text stringlengths 22 455 | relations listlengths 1 24 | messages listlengths 2 2 |
|---|---|---|
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli. | [
{
"ade": "ischaemic cerebrovascular accident",
"drug": "streptokinase"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.\"",
"role": "user"
},
{
"content": "(streptokinase,... |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively. | [
{
"ade": "hepatitis",
"drug": "riluzole"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.\"",
"role": "user"
},
{
"content": "(riluzole, hepatitis)",
"role": "a... |
In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide. | [
{
"ade": "decrease in serum Na+",
"drug": "lorcainide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"In eight patients, a mean decrease in serum Na+ of 8.25 +/- 3.2 mEq/L was observed after a single 200 mg intravenous dose of lorcainide.\"",
"role": "user"
},
{
"content": "(lorcainide, decrease in serum Na+)",
"role": "assistant"... |
A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine. | [
{
"ade": "manic episode",
"drug": "fluoxetine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A depressed woman with no history of bipolar illness developed a manic episode during treatment with fluoxetine.\"",
"role": "user"
},
{
"content": "(fluoxetine, manic episode)",
"role": "assistant"
}
] |
Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia. | [
{
"ade": "bilateral pulmonary infiltrates",
"drug": "methotrexate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Three patients received respectively 190 mg, 175 mg, and 196 mg of methotrexate and developed bilateral pulmonary infiltrates without evidence of peripheral blood eosinophilia.\"",
"role": "user"
},
{
"content": "(methotrexate, bilate... |
We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment. | [
{
"ade": "cranial polyneuropathy",
"drug": "vincristine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.\"",
"role": "user"
},
{
"content": "(vincristine, cranial polyneuropathy)",
"role": "assista... |
RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies. | [
{
"ade": "weight loss",
"drug": "leflunomide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"RESULTS: Five of 70 patients who had begun leflunomide therapy had significant weight loss that could not be linked to other identifiable etiologies.\"",
"role": "user"
},
{
"content": "(leflunomide, weight loss)",
"role": "assist... |
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. | [
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.\"",
"role": "user"
},
{
"content": "(heparin, thrombocytopenia)",
"role": "assistant"
}
] |
Renal injury due to anastrozole has not been published in the English literature. | [
{
"ade": "Renal injury",
"drug": "anastrozole"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Renal injury due to anastrozole has not been published in the English literature.\"",
"role": "user"
},
{
"content": "(anastrozole, Renal injury)",
"role": "assistant"
}
] |
Pulmonary toxicity with mefloquine. | [
{
"ade": "Pulmonary toxicity",
"drug": "mefloquine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Pulmonary toxicity with mefloquine.\"",
"role": "user"
},
{
"content": "(mefloquine, Pulmonary toxicity)",
"role": "assistant"
}
] |
A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain. | [
{
"ade": "acute chest pain",
"drug": "ritodrine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A patient, while on intravenous ritodrine therapy for preterm labor, experienced an episode of acute chest pain.\"",
"role": "user"
},
{
"content": "(ritodrine, acute chest pain)",
"role": "assistant"
}
] |
Recurrent hyponatremia associated with citalopram and mirtazapine. | [
{
"ade": "Recurrent hyponatremia",
"drug": "mirtazapine"
},
{
"ade": "Recurrent hyponatremia",
"drug": "citalopram"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Recurrent hyponatremia associated with citalopram and mirtazapine.\"",
"role": "user"
},
{
"content": "(mirtazapine, Recurrent hyponatremia)",
"role": "assistant"
}
] |
This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate. | [
{
"ade": "hepatitis",
"drug": "artesunate"
},
{
"ade": "hepatitis",
"drug": "amodiaquine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"This report describes an unexpected drug-induced hepatitis in a previously healthy young woman exposed to 2 doses of amodiaquine and artesunate.\"",
"role": "user"
},
{
"content": "(artesunate, hepatitis)",
