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9,394 | Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2 | For almost two years, the COVID-19 pandemic has constituted a major challenge to human health, particularly due to the lack of efficient antivirals to be used against the virus during routine treatment interventions. Multiple treatment options have been investigated for their potential inhibitory effect on SARS-CoV-2. ... | Pharmaceuticals | Fakry F. Mohamed, Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Sharkia, Egypt& Institute of Virology Muenster, Center for Molecular Biology of Inflammation (ZMBE), University Hospital Muenster, 48149 Muenster, Germany; Darisuren Anhlan, Institute of Virology Muenster, Cente... |
898 | Political Secularism and Muslim Integration in the West: Assessing the Effects of the French Headscarf Ban | In response to rising immigration flows and the fear of Islamic radicalization, several Western countries have enacted policies to restrict religious expression and emphasize secularism and Western values. Despite intense public debate, there is little systematic evidence on how such policies influence the behavior of ... | American Political Science Review | AALA ABDELGADIR, Stanford University; VASILIKI FOUKA, Stanford University |
2,398 | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February | The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.3... | Eurosurveillance | Daniel J Grint, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Kevin Wing, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Elizabeth Williamson, Faculty of Epidemiology and Popu... |
5,906 | Realized Volatility Forecasting with Neural Networks | Abstract In the last few decades, a broad strand of literature in finance has implemented artificial neural networks as a forecasting method. The major advantage of this approach is the possibility to approximate any linear and nonlinear behaviors without knowing the structure of the data generating process. This makes... | Journal of Financial Econometrics | Andrea Bucci, Università Politecnica delle Marche& Università degli Studi G. d’Annunzio Chieti e Pescara |
2,343 | Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials | Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current evidence with prospective designs to propose evidence-based suggestions on AD prevention. Electronic databa... | Journal of Neurology Neurosurgery & Psychiatry | Jin-Tai Yu, Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Wei Xu, Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Chen-Chen Tan, Department of Neurology, Qingdao Municipal Hospital, Qingd... |
8,225 | Collaboration, Co-Optation or Navigation? The Role of Civil Society in Disaster Governance in India | Abstract Existing research on civil society organizations (CSOs) facing restricted civic space largely focuses on the crackdown on freedoms and CSOs’ strategies to handle these restrictions, often emphasizing impact on their more confrontational public roles. However, many CSOs shape their roles through collaborative r... | VOLUNTAS International Journal of Voluntary and Nonprofit Organizations | Reetika Syal, Jain Deemed-To-Be University, Bangalore, India; Margit van Wessel, Wageningen University & Research, Hollandseweg 1, 6706 KN, Wageningen, The Netherlands; Sarbeswar Sahoo, Indian Institute of Technology Delhi, New Delhi, India |
5,506 | Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreak | Abstract Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number of secondary transmissions. By using a simple branching process model, we explored the potential of combinin... | medRxiv (Cold Spring Harbor Laboratory) | Akira Endo, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK& Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK& The Alan Turing Institute, London, UK; Quentin J Leclerc, Centre for the Mathematic... |
6,451 | Army ants dynamically adjust living bridges in response to a cost–benefit trade-off | The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions that benefit the entire colony. Here we examine ‟bridges" of linked individuals that ... | Proceedings of the National Academy of Sciences | Chris R. Reid, Department of Biological Sciences, New Jersey Institute of Technology, Newark, NJ 07102;; Matthew J. Lutz, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544;; Scott Powell, Department of Biological Sciences, George Washington University, Washington, DC 20052;; Albe... |
