gwp string | id string | listing_status string | refrigerant string | retrofit_or_new string | safety_class string | source string | source_quote string | url string | verified_fields list | lubricant string | disagreements list | also_reported list | replaces string | trade_name string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0 | ammonia-absorption | Acceptable | Ammonia Absorption | N | B2 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Ammonia Absorption | | N | 0 | 0 | B2 | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/ammonia-absorption/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
10900 | cfc-r-12 | Phased out in 1996 | CFC R-12 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | CFC R-12 10900 L,M MIN AB & MIN Phased out in 1996 | https://referencesource.org/hvac-component-refrigerant-compatibility/cfc-r-12/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
4657 | cfc-r-502 | Phased out in 1996 | CFC R-502 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | CFC R-502 4657 L,M MIN AB & MIN POE-32 Phased out in 1996 | https://referencesource.org/hvac-component-refrigerant-compatibility/cfc-r-502/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
N/A | desiccant-cooling | Acceptable | Desiccant Cooling | N | null | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Desiccant Cooling | | N | 0 | N/A | N/A | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 ; <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/desiccant-cooling/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new"
] | null | null | null | null | null |
N/A | evaporative-cooling | Acceptable | Evaporative Cooling | N | null | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | Evaporative Cooling | | N | 0 | N/A | N/A | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/evaporative-cooling/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new"
] | null | null | null | null | null |
1810 | hcfc-r-22 | No new equipment 2010** | HCFC R-22 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-22 1810 L,M,H MIN AB & MIN POE-32 No new equipment 2010** | https://referencesource.org/hvac-component-refrigerant-compatibility/hcfc-r-22/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | MIN | null | null | null | null |
null | hcr-4141 | acceptable, subject to use conditions | HCR 4141 | null | null | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hcr-4141/ | [
"listing_status",
"refrigerant"
] | null | null | null | null | null |
1,430 | hfc-134a | Acceptable | HFC-134a | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | HFC-134a | | R/N | 0 | 1,430 | A1 | <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB); <https://www.govinfo.gov/content/pkg/FR-2017-07-21/pdf/2017-15379.pdf> July 21, 2017 (pdf) (314 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-134a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
675 | hfc-32 | Acceptable with Use Conditions: See rules for detailed conditions. | HFC-32 | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | HFC-32 | | N | 0 | 675 | A2L | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB); <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB); <https://www.govinfo.gov/content/pkg/FR-2023-04-28/pdf/2023-08663.pdf> April 28, 2023 (p... | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-32/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | [] | null | null | null |
1430 | hfc-r-134a | null | HFC R-134a | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-134a 1430 R-134a manufactured in India | https://referencesource.org/hvac-component-refrigerant-compatibility/hfc-r-134a/ | [
"gwp",
"refrigerant"
] | null | null | null | null | null |
null | hfo-1234yf | null | HFO-1234yf | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hfo-1234yf/ | [
"refrigerant",
"safety_class"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List HFO-1234yf as acceptable, subject to use co... | null | null |
null | hfo-1234ze-e | acceptable, subject to use conditions | HFO-1234ze(E) | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/hfo-1234ze-e/ | [
"listing_status",
"refrigerant",
"safety_class"
] | null | null | null | null | null |
1182 | r-12-hcfc-r-401a | For service applications only | HCFC R-401A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-401A 1182 R-12 M,H AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon™ MP39 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-401a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-12 | Freon™ MP39 |
1288 | r-12-hcfc-r-401b | For service applications only | HCFC R-401B | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-401B 1288 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon MP66 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-401b/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-12 | Freon MP66 |
1909 | r-12-hcfc-r-409a | For service applications only | HCFC R-409A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-409A 1909 R-12 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX56 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-hcfc-r-409a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-12 | FX56 |
