical activities, leading to social isolation, anxiety, depression, and a reduced ... |
p9 | Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting organism. In any type of osteomyelitis, multiple bacterial organisms are usually isolated from the bone. The bacteriology is diverse, but Staphylococcus aureus remains the most commonly isolated organism [1] .
S. aureu... |
p10 | In general, with aging, a decrease in the biodiversity of the composition of the GM is observed, with a trend towards an increase in potentially pathogenic bacteria (pathobionts) with respect to the beneficial ones (symbionts producing butyrate and other short-chain fatty acids) [157] . However, data on the remodelling... |
p11 | nfection is a major problem in the intensive care unit (ICU), and infection is an integral part of sepsis. Almost any epidemiologic or intervention study that deals with infection or its consequences will need to include definitions of infection at various sites as part of its protocol. Although there are a number of p... |
p12 | Patient safety related to medications is of concern within the critical care area. Several medications commonly used in critical care are considered as high-risk medicines, for example, anticoagulants, injectable sedatives, opiates, and insulin. 1 The intravenous (IV) route is one of the most common routes for administ... |
p13 | There is a specifi c chemosensitive subpopulation of C-fi bers that mediate histamine-induced pruritus (Schmelz, 2001; Schmelz et al., 2003) . In this context, H1R antagonists have been tried and demonstrated to reduce pruritus in numerous clinical trials (Sugimoto et al., 2004; Paus et al., 2006) . However, in AD pati... |
p14 | H ealthcare information technology (HIT) is one of the most expensive capital investments for any healthcare organization. HIT adoption is a complex process because adoption and implementation depend on buy-in from physicians, most of whom are not employed by the organization and whose thinking varies widely. HIT compr... |
p15 | Katzenstein, but in addition, also cases showing fibroblastic foci associated with emphysema blebs and fibrosis (Fig. 20) . In these cases, also RB could be seen in different areas. In contrast to UIP, there were no honeycomb lesions and almost all lobules showed changes of centrilobular emphysema. Some of these patien... |
p16 | 2015 .
One example of such services is the setup of a nurse-led annual review clinic in Darent Valley Hospital.
During the clinic appointment (which lasts for 30 minutes) several assessments are carried out including disease activity, comorbidities including CVR (using QRISK) as well as falls and fracture risks usi... |
p17 | Spirometry is the fundamental diagnostic method in obstructive lung diseases because it is easy and inexpensive to perform, and thus it can be used as a screening test. If the expiration is forced, the values of spirometric indices are almost independent of patient's activity; they depend only on the properties of the ... |
p18 | Our hypothesis is that systemic adjuvant therapy is most likely to be effective if started early, when the metastases are not only undetectable but also very small and relatively few in number. Any randomized studies on the impact of ocular or systemic treatment on the development of metastatic disease would require ge... |
p19 | Echocardiogram can be used to rule out structural and inflammatory disorders, such as hypertrophic cardiomyopathy and pericarditis. Chest pain of non-cardiac origin (e.g. gastrointestinal, musculoskeletal, pulmonary, or psychiatric) must be ruled out. The pathogenesis of CSX is considered as the result of myocardial is... |
p20 | In approximately 90% of the sample, pigmentation was rated as mixed and was essentially constant, having little influence on the overall total score.
This study indicates that scar quality, as measured by the mVSS, deteriorates with an increase in wound healing time in a sample of adults with burn scars. The resul... |
p21 | After 45.0 Gy, the treatment volume included the contrast-enhancing lesion (without edema) on the pre-surgery MRI/CT scan plus a 2 cm margin.
Drug was initiated on day 1 of radiotherapy at a daily dose of 5000 units subcutaneously (0.2 ml) up to a planned 24 months. At progression patients could continue dalteparin. ... |
p22 | An interesting scientific finding from a recent study manifested that fisetin downregulates expression and reduces urokinase plasminogen activator (uPA) activity in human cervical adenocarcinoma SiHa and CaSki cells, responsible for activation of MMPs [94] . Furthermore, fisetin in a concentration-dependent manner (10-... |
p23 | The audiology profession in South Africa (SA) is less than 100 years old, with only six of the country's 26 universities offering the training. The training of professional audiologists in SA has its origins at the University of the Witwatersrand 1) . The first programme was established in 1938 by Pierre de Villiers Pi... |
p24 | Moreover, during the late stage of infection, peripheral fibrosis of the bile duct, mucoid degeneration, and adenomatoid hyperplasia of bile duct epithelium could be induced, and malignant transformation of bile duct epithelial cells was developed from atypical hyperplasia.