2,670 | Words without meaning | Many of the words used by scientists when reviewing manuscripts, job candidates and grant applications – words such as incremental, novelty, mechanism, descriptive and impact – have lost their meaning. | eLife | Eve Marder, Biology Department, Brandeis University, Waltham, United States& Center and the Biology Department, Brandeis University, Waltham, United States. |
3,497 | Does Stretching Training Influence Muscular Strength? A Systematic Review With Meta-Analysis and Meta-Regression | Abstract Thomas, E, Ficarra, S, Nunes, JP, Paoli, A, Bellafiore, M, Palma, A, and Bianco, A. Does stretching training influence muscular strength? A systematic review with meta-analysis and meta-regression. J Strength Cond Res 37(5): 1145–1156, 2023—The aim of this study was to review articles that performed stretching... | The Journal of Strength and Conditioning Research | Ewan Thomas, Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy;; Salvatore Ficarra, Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo... |
1,087 | The structure, function and evolution of a complete human chromosome 8 | Abstract The complete assembly of each human chromosome is essential for understanding human biology and evolution 1,2 . Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8. Our assembly resolves the sequence of five previously long-standing gaps, including ... | Nature | Glennis A. Logsdon, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; Mitchell R. Vollger, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; PingHsun Hsieh, Department of Genome Sciences, University of Washington School of Medicine,... |
1,819 | Treatment Emergent Violence To Self And Others; A Literature Review of Neuropsychiatric Adverse Reactions For Antidepressant And Neuroleptic Psychiatric Drugs And General Medications. | This paper reviews the literature linking physical violence, directed towards self or others, to serotonergic and dopaminergic psychiatric drugs and general medications.Data about side effects, pharmacogenetics and homeostasis are obtained from articles, electronic Medicines Compendium, DSM-IV-TR, British National Form... | PubMed | Catherine Clarke; Jan Evans; Kelly Brogan |
2,308 | SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study | AbstractObjective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting Denmark. Participants 4 931 775 individuals aged 12 years or older, followed from 1 October 2020 to 5 October 2021. Main outcome measures The primary outcome,... | BMJ | Anders Husby, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark& Department of Epidemiology and Biostatistics, Imperial College London, London, UK; Jørgen Vinsløv Hansen, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Emil Fosbøl, Department of Cardiol... |
6,084 | Molnupiravir Use and 30-Day Hospitalizations or Death in a Previously Uninfected Nonhospitalized High-risk Population With COVID-19 | Abstract Background Clinical benefit of molnupiravir (MPV) in coronavirus disease 2019 (COVID-19)–infected subpopulations is unclear. Methods We used a matched cohort study design to determine the rate of hospitalization or death within 30 days of COVID-19 diagnosis among MPV treated and untreated controls. Participant... | The Journal of Infectious Diseases | Adeel A Butt, Department of Population Health Sciences, Weill Cornell Medicine , Doha , Qatar& Department of Population Health Sciences, Weill Cornell Medicine , New York, New York , USA& Department of Population Health Sciences, Weill Cornell Medicine, Doha, Qatar& Department of Population Health Sciences, Weill Corne... |
3,724 | Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation? | The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD) nephrotic syndrome (NS), shortly after the first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 12-year-old prev... | PubMed | Luigi Annicchiarico Petruzzelli, Paediatric Nephrology, Dialysis and Renal Transplantation Santobono Pausilipon Children's Hospital, Naples, Italy.; Bruno Minale, Paediatric Nephrology, Dialysis and Renal Transplantation Santobono Pausilipon Children's Hospital, Naples, Italy.; Vittorio Serio, Paediatric Nephrology, Di... |
3,184 | Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease | Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk tissue transcriptomics, integrated droplet– and plate-based single-cell RNA sequencing, and paired blo... | Journal of the American Society of Nephrology | Bryan R. Conway, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Eoin D. O’Sullivan, Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Carolynn Cair... |