601 | r-12-r-134a-r-450a | Solstice N13 for refrigeration applications only | R-450A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-12/R-134a M,H M,H POE-32 Solstice N13 for refrigeration applications only R-450A 601 R12 L,M L,M POE-22D Compressors produced in Brazil | https://referencesource.org/hvac-component-refrigerant-compatibility/r-12-r-134a-r-450a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-12/R-134a | Solstice N13 |
7 (2) | r-123-r-514a | null | R-514A | null | B1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-123 Replacement Opteon™ XP30 R-514A B1 7 (2) POE | https://referencesource.org/hvac-component-refrigerant-compatibility/r-123-r-514a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | null | null | R-123 | Opteon™ XP30 |
1,990 | r-125-r-134a-r-600a-28-1-70-0-1-9 | Acceptable | R-125/R-134a/R-600a (28.1/70.0/1.9) | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-125/R-134a/R-600a (28.1/70.0/1.9) | NU-22 old composition | R/N | 0 | 1,990 | A1 | <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-125-r-134a-r-600a-28-1-70-0-1-9/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | NU-22 old composition |
2,530 | r-125-r-290-r-134a-r-600a-55-0-1-0-42-5-1-5 | Acceptable | R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-125/R-290/R-134a/R-600a (55.0/1.0/42.5/1.5) | ICOR AT-22 | R/N | 0 | 2,530 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-125-r-290-r-134a-r-600a-55-0-1-0-42-5-1-5/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | ICOR AT-22 |
1.8 | r-1270-propylene | Unacceptable , as of January 3, 2017. | R-1270 (Propylene) | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-1270 (Propylene) | | N | 0 | 1.8 | A3 | <https://www.govinfo.gov/content/pkg/FR-2016-12-01/pdf/2016-25167.pdf> December 1, 2016 (pdf) (969 KB) | Unacceptable , as of January 3, 2017. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-1270-propylene/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
4 (1) | r-134a-r-1234yf | null | R-1234yf | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XP10 R-513A R-134a A1 631 (573) -21 Opteon™ XL10 R-1234yf R-134a A2L 4 (1) -21 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-134a-r-1234yf/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | null | null | R-134a | Opteon™ XL10 |
631 (573) | r-134a-r-513a | null | R-513A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-134a Replacement for Lowest GWP retrofit refrigerant for R-134a designed systems. Opteon™ XP10 R-513A A1 631 (573) POE Elastomeric seals replacement or lubricant change not required. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-134a-r-513a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | null | null | R-134a | Opteon™ XP10 |
2107 | r-22-hfc-r-407a | null | HFC R-407A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407A 2107 R-22 L,M L,M POE-32 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22 | null |
1774 | r-22-hfc-r-407c | null | HFC R-407C | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407C 1774 R-22 L,M,H L,M,H POE-32 Freon 9000/KLEA 66 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407c/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-22 | Freon 9000/KLEA 66 |
1825 | r-22-hfc-r-407f | Discus™ and select refrigeration scroll models (ZF/ZB) | HFC R-407F | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-407F 1825 R-22 L,M L,M POE-32 Discus™ and select refrigeration scroll models (ZF/ZB) | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-407f/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22 | null |
3143 | r-22-hfc-r-422a | Discus supermarket racks only | HFC R-422A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-422A 3143 R-22 L,M POE-32 MIN AB Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-422a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22 | null |
2729 | r-22-hfc-r-422d | Discus supermarket racks only | HFC R-422D | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-422D 2729 R-22 L,M POE-32 MIN AB Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-422d/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22 | null |
2265 | r-22-hfc-r-438a | Discus supermarket racks only | HFC R-438A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-438A 2265 R-22 L,M POE-32 MIN AB Discus supermarket racks only; Freon MO99 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r-438a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-22 | Freon MO99 |
2138 | r-22-hfc-r427a | Discus supermarket racks only | HFC-R427A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC-R427A 2138 R-22 L,M POE-32 Discus supermarket racks only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-hfc-r427a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22 | null |
null | r-22-r-404a | null | R-404A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
1495 | r-22-r-404a-r-407h | Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit | R-407H | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-407H 1495 R-22/R-404A L,M POE-32 Discus models and Copeland ZB and ZF scrolls for refrigerated rack retrofit | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-407h/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces"
] | POE-32 | null | null | R-22/R-404A | null |
