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NCT05637320 | Anxiety Disorders, Depressive Disorder, Mood Disorders, Conduct Disorder, Oppositional Defiant Disorder, Regulation, Emotion, Child Behavior Disorders, Trauma and Stressor Related Disorders | Biobehavioural Regulation of Negative Emotion as a Transdiagnostic Mechanism of Children's Psychotherapy | RECRUITING | The goal of this clinical trial is to learn about how psychotherapy works for children and adolescents aged 8 - 15 with anxiety, depression, trauma, or disruptive behaviour. The main question it aims to answer is:
• Is the biobehavioural regulation of negative emotion a transdiagnostic mechanism of treatment response ... | Inclusion Criteria:
* Child must be between the ages of 8 and 15 years old and have English proficiency
* Parents must be over the age of 18 and have English proficiency
* Must be seeking psychosocial treatment for concerns related to anxiety, depression, or disruptive behaviours
Exclusion Criteria:
* Child has low ... | University of Guelph | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Jessica Pun, BA', 'role': 'CONTACT', 'phone': '519-824-4120', 'phoneExt': '53059', 'email': 'punj@uoguelph.ca'}] |
NCT06453720 | Inflammatory Bowel Diseases, Crohn Disease | Optimizing Patient Treatment Involving Microbiome Integration for Specialized Therapeutics | RECRUITING | The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living in British Columbia, Canada. The main questions this study seeks to answer are:
1. Can mic... | Inclusion Criteria:
CD patients
* Adult patients ≥19 years old and ≤ 80 years old.
* CD with distal small bowel and/or colonic involvement that is endoscopically assessable with colonoscopy
* Undergoing colonoscopy as part of routine clinical care
* Active or quiescent disease
* Active disease will be defined as a si... | University of British Columbia | OBSERVATIONAL | null | null | OPTIMIST | [{'name': 'Fanny LeMarié, PhD', 'role': 'CONTACT', 'phone': '6044414992', 'email': 'flemarie@ibdcentrebc.ca'}, {'name': 'Cristian Massaro, BSc', 'role': 'CONTACT', 'phone': '5872235248', 'email': 'cristian.massaro@bcchr.ca'}] |
NCT06107374 | Advanced Non Small Cell Lung Cancer | Imaging of T-cell Activation With [18F]F-araG in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Undergoing PD-1/PD-L1 Directed Therapy | RECRUITING | This pilot study uses \[18F\]F AraG PET imaging to evaluate the immunological response to checkpoint inhibitor therapy (CkIT) in patients with advanced NSCLC tumors. The study's main objectives are to quantify the change in \[18F\]F AraG PET signal before and while on CkIT therapy and to correlate this change in \[18F\... | Inclusion Criteria:
1. Histologically confirmed NSCLC and planned to undergo immunotherapy as monotherapy or as combination therapy for advanced/metastatic disease.
2. Measurable disease.
3. ECOG performance status of 0, 1 or 2.
4. Subjects are willing to be followed at the University of Iowa.
Exclusion Criteria:
1.... | CellSight Technologies, Inc. | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Amy Mundisev', 'role': 'CONTACT', 'phone': '319-356-1445', 'email': 'amy-mundisev@uiowa.edu'}] |
NCT04457674 | Insomnia, Alcohol Use Disorder | Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes | RECRUITING | Insomnia is common in people who are in treatment for alcohol use disorder. It can impact both sleep quality and daytime functioning, as well as make it harder to treat the underlying alcohol use disorder. This study is looking at two types of therapy to help manage insomnia specifically for people also in treatment fo... | Inclusion Criteria:
* Meet probable Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria for Alcohol Use Disorder with ≤12 weeks of abstinence
* Planned enrollment into an abstinence-based treatment program
* Meet probable DSM-5 criteria for chronic insomnia, confirmed with sleep diary
* Ability to t... | University of Michigan | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Libby Cardoni', 'role': 'CONTACT', 'phone': '734.764.7175', 'email': 'mehobson@med.umich.edu'}] |
NCT05878860 | X-linked Retinoschisis | A Phase 1/2, Open-Label, Dose Escalation and Dose Expansion Study to Evaluate the Safety and Tolerability of ATSN-201 Gene Therapy in Male Subjects With RS1-Associated X-linked Retinoschisis | RECRUITING | This study will evaluate the safety and tolerability of ATSN-201 in male subjects ≥ 6 years of age with RS1-associated X-linked retinoschisis (XLRS). | Inclusion Criteria:
1. Age ≥ 18 for Cohorts 1 through 3, and age ≥ 6 years and \< 18 years for Cohort 4.
2. Male patients with clinical diagnosis of XLRS caused by mutations in RS1.
3. Best corrected visual acuity (BCVA) in study eye of 34 to 73 Early Treatment Diabetic Retinopathy Study (ETDRS) letters (corresponding... | Atsena Therapeutics Inc. | INTERVENTIONAL | RANDOMIZED | SEQUENTIAL | LIGHTHOUSE | [{'name': 'Atsena Therapeutics Clinical Trials', 'role': 'CONTACT', 'phone': '984-261-2001', 'email': 'clinicaltrials@atsenatx.com'}] |
NCT03206060 | Pheochromocytoma, Paraganglioma, Neuroendocrine Tumors, Neuroendocrine Neoplasms | Lu-177-DOTATATE (Lutathera) in Therapy of Inoperable Pheochromocytoma/ Paraganglioma | RECRUITING | Background:
Pheochromocytoma and paraganglioma are rare tumors. They usually form inside and near the adrenal gland or in the neck region. Not all these tumors can be removed with surgery, and there are no good treatments if the disease has spread. Researchers think a new drug may be able to help.
Objective:
To lear... | * INCLUSION CRITERIA:
* Surgically inoperable participants with clinical diagnosis of PHEO/PGL who also have demonstrated disease histologically consistent with pheochromocytoma or paraganglioma (preferably confirmed by research site pathology review if initial pathology was done outside of research site, but not manda... | National Cancer Institute (NCI) | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Joy Zou, R.N.', 'role': 'CONTACT', 'phone': '(240) 760-6153', 'email': 'joy.zou@nih.gov'}, {'name': 'Frank I Lin, M.D.', 'role': 'CONTACT', 'phone': '(240) 760-6166', 'email': 'frank.lin2@nih.gov'}] |
NCT02817360 | Heart Diseases, Diabetes Mellitus, Type 2 | NT-proBNP Selected PreventiOn of Cardiac eveNts in a populaTion of dIabetic Patients Without A History of Cardiac Disease: a Prospective Randomized Trial | RECRUITING | Purpose and rationale The purpose of this study is to evaluate the effect of high dose Renin-Angiotensin System (RAS)-antagonists and beta-blocker treatment for the primary prevention of cardiac events in a population of patients with Type 2 diabetes mellitus (T2DM) with no evidence of a preexisting cardiac disease. An... | Inclusion Criteria:
1. Type-2 diabetes for at least six months,
2. ≥ 18 years of age, men or female,
3. Written informed consent to participate in the study and ability to comply with all requirements.
Exclusion Criteria:
1. History of hypersensitivity to any of the investigated drugs as well as known or suspected c... | Martin Huelsmann | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Martin Huelsmann, Doz.Dr.', 'role': 'CONTACT', 'phone': '+43 1 40400', 'phoneExt': '46140', 'email': 'martin.huelsmann@meduniwien.ac.at'}] |
NCT04443660 | Pregnancy Related | Autophagy/Apoptosis Balance During Pregnancy | RECRUITING | The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications.
The study investigators hypothesize that there would be an intra-troph... | Inclusion Criteria:
* Patients followed at the CHU Nîmes prior to 33 weeks gestation who give birth at the hospital
* The patient must have given their free and informed consent and signed the consent form
* The patient must be a member or beneficiary of a health insurance plan
Exclusion Criteria:
* The subject is p... | Centre Hospitalier Universitaire de Nīmes | OBSERVATIONAL | null | null | GROSSAUTOP | [{'name': 'Sylvie Bouvier', 'role': 'CONTACT', 'phone': '04.66.68.32.11', 'email': 'sylvie.bouvier@chu-nimes.fr'}] |
NCT05557760 | Major Depression in Remission | Evaluating the Effects of Personalized Booster Sessions on Depression Vulnerability Following Cognitive Control Training for Remitted Depressed Individuals | RECRUITING | The current study aims to examine the impact of booster sessions of cognitive control training (CCT) on indicators of depression vulnerability. Remitted depressed individuals (RMD) will be randomized over two groups, each receiving 10 sessions of the adaptive Paced Auditory Serial Addition Task, a well-established CCT ... | Inclusion Criteria:
* History of ≥ 1 depressive episode(s)
* Currently in remission (≥ 3 months)
* Access to a computer with an internet connection
* Access to a smartphone
Exclusion Criteria:
* Ongoing depressive episode
* Psychotic disorder (current and/or previous)
* Neurological impairments (current and/or previ... | University Ghent | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Ernst Koster, PhD', 'role': 'CONTACT', 'phone': '+ 32 9 2646446', 'email': 'Ernst.Koster@ugent.be'}] |
NCT06152276 | Colorectal Cancer, Stoma Ileostomy | SafeHeal Diverting Ileostomy Pivotal Study (SH-SOC23) | RECRUITING | This SafeHeal study is designed to assess the overall safety of the low anterior resection (LAR) standard of care cancer treatment by establishing a definition of major complications. The current literature on standard of care reports adverse events/complications but does not provide a single endpoint that can be used ... | Inclusion Criteria:
1. Adult patients (18 years of age or older)
2. Eligible to undergo open or minimally invasive sphincter-sparing low anterior resection with planned diverting loop ileostomy for malignancy, based on multidisciplinary team recommendations.