6,387 | The role of social circle COVID-19 illness and vaccination experiences in COVID-19 vaccination decisions: an online survey of the United States population | Abstract Background Around the world, policymakers have clearly communicated that COVID-19 vaccination programs need to be accepted by a large proportion of the population to allow life return to normal. However, according to the Center for Disease Control, about 31% of the United States population had not completed th... | BMC Infectious Diseases | Mark Skidmore, Department of Agricultural, Food and Resource Economics, Department of Economics, Michigan State University, 91 Morrill Hall of Agriculture, East Lansing, MI, 48824-1039, USA |
3,728 | A Survey and Analysis of TLS Interception Mechanisms and Motivations: Exploring how end-to-end TLS is made “end-to-me” for web traffic | TLS is an end-to-end protocol designed to provide confidentiality and integrity guarantees that improve end-user security and privacy. While TLS helps defend against pervasive surveillance of intercepted unencrypted traffic, it also hinders several common beneficial operations typically performed by middleboxes on the ... | ACM Computing Surveys | Xavier de Carné de Carnavalet, The Hong Kong Polytechnic University, Hong Kong SAR; Paul C. van Oorschot, Carleton University, Ontario, Canada |
2,702 | SARS-CoV-2 RNA levels in Scotland’s wastewater | Abstract Nationwide, wastewater-based monitoring was newly established in Scotland to track the levels of SARS-CoV-2 viral RNA shed into the sewage network, during the COVID-19 pandemic. We present a curated, reference data set produced by this national programme, from May 2020 to February 2022. Viral levels were analy... | medRxiv (Cold Spring Harbor Laboratory) | Livia C. T. Scorza, SynthSys and School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JD, UK; Graeme J. Cameron, Scottish Environment Protection Agency (SEPA), Strathallan House, Stirling FK9 4TZ, UK; Roisin Murray-Williams, Scottish Environment Protection Agency (SEPA), Strathallan House, Stirling FK... |
7,883 | Black Lives Matter's Effect on Police Lethal Use-of-Force | How has Black Lives Matter (BLM) influenced police lethal force? An event study design finds census places with early BLM protests experienced a 10% to 15% decrease in police homicides from 2014 through 2019, around 200 fewer deaths. This decrease was prominent when protests were large and frequent. Potential mechanism... | SSRN Electronic Journal | Travis Campbell, Southern Oregon University |
2,930 | The newly introduced SARS-CoV-2 variant A222V is rapidly spreading in Lazio region, Italy | Abstract A new SARS-CoV-2 clade (GV) characterized by S substitution A222V, first reported from Spain in March, is rapidly spreading across Europe. To establish the A222V variant involvement in the infection rise in Italy, all GISAID sequences from Italy and those from our Laboratory (Lazio) in the period June-October ... | medRxiv (Cold Spring Harbor Laboratory) | Barbara Bartolini, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" IRCCS, Rome, Italy; Martina Rueca, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" IRCCS, Rome, Italy; Cesare Ernesto Maria Gruber, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" I... |
5,988 | Super high-pressure balloon versus scoring balloon to prepare severely calcified coronary lesions: the ISAR-CALC randomised trial | The comparative efficacy of balloon-based techniques to prepare severely calcified coronary lesions before stenting remains poorly studied.We sought to compare stent expansion following preparation of severely calcified coronary lesions with either a super high-pressure balloon or a scoring balloon.In this randomised, ... | EuroIntervention | Tobias Rheude, Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Munich, Germany.; Himanshu Rai; Gert Richardt; Abdelhakim Allali; Mohamed Abdel-Wahab; Dmitriy S Sulimov; Kambis Mashayekhi; Mohamed Ayoub; Florim Cuculi; Matthias Bossard; Sebastian Kufner; Erion Xhepa; Adnan Kastrati; Massimilia... |
4,890 | The UK government’s covid complacency shows lessons haven’t been learned | This week, England’s health secretary, Sajid Javid told a Downing Street covid briefing that the government would not “at this point” be implementing its so-called “Plan B” measures to prevent the NHS being overwhelmed—including mandatory face coverings indoors and advising people to work from home.