"role": "assistant"
}... |
This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy. | [
{
"ade": "acute lung injury",
"drug": "mefloquine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.\"",
"role": "user"
},
{
"con... |
CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities. | [
{
"ade": "dermatologic and ocular 5-FU toxicities",
"drug": "5-FU"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.\"",
"role": "user"
},
{
"content": "(5-FU, dermatologic and ocular 5-FU toxicities)",
"role": "assistant"
}
] |
In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine. | [
{
"ade": "spasm",
"drug": "ergonovine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.\"",
"role": "user"
},
{
"content": "(ergonovine, spasm)",
"role": "assistant"
}
] |
A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%. | [
{
"ade": "postprandial hyperglycemia",
"drug": "betamethasone valerate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A second patient with a similar glucose tolerance test result showed postprandial hyperglycemia when treated similarly with betamethasone valerate cream 0.1%.\"",
"role": "user"
},
{
"content": "(betamethasone valerate, postprandial h... |
One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy. | [
{
"ade": "ceroid-like pigment",
"drug": "clofazimine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.\"",
"role": "user"
},
{
"content": "(clofazimine, ceroid... |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL. | [
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.\"",
"role": "user"
},
{
"content": "(cyclosporine, Hypersensitivity reactions)",
"role": "assistant"
}
] |
A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone. | [
{
"ade": "generalized tonic-clonic seizure",
"drug": "naloxone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A generalized tonic-clonic seizure occurred a few minutes after injection of the morphine antagonist naloxone.\"",
"role": "user"
},
{
"content": "(naloxone, generalized tonic-clonic seizure)",
"role": "assistant"
}
] |
The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs. | [
{
"ade": "radiation recall reactions",
"drug": "gemcitabine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The majority of radiation recall reactions attributed to gemcitabine are reported to affect internal tissue or organs.\"",
"role": "user"
},
{
"content": "(gemcitabine, radiation recall reactions)",
"role": "assistant"
}
] |
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. | [
{
"ade": "Intrahepatic cholestasis",
"drug": "glibenclamide"
},
{
"ade": "cutaneous bullae",
"drug": "glibenclamide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma.\"",
"role": "user"
},
{
"content": "(glibenclamide, Intrahepatic... |
This concerns 2 male patients who experienced incontinence while taking venlafaxine. | [
{
"ade": "incontinence",
"drug": "venlafaxine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"This concerns 2 male patients who experienced incontinence while taking venlafaxine.\"",
"role": "user"
},
{
"content": "(venlafaxine, incontinence)",
"role": "assistant"
}
] |
Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps. | [
{
"ade": "Total blindness with a transient tonic pupillary response",
"drug": "quinine sulfate"
},
{
"ade": "denervation supersensitivity",
"drug": "quinine sulfate"
},
{
"ade": "abnormal visual-evoked potentials",
"drug": "quinine sulfate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Total blindness with a transient tonic pupillary response, denervation supersensitivity, and abnormal visual-evoked potentials developed in a 54-year-old man after the use of quinine sulfate for leg cramps.\"",
"role": "user"
},
{
"co... |
Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline. | [
{
"ade": "Pigmentary disorders",
"drug": "minocycline"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Pigmentary disorders are recognized adverse effects of the semi-synthetic tetracycline derivative antibiotic, minocycline.\"",
"role": "user"
},
{
"content": "(minocycline, Pigmentary disorders)",
"role": "assistant"
}
] |
Ticlopidine-induced marrow aplasia treated with cyclosporine. | [
{
"ade": "marrow aplasia",
"drug": "Ticlopidine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Ticlopidine-induced marrow aplasia treated with cyclosporine.\"",
"role": "user"
},
{
"content": "(Ticlopidine, marrow aplasia)",
"role": "assistant"
}
] |
Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case. | [