3. Eastern Cooperative Oncology Group (ECOG) Performance Sta... | SafeHeal Inc | OBSERVATIONAL | null | null | SH-SOC23 | [{'name': 'VP, Clinical Affairs', 'role': 'CONTACT', 'phone': '+1-203-444-0279', 'email': 'dwhite@safeheal.com'}, {'name': 'Marcos Velez-Duran', 'role': 'CONTACT', 'email': 'mvelezduran@safeheal.com'}] |
NCT06348576 | Hypertension,Essential | A Multicenter, Randomized, Double-blind, Active-control, Phase III Study to Evaluate the Efficacy and Safety of AD-209 in Patients With Essential Hypertension | RECRUITING | The purpose of this study is to evaluate the efficacy and safety of AD-209 | Inclusion Criteria:
* Signed informed consent
* Other inclusions applied
Exclusion Criteria:
* Orthostatic hypotension with symptom
* Other exclusions applied | Addpharma Inc. | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Kyung Tae Kim, D.V.M', 'role': 'CONTACT', 'phone': '82-031-891-5661', 'email': 'ktkim@addpharma.co.kr'}, {'name': 'Chang Gyu Park, M.D., Ph.D', 'role': 'CONTACT'}] |
NCT06423976 | Prostate Cancer | Collection of Clinical Material From Patients With Prostate Cancer or Undergoing Investigation for Diagnostic or Follow up Purposes for Molecular Characterisation and Microbiome Analysis | RECRUITING | Preclinical models of prostate cancer have proved to be poorly predictive of the behaviour of the disease in patients. This protocol describes the acquisition of prostate cancer tissue or cells from patients with treatment naïve/hormone-sensitive and castration-resistant prostate cancer or patients undergoing diagnosti... | Inclusion Criteria:
1. Male \>=18 years.
2. Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 - 2.
3. Undergoing investigation for diagnosis, or with a proven diagnosis of prostate cancer and undergoing further investigation or clinical trial participation.
4. Patients with tumour deemed by the desig... | Institute of Cancer Research, United Kingdom | OBSERVATIONAL | null | null | MMC | [{'name': 'Omobola Fadahunsi', 'role': 'CONTACT', 'phone': '0203 437 3500', 'email': 'bola.fadahunsi@icr.ac.uk'}, {'name': 'Sasha Gayle', 'role': 'CONTACT', 'phone': '0208 722 4672', 'email': 'sasha.gayle@icr.ac.uk'}] |
NCT06305676 | Oropharyngeal Cancer, HPV-Related Carcinoma | Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC) | RECRUITING | Investigators seek to determine the sensitivity and specificity of a combined HPV 16 DNA and host gene methylation oral biomarker panel to distinguish early Oropharyngeal Cancer (OPC) cases from controls among 100 early and 100 late disease pre-treatment OPC cases, and 200 controls matched by sex, age, race/ethnicity, ... | Inclusion Criteria:
Cases:
* Aged at least 18 years
* Newly diagnosed primary tumor, histologically confirmed squamous cell carcinoma of the oropharynx (stages I-IV)
* Has not received treatment (surgery, chemotherapy, radiation, or immunotherapy) within the previous four weeks
* Provided written informed consent und... | H. Lee Moffitt Cancer Center and Research Institute | OBSERVATIONAL | null | null | BASH OPC | [{'name': 'Kimberly Isaacs-Soriano', 'role': 'CONTACT', 'phone': '813-745-6992', 'email': 'kimberly.Isaacs-Soriano@moffitt.org'}] |
NCT05983276 | Ovarian Cancer | Combination of the Hypomethylating Agent Decitabine and the Nuclear Export Receptor XPO-1 Inhibitor Selinexor to Reverse Platinum Resistance in Relapsed/Refractory Epithelial Ovarian Cancer | RECRUITING | The goal of this clinical trial is to learn about the side effects and effectiveness of this novel four-drug combination of chemotherapy (decitabine, selinexor, carboplatin and paclitaxel) on patients with relapsed ovarian, fallopian or primary peritoneal carcinoma.
Recently the investigators have found that the combi... | Inclusion Criteria:
* Participants must be greater than or equal to 18 years of age
* Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status PS less than or equal to 2.
* Participants must have histological or cytological proven epithelial ovarian cancer, fallopian tube or primary perit... | Loyola University | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Patrick Stiff, MD', 'role': 'CONTACT', 'phone': '708-327-3148', 'email': 'pstiff@lumc.edu'}, {'name': 'Agnes Natonton, RN', 'role': 'CONTACT', 'phone': '708-327-3383', 'email': 'anatont@luc.edu'}] |
NCT01999374 | Type 1 Diabetes Mellitus | Long Term Follow up of Recipients of Functional Islet Allografts | RECRUITING | Since its inception, the Diabetes Research Institute (DRI) has made significant contributions to the field of diabetes, pioneering many of the techniques used in diabetes centers around the world. Through several clinical trials, DRI has demonstrated that diabetes can be successfully reversed as a result of islet cell ... | Inclusion Criteria:
1. Participation in any of the following parent studies: 2000/0329; 2000/0196; 2004/0205; 2000/0024; 2006/0200; 2006/0508; 2006/0210
2. A functioning pancreatic islet graft (absence of graft failure as defined in parent study) requiring immunosuppression.
3. Willingness of participants to continue ... | Rodolfo Alejandro | OBSERVATIONAL | null | null | null | [{'name': 'David A Baidal, MD', 'role': 'CONTACT', 'phone': '305 243-7740', 'email': 'dbaidal@med.miami.edu'}] |
NCT06582576 | Gastroparesis, Vomiting, Nausea | Investigation of the Putative Mechanisms Underlying the Symptom-lowering Effect of the Enterra Medical Gastric Electrical Stimulator for Gastroparesis Treatment | RECRUITING | Background: Gastric electrical stimulation applied by a surgically implanted device effectively alleviates upper gastrointestinal symptoms in the majority of individuals with medically refractory gastroparesis. Despite its efficacy, the mechanisms of action have been minimally explored in previous studies, and it is un... | Inclusion Criteria:
* Age 18 and above
* Able to read and understand Danish
* Have an implanted gastric electrical stimulator for treating gastroparesis
* Answering 0 or 1 (non-responders) or 3 or 4 (responders) on the Likert scale describing the symptom improvement gained by gastric electrical stimulation.
* Personal... | University of Aarhus | OBSERVATIONAL | null | null | null | [{'name': 'Ditte Kornum, MD', 'role': 'CONTACT', 'phone': '40517858', 'email': 'Dittiver@rm.dk'}, {'name': 'Asbjørn Drewes, MD', 'role': 'CONTACT', 'phone': '29465969', 'email': 'amd@rn.dk'}] |
NCT06368076 | Spinal Muscular Atrophy | High-intensity Interval Training in Patients With Spinal Muscular Atrophy | RECRUITING | Patients with spinal muscular atrophy who are wheelchair users often experience lower back - and gluteal pain, reduced sleep quality, constipation and reduced quality of life - symptoms that regular exercise could potentially alleviate. However, only very little research has been done on exercise for patients who are w... | Inclusion Criteria:
* Spinal muscular atrophy
* Age: over 15 years
Exclusion Criteria:
* Competing disorders (as arthritis) or other muscle disorders as well as heart- or lung related issues.
* Current psychiatric treatment
* Unable to use the cycle ergometer due to contractures | Rigshospitalet, Denmark | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Sophia Frølich, stud.med', 'role': 'CONTACT', 'phone': '+ 45 3545 3561', 'email': 'sophia.vera.froelich.01@regionh.dk'}, {'name': 'Noémie Receveur, stud.med.', 'role': 'CONTACT', 'phone': '+45 3545 3561', 'email': 'noemie.anne-marie.receveur.03@regionh.dk'}] |
NCT06392776 | COPD, Asthma | Early Diagnosis and Treatment of Undiagnosed Asthma or COPD: THE UCAP 2 TRIAL | RECRUITING | Our research group has found that Canadians with undiagnosed asthma or chronic obstructive pulmonary disease (COPD) have increased respiratory symptoms and worse health-related quality of life.
The investigators recently developed and validated an on-line questionnaire to accurately identify these symptomatic, undiagn... | Inclusion Criteria:
* Individuals at least 18 years old
* Individuals must be symptomatic with respiratory symptoms
* Individuals must complete the UCAP-Q questionnaire and score a ≥ 6% probability of having either asthma or COPD.