To repurpose a phr... | BMJ | Gareth Iacobucci, The BMJ |
6,718 | SARS-CoV-2 Infections and Serologic Responses from a Sample of U.S. Navy Service Members — USS Theodore Roosevelt, April 2020 | Compared with the volume of data on coronavirus disease 2019 (COVID-19) outbreaks among older adults, relatively few data are available concerning COVID-19 in younger, healthy persons in the United States (1,2). In late March 2020, the aircraft carrier USS Theodore Roosevelt arrived at port in Guam after numerous U.S. ... | MMWR Morbidity and Mortality Weekly Report | Daniel C. Payne; Sarah E. Smith-Jeffcoat; Gosia Nowak; Uzo Chukwuma; Jesse R. Geibe; Robert J. Hawkins; Jeffrey A. Johnson; Natalie J. Thornburg; Jarad Schiffer; Zachary Weiner; Bettina Bankamp; Michael D. Bowen; Adam MacNeil; Monita R. Patel; Eric Deussing; Bruce L. Gillingham; Rebekah Tiller; Rene Galloway; Shannon R... |
5,423 | New-Onset Systemic Lupus Erythematosus after mRNA SARS-CoV-2 Vaccination | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease resulting from the interaction of genetic and environmental factors. In addition, some antiviral vaccines have been associated with the onset of SLE. Few cases of SLE occurring after SARS-CoV-2 mRNA have been reported. Herein, we report the case of ... | Case Reports in Rheumatology | Laisha Báez-Negrón, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico; Luis M. Vilá, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico |
3,213 | A Sustainable and Global Health Perspective of the Dietary Pattern of French Population during the 1998–2015 Period from INCA Surveys | In France, the evolution of dietary pattern relative to sustainability and global health remains insufficiently studied. The objective of this study was to assess dietary changes during 1998–2015 through three generic metrics potentially related to sustainability. Food consumption data were collected from three French ... | Sustainability | Anthony Fardet, Unité de Nutrition Humaine& Université Clermont Auvergne; David Thivel, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques; Laurent Gerbaud, CHU Clermont-Ferrand& Institut Pascal; Edmond Rock, Unité de Nutrition Humaine& Université Clermont Auvergne |
3,017 | Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock | Acute myocardial infarction (AMI) complicated by cardiogenic shock is associated with substantial morbidity and mortality. Although intravascular microaxial left ventricular assist devices (LVADs) provide greater hemodynamic support as compared with intra-aortic balloon pumps (IABPs), little is known about clinical out... | JAMA | Sanket S. Dhruva, Section of Cardiology, Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California& University of California, San Francisco School of Medicine, San Francisco; Joseph S. Ross, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connectic... |
382 | Fluvoxamine for outpatients with COVID-19: where do we stand? | Advances in vaccine development have had a major effect on reducing the number of new symptomatic cases, hospitalisations, and deaths due to COVID-19, the viral disease caused by SARS-CoV-2, globally.1Tregoning JS Flight KE Higham SL Wang Z Pierce BF Progress of the COVID-19 vaccine effort: viruses, vaccines and varian... | The Lancet Global Health | Otavio Berwanger, Academic Research Organization (ARO), Hospital Israelita Albert Einstein, Sao Paulo-SP, Brazil |
4,237 | COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance | Abstract Variants of SARS-CoV-2 are evolving under a combination of immune selective pressure in infected hosts and natural genetic drift, raising a global alarm regarding the durability of COVID-19 vaccines. Here, we conducted longitudinal analysis over 1.8 million SARS-CoV-2 genomes from 183 countries or territories ... | medRxiv (Cold Spring Harbor Laboratory) | Michiel J.M. Niesen, nference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 0242, USA; Praveen Anand, nference Labs, Bengaluru, Karnataka, India; Eli Silvert, nference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 0242, USA; Rohit Suratekar, nference Labs, Bengaluru, Karnataka, India; Co... |
4,721 | Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway | Population size has increasingly been taken as the driver of past human environmental impact worldwide, and particularly in the Arctic. However, sedimentary ancient DNA (sedaDNA), pollen and archaeological data show that over the last 12,000 years, paleoeconomy and culture determined human impacts on the terrestrial ec... | PNAS Nexus | Tony Brown, The Arctic University Museum of Norway, UiT, The Arctic University of Norway , N-9037 Tromsø , Norway; Dilli P Rijal, The Arctic University Museum of Norway, UiT, The Arctic University of Norway , N-9037 Tromsø , Norway; Peter D Heintzman, The Arctic University Museum of Norway, UiT, The Arctic University o... |