1387 | r-22-r-404a-r-448a | null | R-448A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-22/R-404A L,M L,M POE-32 Solstice™ N40 R-448A 1387 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-448a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-22/R-404A | Solstice™ N40 |
1396 | r-22-r-404a-r-449a | null | R-449A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-22/R-404A L,M L,M POE-32 Opteon™ XP40 R-449A 1396 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-22/R-404A | Opteon™ XP40 |
2140 | r-22-r-404a-r-452a | OPTEON™ XP44 for U.S. and European pre-approved applications only | R-452A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-452A 2140 R-22/R-404A L,M L,M POE-32 OPTEON™ XP44 for U.S. and European pre-approved applications only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-404a-r-452a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-22/R-404A | OPTEON™ XP44 |
null | r-22-r-407a | null | R-407A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
1397 (1282) | r-22-r-407a-r-407f-r-449a | null | R-449A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 , R-407A, R-407F Opteon™ XP40 R-449A A1 1397 (1282) POE Opteon™ XP40 retrofits will require replacement of critical elastomeric | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407a-r-407f-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | null | null | R-22 , R-407A, R-407F | Opteon™ XP40 |
1774 (1624) | r-22-r-407c | null | R-407C | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement. Closest performance match to R-22 in A/C applications. Freon™ 407C R-407C A1 1774 (1624) POE Retrofits require a lubricant cha... | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407c/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | [] | null | R-22 | Freon™ 407C |
null | r-22-r-407f | null | R-407F | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-407f/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-417a | null | R-417A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-417a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-417b | null | R-417B | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-417b/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-421a | null | R-421A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-421a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-421b | null | R-421B | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-421b/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-422a | null | R-422A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
2525 (2289) | r-22-r-422b | null | R-422B | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-22 Replacements for Great choice in systems where changing to POE oil is not practical, Freon™ NU-22B™ R-422B A1 2525 (2289) MO, AB, POE A/C, Heat Pumps elastomeric seals require replacement. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422b/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | MO, AB, POE | [] | null | R-22 | Freon™ NU-22B™ |
null | r-22-r-422c | null | R-422C | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422c/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-422d | null | R-422D | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-422d/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-424a | null | R-424A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-424a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-427a | null | R-427A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-427a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-428a | null | R-428A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-428a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r-434a | null | R-434A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-434a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
2264 (2059) | r-22-r-438a | null | R-438A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Freon™ MO99™ R-438A A1 2264 (2059) MO, AB, POE elastomeric seals require replacement. R-22 Replacements for Great choice in systems where changing to POE oil is not practical, | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-438a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | MO, AB, POE | [
{
"field": "trade_name",
"versions": [
{
"as_of": "2026-08-11T00:00:00",
"source": "https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf",
"source_quote": "Freon™ MO99™ R-438A A1 2264 (2059) MO, AB, POE elastomeric seals require replacement... | null | R-22 | Freon™ MO99™ |
null | r-22-r-507a | null | R-507A | null | null | https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf | R-22 Retrofit Blends R-404A R-407A R-407C R-407F R-417A R-417B R-421A R-421B R-422A R-422B R-422C R-422D R-424A R-427A R-428A R-434A R-438A R-507A | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r-507a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-22-r427a | null | R427A | null | null | https://forane.arkema.com/en/forane-refrigerants/forane-retrofits/the-drop-in-myth/ | Arkema recommends using Forane® 427A (R427A) - The EASY RETROFIT™ for your R-22 retrofit solution. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-22-r427a/ | [
"refrigerant",
"replaces"