* Individuals who have given written informed consent to participate in this trial in ac... | Ottawa Hospital Research Institute | INTERVENTIONAL | RANDOMIZED | PARALLEL | UCAP2 | [{'name': 'Shawn Aaron, MD', 'role': 'CONTACT', 'phone': '6137378259', 'email': 'saaron@toh.ca'}, {'name': 'Kathy Vandemheen, MScN', 'role': 'CONTACT', 'phone': '6137378259', 'email': 'kvandemheen@toh.ca'}] |
NCT06639776 | Transgenderism, Erectile Dysfunction, Prosthesis Durability, Gender Dysphoria, Sexual Dysfunction | Sexual Functioning After Erection Prosthesis Placement in Post Phalloplasty Transgender Persons: a Retrospective Cohort | RECRUITING | This study aims to explore sexual satisfaction among transgender men and their partners following the placement of erectile prostheses after phalloplasty. While phalloplasty can create a neophallus, the lack of natural erectile tissue often necessitates the use of erectile aids, including internal prostheses. However, ... | Inclusion Criteria:
* Patient and partner age ≥ 18 years.
* Transgender or gender non-conforming individuals diagnosed according to the DSM-5 diagnostic criteria for gender dysphoria.
* Patients have undergone phalloplasty as a form of genital gender affirming surgery (any type of flap combination or technique is allo... | University Hospital, Ghent | OBSERVATIONAL | null | null | null | [{'name': 'Wietse Claeys, MD', 'role': 'CONTACT', 'phone': '003293322276', 'email': 'wietse.claeys@ugent.be'}, {'name': 'Anne-Françoise Spinoit, MD, PhD', 'role': 'CONTACT', 'phone': '003293322276', 'email': 'anne-francoise.spinoit@uzgent.be'}] |
NCT05928260 | Type1 Diabetes Mellitus | Comparison of Real-time CGMS With Intermittently-scanned CGMS in Adolescents and Adults With Type 1 Diabetes Mellitus: an Open Label Randomised Control Cross Over Study | RECRUITING | Type 1 Diabetes Mellitus (T1DM) is characterized by absolute insulin deficiency. Despite multiple daily insulin injections, glycemic targets are usually not achieved in T1DM patients.Use of continuos glucose monitoring system (CGMS) is associated with improvement in glycemic control and reduction in glycemic variabilit... | Inclusion Criteria:
1. Adolescents and adults aged 15-40 years with Type-1 Diabetes mellitus defined by any of the following; i. Diabetic Ketoacidosis or ketonemia or ketonuria at diagnosis with insulin dependence for survival since diagnosis OR ii. Insulin dependence for survival since diagnosis and any one of the fo... | Post Graduate Institute of Medical Education and Research, Chandigarh | INTERVENTIONAL | RANDOMIZED | CROSSOVER | null | [{'name': 'Sanjay Bhadada, DM Endo', 'role': 'CONTACT', 'phone': '+919876602448', 'email': 'bhadadask@rediffmail.com'}, {'name': 'Soham Mukherjee, DM Endo', 'role': 'CONTACT', 'phone': '+919914743222', 'email': 'drsoham.mukherjee@googlemail.com'}] |
NCT04092660 | Obstructive Sleep Apnea | Intervention to Enhance Adherence to Mandibular Advancement Appliance in Patients With Obstructive Sleep Apnoea: A Randomized Control Trial | RECRUITING | Obstructive Sleep Apnoea (OSA) is a sleep-related breathing disorder that is characterized by the repeated collapse of the upper airway during sleep, resulting in sleep deprivation. Mandibular Advancement Appliances (MAA) or Oral Appliances (OA) is prescribed for the patients with OSA and they have been shown to be eff... | Inclusion Criteria:
* Adult (≥ 40 years old)
* Confirmed diagnosis of OSA (AHI ≥ 5)
* Referred for MAA therapy
* Must be able to understand, read and write English; with the assistance of a translator
Exclusion Criteria:
* Insufficient teeth for MAA fabrication
* Poor dental and/or periodontal health
* Symptomatic T... | Queen Mary University of London | INTERVENTIONAL | RANDOMIZED | PARALLEL | IPOSAT | [{'name': 'Ama Johal', 'role': 'CONTACT', 'phone': '0207 377 7686', 'email': 'a.s.johal@qmul.ac.uk'}, {'name': 'Harishri Tallamraju', 'role': 'CONTACT', 'phone': '07788128535', 'email': 'h.tallamraju@qmul.ac.uk'}] |
NCT04948060 | Lung Cancer | Tribally Engaged Approaches to Lung Screening (TEALS) | RECRUITING | Lung cancer is the leading cause of cancer mortality among American Indians and Alaska Natives (AI/AN), and AI/AN have worse lung cancer incidence rates, survival, and death compared to the general population. Because lung cancer screening (LCS) with low-dose computed tomography (LDCT) has been shown to reduce lung can... | Inclusion Criteria:
* adults aged 50-80
* 30 pack-year smoking history
* currently smoke or quit in the past 15 years.
Exclusion Criteria:
* Those who are not willing to be screened or followed up with diagnostic testing or intervention, if positive.
* Those who are otherwise designated by their primary care doctors... | University of Oklahoma | INTERVENTIONAL | RANDOMIZED | PARALLEL | TEALS | null |
NCT05336760 | Amyotrophic Lateral Sclerosis | Dysphagia, Quality of Life and Attitudes Towards Percutaneous Endoscopic Gastrostomy in Patients With Amyotrophic Lateral Sclerosis | RECRUITING | In Amyotrophic Lateral Sclerosis, dysphagia has a high incidence. With deterioration of swallowing function, percutaneous endoscopic gastrostomy (PEG) tube is recommended to ensure sufficient and safe oral intake. Dysphagia and PEG placement alter quality of life (QoL). However, QoL and attitudes toward PEG remain larg... | Inclusion Criteria for patients:
* 18 years of age or older
* diagnosis of ALS
* follow-up at University Medical Centre Ljubljana, Division of Neurophysiology, every 3 months
* be able to visit the study site for in-person procedures every 3 months
Inclusion Criteria for relatives:
* at least 18 years of age
Exclus... | University Rehabilitation Institute, Republic of Slovenia | OBSERVATIONAL | null | null | ALSDPEG | [{'name': 'Metka Moharić, MD, PhD', 'role': 'CONTACT', 'phone': '+386 1 4758441', 'email': 'metka.moharic@ir-rs.si'}] |
NCT06788860 | Trigger Finger | Efficacy of Ultrasound-Guided Tri-Directional Needle Knife Release for Trigger Finger | RECRUITING | Efficacy of ultrasound-guided tri-directional needle knife release in treating patients with trigger finger. The study evaluates safety, effectiveness, and recovery outcomes of a minimally invasive procedure compared to conventional approaches. | Inclusion Criteria:
* Idiopathic TF at the level of A1 pulley
* Trigger finger of Green's grades II or III or IV (moderate to severe)
* Symptoms persist for at least three months despite conservative treatments.
* Ability to provide informed consent and comply with follow-up requirements.
Exclusion Criteria:
* Patie... | Mohamed Maher Ismail Ahmed Elashmawy | INTERVENTIONAL | NON_RANDOMIZED | SINGLE_GROUP | UG-NK | null |
NCT06697860 | Plantar Fascia | Comparative Effect of Radial Shockwave Therapy and Graston Instrument Assisted Soft Tissue Mobilization on Plantar Fasciitis | RECRUITING | Plantar fasciitis is a common musculoskeletal disorder characterized by inflammation of the plantar fascia, causing heel pain and discomfort. Various treatment modalities have been explored to alleviate symptoms, with Radial Shockwave Therapy (RST) and Graston Instrument-Assisted Soft Tissue Mobilization (IASTM) emergi... | Inclusion Criteria:
* Both genders (male/female) Age 20 to 45 (25) unilateral chronic plantar fasciitis of more than 3 months Pre diagnosed with chronic plantar fasciitis soreness and local tenderness bottom of the heel. Searing or piercing type pain (26) Pain greater than four on the visual analogue scale (VAS) durin... | Riphah International University | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Imran Imran Amjad, Phd', 'role': 'CONTACT', 'phone': 'imranamjad@ripha.edu.pk', 'phoneExt': '03324390125', 'email': 'imranamjad@riphah.edu.pk'}, {'name': 'Imran Imran Amjad, PhD', 'role': 'CONTACT', 'phone': '051 5481826', 'email': 'imranamjad@riphah.edu.pk'}] |
NCT06683274 | Pilonidal Sinus | Bascom Cleft Lift for Primary Wound Healing in Complex and Recurrent Sacrococcygeal Pilonidal Sinus Disease | RECRUITING | The goal of this observational study is to improve care for patients with complex or recurrent pilonidal sinus disease by developing and implementing a best practice care pathway, including a standardized cleft lift operation.