9,547 | Patrimonialisations de la littérature | Parmi les domaines caractérisés par une charge patrimoniale forte, la littérature continue d’occuper une position de premier plan dans les sociétés contemporaines. Si nous connaissons la littérature du passé et lui accordons une valeur, c’est en effet dans une large mesure parce qu’elle fait l’objet de processus de pat... | Culture & Musées | Marcela Scibiorska; Mathilde Labbé, Littératures antiques et modernes; David Martens |
9,477 | Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants | ABSTRACT The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to growing concerns over increased transmissibility and the ability of some variants to partially escape immunity. Sera from participants immunized on a prime-boost schedule with the mRNA-1273 COVID-19 vaccine were t... | bioRxiv (Cold Spring Harbor Laboratory) | Angela Choi, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Matthew Koch, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Kai Wu, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Groves Dixon, Moderna Inc., 200 Technology Square, Cambridge, M... |
4,795 | Multisystem Inflammatory Syndrome in Children in the United States | 23 issue) present case series of the multisystem inflammatory syndrome in children (MIS-C; also called the pediatric inflammatory multisystem syndrome); Levin 3 provides commentary.To address the burden of MIS-C in France, a nationwide surveillance program was launched on April 30, 2020, by Santé Publique France (the F... | New England Journal of Medicine | Leora R Feldstein, Centers for Disease Control and Prevention, Atlanta, GA.; Erica B Rose, Centers for Disease Control and Prevention, Atlanta, GA.; Adrienne G Randolph, Boston Children's Hospital, Boston, MA adrienne.randolph@childrens.harvard.edu. |
4,747 | Low HDL and high triglycerides predict COVID-19 severity | Abstract Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study in... | Scientific Reports | Lluís Masana, Facultat de Medicina, Universitat Rovira I Virgili, LIPIDCAS, University Hospital Sant Joan, IISPV, CIBERDEM, C/. Sant Llorenç, 21, 43201, Reus, Spain; Eudald Correig, Statistics Department, Institut Investigació Sanitaria Pere Virgili, Universitat Rovira I Virgili, Reus, Spain; Daiana Ibarretxe, Facultat... |
9,366 | David Oliver: “Considerably transformed”—changing the narrative on admitting older patients | Considerably transformed"-changing the narrative on admitting older patients | BMJ | David Oliver, Berkshire |
5,334 | SARS-CoV-2 spike ectodomain targets α7 nicotinic acetylcholine receptors | Virus entry into animal cells is initiated by attachment to target macromolecules located on host cells. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) trimeric spike glycoprotein targets host angiotensin converting enzyme 2 to gain cellular access. The SARS-CoV-2 glycoprotein contains a neurotoxin-li... | Journal of Biological Chemistry | Brittany C V O'Brien, Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, Alaska, USA.; Lahra Weber, Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, Alaska, USA.; Karsten Hueffer, Department of Veterinary Medicine, University of Alaska Fairbanks, Fai... |
6,652 | The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters | Abstract The emergence of SARS-CoV-2 variants of concern (VoCs) has exacerbated the COVID-19 pandemic. End of November 2021, a new SARS-CoV-2 variant namely the omicron (B.1.1.529) emerged. Since this omicron variant is heavily mutated in the spike protein, WHO classified this variant as the 5th variant of concern (VoC... | bioRxiv (Cold Spring Harbor Laboratory) | Rana Abdelnabi, KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium; Caroline S. Foo, KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laborato... |
9,032 | SARS-CoV-2 Vaccination and Protection Against Clinical Disease: A Retrospective Study, Bouches-du-Rhône District, Southern France, 2021 | From January 18th to August 13th, 2021, 13,804 unvaccinated and 1,156 patients who had received at least one COVID-19 vaccine dose were tested qPCR-positive for SARS-CoV-2 in our center. Among vaccinated patients, 949, 205 and 2 had received a single, two or three vaccine doses, respectively. Most patients (80.3%) had ... | Frontiers in Microbiology | Pierre-Edouard Fournier, IHU Méditerranée Infection, Marseille, France& Vecteurs —Infections Tropicales et Méditerranéennes (VITROME), Aix-Marseille Univ, Marseille, France; Linda Houhamdi, IHU Méditerranée Infection, Marseille, France; Philippe Colson, IHU Méditerranée Infection, Marseille, France& Microbes Evolution ... |