{
"ade": "hypocalcemic tetany",
"drug": "fleet phospho-soda"
},
{
"ade": "hypocalcemic tetany",
"drug": "alendronate sodium"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Postoperative hypocalcemic tetany caused by fleet phospho-soda preparation in a patient taking alendronate sodium: report of a case.\"",
"role": "user"
},
{
"content": "(fleet phospho-soda, hypocalcemic tetany)",
"role": "assistan... |
Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature. | [
{
"ade": "Cryptococcus neoformans fatal sepsis",
"drug": "alemtuzumab"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Cryptococcus neoformans fatal sepsis in a chronic lymphocytic leukemia patient treated with alemtuzumab: case report and review of the literature.\"",
"role": "user"
},
{
"content": "(alemtuzumab, Cryptococcus neoformans fatal sepsis)... |
Cough induced by quinapril with resolution after changing to fosinopril. | [
{
"ade": "Cough",
"drug": "quinapril"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Cough induced by quinapril with resolution after changing to fosinopril.\"",
"role": "user"
},
{
"content": "(quinapril, Cough)",
"role": "assistant"
}
] |
Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed. | [
{
"ade": "catatonia",
"drug": "disulfiram"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Neurophysiological mechanisms which aid in elucidating the role of disulfiram in the etiology of catatonia are discussed.\"",
"role": "user"
},
{
"content": "(disulfiram, catatonia)",
"role": "assistant"
}
] |
Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain. | [
{
"ade": "Fracture of the femoral neck",
"drug": "PSL"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Fracture of the femoral neck occurred in one patient during PSL therapy, although the relationship between the fracture and PSL therapy was uncertain.\"",
"role": "user"
},
{
"content": "(PSL, Fracture of the femoral neck)",
"role... |
Visual loss after a single small dose of vincristine has never been reported. | [
{
"ade": "Visual loss",
"drug": "vincristine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Visual loss after a single small dose of vincristine has never been reported.\"",
"role": "user"
},
{
"content": "(vincristine, Visual loss)",
"role": "assistant"
}
] |
Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia. | [
{
"ade": "cranial nerve areflexia",
"drug": "CBZ"
},
{
"ade": "cortical hyperexcitability",
"drug": "CBZ"
},
{
"ade": "profound burst-suppression EEG pattern",
"drug": "CBZ"
},
{
"ade": "reversible encephalopathy",
"drug": "CBZ"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.\"",
"role": "user"
},
{
"content": "(CBZ, cranial nerve areflexia)... |
When measured, the serum lithium level had increased 4-fold during acyclovir therapy. | [
{
"ade": "serum lithium level had increased",
"drug": "acyclovir"
},
{
"ade": "serum lithium level had increased",
"drug": "lithium"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"When measured, the serum lithium level had increased 4-fold during acyclovir therapy.\"",
"role": "user"
},
{
"content": "(acyclovir, serum lithium level had increased)",
"role": "assistant"
}
] |
Ezetimibe-induced acute pancreatitis. | [
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Ezetimibe-induced acute pancreatitis.\"",
"role": "user"
},
{
"content": "(Ezetimibe, acute pancreatitis)",
"role": "assistant"
}
] |
The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA. | [
{
"ade": "ulcer",
"drug": "ATRA"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The ulcer did not respond to antibiotic treatment and healed shortly after withholding ATRA.\"",
"role": "user"
},
{
"content": "(ATRA, ulcer)",
"role": "assistant"
}
] |
Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature. | [
{
"ade": "pulmonary toxicity",
"drug": "fludarabine"
},
{
"ade": "Multiple pulmonary nodules",
"drug": "fludarabine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Multiple pulmonary nodules: an unusual presentation of fludarabine pulmonary toxicity: case report and review of literature.\"",
"role": "user"
},
{
"content": "(fludarabine, pulmonary toxicity)",
"role": "assistant"
}
] |
Fulminant hepatic failure associated with bicalutamide. | [
{
"ade": "Fulminant hepatic failure",
"drug": "bicalutamide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Fulminant hepatic failure associated with bicalutamide.\"",
"role": "user"
},
{