The main question it aims to answer is: Does a best practice care pathway with standardized ... | Inclusion Criteria:
* 16 years of age and older
* Symptomatic complex or recurrent pilonidal sinus disease
* Planned for surgical treatment
* Signed informed consent
Exclusion Criteria:
* Pregnant
* Insufficient understanding of the Dutch language or otherwise unable to give consent | Albert Schweitzer Ziekenhuis, Netherlands | OBSERVATIONAL | null | null | BATCRAC | [{'name': 'Max Goudberg, MD', 'role': 'CONTACT', 'phone': '+31622577653', 'email': 'm.r.goudberg@asz.nl'}] |
NCT04676360 | Relapsed Plasmablastic Lymphoma, Refractory Plasmablastic Lymphoma, Anaplastic Lymphoma Kinase Positive Large B-Cell Lymphoma | A Multicenter Phase 2 Study of Belantamab Mafodotin in Relapsed or Refractory Plasmablastic Lymphoma and ALK+ Large B-cell Lymphoma | RECRUITING | In this research study is looking to see how safe and effective belantamab mafodotin is in relapsed or refractory plasmablastic lymphoma or ALK+ large B-cell lymphoma.
* This research study involves the study drug belantamab mafodotin.
* Belantamab mafodotin is an antibody-drug conjugate (ADC), which is the combinatio... | Inclusion Criteria:
* Participants must have relapsed or refractory plasmablastic lymphoma or ALK+ large Bcell lymphoma by WHO criteria.
* Participants must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter \[LDi\] to be recorded for non... | Jacob Soumerai, MD | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Jacob Soumerai, MD', 'role': 'CONTACT', 'phone': '(617) 724-4000', 'email': 'jsoumerai@mgh.harvard.edu'}] |
NCT06450860 | Nutrition Assessment, Food Insecurity | Developing and Testing a Nutrition Support Assessment Tool - An Implementation Trial | RECRUITING | The research team developed the Nutrition Support Assessment Tool (NSAT) that incorporates key patient life information (e.g., ability to cook, access to refrigerator/stove, medical conditions and nutritional status) to facilitate individualized nutrition referral. The overall goal of this study is to refine and test t... | Inclusion Criteria:
* 18 years of age or older
* Currently admitted to Thomas Jefferson University or Methodist Hospital or Emergency Department
* Has working phone number and is willing to participate in follow-up data collection
* Eats by mouth
* Lives in MANNA's geographic service area
* Patient reports food insecu... | Thomas Jefferson University | INTERVENTIONAL | null | SINGLE_GROUP | NSAT | [{'name': 'Nina Diamond, MPH', 'role': 'CONTACT', 'phone': '267-872-1302', 'email': 'Nina.Diamond@jefferson.edu'}] |
NCT03720860 | Sepsis, Surgery, Acute Kidney Injury | Prospective Studie of Inflammatory Markers in Urine, Plasma and Sputum Associated With Acute Kidney Injury | RECRUITING | Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory respons... | Inclusion Criteria:
Patients admitted to the intensive/post operative care unit
* with septic shock or
* post major surgery or
* after intoxication with a chemical compund
Exclusion Criteria:
* Pregnancy or
* Breast feeding or
* Chronic kidney disease or
* intoxication with nephrotoxic compund or
* lack of informed... | Uppsala University | OBSERVATIONAL | null | null | PronMed | [{'name': 'Sara Bulow, MD', 'role': 'CONTACT', 'phone': '+46730247414', 'email': 'sara.bulow.anderberg@akademiska.se'}] |
NCT06394076 | Infraorbital Hollowing | A Multicenter, Evaluator-blinded, Randomized, No-treatment Controlled Study to Evaluate the Safety and Effectiveness of MAILI PRECISE With Lidocaine Injectable Gel for Correction of Infraorbital Hollowing in Chinese Population | RECRUITING | A Multicenter, Evaluator-blinded, Randomized, No-treatment Controlled Study to Evaluate the Safety and Effectiveness of MAILI PRECISE With Lidocaine Injectable Gel for Correction of Infraorbital Hollowing in Chinese Population | Inclusion Criteria:
1. Aged 18 or above (subject to the time of signing the informed consent form) , gender is not limited;
2. According to Allergan Infraorbital Rim Scale (AIHS), the subjects were judged by blinded evaluator as having "moderate" or "severe" infraorbital rim hallowing (grade 2-3) in each eye, and both... | Sinclair Pharmaceuticals Limited | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'MENG YAN', 'role': 'CONTACT', 'phone': '020-89168071', 'email': 'clinical.development@sinclairaesthetics.com'}, {'name': 'ZHONGXING ZHANG', 'role': 'CONTACT', 'phone': '020-89168071', 'email': 'Medical.Committee@sinclairaesthetics.com'}] |
NCT05378776 | Gastroenteritis Acute, Vomiting | Triage Administration of Sucrose for Gastroenteritis in Children; a Randomized Controlled Trial | RECRUITING | Background: Acute viral gastroenteritis is a very common pediatric medical condition that results in a large number of emergency department (ED) visits. Fasting-induced ketosis has been suggested to contribute to nausea and vomiting in children with VGE. To date, there is no data on the impact of oral sucrose intake du... | Inclusion Criteria:
* Children aged 6 months to 6 years. We will restrict to this age group to have a more homogenous group.
* At least 3 non-bilious, non-bloody, vomiting in the last 24 hours
* No other diagnostic more likely than acute viral gastroenteritis suspected at triage
Exclusion Criteria:
* Severe dehydrat... | Jocelyn Gravel | INTERVENTIONAL | RANDOMIZED | PARALLEL | STAGE | [{'name': 'Jocelyn Gravel, MD', 'role': 'CONTACT', 'phone': '15143454931', 'phoneExt': '2559', 'email': 'graveljocelyn@hotmail.com'}, {'name': "Soha Rached-D'Astous, MD", 'role': 'CONTACT', 'phone': '15143454931', 'email': 'soha.rached-dastous.med@ssss.gouv.qc.ca'}] |
NCT04564976 | Fear, Anxiety | Can Social Support Figures Enhance Fear Extinction in Patients with Social Anxiety? | RECRUITING | University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to prevent the acquisition of fear in healthy partici... | Inclusion Criteria:
* healthy adults 18 and 35
* fluent in English
* no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional)
* diagnosis of social anxiety disorder (anxious participants: allowed co... | University of California, Los Angeles | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Erica Hornstein, PhD', 'role': 'CONTACT', 'phone': '9175664470', 'email': 'ericahornstein@ucla.edu'}, {'name': 'Naomi Eisenberger, PhD', 'role': 'CONTACT'}] |
NCT06703476 | Bladder Cancer | A Clinically Integrated Randomized Clinical Trial (RCT) of Modifications to Radical Cystectomy and Postoperative Care | RECRUITING | The purpose of this study is to look at two standard surgical techniques used during a radical cystectomy and see whether they influence outcomes such as length of stay in the hospital and infections after surgery. This trial will evaluate whether the following surgical methods influence outcomes:
A ureteral stent is ... | Inclusion Criteria:
Stent vs. no stent
* Patients aged ≥21 years who are scheduled to undergo radical cystectomy for treatment of bladder cancer with one of the consenting surgeons at MSK Alvimopan vs. no alvimopan
* Patients aged ≥21 years who are scheduled to undergo radical cystectomy for treatment of bladder canc... | Memorial Sloan Kettering Cancer Center | INTERVENTIONAL | RANDOMIZED | FACTORIAL | null | [{'name': 'Alvin Goh, MD', 'role': 'CONTACT', 'phone': '646-422-4667', 'email': 'goha@mskcc.org'}, {'name': 'Bernard Bochner, MD', 'role': 'CONTACT', 'phone': '646-422-4387'}] |
NCT05439876 | Epilepsy in Children | Getting SMART for Pediatric Epilepsy (Sleep, Melatonin, and Research Trial, SMART) | RECRUITING | The purpose of this study is to evaluate the effect of melatonin for improving sleep in pediatric epilepsy. | Inclusion Criteria:
- Children aged between 1 and 18 years with a confirmed diagnosis of epilepsy and with sleep problems
Exclusion Criteria:
* Children who are bedridden with limited mobility
* Children with liver or kidney dysfunction
* Children on medication for sleep or mood problems within 4 weeks before the ba... | National Taiwan University Hospital | INTERVENTIONAL | RANDOMIZED | CROSSOVER | null | [{'name': 'Shao-Yu Tsai', 'role': 'CONTACT', 'phone': '2312-3456', 'phoneExt': '88904', 'email': 'stsai@ntu.edu.tw'}, {'name': 'Sabrina Lai', 'role': 'CONTACT', 'phone': '2312-3456', 'phoneExt': '88904', 'email': 'sabrina0530s@gmail.com'}] |
NCT05157776 | NSCLC, Stage IIIA, EGF-R Negative Non-Small Cell Lung Cancer, ALK Negative NSCLC | Neoadjuvant Sintilimab and Platinum-based Chemotherapy for Resectable Locally Advanced NSCLC Harboring no Driver Mutations: A Prospective, Randomized, Multicenter Phase III Trial | RECRUITING | This is a randomized, open-label study designed to evaluate the safety and efficacy of neoadjuvant PD-1 antibody plus chemotherapy followed by surgery in resectable stage IIIA non-small cell lung cancer.
