Datasets:

paulhub1
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sarms-pharmacokinetics

compound_name stringlengths 3 12	alias stringlengths 4 20	compound_class stringclasses 6 values	primary_receptor stringclasses 5 values	secondary_targets stringclasses 10 values	mechanism_of_action stringlengths 17 44	half_life_hours int64 4 60	bioavailability stringclasses 3 values	metabolism_pathway stringclasses 2 values	primary_tissue_selectivity stringclasses 8 values	hpt_axis_suppression stringclasses 3 values	potential_hepatotoxicity stringclasses 3 values	lipid_impact stringclasses 7 values	water_retention stringclasses 1 value	aromatization_status stringclasses 2 values	estrogenic_activity stringclasses 3 values	androgenic_activity stringclasses 2 values	solubility stringclasses 3 values	logp float64 2.3 4.5	purity_percent float64 98.7 99.5	analytical_methods stringclasses 1 value	status stringclasses 2 values	regulatory_classification stringclasses 3 values
Ostarine	MK-2866	SARM	Androgen Receptor	IGF-1 Pathway	Selective androgen receptor modulation	24	High	Hepatic via CYP3A4	Muscle and Bone	Low	Low	Moderate reduction	Low	Non-aromatizing	Minimal	Moderate	Poor aqueous solubility	3.1	99.2	HPLC MS NMR	Research Only	Unapproved Research Chemical
RAD-140	Testolone	SARM	Androgen Receptor	Neuroprotective pathways	High affinity AR agonist	60	High	Hepatic	Muscle Dominant	Moderate	Moderate	Negative HDL impact	Low	Non-aromatizing	null	High	Poor aqueous solubility	4	99.1	HPLC MS NMR	Research Only	Unapproved Research Chemical
LGD-4033	Ligandrol	SARM	Androgen Receptor	Osteogenic pathways	Potent AR agonist	30	High	Hepatic	Muscle and Bone	Moderate	Low	Negative HDL impact	Low	Non-aromatizing	null	High	Poor aqueous solubility	3.5	99.3	HPLC MS NMR	Research Only	Unapproved Research Chemical
YK-11	YK-11	SARM/Myostatin Modulator	Androgen Receptor	Myostatin inhibition	Partial AR agonism and myostatin suppression	10	Moderate	Hepatic	Muscle	Moderate	Unknown	Unknown	Low	Non-aromatizing	null	Moderate	Poor aqueous solubility	3.7	98.9	HPLC MS NMR	Research Only	Unapproved Research Chemical
S-23	S-23	SARM	Androgen Receptor	HPG Axis	High potency AR agonist	12	High	Hepatic	Muscle Dominant	High	Moderate	Negative HDL impact	Low	Non-aromatizing	null	High	Poor aqueous solubility	4.2	99	HPLC MS NMR	Research Only	Unapproved Research Chemical
ACP-105	ACP-105	SARM	Androgen Receptor	CNS pathways	Neuroactive AR modulation	7	Moderate	Hepatic	Muscle and CNS	Low	Low	Minimal lipid impact	Low	Non-aromatizing	null	Moderate	Poor aqueous solubility	3	98.8	HPLC MS NMR	Research Only	Unapproved Research Chemical
S-4	Andarine	SARM	Androgen Receptor	Prostate tissue	Partial AR agonist	4	Moderate	Hepatic	Muscle and Prostate	Moderate	Low	Moderate lipid impact	Low	Non-aromatizing	null	Moderate	Poor aqueous solubility	3.2	99.1	HPLC MS NMR	Research Only	Unapproved Research Chemical
GW-501516	Cardarine	PPARδ Agonist	PPAR-Delta	Metabolic gene regulators	Metabolic transcription activation	24	High	Hepatic	Muscle and Fat	null	Moderate	Positive lipid modulation	null	Non-aromatizing	null	null	Poor aqueous solubility	4.5	99.2	HPLC MS NMR	Research Only	Unapproved Research Chemical
SR-9009	Stenabolic	REV-ERB Agonist	REV-ERBα	Clock genes	Circadian rhythm modulation	4	Low	Hepatic	Muscle and Liver	null	Low	Positive lipid modulation	null	Non-aromatizing	null	null	Poor aqueous solubility	3.8	98.7	HPLC MS NMR	Research Only	Unapproved Research Chemical
MK-677	Ibutamoren	Ghrelin Mimetic	Growth Hormone Receptor	IGF-1 Axis	GH secretagogue activation	24	High	Hepatic	Systemic	null	Low	Neutral	null	Non-aromatizing	null	null	Good aqueous solubility	2.9	99.4	HPLC MS NMR	Research Only	Unapproved Research Chemical
Enclomiphene	Enclomiphene Citrate	SERM	Estrogen Receptor	HPG Axis	Estrogen antagonism with LH/FSH elevation	10	High	Hepatic	Systemic	null	Low	Neutral	null	Non-aromatizing	Anti-estrogenic	null	Moderate aqueous solubility	2.5	99.5	HPLC MS NMR	Research Only	Prescription Drug (Off-label Research)
Clomiphene	Clomid	SERM	Estrogen Receptor	HPG Axis	Mixed estrogen agonist/antagonist	5	High	Hepatic	Systemic	null	Moderate	Neutral	null	Partial aromatization	Mixed	null	Good aqueous solubility	2.3	99	HPLC MS NMR	Prescription	Prescription Drug