"content": "(bicalutamide, Fulminant hepatic failure)",
"role": "assistant"
}
] |
These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacute and silent thyroiditis. | [
{
"ade": "TRAb/TBII without thyroid-stimulating activity",
"drug": "amiodarone"
},
{
"ade": "thyroiditis",
"drug": "amiodarone"
},
{
"ade": "destructive thyroiditis",
"drug": "amiodarone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"These in vitro findings and clinical course suggest that TRAb/TBII without thyroid-stimulating activity may develop in patients with amiodarone-induced destructive thyroiditis, as reported in patients with destructive thyroiditis, such as subacut... |
The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range. | [
{
"ade": "lethargy",
"drug": "lithium"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The newborn manifested a four day course of lethargy with unexplained high lithium levels in the adult toxic range.\"",
"role": "user"
},
{
"content": "(lithium, lethargy)",
"role": "assistant"
}
] |
Spindle coma in benzodiazepine toxicity: case report. | [
{
"ade": "Spindle coma",
"drug": "benzodiazepine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Spindle coma in benzodiazepine toxicity: case report.\"",
"role": "user"
},
{
"content": "(benzodiazepine, Spindle coma)",
"role": "assistant"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment. | [
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.\"",
"role": "user"
},
{
"content": "(clozapine, Sudden cardiac death)",
"role": "assistant"
}
] |
PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment. | [
{
"ade": "anemia",
"drug": "ribavirin"
},
{
"ade": "anemia",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "progressive malaise",
"drug": "ribavirin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"PATIENT AND METHOD: A 34-year-old woman with chronic hepatitis C, genotype 3, receiving pegylated interferon alpha-2a and ribavirin for 6 months, developed progressive malaise and anemia 6 months after the end of treatment.\"",
"role": "user"... |
Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon. | [
{
"ade": "congestive heart failure",
"drug": "recombinant alpha-interferon"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Multiple myeloma complicated by congestive heart failure following first administration of recombinant alpha-interferon.\"",
"role": "user"
},
{
"content": "(recombinant alpha-interferon, congestive heart failure)",
"role": "assis... |
However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "ofloxacin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.\"",
"role": "user"
},
{
"content": "(oflo... |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders. | [
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.\"",
"role": "user"
},
{
"content": "(Foscarnet, electrolyte disorders)",
"role": "assistant"
}
] |
Intravenous valproate associated with significant hypotension in the treatment of status epilepticus. | [
{
"ade": "hypotension",
"drug": "valproate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Intravenous valproate associated with significant hypotension in the treatment of status epilepticus.\"",
"role": "user"
},
{
"content": "(valproate, hypotension)",
"role": "assistant"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy. | [
{
"ade": "gastric LPD",
"drug": "MTX"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.\"",
"role": "user"
},
{
"content": "(MTX, gastric LPD)",
"role": "assistant"
}
] |
Ofloxacin: a probable cause of toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "Ofloxacin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Ofloxacin: a probable cause of toxic epidermal necrolysis.\"",
"role": "user"
},
{
"content": "(Ofloxacin, toxic epidermal necrolysis)",
"role": "assistant"
}
] |
Trimethoprim-sulfamethoxazole-induced aseptic meningitis. | [
{
"ade": "aseptic meningitis",
"drug": "Trimethoprim-sulfamethoxazole"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Trimethoprim-sulfamethoxazole-induced aseptic meningitis.\"",
"role": "user"
},
{
"content": "(Trimethoprim-sulfamethoxazole, aseptic meningitis)",
"role": "assistant"
}
] |
Hepatotoxicity induced by cyproterone acetate: a report of three cases. | [
{
"ade": "Hepatotoxicity",
"drug": "cyproterone acetate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Hepatotoxicity induced by cyproterone acetate: a report of three cases.\"",
"role": "user"
},
{
"content": "(cyproterone acetate, Hepatotoxicity)",