] | null | null | null | R-22 | null |
null | r-290 | null | R-290 | null | A3 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | Using these safety groups, HFO-1234ze(E), HFC-32 and the refrigerant blends R-452B, R-454A, R-454B, R-454C, R-457A, and R-516A are in the A2L Safety Group, while R-290, R-441A, and the components of HCR 4141 are in the A3 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290/ | [
"refrigerant",
"safety_class"
] | null | null | null | null | null |
3 | r-290-propane | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. | R-290 (Propane) | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-290 (Propane) | | N | 0 | 3 | A3 | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290-propane/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
3 | r-290-propane-2 | For use with specific Copeland compressors manufactured in India for R-290 | R-290 propane | null | A3 | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-290 propane A3 3 POE-32 For use with specific Copeland compressors manufactured in India for R-290 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-290-propane-2/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"safety_class"
] | POE-32 | null | null | null | null |
3,920 | r-404a | Acceptable | R-404A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-404A | SUVA HP-62 | R/N | 0 | 3,920 | A1 | <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | SUVA HP-62 |
239 (238) | r-404a-r-454a | null | R-454A | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL40 R-454A R-404A A2L 239 (238) -54 Freon™ 410A R-410A N/A A1 2088 (1924) -61 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-454a/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | null | null | R-404A | Opteon™ XL40 |
1397 (1282) | r-404a-r-507-r-449a | null | R-449A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XP40 R-449A A1 1397 (1282) POE TXVs and in most cases it is suggested to replace the R-404A power element to a R-449A power element. Consult compressor manufacturer R-404A, R-507 guidelines for necessity of demand cooling in low temperature | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-507-r-449a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | null | null | R-404A, R-507 | Opteon™ XP40 |
2140 (1945) | r-404a-r-507-r-452a | null | R-452A | null | A1 | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | R-404A, R-507 guidelines for necessity of demand cooling in low temperature applications. Replacements Discharge temperature and mass flow match to R-404A/R-507. Best Opteon™ XP44 R-452A A1 2140 (1945) POE used in situations where liquid injection cannot be installed on the low | https://referencesource.org/hvac-component-refrigerant-compatibility/r-404a-r-507-r-452a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | POE | null | null | R-404A, R-507 | Opteon™ XP44 |
2,110 | r-407a | Acceptable | R-407A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407A | Klea 60, Klea 407A | R/N | 0 | 2,110 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Klea 60, Klea 407A |
148 (146) | r-407a-r-454c | null | R-454C | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407a-r-454c/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | null | null | R-407A | Opteon™ XL20 |
1,770 | r-407c | Acceptable | R-407C | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407C | Suva 407C, Klea 407C | R/N | 0 | 1,770 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB); <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB); <https://www.govinfo.gov/content/pkg/FR-2003-08-21/pdf/03-214... | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Suva 407C, Klea 407C |
148 (146) | r-407c-r-454c | null | R-454C | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL10 R-1234yf R-134a A2L 4 (1) -21 Opteon™ XL20 R-454C R-407C A2L 148 (146) -50 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407c-r-454c/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | null | null | R-407C | Opteon™ XL20 |
1,820 | r-407f | Acceptable | R-407F | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-407F | Genetron Performax LT | R/N | 0 | 1,820 | A1 | <https://www.govinfo.gov/content/pkg/FR-2011-10-04/pdf/2011-25391.pdf> October 4, 2011 (pdf) (201 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-407f/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Genetron Performax LT |
2,090 | r-410a | Acceptable | R-410A | N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-410A | AZ-20, Suva 9100, Puron | N | 0 | 2,090 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB); <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | AZ-20, Suva 9100, Puron |
466 (467) | r-410a-r-454b | null | R-454B | null | A2L | https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf | Opteon™ XL20 R-454C R-407A A2L 148 (146) -50 Opteon™ XL41 R-454B R-410A A2L 466 (467) -51 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410a-r-454b/ | [
"gwp",
"refrigerant",
"replaces",
"safety_class",
"trade_name"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "lubricant",
"source": "https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf",
"source_quote": "R-454B is now a primary replacement for R-410A. Due to • \u0007Liquid dr... | R-410A | Opteon™ XL41 |