Long-term liver fluke infection induces re... |
p25 | Many epidemiological studies that evaluate dietedisease associations, such as large-scale prospective cohort studies, assess the usual long-term diet and rank individuals by intake of specific nutrients using food frequency questionnaires (FFQ). 1 Typically, a printed questionnaire is sent to the subject and returned t... |
p26 | The precautionary principle, first applied to the field of environmental safety, states that, in the face of uncertain risk and incomplete data, policy-makers should err on the side of restraint. The corollary of the principle states the prominence of health over all other considerations, especially economic.
In Mala... |
p27 | H ealthcare registries are widely used for data collection and research. It is therefore of the utmost importance that they are valid and robust. The Swedish healthcare registries are recognized worldwide for their high quality and completeness. Sweden offers outstanding possibilities to perform register-based epidemio... |
p28 | Progesterone also activates γ-aminobutyric acid type A (GABA A ) receptors via its metabolite allopregnanolone.
progesterone withdrawal is a decrease in PR coactivators, resulting in impaired progesterone-PR interaction, and thus reduced expression of progesterone-responsive genes. The differential expression of ... |
p29 | Where appropriate, cells were permeabilized following fixation, by incubation in 0.01% triton X-100 in DPBS at 4°C for 10 min. Conjugation to the pHAb Amine Reactive Dye was done according to the manufacturer's instructions (Promega, UK, Cat. No. G983). Cells were then washed and stained with goat anti-mouse IgG-Alexaf... |
p30 | 111 an earlier study, Boissonnault and Blaschak" found that only 11% of their subjects had rectus abdominis muscle separation below the umbilicus in their third trimester. The authors noted, however, that a higher incidence would have been found if the diastasis criteria had approached the normal linea alba width at th... |
p31 | Interestingly, antibodies to TGF-β have been shown in a recent study to reverse tamoxifen resistance in LCC2 breast cancer cells (Arteaga et al, 1999) , strongly implicating the pleotrophic properties of TGF-β in the development of this condition.
Genetic events in growth factor expression and cell cycle control Brea... |
p32 | Microtubules coordinate E-cadherin-mediated cell adhesion [32] and the microtubule destabilizer eribulin has been shown to reverse EMT in triple negative breast cancer (TNBC) cell lines and a xenograft model [33] , however the mechanistic link between acute microtubule disruption and E-cadherin localization has not bee... |
p33 | After surgery the correct position of the GMS+ was confirmed by slit lamp examination in all cases ( Figure 1A ) and in 12 eyes (39%) the position was also confirmed by 50 Mhz ultrasound (Zeiss-Humphrey, System Model 840).
The primary outcome measure was surgical success, defined as IOP less than 21 mmHg and greater ... |
p34 | The organization and management of services for the mentally ill involve the use of conceptual models which underlie patterns of care and service delivery. These models are usually fairly simplistic in character, but they may make the difference between the encouragement or the destruction of good psychiatric practice.... |
p35 | Subtyping data revealed that all isolates from humans in this area were type A, the subtype most commonly associated with rabbits (7), thereby supporting a likely connection between these events. Deerflies have been implicated in two previous outbreaks of tularemia; in both instances, a concomitant epizootic among rabb... |
p36 | [3, 26, 27] Rehabilitation for persons with NMD should have as a main goal to maintain their independence for as long as possible [28] and to include recurrent assessments regarding their ability to ambulate and participate in their work and home environments, as well as their need for AT. Therefore, Occupational Thera... |
p37 | Continuous monitoring may be advantageous for the critically ill patient, as the clinician is provided information every minute that could potentially be used to support and evaluate the given treatment.
Interestingly, we observed a higher complication rate in patients with a postoperative lactate level >3 mmol/L. It... |
p38 | Considering the documented, widespread vitamin D deficiency in Polish population [54] , the aim of our research was to evaluate the relationship between a vitamin D level and the stage of coronary disease in patients at risk of cardiovascular death.
In our previous study performed in over 600 Polish patients includin... |
p39 | ) is a large mucin-containing complex implicated in tumor progression. Overexpression of the membrane mucin MUC4/Sialomucin complex (SMC) has been observed during malignant progression of mammary tumors in both humans and rats, suggesting that deregulation of MUC4/SMC expression facilitates development of these maligna... |
p40 | While this patient under our treatment appears to have marginal improvement in depressive symptoms associated with schizoaffective disorder, there are several more qualitative points to consider even with the fluctuation in quantitative scores.