"role": "assistant"
}
] |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine. | [
{
"ade": "Prolongation of the QT interval",
"drug": "halofantrine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.\"",
"role": "user"
},
{
"content": "(halofantrine, Prolongation of the QT interval)",
"role": "assistant"
}... |
We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer. | [
{
"ade": "skin toxicity",
"drug": "aminoglutethimide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report a case of radiotherapy-enhanced aminoglutethimide skin toxicity in a patient with metastatic breast cancer.\"",
"role": "user"
},
{
"content": "(aminoglutethimide, skin toxicity)",
"role": "assistant"
}
] |
Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration. | [
{
"ade": "Acute myocardial ischemia",
"drug": "epinephrine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Acute myocardial ischemia following accidental intravenous administration of epinephrine in high concentration.\"",
"role": "user"
},
{
"content": "(epinephrine, Acute myocardial ischemia)",
"role": "assistant"
}
] |
After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin. | [
{
"ade": "anaphylaxis",
"drug": "cisplatin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"After nine previous uncomplicated cycles she developed severe anaphylaxis to cisplatin.\"",
"role": "user"
},
{
"content": "(cisplatin, anaphylaxis)",
"role": "assistant"
}
] |
A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium. | [
{
"ade": "generalized rigidity",
"drug": "olanzapine"
},
{
"ade": "leukocytosis",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "olanzapine"
},
{
"ade": "fever",
"drug": "lithium"
},
{
"ade": "leukocytosis",
"drug": "lithium"
},
{
"ade": "increased... | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A 16-year-old boy developed fever, generalized rigidity, leukocytosis, and increased serum transaminase and creatine kinase levels while receiving treatment with olanzapine and lithium.\"",
"role": "user"
},
{
"content": "(olanzapine,... |
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. | [
{
"ade": "exacerbation of a preexisting maladaptive behavior",
"drug": "phenobarbital"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.\"",
"role": "user"
},
{
"content": "(phenobarbital, exacerbation of a pre... |
Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity. | [
{
"ade": "Cardiac arrest",
"drug": "esmolol"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Cardiac arrest after esmolol administration: a review of acute beta-blocker toxicity.\"",
"role": "user"
},
{
"content": "(esmolol, Cardiac arrest)",
"role": "assistant"
}
] |
Interference with the cortisol axis by the microtubule antagonist, CPH82. | [
{
"ade": "Interference with the cortisol axis",
"drug": "CPH82"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Interference with the cortisol axis by the microtubule antagonist, CPH82.\"",
"role": "user"
},
{
"content": "(CPH82, Interference with the cortisol axis)",
"role": "assistant"
}
] |
A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis. | [
{
"ade": "sarcoma",
"drug": "cyclophosphamide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.\"",
"role": "user"
},
{
"content": "(cyclophosphamide, sarcoma)",
"role": "assistant"
}
] |
Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range. | [
{
"ade": "blood levels in the toxic range",
"drug": "phenytoin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Seventy-four per cent of patients with epileptogenic disorders seen at the Emergency Unit at Groote Schuur Hospital were on phenytoin and 11.6% of these had blood levels in the toxic range.\"",
"role": "user"
},
{
"content": "(phenyto... |
CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications. | [
{
"ade": "ischemic skin complications",
"drug": "vasopressin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"CONCLUSIONS: Peripheral administration of low-dose vasopressin for septic shock should be discouraged because of the risk of ischemic skin complications.\"",
"role": "user"
},
{
"content": "(vasopressin, ischemic skin complications)",... |
Transient global amnesia after clioquinol: five personal observations from outside Japan. | [
{
"ade": "Transient global amnesia",
"drug": "clioquinol"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Transient global amnesia after clioquinol: five personal observations from outside Japan.\"",
"role": "user"