580 | A Meta-Analysis of the Impacts of Genetically Modified Crops | Background Despite the rapid adoption of genetically modified (GM) crops by farmers in many countries, controversies about this technology continue. Uncertainty about GM crop impacts is one reason for widespread public suspicion. Objective We carry out a meta-analysis of the agronomic and economic impacts of GM crops t... | PLoS ONE | Wilhelm Klümper, Department of Agricultural Economics and Rural Development , Georg-August University of Goettingen , Goettingen, Germany; Matin Qaim, Department of Agricultural Economics and Rural Development , Georg-August University of Goettingen , Goettingen, Germany |
9,491 | Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville, Tennessee | Hui Zeng, MD; Chen Xu, BS; Junli Fan, MD; Yueting Tang, PhD; Qiaoling Deng, MD; Wei Zhang, MD, PhD; Xinghua Long, MD, PhD | JAMA | Manish M. Patel, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia; Natalie J. Thornburg, CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia; William B. Stubblefield, Department of Emergency Medicine, Vanderbilt University Medical Center, Nash... |
6,526 | Association of Logic’s hip hop song “1-800-273-8255” with Lifeline calls and suicides in the United States: interrupted time series analysis | Abstract Objective To assess changes in daily call volumes to the US National Suicide Prevention Lifeline and in suicides during periods of wide scale public attention to the song “1-800-273-8255” by American hip hop artist Logic. Design Time series analysis. Setting United States, 1 January 2010 to 31 December 2018. P... | BMJ | Thomas Niederkrotenthaler, Unit Suicide Research & Mental Health Promotion, Department of Social and Preventive Medicine, Center for Public Health, Medical University of Vienna, Vienna, Austria& Wiener Werkstaette for Suicide Research, Vienna, Austria; Ulrich S Tran, Department of Cognition, Emotion, and Methods in Psy... |
4,346 | Skill utilization at work: Opportunity and motivation | Technological choices, product market strategies, and other organizational characteristics affect how tasks are grouped into jobs.The design of jobs determines the skills needed by workers in order to do them effectively.However, people possess skills and organizations need to find the right incentives to motivate work... | IZA World of Labor | Giovanni Russo |
4,974 | COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study | The COVID-19 pandemic is responsible for increasing deaths globally. Most estimates have focused on numbers of deaths, with little direct quantification of years of life lost (YLL) through COVID-19. As most people dying with COVID-19 are older with underlying long-term conditions (LTCs), some have speculated that YLL a... | Wellcome Open Research | Peter Hanlon, . University of Manchester, Manchester, UK& University of Glasgow, Glasgow, UK; Fergus Chadwick, . University of Manchester, Manchester, UK& University of Glasgow, Glasgow, UK; Anoop Shah, . University of Oxford, Oxford, UK& University College London, London, UK& University of Edinburgh, Edinburgh, UK; Ra... |
7,913 | Global food system emissions could preclude achieving the 1.5° and 2°C climate change targets | The Paris Agreement's goal of limiting the increase in global temperature to 1.5° or 2°C above preindustrial levels requires rapid reductions in greenhouse gas emissions. Although reducing emissions from fossil fuels is essential for meeting this goal, other sources of emissions may also preclude its attainment. We sho... | Science | Michael A. Clark, Oxford Martin School and Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Nina G. G. Domingo, Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.; Kimberly Colgan, Department of Bioproducts and Biosystems Engineering, University... |
5,611 | Time is of the essence: containment of the SARS-CoV-2 epidemic in Switzerland from February to May 2020 | ABSTRACT AIM In late February and early March 2020, Switzerland experienced rapid growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections with 30,243 confirmed cases and 1,860 deaths as of 10 May 2020. The sequential introduction of non-pharmaceutical interventions (NPIs) resulted in successfu... | medRxiv (Cold Spring Harbor Laboratory) | Christian L. Althaus, Institute of Socil nd Preventive Medicine, University of Bern, Bern, Switzerlnd; Daniel Probst, Department of Chemistry and Biochemistry, National Center for Competence in Research NCCR TransCure, University of Bern, Bern, Switzerland; Anthony Hauser, Institute of Socil nd Preventive Medicine, Uni... |