2,230 | r-410b | Acceptable | R-410B | N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-410B | | N | 0 | 2,230 | A1 | <https://www.govinfo.gov/content/pkg/FR-1996-02-08/pdf/96-2723.pdf> February 8, 1996 (pdf) (152 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-410b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
2,350 | r-417a | Acceptable | R-417A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-417A | ISCEON 59, NU-22 | R/N | 0 | 2,350 | A1 | <https://www.govinfo.gov/content/pkg/FR-1999-12-06/pdf/99-31544.pdf> December 6, 1999 (pdf) (226 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-417a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | ISCEON 59, NU-22 |
1,820 | r-417c | Acceptable | R-417C | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-417C | Hot Shot 2 | R | 0 | 1,820 | A1 | <https://www.govinfo.gov/content/pkg/FR-2011-10-04/pdf/2011-25391.pdf> October 4, 2011 (pdf) (201 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-417c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Hot Shot 2 |
2,630 | r-421a | Acceptable | R-421A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-421A | Choice R-421A | R/N | 0 | 2,630 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-421a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Choice R-421A |
2,530 | r-422b | Acceptable | R-422B | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422B | ICOR XAC1, NU-22B | R/N | 0 | 2,530 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | ICOR XAC1, NU-22B |
3,390 | r-422c | Acceptable | R-422C | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422C | ICOR XLT1 | R/N | 0 | 3,390 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-03-29/pdf/06-3030.pdf> March 29, 2006 (pdf) (181 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | ICOR XLT1 |
2,730 | r-422d | Acceptable | R-422D | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-422D | ISCEON MO29 | R/N | 0 | 2,730 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-422d/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | ISCEON MO29 |
2,440 | r-424a | Acceptable | R-424A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-424A | RS-44 | R/N | 0 | 2,440 | A1 | <https://www.govinfo.gov/content/pkg/FR-2006-09-28/pdf/E6-15833.pdf> September 28, 2006 (pdf) (183 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-424a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | RS-44 |
2,140 | r-427a | Acceptable | R-427A | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-427A | Forane 427A | R | 0 | 2,140 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-427a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Forane 427A |
3,250 | r-434a | Acceptable | R-434A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-434A | RS-45 | R/N | 0 | 3,250 | A1 | <https://www.govinfo.gov/content/pkg/FR-2007-10-04/pdf/E7-19545.pdf> October 4, 2007 (pdf) (163 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-434a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | RS-45 |
1,810 | r-437a | Acceptable | R-437A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-437A | KDD6, ISCEON MO49 Plus | R/N | 0 | 1,810 | A1 | <https://www.govinfo.gov/content/pkg/FR-2009-01-02/pdf/E8-31225.pdf> January 2, 2009 (pdf) (173 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-437a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | KDD6, ISCEON MO49 Plus |
2,270 | r-438a | Acceptable | R-438A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-438A | KDD5, ISCEON MO99 | R/N | 0 | 2,270 | A1 | <https://www.govinfo.gov/content/pkg/FR-2007-10-04/pdf/E7-19545.pdf> October 4, 2007 (pdf) (163 KB); <https://www.govinfo.gov/content/pkg/FR-2010-06-16/pdf/2010-14510.pdf> June 16, 2010 (pdf) (229 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-438a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | KDD5, ISCEON MO99 |
<5 | r-441a | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. | R-441A | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-441A | | N | 0 | <5 | A3 | <https://www.govinfo.gov/content/pkg/FR-2015-04-10/pdf/2015-07895.pdf> April 10, 2015 (pdf) (769 KB) | Acceptable with Use Conditions : For use in self-contained room air conditioning; see rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-441a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | [] | null | null | null |
2.5 | r-443a | Unacceptable , as of January 3, 2017. | R-443A | N | A3 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-443A | | N | 0 | 2.5 | A3 | <https://www.govinfo.gov/content/pkg/FR-2016-12-01/pdf/2016-25167.pdf> December 1, 2016 (pdf) (969 KB) | Unacceptable , as of January 3, 2017. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-443a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class"
] | null | null | null | null | null |
null | r-444a | null | R-444A | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-444a/ | [
"refrigerant",
"safety_class"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-444A as acceptable, subject to ... | null | null |