},
{
"content": "(clioquinol, Transient global amnesia)",
"role": "assistant"
}
] |
Withdrawal of Depakote resulted in resolution of the effusion. | [
{
"ade": "effusion",
"drug": "Depakote"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Withdrawal of Depakote resulted in resolution of the effusion.\"",
"role": "user"
},
{
"content": "(Depakote, effusion)",
"role": "assistant"
}
] |
Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide. | [
{
"ade": "fibrotic lesions",
"drug": "cyclophosphamide"
},
{
"ade": "fibrotic lesions",
"drug": "bleomycin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Thoracoscopic biopsy to confirm metastasis revealed instead fibrotic lesions apparently attributable to bleomycin or cyclophosphamide.\"",
"role": "user"
},
{
"content": "(cyclophosphamide, fibrotic lesions)",
"role": "assistant"
... |
We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren. | [
{
"ade": "hyperkalemia",
"drug": "aliskiren"
},
{
"ade": "acute renal failure",
"drug": "aliskiren"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren.\"",
"role": "user"
},
{
"content": "(aliskiren, hyperkalemia)",
"role": "assistant"
}
] |
We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants. | [
{
"ade": "hypernatraemia",
"drug": "Kayexalate"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We describe two ELBW infants affected by hyperkalaemia, treated with Kayexalate, who developed serious hypernatraemia, that has never been reported before in preterm infants.\"",
"role": "user"
},
{
"content": "(Kayexalate, hypernatra... |
The mechanism of RTA induced by FK506 has not yet been clearly elucidated. | [
{
"ade": "RTA",
"drug": "FK506"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The mechanism of RTA induced by FK506 has not yet been clearly elucidated.\"",
"role": "user"
},
{
"content": "(FK506, RTA)",
"role": "assistant"
}
] |
We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association. | [
{
"ade": "SJS",
"drug": "nevirapine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We describe 2 cases of SJS related to nevirapine use and review the literature on this newly recognized association.\"",
"role": "user"
},
{
"content": "(nevirapine, SJS)",
"role": "assistant"
}
] |
Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines. | [
{
"ade": "Osteonecrosis",
"drug": "dexamethasone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Osteonecrosis is a serious side effect of antiemetic treatment with dexamethasone and this serious complication should be incorporated in the current guidelines.\"",
"role": "user"
},
{
"content": "(dexamethasone, Osteonecrosis)",
... |
Adenosine-induced ventricular fibrillation. | [
{
"ade": "ventricular fibrillation",
"drug": "Adenosine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Adenosine-induced ventricular fibrillation.\"",
"role": "user"
},
{
"content": "(Adenosine, ventricular fibrillation)",
"role": "assistant"
}
] |
The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. | [
{
"ade": "severe thrombocytopoaenia",
"drug": "quinine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine.\"",
"role": "user"
},
{
"content": "(quinine, severe thrombocytopoaenia)",
"role": "assistant"
}
] |
Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside. | [
{
"ade": "demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Horner's syndrome and demyelinating peripheral neuropathy caused by high-dose cytosine arabinoside.\"",
"role": "user"
},
{
"content": "(cytosine arabinoside, demyelinating peripheral neuropathy)",
"role": "assistant"
}
] |
Carbamazepine-induced hyperammonemia. | [
{
"ade": "hyperammonemia",
"drug": "Carbamazepine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Carbamazepine-induced hyperammonemia.\"",
"role": "user"
},
{
"content": "(Carbamazepine, hyperammonemia)",
"role": "assistant"
}
] |
Corneal endothelial deposits associated with rifabutin use. | [
{
"ade": "Corneal endothelial deposits",
"drug": "rifabutin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Corneal endothelial deposits associated with rifabutin use.\"",
"role": "user"
},
{
"content": "(rifabutin, Corneal endothelial deposits)",
"role": "assistant"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.\"",
"role": "user"
},
{
"content": "(ofloxacin, toxic epidermal necrolysis)",
"role": "assistant"
}
] |
We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. | [
{
"ade": "severe hepatotoxicity",