8,480 | Comment devenir docteur en sociologie sans posséder le métier de sociologue ?1 | Peut-on devenir docteur en sociologie sans avoir acquis les compétences constitutives du métier de sociologue ? Une telle interrogation peut paraître provocatrice. Or, l'examen rigoureux et détaillé d'une thèse soutenue le 7 avril 2001 à l'université de Paris V, sous la direction de Michel Maffesoli (G. Elizabeth Hanse... | Revue européenne des sciences sociales | Bernard Lahire, Ecole Normale Supérieure& Lettres et Sciences Humaines |
6,625 | Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants | Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time affects antibody potency. To assess the impact of antibody maturation on durable neutralizing activity against original SARS-CoV-2 and emerging variants of concern (VOCs), we analyzed receptor binding domain (RBD)-specific IgG antibodi... | Immunity | Saya Moriyama, Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan; Yu Adachi, Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan; Takashi Sato, Tokyo Shinagawa Hospital, Tokyo, 140-8522, Jap... |
5,615 | Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism. | Pulmonary embolism is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. In the present article, the authors offer a comprehensive review focused mainly on epidemiology, risk factors, risk stratification, pathophysiological considerations and clinical presentation. Dia... | PubMed | Jan Bĕlohlávek, 2nd Department of Medicine - Department of Cardiovascular Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.; Vladimír Dytrych; Aleš Linhart |
5,602 | Chloroquine-Induced First-Episode Psychosis in a Patient Self-medicated for COVID-19 | Hydroxychloroquine is one of the most promising therapies tested in patients with COVID-19, despite worldwide controversies (1Fihn S.D. Perencevich E. Bradley S.M. Caution needed on the use of chloroquine and hydroxychloroquine for coronavirus disease 2019.JAMA Netw Open. 2020; 3e209035Crossref PubMed Scopus (38) Googl... | Biological Psychiatry | Marine Ambar Akkaoui, Department of Psychiatry and Addictive Medicine, Hôpital Bichat-Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France; Michel Lejoyeux, Department of Psychiatry and Addictive Medicine, Hôpital Bichat-Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, France& Université de... |
4,857 | Clinical Portrait of the SARS-CoV-2 Epidemic in European Patients with Cancer | Abstract The SARS-CoV-2 pandemic significantly affected oncology practice across the globe. There is uncertainty as to the contribution of patients' demographics and oncologic features to severity and mortality from COVID-19 and little guidance as to the role of anticancer and anti–COVID-19 therapy in this population. ... | Cancer Discovery | David J. Pinato, 1Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, London, United Kingdom.; Alberto Zambelli, 2Oncology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.; Juan Aguilar-Company, 3Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Barcelona,... |
6,734 | Improving sleep quality leads to better mental health: A meta-analysis of randomised controlled trials | The extent to which sleep is causally related to mental health is unclear.One way to test the causal link is to evaluate the extent to which interventions that improve sleep quality also improve mental health.We conducted a meta-analysis of randomised controlled trials that reported the effects of an intervention that ... | Sleep Medicine Reviews | Alexander J. Scott, Keele University, School of Psychology, Keele, UK; Thomas L. Webb, Department of Psychology, The University of Sheffield, UK; Marrissa Martyn-St James, School of Health and Related Research (ScHARR), The University of Sheffield, UK; Georgina Rowse, Clinical Psychology Unit, Department of Psychology,... |
8,451 | Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice | Meningoencephalitis caused by Escherichia coli is associated with high rates of mortality and risk of neurological sequelae in newborns and infants and in older or immunocompromised adults. A high prevalence of neurological disorders has been observed in geriatric populations at risk of hypovitaminosis D. In vivo, we s... | Journal of Neuroinflammation | Marija Djukic, Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, Göttingen, Germany. mdjukic@gwdg.de.& Department of Neuropathology, University Medical School Göttingen, Göttingen, Germany. mdjukic@gwdg.de.; Nadine Sostmann, Department of Neuropathology, University Medical School Göttingen, Göttinge... |