700 | r-452b | Acceptable with Use Conditions: See rule for detailed conditions. | R-452B | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-452B | Opteon™ XL55 | N | 0 | 700 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-452b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | [] | null | null | Opteon™ XL55 |
null | r-453a | null | R-453A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-453a/ | [
"refrigerant",
"safety_class"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-453A as acceptable, subject to ... | null | null |
240 | r-454a | Acceptable with Use Conditions: See rule for detailed conditions. | R-454A | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454A | Opteon™ XL40 | N | 0 | 240 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | [] | null | null | Opteon™ XL40 |
470 | r-454b | Acceptable with Use Conditions: See rule for detailed conditions. | R-454B | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454b/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | [
{
"field": "trade_name",
"versions": [
{
"as_of": "2026-08-11T00:00:00",
"source": "https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps",
"source_quote": "R-454B | Opteon™ XL41 | N | 0 | 470 | A2L | <https://www.govinfo.gov/content/... | [
{
"as_of": "2026-08-11T00:00:00",
"field": "lubricant",
"source": "https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf",
"source_quote": "than R-454B will need to be upgraded. As of this docume... | null | Opteon™ XL41 |
150 | r-454c | Acceptable with Use Conditions: See rule for detailed conditions. | R-454C | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-454C | Opteon™ XL20 | N | 0 | 150 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-454c/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | [] | null | null | Opteon™ XL20 |
null | r-456a | null | R-456A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-456a/ | [
"refrigerant",
"safety_class"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-456A as acceptable, subject to ... | null | null |
140 | r-457a | Acceptable with Use Conditions: See rule for detailed conditions. | R-457A | N | A2L | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-457A | Forane® 457A | N | 0 | 140 | A2L | <https://www.govinfo.gov/content/pkg/FR-2021-05-06/pdf/2021-08968.pdf> May 6, 2021 (pdf) (583 KB) | Acceptable with Use Conditions: See rule for detailed conditions. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-457a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | [] | null | null | Forane® 457A |
1,650 | r-458a | Acceptable | R-458A | R | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-458A | Bluon TdX 20 | R | 0 | 1,650 | A1 | <https://www.govinfo.gov/content/pkg/FR-2017-07-21/pdf/2017-15379.pdf> July 21, 2017 (pdf) (314 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-458a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Bluon TdX 20 |
null | r-480a | null | R-480A | null | A1 | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | ASHRAE 34-2024 categorizes HFO-1234yf and R-444A as being in the A2L Safety Group and R-453A, R-456A, and R-480A in the A1 Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-480a/ | [
"refrigerant",
"safety_class"
] | null | [] | [
{
"as_of": "2026-08-11T00:00:00",
"field": "retrofit_or_new",
"source": "https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives",
"source_quote": "List the blend R-480A as acceptable, subject to ... | null | null |
2788 | r-502-hcfc-r-402a | For service applications only | HCFC R-402A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-402A 2788 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP80 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-402a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-502 | Freon HP80 |
2416 | r-502-hcfc-r-402b | For service applications only | HCFC R-402B | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-402B 2416 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: Freon HP81 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-402b/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-502 | Freon HP81 |
3152 | r-502-hcfc-r-408a | For service applications only | HCFC R-408A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HCFC R-408A 3152 R-502 L,M AB & MIN POE-32 & MIN POE-32 For service applications only, trade name: FX10 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hcfc-r-408a/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | AB & MIN | null | null | R-502 | FX10 |
3922 | r-502-hfc-r-404a | null | HFC R-404A | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-502 L,M L,M POE-32 Freon HP62, Forane™ FX70 HFC R-404A 3922 R-502 L,M L,M POE-22C For use with compressors manufactured in India | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hfc-r-404a/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-502 | Freon HP62, Forane™ FX70 |
3985 | r-502-hfc-r-507 | null | HFC R-507 | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | HFC R-507 3985 R-502 L,M L,M POE-32 Genetron™ AZ50 | https://referencesource.org/hvac-component-refrigerant-compatibility/r-502-hfc-r-507/ | [
"gwp",
"lubricant",
"refrigerant",
"replaces",
"trade_name"
] | POE-32 | null | null | R-502 | Genetron™ AZ50 |