"drug": "benzarone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative.\"",
"role": "user"
},
{
"content": "(benzarone, severe hepatotoxicity)",
"role": "assistant"
}
] |
The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism. | [
{
"ade": "hypercortisolism",
"drug": "CPH82"
},
{
"ade": "suppression of the endogeneous production of ACTH and cortisol",
"drug": "CPH82"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The results clearly demonstrate that CPH82 was associated with suppression of the endogeneous production of ACTH and cortisol with a concomitant paradoxical picture of clinical hypercortisolism.\"",
"role": "user"
},
{
"content": "(CP... |
Severe acidosis from acetazolamide in a diabetic patient. | [
{
"ade": "Severe acidosis",
"drug": "acetazolamide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Severe acidosis from acetazolamide in a diabetic patient.\"",
"role": "user"
},
{
"content": "(acetazolamide, Severe acidosis)",
"role": "assistant"
}
] |
Rupture of a cerebral aneurysm associated with nifedipine treatment. | [
{
"ade": "Rupture of a cerebral aneurysm",
"drug": "nifedipine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Rupture of a cerebral aneurysm associated with nifedipine treatment.\"",
"role": "user"
},
{
"content": "(nifedipine, Rupture of a cerebral aneurysm)",
"role": "assistant"
}
] |
CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing. | [
{
"ade": "delay corneal wound healing",
"drug": "colchicine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"CONCLUSION: The findings in these two patients suggest that colchicine may delay corneal wound healing.\"",
"role": "user"
},
{
"content": "(colchicine, delay corneal wound healing)",
"role": "assistant"
}
] |
We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved. | [
{
"ade": "syndrome of inappropriate secretion of antidiuretic hormone",
"drug": "mizoribin"
},
{
"ade": "SIADH",
"drug": "mizoribin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.\"",
"role"... |
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed. | [
{
"ade": "methanol poisoning",
"drug": "methanol"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.\"",
"role": "user"
},
{
"content": "... |
We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome. | [
{
"ade": "prolonged QT",
"drug": "methadone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We present a case report of a patient who developed a prolonged QT while being treated with oral methadone for a chronic pain syndrome.\"",
"role": "user"
},
{
"content": "(methadone, prolonged QT)",
"role": "assistant"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen. | [
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.\"",
"role": "user"
},
{
"content": "(hyperbaric oxygen, morbidity)",
"role": "assistant"
}
] |
We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements. | [
{
"ade": "diphasic dyskinesias",
"drug": "levo-dopa"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report on three observations of parkinsonian patients with levo-dopa-induced diphasic dyskinesias, who received subcutaneous apomorphine to reduce the duration of abnormal movements.\"",
"role": "user"
},
{
"content": "(levo-dopa, ... |
BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported. | [
{
"ade": "hemolytic-uremic syndrome",
"drug": "gemcitabine"
},
{
"ade": "HUS",
"drug": "Gemcitabine"
},
{
"ade": "HUS",
"drug": "gemcitabine"
},
{
"ade": "renal toxicity",
"drug": "Gemcitabine"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "Gemcitabine"
}... | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.\"",
"role": "user"
},
{
"content": "(gemcitabine, hemolytic-uremic syndrome)",
"role": "assis... |
A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication. | [
{
"ade": "bromide intoxication",
"drug": "pyridostigmine bromide"
},
{
"ade": "postoperative psychosis",
"drug": "pyridostigmine bromide"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"A 59-year-old woman with myasthenia gravis who received a large dose of pyridostigmine bromide developed postoperative psychosis and was diagnosed as having bromide intoxication.\"",
"role": "user"
},
{
"content": "(pyridostigmine bro... |
Capecitabine-induced headache responding to diltiazem. | [
{
"ade": "headache",
"drug": "Capecitabine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Capecitabine-induced headache responding to diltiazem.\"",
"role": "user"
},
{
"content": "(Capecitabine, headache)",
"role": "assistant"