The primary endpoint: pCR rate The second endpoint: MPR, DFS, MRD | Inclusion Criteria:
1. Resectable stage IIIA NSCLC, EGFR mutation-negative and ALK rearrangement negative (8th UICC TNM staging);
2. No prior anti-tumor therapy for NSCLC;
3. Age from 18 to 75 years old;
4. Adequate organ function:
Hemoglobin ≥9.0g/L; White blood cell count 4.0\~10×109/L; The absolute value of neu... | Tongji University | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Jiang Fan, MD', 'role': 'CONTACT', 'phone': '15901013210', 'email': 'fan_jiang@tongji.edu.cn'}, {'name': 'Dong Lin, MD', 'role': 'CONTACT', 'phone': '18121299433', 'email': 'dlin2014@126.com'}] |
NCT06062576 | Diabetic Foot, Therapeutics | Clinical Efficacy Observation and Mechanism Study of Yunnan Baiyao in Different Stages of Diabetic Foot | RECRUITING | Yunnan Baiyao has been treating all kinds of wounds for 120 years, but the evidence of Evidence-based medicine that is truly convincing is insufficient, making its best application method unclear. This study explored the possible indications and use methods of Yunnan Baiyao in different stages of Diabetic foot, and obt... | Inclusion Criteria:
1. The age of the subjects is 18-80 years old;
2. Diagnose diabetes according to WHO standards;
3. Diagnosis of Diabetic foot;
4. Confirmed as one of the stages of infection progression and granulation growth;
5. Voluntarily participate in this study and sign an informed consent form.
Exclusion Cr... | Peking University Third Hospital | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | null |
NCT05067374 | Hepatitis C, Breast Cancer | Screening for the Hepatitis C Virus by TROD Paired With Mammography and Management of Chronic Hepatitis C in Women Aged 50 to 74 in the Agglomeration of Montpellier | RECRUITING | In France, a breast cancer screening is organized since 2004 for women aged 50-74. On the other hand, even though the seroprevalence of hepatitis C in the general French population is less than 1%, it is estimated that more than 75,000 people live with the virus without knowing it. To answer the WHO objective of elimin... | Inclusion Criteria:
* - Women aged 50-74 inclusive
* Doing a breast cancer screening
* Able to understand and complete a questionnaire on their own or with the help of a third party
* Able to understand the study and follow the protocol
* Having signed the consent form
* With social security plan
Exclusion Criteria:
... | University Hospital, Montpellier | OBSERVATIONAL | null | null | Mammo'C | [{'name': 'Helene DONNADIEU RIGOLE, MH PD', 'role': 'CONTACT', 'phone': '04 67 33 70 20', 'email': 'h-donnadieu_rigole@chu-montpellier.fr'}] |
NCT04619576 | Occupational Health | Influence of the COVId-19 Pandemic on STRESS of Occupational Health Workers | RECRUITING | Coronavirus has caused containment of more than half of the world's population and a major and rapid reorganization of clinical and support services. The spread of coronavirus (COVID-19) has posed significant challenges for occupational health services. However, there is currently no data on the influence of this epide... | Inclusion Criteria:
* All volunteers who are screened
Exclusion Criteria:
* None | University Hospital, Clermont-Ferrand | OBSERVATIONAL | null | null | COVISTRESSWork | [{'name': 'Lise Laclautre', 'role': 'CONTACT', 'phone': '0473754963', 'email': 'promo_interne_drci@chu-clermontferrand.fr'}] |
NCT06863376 | Non-Alcoholic Fatty Liver Disease | Evaluating the Safety and Efficacy of Carbocisteine in the Treatment of Nonalcoholic Fatty Liver Disease Patients | RECRUITING | Nonalcoholic fatty liver disease (NAFLD) is a global public health concern, and the leading cause of chronic liver disease, especially in developed countries. NAFLD is characterized by lipid accumulation in the liver not attributed to other causes. Lifestyle interventions, including dietary modification and exercise, r... | Inclusion Criteria:
* Either male or female adult patients (\>18 years) with fatty liver diagnosis by using upper abdominal ultrasound echography
Exclusion Criteria:
* Pregnant and/or lactating women
* Excessive alcohol use (defined as an average alcohol intake \> 30 g per day in men and \> 20 g per day in women)
* ... | Tanta University | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | null |
NCT06436976 | Pancreatic Cancer, Colon Cancer | The Effect of Probiotics ATG-F4 in Cancer Patients | RECRUITING | Patients with advanced colorectal cancer or pancreatic cancer who are receiving oxaliplatin-based chemotherapy will be included. The research participants in this study will consume probiotics along with safety and anti-cancer agent side effect-related questionnaires, blood, and fecal sample collection for up to 12 wee... | Inclusion Criteria:
* Patients diagnosed with advanced colorectal cancer or pancreatic cancer who are undergoing treatment with Oxaliplatin-based chemotherapy at Chungnam National University Hospital, including both newly diagnosed and recurrent cases.
* Aged 19 years or older.
* Eastern Cooperative Oncology Group (EC... | Chungnam National University Hospital | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Hyewon Ryu, Professor', 'role': 'CONTACT', 'phone': '82 + 42 280 6834', 'email': 'ryhw001@naver.com'}, {'name': 'Sora Kang, clinical professor', 'role': 'CONTACT', 'email': 'sorakang0515@gmail.com'}] |
NCT06661876 | Heart Failure, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy | Cardiac RadiothErapy for HEart FaiLure | RECRUITING | Preliminary data suggests that patients suffering from advanced refractory heart failure (HF) could benefit from single low dose whole heart external beam radiotherapy (EBRT).
Objective: To explore in our center the efficacy of administering a EBRT treatment of 5Gy to the whole heart in patients with advanced and refr... | Inclusion Criteria:
* Patient ≥ 18 years
* Advanced refractory HF NYHA III and IV class
* Stable HF for the last 6 months with maximal guideline-directed HF therapy
* Ischemic or dilated cardiomyopathy
* LVEF at baseline ≤ 35%
* Ability to give a written informed consent and willingness to return for follow-up
Exclus... | Universitaire Ziekenhuizen KU Leuven | INTERVENTIONAL | null | SINGLE_GROUP | CREFEL | [{'name': 'Patrick Berkovic, MD PhD', 'role': 'CONTACT', 'phone': '+32 16 34 51 15', 'email': 'patrick.berkovic@uzleuven.be'}, {'name': 'Bert Vandenberk, MD PhD', 'role': 'CONTACT', 'phone': '+32 16 33 86 86', 'email': 'bert.vandenberk@uzleuven.be'}] |
NCT03561376 | Surgical Incision, Surgery--Complications, Surgical Wound, Surgical Site Infection, Scar, Hypertrophic Scar | Zinc Oxide Versus Petrolatum Following Skin Surgery: a Head-to-head, Prospective, Split-scar Study | RECRUITING | Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respect... | Inclusion Criteria:
1. ≥ 18 years of age
2. Linear closure, non-scalp site
3. ≥ 4.5 cm in length (final incision/closure length)
4. End to end symmetry (surgical site is not grossly asymmetric from end to end)
5. Grossly uninfected site
Exclusion Criteria:
1. ≤ 18 years
2. Visibly asymmetric linear scar
3. Grossly i... | University of Pittsburgh | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Lauren Crow, MD', 'role': 'CONTACT', 'phone': '4126474279', 'email': 'crowld@upmc.edu'}] |
NCT06098560 | Colorectal Cancer | Study on the Clinical Potential of Circulating Tumor DNA in Advanced or Locally Advanced dMMR/MSI-H Colorectal Patients Treated With Immunotherapy | RECRUITING | dMMR/MSI-H colorectal cancer patients are the dominant population of immunotherapy/neoadjuvant immunotherapy, but imaging evaluation of immunotherapy efficacy is insufficient. There are some cases, although no disease remission was found on imaging,pathological complete response (pCR) was confirmed after surgery. Meanw... | Inclusion Criteria:
- advanced or locally advanced dMMR/MSI-H colorectal cancer Expected to receive/be receiving immune checkpoint inhibitor therapy ECOG performance score is 0-1, life expectancy ≥12 weeks
Exclusion Criteria:
- The presence of other uncured malignancies Patients with one or more serious concomitant ... | Geneplus-Beijing Co. Ltd. | OBSERVATIONAL | null | null | null | [{'name': 'Xiaoyan Zhou, PhD', 'role': 'CONTACT', 'phone': '+86 13524324387', 'email': 'xyzhou100@163.com'}, {'name': 'Junjie Peng, PhD', 'role': 'CONTACT', 'phone': '+86 13917373312', 'email': 'pengjj@shca.org.cn'}] |
NCT05015660 | Pacemaker DDD, Heart Block | LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure | RECRUITING | High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ej... | Inclusion Criteria:
1. Age ≥ 18 years
2. Patients with an ejection fraction of \>35%
3. Patients with an indication for ventricular pacing and high-degree atrioventricular block where the degree of anticipated RV pacing is \>90% including:
1. Third degree AV block
2. Symptomatic or asymptomatic second-degree AV... | McGill University Health Centre/Research Institute of the McGill University Health Centre | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Jacqueline Joza, MD MSc', 'role': 'CONTACT', 'phone': '514-934-1934', 'phoneExt': '43158', 'email': 'jacqueline.joza@gmail.com'}, {'name': 'Fiorella Rafti, PhD', 'role': 'CONTACT', 'phone': '514-934-1934', 'email': 'fiorella.rafti@mail.mcgill.ca'}] |
NCT05971160 | Psychological Distress | Creating Access to Resources and Economic Support | RECRUITING | The goal of this study is to test the ability of small grants and/or peer support to improve mental health among transgender people experiencing material hardship. The main questions the study will answer are:
1. Do microgrants with or without peer mentoring improve mental health?
2. Do microgrants with or without pee... | Inclusion Criteria:
* age 18 years or older
* gender identity different from sex assigned on original birth certificate
* access to a mobile phone or email
* score \> 0 on the material hardship index
Exclusion Criteria:
* inability to provide informed consent in English | Duke University | INTERVENTIONAL | RANDOMIZED | PARALLEL | CARES | [{'name': 'Jennifer Williams, PhD', 'role': 'CONTACT', 'phone': '919-660-1693', 'email': 'jennifer.williams@duke.edu'}, {'name': 'Tonia C Poteat, PhD', 'role': 'CONTACT', 'phone': '919-684-9303', 'email': 'tonia.poteat@duke.edu'}] |
NCT06207760 | Depression | Targeting Inflammation in Depression Using Minocycline: a Patient Stratification Approach Using Peripheral Inflammatory Biomarkers, PET and MRI | RECRUITING | The study aims to evaluate or to assess:
* An improvement in the peripheral inflammatory levels in depressed patients after 8 weeks of treatment with Minocycline in addition to their current antidepressant treatment;
* Any improvements in depressive symptoms after 8 weeks of treatment with Minocycline given as adjuvan... | Inclusion Criteria:
1. Being male or female depressed patients (aged 25-45);
2. Having a current DSM-V diagnosis of non-psychotic major depressive disorder confirmed by SCID;
3. Being non-responder to a current SSRI for at least 8 weeks, and historically to one other SSRI;
4. Being in stable antidepressant therapy for... | IRCCS Centro San Giovanni di Dio Fatebenefratelli | INTERVENTIONAL | null | SINGLE_GROUP | null | null |
NCT06389760 | Pancreatic Cancer | Nimotuzumab Combined With mFOLFIRINOX/GX as Postoperative Adjuvant Therapy in Pancreatic Cancer: a Prospective, Multicenter, Single-arm, Open-label Study | RECRUITING | This is a prospective, multicenter, single-arm, open-label study. The main purpose of the study is to evaluate the efficacy and safety of Nimotuzumab combined with mFOLFIRINOX/GX for postoperative adjuvant treatment of pancreatic cancer. | Inclusion Criteria:
* 1. Age 18 years or older, gender unlimited;
* 2. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1;
* 3. Had undergone complete macroscopic resection for pancreatic cancer (R0 or R1 resection) with histological confirmation and with no evidence of distant metastasis as demons... | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Juan Du, MD', 'role': 'CONTACT', 'phone': '86-25-83106666', 'email': 'dujuanglyy@163.com'}] |
NCT06398574 | Shoulder Pain | Effect of Dry Needling Technique on Shoulder Muscle Functionality in Subjects With and Without Shoulder Pain. | RECRUITING | The main objective of this study will be to evaluate the effects of the application of the dry needling technique on the activity of the rotator cuff muscles in the shoulder.
The evaluation of the effects of the application of the dry needling technique will be carried out in subjects with and without shoulder pain.To... | Inclusion Criteria:
* Subjects of legal age
* Subjects without shoulder pain or with unilateral shoulder pain of \> 3 months duration.
* Have shoulder mobility of 90º of abduction and at least 30º of glenohumeral external rotation.
Exclusion Criteria:
* Have neck pain.
* Whiplash
* Having had trauma to the shoulder.... | University of Alcala | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Marina Ortega-Santamaria, PhD student', 'role': 'CONTACT', 'phone': '(+34) 683 378 391', 'email': 'marinaortegasantamaria@gmail.com'}, {'name': 'Centro Investigacion Fisioterapia y Dolor', 'role': 'CONTACT'}] |
NCT06323460 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC V8, Oropharyngeal Squamous Cell Carcinoma | A Pilot Study of Adaptive De-Intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer | RECRUITING | This phase II trial studies how well using circulating tumor deoxyribonucleic acid (DNA) to guide lower dose radiation therapy works in treating patients with human papillomavirus infection (HPV)-associated oropharyngeal cancer. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer c... | Inclusion Criteria:
* Pathologically confirmed diagnosis of squamous cell carcinoma of the oropharynx (unknown primary, base of tongue, tonsil, oropharyngeal walls, soft palate). Cytologic or fine needle aspiration (FNA) confirmation is sufficient if a biopsy of the primary tumor is not feasible
* P16 positive immunoh... | Ohio State University Comprehensive Cancer Center | INTERVENTIONAL | NON_RANDOMIZED | PARALLEL | null | null |
NCT06127160 | Pyelonephritis Acute | Personalized Antibiotic Treatment in the Emergency Department: Panther Trial | RECRUITING | This pilot study will randomize 40 female patients with acute uncomplicated pyelonephritis to receive standard duration of therapy versus patient-directed antimicrobial duration (PDAD). The primary objectives of this pilot trial are to determine the feasibility and safety of conducting a full-scale multi-center randomi... | Inclusion:
* Females between 18 and 55 years of age
* Diagnosis of acute uncomplicated pyelonephritis
* Can be discharged home on oral antimicrobial treatment
* Ability to provide written informed consent in English or Spanish
Exclusion:
* Took antibiotics in the prior 48 hours
* Insulin-dependent diabetes
* End-sta... | Brett A Faine | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Brett Faine, PharmD', 'role': 'CONTACT', 'phone': '+1 319 356 2577', 'email': 'brett-faine@uiowa.edu'}] |
NCT04409860 | Cervical Cancer | Randomized Controlled Trial of the Efficacy of Adjuvant Chemotherapy in Patients With Residual Lesions After Concurrent Radiochemotherapy for Locally Advanced Cervical Cancer | RECRUITING | The aim of this trial was to evaluate the efficacy of adjuvant chemotherapy in the locally advanced cervical cancer with residual lesions after concurrent chemoradiation therapy. | Inclusion Criteria:
1. Cervical cancer stage IIb to IVa with histopathology of squamous cell carcinoma, adenosquamous cell carcinoma, adenocarcinoma
2. Complete CCRT(Radiation Does: A point 85Gy(+/-10%)，B点50Gy(+/-10%)，concurrent platinum-containing chemotherapy (cisplatin or carboplatin))
3. MRI is performed within 4 ... | Chongqing University Cancer Hospital | INTERVENTIONAL | RANDOMIZED | PARALLEL | CQGOG0102 | [{'name': 'Dongling Zou, M.D.', 'role': 'CONTACT', 'phone': '13657690699', 'email': 'cqzl_zdl@163.com'}] |
NCT06783660 | Alveolar Ridge Augmentation | A Multicenter, Open-label, Randomized, Independent Evaluation, Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of the Periodontal Tissue Inducing Photoresponsive PeptiCol EZgraft in the Extraction Socket Preservation Process After Tooth Extraction. | RECRUITING | This clinical trial aims to compare the efficacy and safety of applying "PeptiCol EZgraft" in extraction socket preservation procedures against "Regenomer," in terms of reducing the amount of alveolar bone change during the healing process following tooth extraction. | Inclusion Criteria:
1. Adults aged 19 to 75 years.
2. Systemically healthy or with mild systemic disease, classified as ASA I or II.
3. Planning to place implants in the maxilla or mandible after extraction, or having such plans for the future. If there are multiple extraction sockets, only one socket will be included... | NIBEC Co., Ltd. | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Park Shin young', 'role': 'CONTACT', 'phone': '82 + 262563354', 'email': 'nalby99@snu.ac.kr'}] |
NCT05958160 | Epileptic Spasms, Failed Hormonal Therapy | Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study | RECRUITING | This study has been planned to compare the efficacy and tolerability of topiramate, a commonly used second line agent, with modified Atkins diet in children with epileptic spasms refractory to hormonal treatment, in a randomized open label study. | Inclusion Criteria:
1) Age: 9 months to 3 years 2) Diagnosis of infantile epileptic spasms syndrome as per the ILAE 2022 diagnostic criteria 3) Failure of hormonal therapy, i.e. oral prednisolone or ACTH
-
Exclusion Criteria:
1) Known or suspected inborn error of metabolism 2) Prior use of the ketogenic or modified... | Lady Hardinge Medical College | INTERVENTIONAL | RANDOMIZED | PARALLEL | TOPAMAD | [{'name': 'Suvasini Sharma, MD, DM', 'role': 'CONTACT', 'phone': '9910234344', 'phoneExt': '0091', 'email': 'sharma.suvasini@gmail.com'}, {'name': 'Sharmila B Mukherjee, MD', 'role': 'CONTACT', 'phone': '9818158699', 'phoneExt': '0091', 'email': 'theshormi@gmail.com'}] |
NCT06531460 | Lung Cancer, Surgery | Effect of Perioperative Nutrition Enriched With Omega-3 on the Incidence of Infections in Oncologic Patients Following Lung Resection | RECRUITING | The aim of this study is to analyze the effect of enriched formula with omega-3 in the 30-day incidence infection and inflammatory response following lung resection surgery in lung cancer patients. | Inclusion Criteria:
* Lung cancer diagnosis
* Elective surgery for lung resection schedule at least four days before surgery
* Signed informed consent.