First, the self-reported nature of the scores cannot be overlooked while ... |
p41 | Endotoxins are inflammatory lipopolysaccharide (LPS) molecules from Gram negative bacteria that are ubiquitous in the indoor environment (1) . Endotoxins are amphipathic molecules bearing both polysaccharide and lipid moieties. The Lipid A component of the molecule is conserved across bacterial species and carries the ... |
p42 | 32 A more recent study measured cardiac index by esophageal Doppler, LiDCO Rapid (LiDCO LTD, London, UK), and the FloTrac (Edwards Lifesciences, Irvine, CA) side by side in cardiac surgery patients and found a percentage error of 64.5%, 54.2%, and 47.6%, respectively, when compared with thermodilution. Moreover, the sa... |
MIRIAD Benchmark 200k
A medical retrieval benchmark: 1,000 questions searching 200,000 passages, in the BEIR layout
(corpus, queries, qrels) so it works with standard IR evaluators out of the box.
It is deliberately hard. Scoring questions against only their own ~10k source passages saturates above 0.97 NDCG@10 for almost every model, which tells you nothing. Adding 190,015 deduplicated distractor passages spreads the field out across roughly 0.43 to 0.91.
This is the evaluation set. If you want to train on this domain, use tomaarsen/miriad-4.4M-split, which holds 4.4M question-passage pairs. The 9,985 gold passages here are held out from it, though the 190,015 distractors are train passages, so exclude them if you train on the full split.
Usage
from datasets import load_dataset
corpus = load_dataset("tomaarsen/miriad-benchmark-200k", "corpus", split="corpus")
queries = load_dataset("tomaarsen/miriad-benchmark-200k", "queries", split="queries")
qrels = load_dataset("tomaarsen/miriad-benchmark-200k", "qrels", split="test")
With Sentence Transformers, for a multi-vector model:
from sentence_transformers import MultiVectorEncoder
from sentence_transformers.multi_vector_encoder.evaluation import MultiVectorInformationRetrievalEvaluator
model = MultiVectorEncoder("multi-vector-encoder/mLateOn-medical")
# The headline protocol uses the first 1,000 queries
queries = queries.select(range(1000))
query_ids = set(queries["_id"])
evaluator = MultiVectorInformationRetrievalEvaluator(
queries=dict(zip(queries["_id"], queries["text"])),
corpus=dict(zip(corpus["_id"], corpus["text"])),
relevant_docs={row["query-id"]: {row["corpus-id"]} for row in qrels if row["query-id"] in query_ids},
name="miriad-200k",
)
print(evaluator(model))
InformationRetrievalEvaluator and SparseInformationRetrievalEvaluator take the same arguments
for dense and sparse models.
How it was built
Everything is derived deterministically from tomaarsen/miriad-4.4M-split.
| part | rows | recipe |
|---|---|---|
queries |
5,000 | The first 5,000 questions of the eval split, in order. The headline protocol uses the first 1,000. |
corpus (gold) |
9,985 | Every deduplicated passage of the eval split, ids p0...p9984. |
corpus (distractors) |
190,015 | The first unique train split passages, ids d0...d190014. |
qrels |
5,000 | One relevant passage per question, score 1. |
Two details worth knowing:
- All 9,985 eval passages are in the corpus, not only the ones belonging to the sampled queries. The rest act as hard in-domain distractors.
- Distractors are deduplicated against the gold passages and against each other. A train passage identical to a gold one would be scored as a miss even when the model is right.
Passages are long, averaging 941 tokens, so check your model's document length cap before evaluating. Truncating at 180 to 512 tokens, as many released retrieval checkpoints do by default, costs up to 0.24 NDCG@10 here, more than any difference between model architectures.
Reference scores
NDCG@10 on the 1,000-query protocol, from Training and Finetuning Multi-Vector Embedding Models, which evaluated 47 model configurations across four architecture families.
| model | family | NDCG@10 |
|---|---|---|
| multi-vector-encoder/mLateOn-medical | Multi-vector, finetuned | 0.9139 |
| lightonai/mLateOn | Multi-vector | 0.8520 |
| Qwen/Qwen3-Embedding-4B | Dense | 0.7817 |
| BM25 | Lexical | 0.7501 |
| naver/splade-v3 | Sparse | 0.6853 |
Citation
This dataset is derived from MIRIAD. Please cite the original work:
@misc{zheng2025miriadaugmentingllmsmillions,
title={MIRIAD: Augmenting LLMs with millions of medical query-response pairs},
author={Qinyue Zheng and Salman Abdullah and Sam Rawal and Cyril Zakka and Sophie Ostmeier and Maximilian Purk and Eduardo Reis and Eric J. Topol and Jure Leskovec and Michael Moor},
year={2025},
eprint={2506.06091},
archivePrefix={arXiv},
primaryClass={cs.CL},
url={https://arxiv.org/abs/2506.06091},
}
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