}
] |
Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan). | [
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "Treosulfan"
},
{
"ade": "Acute non-lymphocytic leukemia",
"drug": "dihydroxybusulfan"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Acute non-lymphocytic leukemia in patients with ovarian carcinoma following long-term treatment with Treosulfan (= dihydroxybusulfan).\"",
"role": "user"
},
{
"content": "(Treosulfan, Acute non-lymphocytic leukemia)",
"role": "ass... |
Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl. | [
{
"ade": "serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "serotonin syndrome",
"drug": "fentanyl"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Based on the Naranjo probability scale, serotonin syndrome was a probable adverse reaction associated with co-administration of citalopram and fentanyl.\"",
"role": "user"
},
{
"content": "(citalopram, serotonin syndrome)",
"role"... |
The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare. | [
{
"ade": "hypotension",
"drug": "verapamil"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The incidence of oral-verapamil-induced hypotension in the presence of concomitant beta-adrenergic blockade by the oral route is quite rare.\"",
"role": "user"
},
{
"content": "(verapamil, hypotension)",
"role": "assistant"
}
] |
Acute acoustic nerve palsy associated with vincristine therapy. | [
{
"ade": "Acute acoustic nerve palsy",
"drug": "vincristine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Acute acoustic nerve palsy associated with vincristine therapy.\"",
"role": "user"
},
{
"content": "(vincristine, Acute acoustic nerve palsy)",
"role": "assistant"
}
] |
Disopyramide (Norpace)-induced hypoglycemia. | [
{
"ade": "hypoglycemia",
"drug": "Disopyramide"
},
{
"ade": "hypoglycemia",
"drug": "Norpace"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Disopyramide (Norpace)-induced hypoglycemia.\"",
"role": "user"
},
{
"content": "(Disopyramide, hypoglycemia)",
"role": "assistant"
}
] |
We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injection after the administration of weekly subcutaneous injections of pegylated ... | [
{
"ade": "local cutaneous reactions",
"drug": "pegylated interferon alfa-2b"
},
{
"ade": "local cutaneous reactions",
"drug": "ribavirin"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"We report 5 patients (3 patients with chronic hepatitis C treated with pegylated interferon alfa-2b in association with oral ribavirin and two patients with chronic myelocytic leukemia) who developed local cutaneous reactions at sites of injectio... |
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases. | [
{
"ade": "multifocal leukoencephalopathy",
"drug": "Capecitabine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.\"",
"role": "user"
},
{
"content": "(Capecitabine, multifocal leukoencephalopathy)",
"role": "assistant"
}
] |
This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances. | [
{
"ade": "dysphagia",
"drug": "haloperidol"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.\"",
"role": "user"
},
{
"content": "(haloperidol, dysphagia)",
"role": "assista... |
The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia. | [
{
"ade": "dystonia",
"drug": "carbamazepine"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"The currently available clinical and neuropharmacologic data suggest that carbamazepine may be an antagonist of dopamine and that this property is responsible for the production of dystonia.\"",
"role": "user"
},
{
"content": "(carbam... |
One patient had severe temporary weakness after an ampicillin sodium challenge. | [
{
"ade": "severe temporary weakness",
"drug": "ampicillin sodium"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"One patient had severe temporary weakness after an ampicillin sodium challenge.\"",
"role": "user"
},
{
"content": "(ampicillin sodium, severe temporary weakness)",
"role": "assistant"
}
] |
Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review. | [
{
"ade": "hypertrophic obstructive cardiomyopathy",
"drug": "dexamethasone"
}
] | [
{
"content": "Extract the (DRUG, ADE) pair from this sentence:\n\"Effect of beta-blockade on symptomatic dexamethasone-induced hypertrophic obstructive cardiomyopathy in premature infants: three case reports and literature review.\"",
"role": "user"
},
{
"content": "(dexamethasone, hypertrophic obst... |
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