Exclusion Criteria:
* Acute or chronic organ failure as hepatic or renal insufficiency
* Patients with fish-allergy
* History of any surgery within 3 months
* Immuno... | National Institute of Respiratory Diseases, Mexico | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Ivan A Osuna-Padilla, PhD', 'role': 'CONTACT', 'phone': '5487-1700', 'phoneExt': '5059', 'email': 'ivan.osuna@iner.gob.mx'}, {'name': 'Ana L Gómez-Rodriguez, MSc', 'role': 'CONTACT', 'phone': '5487-1700', 'phoneExt': '5059', 'email': 'grolucia@yahoo.es'}] |
NCT05802160 | Parenting Practices, Co-parenting Practices, Child Eating and Dietary Behaviors, Child Physical Activity/active Play/outdoor Play, Child Screen Time | A Good Start Matters for Parents and Children: an MHealth Parenting Intervention to Promote a Healthy Child Development | RECRUITING | Early childhood is an important period where the family can support the development and maintenance of healthy eating and active behaviors to prevent or reduce childhood obesity. With this ultimate goal, we designed the Good Start Matters - Parenting program, which aims to engage families in positive parenting practice... | Inclusion Criteria:
Children must be:
* Attending a childcare center invited to participate in the Good Start Matters study.
* Older than 2.5 and younger than 6 years
Parents must:
* Be the primary caregiver/legal guardian of an eligible child OR share childrearing responsibilities with an already enrolled primary ... | University of British Columbia | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Louise Masse, PhD', 'role': 'CONTACT', 'phone': '604 875 2000', 'phoneExt': '5563', 'email': 'lmasse@bcchr.ubc.ca'}, {'name': 'Olivia de Jongh, PhD', 'role': 'CONTACT', 'phone': '6048752000', 'phoneExt': '6393', 'email': 'olivia.djgonzalez@bcchr.ca'}] |
NCT06270160 | Financial Stress, Social Functioning, Social Skills | Tushirikiane-4-Uthabiti (Supporting Each Other For Resilience) | RECRUITING | Displaced and refugee youth in Uganda are more vulnerable to health risks due to financial insecurity. As such, the investigators aim to explore the utility of an intervention aimed at improving livelihoods, called Creating Futures. Creating Futures is a group intervention that aims to help young people build their liv... | Inclusion Criteria:
* Living in one of the five selected Kampala informal settlements (Kabalagala, Kansanga, Katwe, Nsambya, or Rubaga)
* Identify as a displaced person, refugee, or as having a refugee or displaced parent(s)
* Aged 16-25 years
* Own or have daily access to a mobile phone
* Speak French, English, Kirun... | University of Toronto | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Carmen Logie, PhD', 'role': 'CONTACT', 'phone': '6474544203', 'email': 'carmen.logie@utoronto.ca'}, {'name': 'Moses Okumu, PhD', 'role': 'CONTACT', 'phone': '6476067832', 'email': 'okumu@illinois.edu'}] |
NCT04981860 | Eye Infections, Bacterial | Comparison of Conjunctival Antimicrobial Activity and Patient Comfort Between Topical Hypochlorous Acid (Avenova) and Betadine | RECRUITING | The purpose of this research study is to find out how Avenova (0.01 % hypochlorous acid) works compared to Betadine (Povidone iodide) for reducing bacteria and patient discomfort in the eyes. | Inclusion criteria:
Treatment Naïve patients:
- Any patient who is able to give consent for the study and did not receive an intravitreal injection in the past 6 months
Patients receiving injections:
- Patient currently undergoing treatment for which he/she receives a intravitreal injection in one eye.
Exclusion C... | University of Miami | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Marilyn Marquez, MD', 'role': 'CONTACT', 'phone': '919-943-2314', 'email': 'mam8757@med.miami.edu'}] |
NCT06749860 | Lung Cancer | Disitamab Vedotin in Combination with Tislelizumab and Bevacizumab in a Phase II Clinical Study of Locally Advanced or Metastatic Non-small Cell Lung Cancer with HER2 Mutation/amplification/expression | RECRUITING | The goal of this clinical trial is to learn ifDisitamab Vedotin in combination with tislelizumab and bevacizumab can treat in locally advanced or metastatic non-small cell lung cancer patients with HER2 mutation/amplification/expression. The main questions it aims to answer are:
1. objective response rate;
2. Progress... | Inclusion Criteria:
1. Prior to the implementation of any trial-related procedures, written informed consent must be obtained;
2. Aged \>= 18 years;
3. Patients with locally advanced (Stage III B/III C), metastatic, or recurrent (Stage IV) non-small cell lung cancer (NSCLC) confirmed histologically or cytologically, w... | Shanghai Pulmonary Hospital, Shanghai, China | INTERVENTIONAL | NON_RANDOMIZED | PARALLEL | null | [{'name': 'Chunxia Su, doctor', 'role': 'CONTACT', 'phone': '+8613601899076', 'email': 'susu_mail@126.com'}] |
NCT06334874 | Community-acquired Pneumonia | Study of the Efficacy and Safety of Astaxanthin as an Adjuvant Therapy for Community Acquired Pneumonia Patients. | RECRUITING | Community acquired pneumonia (CAP) is one of the most common and morbid conditions encountered in clinical practice, which causes serious morbidity worldwide. In CAP, oxidative stress is linked to inflammation, demonstrated by increased production of interleukin (IL)-6 and tumor necrosis factor (TNF)-α, which attract i... | Inclusion Criteria:
* Age ≥ 18 year
* Clinical: Having symptoms suggestive of CAP such as cough (with or without sputum), fever (\> 38.5°C), pleuritic chest pain or dyspnea.
* Radiologic: consolidations on computed Tomography (CT).
Exclusion Criteria:
* Advanced age (≥70 years old). Presence of severe immunosuppress... | Future University in Egypt | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'fatma makram', 'role': 'CONTACT', 'phone': '01015000329', 'email': 'fatma.aboelhassan@fue.edu.eg'}, {'name': 'eman elmokadam', 'role': 'CONTACT', 'email': 'Eman.abdellatif@fue.edu.eg'}] |
NCT06484660 | Fistula Perianal | Efficacy Of Minimally Invasive Approach In The Mucosal Advancement Flap Technique For The Surgical Treatment Of Previously Untreated Complex Perianal Fistula | RECRUITING | The goal of this clinical trial is to study whether the minimally invasive approach in the mucosal advancement flap technique for the treatment of complex perianal fistula improves the healing rate compared to non-minimally invasive surgery.
The main question it aims to answer is:
- Does the healing rate of patients ... | Inclusion Criteria:
* Age older than 18.
* Present with a complex perianal fistula not surgically treated with curative intention.
* Present only one main fistulous tract.
* Mucosal advancement flap as the chosen technique for the treatment of the fistula.
* Patient has given informed consent to participate in the stu... | Hospital Son Llatzer | INTERVENTIONAL | null | SINGLE_GROUP | null | [{'name': 'Ignacio Fernández_Hurtado', 'role': 'CONTACT', 'phone': '+34871202000', 'phoneExt': '2134', 'email': 'ifernandez@hsll.es'}] |
NCT05026060 | Cerebral Arteriopathy | Measurement of Brain Perfusion by a Magnetic Resonance (MR) Perfusion Imaging Called eASL in Children's Cerebral Arteriopathies. | RECRUITING | The MR sequence called MR-ASL is used to measure cerebral perfusion in children. This ASL sequence is used with a unique post-labeling delay (PLD) due to the technical impossibility of setting different post-labeling delays. The use of a single post-labeling, chosen by the pediatric radiology department of the Necker h... | Inclusion Criteria:
* Minor patients aged 0 to 18 with acute or chronic arterial disease: diagnosis of Moya-moya, diagnosis of sickle cell disease, acute and chronic arterial infarction.
* Necessity of diagnostic MR with standard ASL sequences for the care.