6,332 | Comparing Risks of Firearm-Related Death and Injury Among Young Adult Males in Selected US Cities With Wartime Service in Iraq and Afghanistan | Importance In 2020, homicides in the United States saw a record single-year increase, with firearm injuries becoming the leading cause of death for children, adolescents, and young adults. It is critical to understand the magnitude of this crisis to formulate an effective response. Objective To evaluate whether young a... | JAMA Network Open | Brandon del Pozo, Division of General Internal Medicine, Rhode Island Hospital, Providence& The Warren Alpert Medical School of Brown University, Providence, Rhode Island; Alex Knorre, Department of Criminology, University of Pennsylvania, Philadelphia; Michael J. Mello, Injury Prevention Center at Rhode Island Hospita... |
6,798 | The Efficacy of Facemasks in the Prevention of COVID-19: A Systematic Review | Abstract Facemasks have become a symbol of disease prevention in the context of COVID-19; yet, there still exists a paucity of collected scientific evidence surrounding their epidemiological efficacy in the prevention of SARS-CoV-2 transmission. This systematic review sought to analyze the efficacy of facemasks, regard... | medRxiv (Cold Spring Harbor Laboratory) | Bedir Alihsan, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Arrianna Mohammed, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Yash Bisen, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Janice Lester... |
5,313 | Seroprevalence of novel coronavirus disease (COVID-19) in Kobe, Japan | Abstract Background Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been affecting many people on earth and our society. Japan is known to have relatively less number of infections as well as deaths among developed nations. However, accurate prevalence of COVID-19 in Japan remains unknown. Therefo... | medRxiv (Cold Spring Harbor Laboratory) | Asako Doi, Department of Infection Control, Kobe City Medical Center General Hospital, Chuoku 6500047, Kobe, Hyogo, Japan& Department of Infectious Diseases, Kobe City Medical Center General Hospital, Chuoku 6500047, Kobe, Hyogo, Japan& Division of Infectious Diseases Therapeutics, Kobe University Graduate School of Me... |
2,821 | Manage wisely: poly (ADP-ribose) polymerase inhibitor (PARPi) treatment and adverse events | Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have transformed the treatment landscape in front-line and recurrent high-grade serous ovarian cancer. Maintenance strategies with PARPi have been assessed in randomized phase III trials in ovarian cancer; switch maintenance in the case of olaparib, niraparib, and ... | International Journal of Gynecological Cancer | Ainhoa Madariaga, Medical Oncology & Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada; Valerie Bowering, Medical Oncology & Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada; Soha Ahrari, Pharmacy, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Can... |
9,300 | Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies | Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. ... | The Lancet | Angela M Wood, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Stephen Kaptoge, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Adam S Butterworth, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Peter Will... |
2,375 | The Novel Coronavirus, 2019-nCoV, is Highly Contagious and More Infectious Than Initially Estimated | Abstract The novel coronavirus (2019-nCoV) is a recently emerged human pathogen that has spread widely since January 2020. Initially, the basic reproductive number, R 0 , was estimated to be 2.2 to 2.7. Here we provide a new estimate of this quantity. We collected extensive individual case reports and estimated key epi... | medRxiv (Cold Spring Harbor Laboratory) | Steven Sanche, T-6 Theoretical Biology and Biophysics, Theoretical Division, Los Alamos National Laboratory, NM87544, USA& T-CNLS Center for Nonlinear Studies, Los Alamos National Laboratory, NM87544, USA; Yen Ting Lin, CCS- Information Sciences Group, Computer, Computational and Statistical Sciences Division, Los Alam... |
1,478 | Organic Agriculture, Food Security, and the Environment | Organic agriculture is often perceived as more sustainable than conventional farming. We review the literature on this topic from a global perspective. In terms of environmental and climate change effects, organic farming is less polluting than conventional farming when measured per unit of land but not when measured p... | Annual Review of Resource Economics | Eva-Marie Meemken, Department of Agricultural Economics and Rural Development, University of Goettingen, 37073 Goettingen, Germany;; Matin Qaim, Center of Biodiversity and Sustainable Land Use (CBL), University of Goettingen, 37073 Goettingen, Germany& Department of Agricultural Economics and Rural Development, Univers... |
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