3,990 | r-507-r-507a | Acceptable | R-507, R-507A | R/N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-507, R-507A | AZ-50 | R/N | 0 | 3,990 | A1 | <https://www.govinfo.gov/app/details/FR-1996-09-05/96-22649> September 5, 1996 ; <https://www.govinfo.gov/content/pkg/FR-2002-12-20/pdf/02-32130.pdf> December 20, 2002 (pdf) (168 KB) | Acceptable | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-507-r-507a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | AZ-50 |
630 | r-513a | Acceptable in self-contained units. | R-513A | N | A1 | https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps | R-513A | Opteon® XP-10 | N | 0 | 630 | A1 | <https://www.govinfo.gov/content/pkg/FR-2024-12-11/pdf/2024-28307.pdf> December 11, 2024 (pdf) (300 KB) | Acceptable in self-contained units. | | https://referencesource.org/hvac-component-refrigerant-compatibility/r-513a/ | [
"gwp",
"listing_status",
"refrigerant",
"retrofit_or_new",
"safety_class",
"trade_name"
] | null | null | null | null | Opteon® XP-10 |
null | r-516a | acceptable, subject to use conditions | R-516A | null | A2L | https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives | The EPA is proposing to list HCR 4141, HFO-1234ze(E), and R-516A as acceptable, subject to use conditions, for this end-use. HCR 4141 is a higher flammability refrigerant blend with each component in the A3 Safety Group. HFO-1234ze(E) and R-516A are lower flammability refrigerants, both in the A2L Safety Group. | https://referencesource.org/hvac-component-refrigerant-compatibility/r-516a/ | [
"listing_status",
"refrigerant",
"safety_class"
] | null | null | null | null | null |
1 | r-704-helium | Copeland ZC scroll models only | R-704 helium | null | null | https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11 | R-704 helium 1 Cryogenic PAG Copeland ZC scroll models only | https://referencesource.org/hvac-component-refrigerant-compatibility/r-704-helium/ | [
"gwp",
"listing_status",
"lubricant",
"refrigerant"
] | PAG | null | null | null | null |
End of preview. Expand in Data Studio
HVAC refrigerant replacements: retrofit compatibility, safety class, GWP and lubricant
Canonical, always-current version: https://referencesource.org/hvac-component-refrigerant-compatibility/ Machine-readable: https://referencesource.org/hvac-component-refrigerant-compatibility/data.json — this mirror is a point-in-time copy.
- Last verified: 2026-08-11
- Stale after: 2027-08-11 (past this date, prefer the canonical copy — it re-verifies on a cadence this snapshot does not)
- Records: 109
Which refrigerant substitutes for which in air conditioning, heat pump and refrigeration equipment, drawn from the EPA SNAP substitutes list, compressor-manufacturer bulletins (Copeland) and refrigerant-manufacturer replacement guides (Chemours, Honeywell, Arkema). Each record carries the ASHRAE safety classification, GWP, whether the substitute is approved for retrofit or new equipment only, and the compatible lubricant. Answers 'can I put R-454B in an R-410A system', 'what replaces R-22 without changing the oil', and 'is this substitute EPA-acceptable' — questions where the wrong answer damages equipment or breaks federal rules.
Provenance — what every record carries
Every record carries source (the URL the value was read from) and
source_quote (a verbatim quote from that page stating it). A value you
cannot check against its page is indistinguishable from an invented one;
these can all be checked. Each record is also individually addressable on
the canonical site at its url.
Licence position
Factual compilation with source citations. EPA SNAP substitute listings are US government work (public domain). Manufacturer figures (Copeland, Chemours, Honeywell, Trane, Arkema) are facts taken with short attributed quotes linking back to the published guide.
Facts are not copyrightable; what this dataset takes from each source is a fact plus a short attributed quote linking back to the page that states it.
Sources
- https://epa.gov/snap/substitutes-residential-and-light-commercial-air-conditioning-and-heat-pumps
- https://webapps.copeland.com/online-product-information/Publication/LaunchPDF?Index=AEB&PDF=93-11
- https://www.federalregister.gov/documents/2025/11/10/2025-19812/protection-of-stratospheric-ozone-listing-of-substitutes-under-the-significant-new-alternatives
- https://www.chemours.com/en/-/media/files/freon/opteon-freon-general-replacement-guide.pdf
- https://www.epa.gov/sites/default/files/documents/Choosing_Right_R22_Retrofit.pdf
- https://www.freon.com/en/-/media/files/freon/freon-mo99-faq.pdf
- https://forane.arkema.com/en/forane-refrigerants/forane-retrofits/the-drop-in-myth/
- https://prod-edam.honeywell.com/content/dam/honeywell-edam/pmt/oneam/en-us/refrigerants/documents/pmt-am-solstice-454b-applications-guide.pdf
- https://www.shareddocs.com/hvac/docs/1006/Public/06/570-178.pdf
- https://www.trane.com/content/dam/Trane/Commercial/global/products-systems/equipment/unitary/split-systems/rauj-cauj-20-to-120-tons/SS-APG018A-EN_11102024.pdf
Fields
See any record in data/records.jsonl — field names are self-describing,
and the canonical page for each record renders them with labels:
https://referencesource.org/hvac-component-refrigerant-compatibility/
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