* Holders of parental authority and patients informed and not... | Assistance Publique - Hôpitaux de Paris | OBSERVATIONAL | null | null | PEACE | [{'name': 'Nathalie BODDAERT, MD, PhD', 'role': 'CONTACT', 'phone': '1 71 39 65 30', 'phoneExt': '+33', 'email': 'nathalie.boddaert@aphp.fr'}, {'name': 'Hélène Morel', 'role': 'CONTACT', 'phone': '1 44 38 16 53', 'phoneExt': '+33', 'email': 'helene.morel@aphp.fr'}] |
NCT05861960 | Osteo Arthritis Shoulders, Osteoarthritis Shoulder | Endogenous Pain Modulation in Patients With Shoulder Arthroplasty for Osteoarthritis | RECRUITING | Rationale: Although most patients experience significant pain relief after total shoulder arthroplasty (TSA), pain persists for some patients even after surgery. The endogenous pain system may be involved in persisting postoperative pain in total knee arthroplasty (TKA) and total hip arthroplasty (THA) patients, but th... | Inclusion Criteria:
* Age ≥ 18 yrs
* Scheduled to undergo primary total shoulder arthroplasty (TSA) or reversed shoulder arthroplasty (RSA) for primary shoulder osteoarthritis or cuff tear arthropathy
* American Society of Anesthesiologists score 1, 2 or 3
* Able to provide written informed consent
Exclusion Criteria... | Reinier Haga Orthopedisch Centrum | OBSERVATIONAL | null | null | EPM | [{'name': 'Brechtje Hesseling, MSc', 'role': 'CONTACT', 'phone': '+31792065595', 'email': 'onderzoek@rhoc.nl'}, {'name': 'Roos Bazuin, BSc', 'role': 'CONTACT', 'phone': '+31792065595', 'email': 'onderzoek@rhoc.nl'}] |
NCT06075576 | Myopia | Characterization of the Central and Peripheral Wavefront Aberration Profile in Pediatric Myopic Subjects | RECRUITING | This is a 3-visit, single site, observational clinical study to evaluate the characterization of the central and peripheral wavefront aberration profiles in pediatric myopic subjects. | Inclusion Criteria:
Potential subjects must satisfy all of the following criteria to be enrolled in the study:
The subject must:
1. Read or (be read to) and sign the CHILDREN'S ASSENT (information and assessment form) and receive a fully executed copy of the form.
2. Have parents or legal guardians who must read, un... | Johnson & Johnson Vision Care, Inc. | OBSERVATIONAL | null | null | null | [{'name': 'Study Contact', 'role': 'CONTACT', 'phone': '1-800-843-2020', 'email': 'NJoshi30@ITS.JNJ.com'}] |
NCT03723460 | Dietary Intake Assessment, Passive Dietary Monitoring, Malnutrition | Development of a Passive Dietary Monitoring System to Estimate an Individual's Dietary Intake in Households in Low and Middle-income Countries | RECRUITING | Currently, there is no accurate measurement of dietary intake. All current methodologies of assessing dietary intake have inaccuracy rates of 30 -70%. Accurate assessment of dietary intake is critical in understanding individual and population nutritional status and monitoring the effectiveness of public health interve... | Inclusion Criteria:
1. Household comprising of both parents (mother and father) and at least a child/children under 5 years of age and/or an adolescent child
2. Members of the household eat the same prepared meal
3. Willingness to use a camera/video recording device to capture household food preparation and consumptio... | Imperial College London | OBSERVATIONAL | null | null | PDIAS | [{'name': 'Gary Frost, PhD', 'role': 'CONTACT', 'phone': '02083838037', 'email': 'g.frost@imperial.ac.uk'}, {'name': 'Modou L Jobarteh, PhD', 'role': 'CONTACT', 'phone': '02083838037', 'email': 'm.jobarteh@imperial.ac.uk'}] |
NCT05989776 | Breast Cancer | Assessment and Improvement of Regional Information and Coordination Tools to Promote Access to Fertility Preservation | RECRUITING | The EVAPREF project aims to increase access to fertility preservation by developing an approach to improve and evaluate existing information and coordination tools developed by the Pays-de-la-Loire and Occitanie Regional Cancer networks. First, the investigators will use a qualitative, iterative, user-centered and part... | Inclusion Criteria:
* Patients over 18 and under 40 years of age treated for newly diagnosed breast cancer and receiving chemotherapy.
* People who are able to read the study information poster and the fertility preservation information brochure in French, either alone or with help from a caregiver or relative or an i... | University Paul Sabatier of Toulouse | INTERVENTIONAL | RANDOMIZED | PARALLEL | EVAPREF | [{'name': 'Marie-Anne Durand, PhD', 'role': 'CONTACT', 'phone': '0033648038356', 'email': 'marie-anne.durand@univ-tlse3.fr'}, {'name': 'Sébastien Lamy, PhD', 'role': 'CONTACT', 'phone': '0033684449479', 'email': 'lamy.sebastien@iuct-oncopole.fr'}] |
NCT05872776 | Paroxysmal Atrial Fibrillation | A Multi Center Randomized, Double Blinded, Sham Controlled, Clinical Study Aimed to Determine the Efficacy of CardiaCare™ RR2 Home-care Neuromodulation System in Reducing Atrial Fibrillation Burden and Symptoms in Paroxysmal AF Patients | RECRUITING | Paroxysmal AF subjects with a documented ECG event of AF will be recruited to the study To assess the efficacy of CardiaCare™ RR2 wearable home-care neuromodulation system in reducing AF burden and symptoms in Paroxysmal AF patients | Inclusion Criteria:
* Men and women ages 18-85 years with history of documented paroxysmal (\<7 days) atrial fibrillation
* AF Burden (% time in AF) of more than 0.5% and less than 25% as evident by a continuous 14 days ECG recording at baseline (at minimum 168 hours)
* Ability and willingness to sign an informed cons... | Ziv HealthCare Ltd. | INTERVENTIONAL | RANDOMIZED | PARALLEL | null | [{'name': 'Adi Benari, MSc', 'role': 'CONTACT', 'phone': '+972-52-3863087', 'email': 'adi.b@my-cardiacare.com'}, {'name': 'Amos Ziv', 'role': 'CONTACT', 'phone': '+972524419884', 'email': 'amos@my-cardiacare.com'}] |
NCT05536076 | Sleep Apnea, SCI/D, Hypercapnia | Effect of Hypercapnia Treatment on Respiratory Recovery After Spinal Cord Injury | RECRUITING | It is estimated that 1,275,000 people in the United States alone live with spinal cord injury, including around 100,000 Veterans with spinal cord injury, making the V.A. the largest integrated health care system in the world for spinal cord injuries injury care. New therapies are needed to prevent the morbidities and m... | Inclusion Criteria:
* Adult patients with chronic SCI/D (\>6 months post-injury)
* American Spinal Injury Association (ASIA) classification A-D who have evidence of SDB (excluding those with no evidence of a neurologic deficit based on ASIA classification)
* Able-bodied patients (without SCI/D0 who have OSA.
Exclusio... | VA Office of Research and Development | INTERVENTIONAL | NON_RANDOMIZED | PARALLEL | RECOV2SCI | [{'name': 'Abdulghani Sankari, MD PhD', 'role': 'CONTACT', 'phone': '(313) 576-1000', 'phoneExt': '63499', 'email': 'Abdulghani.Sankari@va.gov'}] |
NCT04307576 | Leukemia, Acute Lymphoblastic | ALLTogether1 - A Treatment Study Protocol of the ALLTogether Consortium for Children and Young Adults (0-45 Years of Age) With Newly Diagnosed Acute Lymphoblastic Leukaemia (ALL) | RECRUITING | ALLTogether collects the experience of previously successful treatment of infants, children and young adults, with ALL from a number of well-renowned study groups into a new master protocol, which is both a comprehensive system for stratification and treatment of ALL in this age-group as well as the basis for several r... | Inclusion Criteria:
* Patients newly diagnosed with T-lymphoblastic (T-cell) or B-lymphoblastic precursor (BCP) leukaemia (ALL) according to the WHO-classification of Tumours of Haematopoetic and Lymphoid Tissues (Revised 4th edition 2017) and with a diagnosis confirmed by an accredited laboratory at a participating p... | Mats Heyman | INTERVENTIONAL | RANDOMIZED | SEQUENTIAL | null | [{'name': 'Global Clinical Trial Manager ALLTogether1', 'role': 'CONTACT', 'phone': '+46 8 524 800 00', 'email': 'karin.flood@ki.se'}] |
NCT04815876 | Infection | Randomized Trial Comparing Transperineal vs. Transrectal MRI-targeted Prostate Biopsy; Randomized Controlled Trial Assessing Transperineal Prostate Biopsy to Reduce Infection Complications | RECRUITING | Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora. Preliminary data demonstrates that a transperineal MRI-targeted biopsy approach under local anesthesia compared to the st... | Inclusion Criteria:
* Active surveillance cohort: History of Grade Group 1 prostate cancer, first diagnosed ≤24 months prior to date of planned confirmatory biopsy and diagnostic biopsy was preceded by a multiparametric MRI of the prostate
* Prior negative cohort: Clinical concern for the presence of prostate cancer a... | Weill Medical College of Cornell University | INTERVENTIONAL | RANDOMIZED | PARALLEL | PREVENT2 | [{'name': 'Dianis Rivera, BS', 'role': 'CONTACT', 'phone': '212.746.1496', 'email': 'dir4010@med.cornell.edu'}, {'name': 'Xiaohong Jing, PhD', 'role': 'CONTACT', 'phone': '212-746-4739', 'email': 'xij2004@med.cornell.edu'}] |
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